PT1572641E - Processo para a preparação do estereoisómero de glicopirrónio de configuração r,r (ou s,s) - Google Patents
Processo para a preparação do estereoisómero de glicopirrónio de configuração r,r (ou s,s) Download PDFInfo
- Publication number
- PT1572641E PT1572641E PT03782435T PT03782435T PT1572641E PT 1572641 E PT1572641 E PT 1572641E PT 03782435 T PT03782435 T PT 03782435T PT 03782435 T PT03782435 T PT 03782435T PT 1572641 E PT1572641 E PT 1572641E
- Authority
- PT
- Portugal
- Prior art keywords
- formula
- diastereomers
- isomer
- mixtures
- quaternization
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/06—Anti-spasmodics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0189602A AT412088B (de) | 2002-12-18 | 2002-12-18 | Verfahren zur herstellung der r,r oder s,s konfigurierten glycopyrronium-isomere |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1572641E true PT1572641E (pt) | 2012-06-15 |
Family
ID=31192804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT03782435T PT1572641E (pt) | 2002-12-18 | 2003-12-18 | Processo para a preparação do estereoisómero de glicopirrónio de configuração r,r (ou s,s) |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7569598B2 (enExample) |
| EP (1) | EP1572641B1 (enExample) |
| JP (1) | JP2007524565A (enExample) |
| CN (1) | CN100349867C (enExample) |
| AT (2) | AT412088B (enExample) |
| AU (1) | AU2003290075B2 (enExample) |
| CA (1) | CA2510280C (enExample) |
| DK (1) | DK1572641T3 (enExample) |
| ES (1) | ES2383799T3 (enExample) |
| NO (1) | NO330851B1 (enExample) |
| NZ (1) | NZ541098A (enExample) |
| PL (1) | PL214802B1 (enExample) |
| PT (1) | PT1572641E (enExample) |
| RU (1) | RU2337096C2 (enExample) |
| WO (1) | WO2004054971A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0504463D0 (en) | 2005-03-03 | 2005-04-13 | Arakis Ltd | Method of crystallisation and purification |
| JP5902612B2 (ja) * | 2009-04-09 | 2016-04-13 | ノバルティス アーゲー | ピロリジニウム塩の調製方法 |
| WO2011157387A1 (en) * | 2010-06-14 | 2011-12-22 | Chiesi Farmaceutici S.P.A. | Crystal form of glycopyrronium chloride |
| CN103159659A (zh) * | 2011-12-19 | 2013-06-19 | 沈阳药科大学 | 一种毒蕈碱受体拮抗剂格隆溴铵的制备方法 |
| DK2607351T3 (en) * | 2011-12-22 | 2017-06-06 | Cerbios-Pharma S A | CONTINUOUS PROCEDURE FOR ALKYLICATION OF CYCLIC TERTIARY AMINES |
| CN102627595A (zh) * | 2012-03-09 | 2012-08-08 | 徐奎 | 一种制备格隆溴铵的方法 |
| US8558008B2 (en) | 2013-02-28 | 2013-10-15 | Dermira, Inc. | Crystalline glycopyrrolate tosylate |
| KR20150119468A (ko) | 2013-02-28 | 2015-10-23 | 더미라, 인코포레이티드 | 글리코피롤레이트 염 |
| US9006462B2 (en) | 2013-02-28 | 2015-04-14 | Dermira, Inc. | Glycopyrrolate salts |
| CN104586841A (zh) * | 2013-10-30 | 2015-05-06 | 中国药科大学 | (3r,2’r)-格隆溴铵作为m3毒蕈碱性受体拮抗剂在制药中的用途 |
| CN107304178B (zh) * | 2016-04-21 | 2020-03-27 | 辽宁药联制药有限公司 | 一种毒蕈碱受体拮抗剂格隆溴铵手性对映体的制备方法 |
| CN107345945B (zh) * | 2016-05-05 | 2019-12-17 | 辽宁药联制药有限公司 | 一种拆分格隆溴铵对映体及杂质检查的高效液相色谱方法 |
| CN113234003B (zh) * | 2021-04-23 | 2024-02-02 | 广东嘉博制药有限公司 | 一种格隆溴铵及其制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ336202A (en) * | 1996-11-11 | 2000-10-27 | Christian R Noe | Pure enantiomer aryl-cycloalkyl-hydroxycarboxylic acid esters and use in treating smooth muscle spasms and respiritory diseases |
-
2002
- 2002-12-18 AT AT0189602A patent/AT412088B/de not_active IP Right Cessation
-
2003
- 2003-12-18 CA CA2510280A patent/CA2510280C/en not_active Expired - Fee Related
- 2003-12-18 EP EP03782435A patent/EP1572641B1/de not_active Expired - Lifetime
- 2003-12-18 RU RU2005122497/04A patent/RU2337096C2/ru active
- 2003-12-18 AU AU2003290075A patent/AU2003290075B2/en not_active Ceased
- 2003-12-18 CN CNB2003801098187A patent/CN100349867C/zh not_active Expired - Fee Related
- 2003-12-18 WO PCT/EP2003/014432 patent/WO2004054971A1/de not_active Ceased
- 2003-12-18 US US10/540,187 patent/US7569598B2/en not_active Expired - Lifetime
- 2003-12-18 NZ NZ541098A patent/NZ541098A/en not_active IP Right Cessation
- 2003-12-18 DK DK03782435.6T patent/DK1572641T3/da active
- 2003-12-18 PT PT03782435T patent/PT1572641E/pt unknown
- 2003-12-18 PL PL377441A patent/PL214802B1/pl unknown
- 2003-12-18 AT AT03782435T patent/ATE548348T1/de active
- 2003-12-18 JP JP2004560470A patent/JP2007524565A/ja active Pending
- 2003-12-18 ES ES03782435T patent/ES2383799T3/es not_active Expired - Lifetime
-
2005
- 2005-07-15 NO NO20053473A patent/NO330851B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ541098A (en) | 2008-08-29 |
| RU2337096C2 (ru) | 2008-10-27 |
| CN100349867C (zh) | 2007-11-21 |
| ATA18962002A (de) | 2004-02-15 |
| PL214802B1 (pl) | 2013-09-30 |
| US20060167275A1 (en) | 2006-07-27 |
| ES2383799T3 (es) | 2012-06-26 |
| AT412088B (de) | 2004-09-27 |
| EP1572641B1 (de) | 2012-03-07 |
| JP2007524565A (ja) | 2007-08-30 |
| WO2004054971A1 (de) | 2004-07-01 |
| NO330851B1 (no) | 2011-08-01 |
| CA2510280C (en) | 2011-09-27 |
| CN1751022A (zh) | 2006-03-22 |
| AU2003290075B2 (en) | 2009-01-29 |
| EP1572641A1 (de) | 2005-09-14 |
| PL377441A1 (pl) | 2006-02-06 |
| AU2003290075A1 (en) | 2004-07-09 |
| CA2510280A1 (en) | 2004-07-01 |
| US7569598B2 (en) | 2009-08-04 |
| NO20053473L (no) | 2005-09-19 |
| ATE548348T1 (de) | 2012-03-15 |
| DK1572641T3 (da) | 2012-07-02 |
| RU2005122497A (ru) | 2006-01-20 |
| NO20053473D0 (no) | 2005-07-15 |
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