PL377441A1 - Sposób wytwarzania stereoizomeru glikopironiowego o konfiguracji R,R (lub S,S) - Google Patents

Sposób wytwarzania stereoizomeru glikopironiowego o konfiguracji R,R (lub S,S)

Info

Publication number
PL377441A1
PL377441A1 PL377441A PL37744103A PL377441A1 PL 377441 A1 PL377441 A1 PL 377441A1 PL 377441 A PL377441 A PL 377441A PL 37744103 A PL37744103 A PL 37744103A PL 377441 A1 PL377441 A1 PL 377441A1
Authority
PL
Poland
Prior art keywords
glycopyrronium
configuration
stereoisomers
production
enriching
Prior art date
Application number
PL377441A
Other languages
English (en)
Other versions
PL214802B1 (pl
Inventor
Christian R. Noe
Martin R. Walter
Original Assignee
Pharmacon Forschung Und Beratung G.M.B.H.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacon Forschung Und Beratung G.M.B.H. filed Critical Pharmacon Forschung Und Beratung G.M.B.H.
Publication of PL377441A1 publication Critical patent/PL377441A1/pl
Publication of PL214802B1 publication Critical patent/PL214802B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/06—Anti-spasmodics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Wynalazek dotyczy nowych sposobu wzbogacania R, R (lub (S, S) skonfigurowanego stereoizomeru glikopironiowego i jego pochodnych tienylowych o konfiguracji R, S lub S,R.
PL377441A 2002-12-18 2003-12-18 Sposób wytwarzania stereoizomeru glikopironiowego PL214802B1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0189602A AT412088B (de) 2002-12-18 2002-12-18 Verfahren zur herstellung der r,r oder s,s konfigurierten glycopyrronium-isomere

Publications (2)

Publication Number Publication Date
PL377441A1 true PL377441A1 (pl) 2006-02-06
PL214802B1 PL214802B1 (pl) 2013-09-30

Family

ID=31192804

Family Applications (1)

Application Number Title Priority Date Filing Date
PL377441A PL214802B1 (pl) 2002-12-18 2003-12-18 Sposób wytwarzania stereoizomeru glikopironiowego

Country Status (15)

Country Link
US (1) US7569598B2 (pl)
EP (1) EP1572641B1 (pl)
JP (1) JP2007524565A (pl)
CN (1) CN100349867C (pl)
AT (2) AT412088B (pl)
AU (1) AU2003290075B2 (pl)
CA (1) CA2510280C (pl)
DK (1) DK1572641T3 (pl)
ES (1) ES2383799T3 (pl)
NO (1) NO330851B1 (pl)
NZ (1) NZ541098A (pl)
PL (1) PL214802B1 (pl)
PT (1) PT1572641E (pl)
RU (1) RU2337096C2 (pl)
WO (1) WO2004054971A1 (pl)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0504463D0 (en) * 2005-03-03 2005-04-13 Arakis Ltd Method of crystallisation and purification
MX344153B (es) * 2009-04-09 2016-12-07 Novartis Ag Proceso para la preparación de sales de pirrolidinio.
EP2580195B1 (en) * 2010-06-14 2014-12-03 Chiesi Farmaceutici S.p.A. Crystal form of glycopyrronium chloride
CN103159659A (zh) * 2011-12-19 2013-06-19 沈阳药科大学 一种毒蕈碱受体拮抗剂格隆溴铵的制备方法
RS55996B1 (sr) * 2011-12-22 2017-09-29 Cerbios-Pharma S A Kontinuirani postupak za alkilaciju cikličnih tercijarnih amina
CN102627595A (zh) * 2012-03-09 2012-08-08 徐奎 一种制备格隆溴铵的方法
US9006462B2 (en) 2013-02-28 2015-04-14 Dermira, Inc. Glycopyrrolate salts
KR20160081989A (ko) 2013-02-28 2016-07-08 더미라, 인코포레이티드 글리코피롤레이트 염
US8558008B2 (en) 2013-02-28 2013-10-15 Dermira, Inc. Crystalline glycopyrrolate tosylate
CN104586841A (zh) * 2013-10-30 2015-05-06 中国药科大学 (3r,2’r)-格隆溴铵作为m3毒蕈碱性受体拮抗剂在制药中的用途
CN107304178B (zh) * 2016-04-21 2020-03-27 辽宁药联制药有限公司 一种毒蕈碱受体拮抗剂格隆溴铵手性对映体的制备方法
CN107345945B (zh) * 2016-05-05 2019-12-17 辽宁药联制药有限公司 一种拆分格隆溴铵对映体及杂质检查的高效液相色谱方法
CN113234003B (zh) * 2021-04-23 2024-02-02 广东嘉博制药有限公司 一种格隆溴铵及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE238280T1 (de) * 1996-11-11 2003-05-15 Christian R Noe Verwendung eines pharmazeutisch geeigneten salzes von (3r,2'r)-3-((cyclopentyl- hydroxyphenylacetyl)oxy)-1,1-dimethyl- pyrrolidinium zur herstellung eines arzneimittels

Also Published As

Publication number Publication date
CA2510280C (en) 2011-09-27
NZ541098A (en) 2008-08-29
PT1572641E (pt) 2012-06-15
US7569598B2 (en) 2009-08-04
ATA18962002A (de) 2004-02-15
DK1572641T3 (da) 2012-07-02
EP1572641A1 (de) 2005-09-14
ATE548348T1 (de) 2012-03-15
WO2004054971A1 (de) 2004-07-01
CN100349867C (zh) 2007-11-21
AT412088B (de) 2004-09-27
ES2383799T3 (es) 2012-06-26
NO330851B1 (no) 2011-08-01
JP2007524565A (ja) 2007-08-30
NO20053473D0 (no) 2005-07-15
EP1572641B1 (de) 2012-03-07
CA2510280A1 (en) 2004-07-01
NO20053473L (no) 2005-09-19
AU2003290075A1 (en) 2004-07-09
PL214802B1 (pl) 2013-09-30
US20060167275A1 (en) 2006-07-27
CN1751022A (zh) 2006-03-22
AU2003290075B2 (en) 2009-01-29
RU2005122497A (ru) 2006-01-20
RU2337096C2 (ru) 2008-10-27

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