JP2007524565A - Ｒ，ｒ（又はｓ，ｓ）配置されたグリコピロニウム−立体異性体の製造方法 - Google Patents

Ｒ，ｒ（又はｓ，ｓ）配置されたグリコピロニウム−立体異性体の製造方法 Download PDF

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Publication number
JP2007524565A
JP2007524565A JP2004560470A JP2004560470A JP2007524565A JP 2007524565 A JP2007524565 A JP 2007524565A JP 2004560470 A JP2004560470 A JP 2004560470A JP 2004560470 A JP2004560470 A JP 2004560470A JP 2007524565 A JP2007524565 A JP 2007524565A
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solvent
formula
diastereomeric mixture
isomers
diastereomeric
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Japanese (ja)
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JP2007524565A5 (enExample
Inventor
ノエ・クリスチャン・エル
ヴァルター・マルティン・エル
Original Assignee
ファルマコン・フォルシュング・ウント・ベラートゥング・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング
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Publication of JP2007524565A publication Critical patent/JP2007524565A/ja
Publication of JP2007524565A5 publication Critical patent/JP2007524565A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/06—Anti-spasmodics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
JP2004560470A 2002-12-18 2003-12-18 Ｒ，ｒ（又はｓ，ｓ）配置されたグリコピロニウム−立体異性体の製造方法 Pending JP2007524565A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0189602A AT412088B (de) 2002-12-18 2002-12-18 Verfahren zur herstellung der r,r oder s,s konfigurierten glycopyrronium-isomere
PCT/EP2003/014432 WO2004054971A1 (de) 2002-12-18 2003-12-18 Verfaren zur herstellung des r,r (oder s,s) konfugurierten glycopyrronium-stereoisomers

Publications (2)

Publication Number Publication Date
JP2007524565A true JP2007524565A (ja) 2007-08-30
JP2007524565A5 JP2007524565A5 (enExample) 2010-09-16

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ID=31192804

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JP2004560470A Pending JP2007524565A (ja) 2002-12-18 2003-12-18 Ｒ，ｒ（又はｓ，ｓ）配置されたグリコピロニウム−立体異性体の製造方法

Country Status (15)

Country Link
US (1) US7569598B2 (enExample)
EP (1) EP1572641B1 (enExample)
JP (1) JP2007524565A (enExample)
CN (1) CN100349867C (enExample)
AT (2) AT412088B (enExample)
AU (1) AU2003290075B2 (enExample)
CA (1) CA2510280C (enExample)
DK (1) DK1572641T3 (enExample)
ES (1) ES2383799T3 (enExample)
NO (1) NO330851B1 (enExample)
NZ (1) NZ541098A (enExample)
PL (1) PL214802B1 (enExample)
PT (1) PT1572641E (enExample)
RU (1) RU2337096C2 (enExample)
WO (1) WO2004054971A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012523390A (ja) * 2009-04-09 2012-10-04 ノバルティス アーゲー ピロリジニウム塩の調製方法
JP2013133335A (ja) * 2011-12-22 2013-07-08 Cerbios - Pharma Sa 環式第３級アミンをアルキル化するための連続方法

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0504463D0 (en) 2005-03-03 2005-04-13 Arakis Ltd Method of crystallisation and purification
WO2011157387A1 (en) * 2010-06-14 2011-12-22 Chiesi Farmaceutici S.P.A. Crystal form of glycopyrronium chloride
CN103159659A (zh) * 2011-12-19 2013-06-19 沈阳药科大学 一种毒蕈碱受体拮抗剂格隆溴铵的制备方法
CN102627595A (zh) * 2012-03-09 2012-08-08 徐奎 一种制备格隆溴铵的方法
US8558008B2 (en) 2013-02-28 2013-10-15 Dermira, Inc. Crystalline glycopyrrolate tosylate
KR20150119468A (ko) 2013-02-28 2015-10-23 더미라, 인코포레이티드 글리코피롤레이트 염
US9006462B2 (en) 2013-02-28 2015-04-14 Dermira, Inc. Glycopyrrolate salts
CN104586841A (zh) * 2013-10-30 2015-05-06 中国药科大学 (3r,2’r)-格隆溴铵作为m3毒蕈碱性受体拮抗剂在制药中的用途
CN107304178B (zh) * 2016-04-21 2020-03-27 辽宁药联制药有限公司 一种毒蕈碱受体拮抗剂格隆溴铵手性对映体的制备方法
CN107345945B (zh) * 2016-05-05 2019-12-17 辽宁药联制药有限公司 一种拆分格隆溴铵对映体及杂质检查的高效液相色谱方法
CN113234003B (zh) * 2021-04-23 2024-02-02 广东嘉博制药有限公司 一种格隆溴铵及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001504459A (ja) * 1996-11-11 2001-04-03 ノエ・クリスティアン・エル 対掌体純粋な、塩基性アリール―シクロアルキル―ヒドロキシカルボン酸エステル、その製造方法及びこれを薬剤に使用する方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001504459A (ja) * 1996-11-11 2001-04-03 ノエ・クリスティアン・エル 対掌体純粋な、塩基性アリール―シクロアルキル―ヒドロキシカルボン酸エステル、その製造方法及びこれを薬剤に使用する方法

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012523390A (ja) * 2009-04-09 2012-10-04 ノバルティス アーゲー ピロリジニウム塩の調製方法
JP2015007081A (ja) * 2009-04-09 2015-01-15 ノバルティス アーゲー ピロリジニウム塩の調製方法
JP2013133335A (ja) * 2011-12-22 2013-07-08 Cerbios - Pharma Sa 環式第３級アミンをアルキル化するための連続方法

Also Published As

Publication number Publication date
NZ541098A (en) 2008-08-29
RU2337096C2 (ru) 2008-10-27
CN100349867C (zh) 2007-11-21
ATA18962002A (de) 2004-02-15
PL214802B1 (pl) 2013-09-30
PT1572641E (pt) 2012-06-15
US20060167275A1 (en) 2006-07-27
ES2383799T3 (es) 2012-06-26
AT412088B (de) 2004-09-27
EP1572641B1 (de) 2012-03-07
WO2004054971A1 (de) 2004-07-01
NO330851B1 (no) 2011-08-01
CA2510280C (en) 2011-09-27
CN1751022A (zh) 2006-03-22
AU2003290075B2 (en) 2009-01-29
EP1572641A1 (de) 2005-09-14
PL377441A1 (pl) 2006-02-06
AU2003290075A1 (en) 2004-07-09
CA2510280A1 (en) 2004-07-01
US7569598B2 (en) 2009-08-04
NO20053473L (no) 2005-09-19
ATE548348T1 (de) 2012-03-15
DK1572641T3 (da) 2012-07-02
RU2005122497A (ru) 2006-01-20
NO20053473D0 (no) 2005-07-15

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