CN100345850C - 3－苯基取代的吡啶并吲哚酮,其制备和治疗用途 - Google Patents

3－苯基取代的吡啶并吲哚酮,其制备和治疗用途 Download PDF

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Publication number
CN100345850C
CN100345850C CNB2003801072280A CN200380107228A CN100345850C CN 100345850 C CN100345850 C CN 100345850C CN B2003801072280 A CNB2003801072280 A CN B2003801072280A CN 200380107228 A CN200380107228 A CN 200380107228A CN 100345850 C CN100345850 C CN 100345850C
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China
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group
methyl
compound
phenyl
amino
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Expired - Fee Related
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CNB2003801072280A
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English (en)
Chinese (zh)
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CN1729190A (zh
Inventor
B·宝利
P·卡塞拉斯
P·恰佩蒂
J－M·德洛寇
S·杰格汉姆
Y·穆涅奥克斯
C－G·韦穆特
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Sanofi Aventis France
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Sanofi Aventis France
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNB2003801072280A 2002-10-23 2003-10-21 3－苯基取代的吡啶并吲哚酮,其制备和治疗用途 Expired - Fee Related CN100345850C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR02/13264 2002-10-23
FR0213264A FR2846329B1 (fr) 2002-10-23 2002-10-23 Derives de pyridoindolone substitues en -3 par un phenyle, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
CN1729190A CN1729190A (zh) 2006-02-01
CN100345850C true CN100345850C (zh) 2007-10-31

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CNB2003801072280A Expired - Fee Related CN100345850C (zh) 2002-10-23 2003-10-21 3－苯基取代的吡啶并吲哚酮,其制备和治疗用途

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US (2) US7390818B2 (enExample)
EP (1) EP1556382B1 (enExample)
JP (1) JP4488899B2 (enExample)
KR (1) KR101051859B1 (enExample)
CN (1) CN100345850C (enExample)
AR (1) AR041689A1 (enExample)
AT (1) ATE396994T1 (enExample)
AU (1) AU2003296769B2 (enExample)
BR (1) BR0314883A (enExample)
CA (1) CA2502769C (enExample)
CY (1) CY1109785T1 (enExample)
DE (1) DE60321372D1 (enExample)
DK (1) DK1556382T3 (enExample)
EA (1) EA010833B1 (enExample)
ES (1) ES2304546T3 (enExample)
FR (1) FR2846329B1 (enExample)
HR (1) HRP20050362B1 (enExample)
IL (1) IL168133A (enExample)
IS (1) IS2641B (enExample)
MA (1) MA27455A1 (enExample)
ME (1) ME00102B (enExample)
MX (1) MXPA05004349A (enExample)
NO (1) NO331297B1 (enExample)
NZ (1) NZ539866A (enExample)
PL (1) PL214867B1 (enExample)
PT (1) PT1556382E (enExample)
RS (1) RS51605B (enExample)
SI (1) SI1556382T1 (enExample)
TW (1) TWI325864B (enExample)
UA (1) UA79317C2 (enExample)
WO (1) WO2004041817A1 (enExample)
ZA (1) ZA200503231B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020156453A1 (zh) * 2019-02-01 2020-08-06 南京明德新药研发有限公司 作为c-Met抑制剂的含嘧啶基团的三并环类化合物
KR20220054335A (ko) * 2020-02-28 2022-05-02 후아웨이 테크놀러지 컴퍼니 리미티드 데이터 전송 방법 및 장치, 게이트웨이, 칩 및 저장 매체

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2823975B1 (fr) 2001-04-27 2003-05-30 Sanofi Synthelabo Nouvelle utilisation de pyridoindolone
US7456193B2 (en) 2002-10-23 2008-11-25 Sanofi-Aventis Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics
US20100297252A1 (en) 2003-03-03 2010-11-25 Elan Pharma International Ltd. Nanoparticulate meloxicam formulations
US8512727B2 (en) * 2003-03-03 2013-08-20 Alkermes Pharma Ireland Limited Nanoparticulate meloxicam formulations
FR2869316B1 (fr) * 2004-04-21 2006-06-02 Sanofi Synthelabo Derives de pyridoindolone substitues en -6, leur preparation et leur application en therapeutique.
FR2876377B1 (fr) * 2004-10-11 2007-03-16 Univ Claude Bernard Lyon Nouveaux derives de 9h-pyrido[2,3-b]indole, leur procede de preparation, ainsi que les compositions pharmaceutiques contenant de tels composes
FR2892416B1 (fr) * 2005-10-20 2008-06-27 Sanofi Aventis Sa Derives de 6-heteroarylpyridoindolone, leur preparation et leur application en therapeutique
FR2945950A1 (fr) 2009-05-27 2010-12-03 Elan Pharma Int Ltd Compositions de nanoparticules anticancereuses et procedes pour les preparer
FR2959133A1 (fr) 2010-04-22 2011-10-28 Sanofi Aventis Formulation pharmaceutique anticancereuse
HUE032426T2 (en) 2009-05-27 2017-09-28 Alkermes Pharma Ireland Ltd Inhibition of flake aggregation in nanoparticulate meloxicam formulations
CN107459481A (zh) * 2017-07-25 2017-12-12 广州大学 一种3‑（4‑甲氧基苯基）‑6‑甲氧基‑4‑氯‑5,7‑二溴喹啉的合成方法
CN116171156B (zh) * 2020-07-31 2025-07-04 江苏奥赛康药业有限公司 含嘧啶基团的三并环类化合物的盐型、晶型及其制备方法
US20240132446A1 (en) * 2021-05-26 2024-04-25 Refined Technologies, Inc. Compositions and methods for removal of n-methyl-2-pyrrolidone (nmp) degradation products and other foulants from nmp purification systems

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2765581A1 (fr) * 1997-07-03 1999-01-08 Synthelabo Derives de 3-aryl-1,9-dihydro-2h-pyrido[2,3-b]indol-2-one, leur preparation et leur application en therapeutique
US5880126A (en) * 1995-01-23 1999-03-09 Schering Aktiengesellschaft 9H-Pyridu ((3,4-b) indole derivatives
WO2001009129A2 (en) * 1999-08-03 2001-02-08 Novuspharma S.P.A. 1h-pirido[3, 4-b]indol-1-one derivatives

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1268772A (en) 1968-03-15 1972-03-29 Glaxo Lab Ltd NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME
US4263304A (en) * 1978-06-05 1981-04-21 Sumitomo Chemical Company, Limited 7 H-indolo[2,3-c]isoquinolines
SU833971A1 (ru) 1979-07-10 1981-05-30 Ленинградский Химико-Фармацевтическийинститут Способ получени 3-фенил-2-оксо- - КАРбОлиНОВ
FR2595701B1 (fr) * 1986-03-17 1988-07-01 Sanofi Sa Derives du pyrido-indole, leur application a titre de medicaments et les compositions les renfermant
JPH10501686A (ja) 1994-04-13 1998-02-17 ザ ロックフェラー ユニヴァーシティ 神経系の細胞へのｄｎａのａａｖ仲介送達
FR2765582B1 (fr) 1997-07-03 1999-08-06 Synthelabo Derives de 3-alkyl-1,9-dihydro-2h-pyrido[2,3-b]indol-2-one leur preparation et leur application en therapeutique
CA2326319A1 (en) 1998-04-02 1999-10-14 Neurogen Corporation Aminoalkyl substituted 5,6,7,8-tetrahydro-9h pyrimidino[2,3-b]indole and 5,6,7,8-tetrahydro-9h-pyrimidino[4,5-b]indole derivatives: crf1 specific ligands
US20020156016A1 (en) 2001-03-30 2002-10-24 Gerald Minuk Control of cell growth by altering cell membrane potentials
FR2823975B1 (fr) * 2001-04-27 2003-05-30 Sanofi Synthelabo Nouvelle utilisation de pyridoindolone
FR2846330B1 (fr) 2002-10-23 2004-12-03 Sanofi Synthelabo Derives de pyridoindolone substitues en -3 par groupe heterocyclique, leur preparation et leur application en therapeutique
US7456193B2 (en) * 2002-10-23 2008-11-25 Sanofi-Aventis Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics
FR2869316B1 (fr) 2004-04-21 2006-06-02 Sanofi Synthelabo Derives de pyridoindolone substitues en -6, leur preparation et leur application en therapeutique.
FR2892416B1 (fr) 2005-10-20 2008-06-27 Sanofi Aventis Sa Derives de 6-heteroarylpyridoindolone, leur preparation et leur application en therapeutique

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5880126A (en) * 1995-01-23 1999-03-09 Schering Aktiengesellschaft 9H-Pyridu ((3,4-b) indole derivatives
FR2765581A1 (fr) * 1997-07-03 1999-01-08 Synthelabo Derives de 3-aryl-1,9-dihydro-2h-pyrido[2,3-b]indol-2-one, leur preparation et leur application en therapeutique
WO2001009129A2 (en) * 1999-08-03 2001-02-08 Novuspharma S.P.A. 1h-pirido[3, 4-b]indol-1-one derivatives

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020156453A1 (zh) * 2019-02-01 2020-08-06 南京明德新药研发有限公司 作为c-Met抑制剂的含嘧啶基团的三并环类化合物
CN113365997A (zh) * 2019-02-01 2021-09-07 南京明德新药研发有限公司 作为c-Met抑制剂的含嘧啶基团的三并环类化合物
KR20210123360A (ko) * 2019-02-01 2021-10-13 메드샤인 디스커버리 아이엔씨. c-Met억제제로서 피리미디닐기를 포함하는 삼환식 화합물
CN113365997B (zh) * 2019-02-01 2022-06-07 南京明德新药研发有限公司 作为c-Met抑制剂的含嘧啶基团的三并环类化合物
US12122780B2 (en) 2019-02-01 2024-10-22 Jiangsu Aosaikang Pharmaceutical Co., Ltd. Pyrimidinyl group-containing tricyclic compound serving as c-Met inhibitor
KR20220054335A (ko) * 2020-02-28 2022-05-02 후아웨이 테크놀러지 컴퍼니 리미티드 데이터 전송 방법 및 장치, 게이트웨이, 칩 및 저장 매체
US11916803B2 (en) 2020-02-28 2024-02-27 Huawei Technologies Co., Ltd. Data transmission method and apparatus, gateway, chip, and storage medium

Also Published As

Publication number Publication date
DK1556382T3 (da) 2008-10-06
NZ539866A (en) 2008-01-31
BR0314883A (pt) 2005-08-02
NO20051983L (no) 2005-07-22
EA010833B1 (ru) 2008-12-30
UA79317C2 (en) 2007-06-11
FR2846329B1 (fr) 2004-12-03
IS7815A (is) 2005-04-20
ATE396994T1 (de) 2008-06-15
US20080214538A1 (en) 2008-09-04
DE60321372D1 (de) 2008-07-10
MA27455A1 (fr) 2005-07-01
PL214867B1 (pl) 2013-09-30
ES2304546T3 (es) 2008-10-16
ZA200503231B (en) 2006-06-28
ME00102B (me) 2010-10-10
EP1556382B1 (fr) 2008-05-28
CA2502769C (en) 2011-03-15
EP1556382A1 (fr) 2005-07-27
AR041689A1 (es) 2005-05-26
PL376790A1 (pl) 2006-01-09
MEP22208A (en) 2010-06-10
NO20051983D0 (no) 2005-04-22
NO331297B1 (no) 2011-11-21
EA200500521A1 (ru) 2005-12-29
WO2004041817A1 (fr) 2004-05-21
SI1556382T1 (sl) 2008-10-31
US7390818B2 (en) 2008-06-24
CA2502769A1 (en) 2004-05-21
CN1729190A (zh) 2006-02-01
JP2006511498A (ja) 2006-04-06
FR2846329A1 (fr) 2004-04-30
IS2641B (is) 2010-08-15
KR101051859B1 (ko) 2011-07-25
US20050288318A1 (en) 2005-12-29
JP4488899B2 (ja) 2010-06-23
HK1074446A1 (zh) 2005-11-11
CY1109785T1 (el) 2014-09-10
KR20050086421A (ko) 2005-08-30
RS20050362A (sr) 2007-11-15
IL168133A (en) 2010-05-31
PT1556382E (pt) 2008-07-09
MXPA05004349A (es) 2005-08-26
TWI325864B (en) 2010-06-11
AU2003296769A1 (en) 2004-06-07
US8012991B2 (en) 2011-09-06
HRP20050362A2 (en) 2005-12-31
HRP20050362B1 (hr) 2014-01-31
TW200413368A (en) 2004-08-01
AU2003296769B2 (en) 2010-02-04
RS51605B (sr) 2011-08-31

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