CN113365997A - 作为c-Met抑制剂的含嘧啶基团的三并环类化合物 - Google Patents

作为c-Met抑制剂的含嘧啶基团的三并环类化合物 Download PDF

Info

Publication number
CN113365997A
CN113365997A CN202080012066.6A CN202080012066A CN113365997A CN 113365997 A CN113365997 A CN 113365997A CN 202080012066 A CN202080012066 A CN 202080012066A CN 113365997 A CN113365997 A CN 113365997A
Authority
CN
China
Prior art keywords
compound
lcms
esi
mmol
400mhz
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN202080012066.6A
Other languages
English (en)
Other versions
CN113365997B (zh
Inventor
刘希乐
丁照中
陈曙辉
胡利红
万海文
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Aosaikang Pharmaceutical Co Ltd
Original Assignee
Medshine Discovery Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medshine Discovery Inc filed Critical Medshine Discovery Inc
Publication of CN113365997A publication Critical patent/CN113365997A/zh
Application granted granted Critical
Publication of CN113365997B publication Critical patent/CN113365997B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

公开了一类含嘧啶基团的三并环类化合物，及其在制备治疗癌症的药物中的应用。具体公开了式(I)所示化合物、其药学上可接受的盐或其异构体。

Description

PCT国内申请，说明书已公开。

Claims (29)

  1. PCT国内申请，权利要求书已公开。
CN202080012066.6A 2019-02-01 2020-01-22 作为c-Met抑制剂的含嘧啶基团的三并环类化合物 Active CN113365997B (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
CN2019101054815 2019-02-01
CN201910105481 2019-02-01
CN2019104697807 2019-05-31
CN201910469780 2019-05-31
CN201910865757 2019-09-12
CN201910865757X 2019-09-12
CN202010006610 2020-01-03
CN2020100066108 2020-01-03
PCT/CN2020/073842 WO2020156453A1 (zh) 2019-02-01 2020-01-22 作为c-Met抑制剂的含嘧啶基团的三并环类化合物

Publications (2)

Publication Number Publication Date
CN113365997A true CN113365997A (zh) 2021-09-07
CN113365997B CN113365997B (zh) 2022-06-07

Family

ID=71841636

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080012066.6A Active CN113365997B (zh) 2019-02-01 2020-01-22 作为c-Met抑制剂的含嘧啶基团的三并环类化合物

Country Status (6)

Country Link
US (1) US20230056559A1 (zh)
EP (1) EP3919492A4 (zh)
JP (1) JP7214879B2 (zh)
KR (1) KR102660608B1 (zh)
CN (1) CN113365997B (zh)
WO (1) WO2020156453A1 (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116171156A (zh) * 2020-07-31 2023-05-26 南京明德新药研发有限公司 含嘧啶基团的三并环类化合物的盐型、晶型及其制备方法
CN113292405A (zh) * 2021-06-01 2021-08-24 湖南华腾制药有限公司 一种2-溴-4氯苯甲醛的制备方法
CN116120213A (zh) * 2021-06-11 2023-05-16 重庆医药高等专科学校 反式4-(叔丁氧羰氨基)环己烷羧酸的合成方法
CN113461567B (zh) * 2021-07-30 2023-08-22 长沙创新药物工业技术研究院有限公司 一种2-溴-4腈基苯甲醛的制备方法
WO2023138492A1 (zh) * 2022-01-19 2023-07-27 南京明德新药研发有限公司 一种包含嘧啶基团的三并环类化合物的组合物及其制备方法和应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050222192A1 (en) * 2002-10-23 2005-10-06 Sanofi-Aventis Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics
CN100345850C (zh) * 2002-10-23 2007-10-31 赛诺菲-安万特 3－苯基取代的吡啶并吲哚酮,其制备和治疗用途
WO2010138661A1 (en) * 2009-05-27 2010-12-02 Elan Pharma International Ltd. Nanoparticulate anticancer compositions and methods for making the same
CN105153164A (zh) * 2014-05-30 2015-12-16 南京明德新药研发股份有限公司 作为hbv抑制剂的二氢嘧啶并环衍生物
CN106459061A (zh) * 2014-05-30 2017-02-22 南京明德新药研发股份有限公司 作为hbv抑制剂的二氢嘧啶并环衍生物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2846330B1 (fr) 2002-10-23 2004-12-03 Sanofi Synthelabo Derives de pyridoindolone substitues en -3 par groupe heterocyclique, leur preparation et leur application en therapeutique
DE102007032507A1 (de) 2007-07-12 2009-04-02 Merck Patent Gmbh Pyridazinonderivate
DE102009003975A1 (de) 2009-01-07 2010-07-08 Merck Patent Gmbh Benzothiazolonderivate
HUE051734T2 (hu) 2016-10-27 2021-03-29 Fujian Cosunter Pharmaceutical Co Ltd Piridon-vegyület, mint C-Met inhibitor

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050222192A1 (en) * 2002-10-23 2005-10-06 Sanofi-Aventis Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics
CN100345850C (zh) * 2002-10-23 2007-10-31 赛诺菲-安万特 3－苯基取代的吡啶并吲哚酮,其制备和治疗用途
WO2010138661A1 (en) * 2009-05-27 2010-12-02 Elan Pharma International Ltd. Nanoparticulate anticancer compositions and methods for making the same
CN105153164A (zh) * 2014-05-30 2015-12-16 南京明德新药研发股份有限公司 作为hbv抑制剂的二氢嘧啶并环衍生物
CN106459061A (zh) * 2014-05-30 2017-02-22 南京明德新药研发股份有限公司 作为hbv抑制剂的二氢嘧啶并环衍生物

Also Published As

Publication number Publication date
JP2022519125A (ja) 2022-03-18
EP3919492A1 (en) 2021-12-08
US20230056559A1 (en) 2023-02-23
CN113365997B (zh) 2022-06-07
JP7214879B2 (ja) 2023-01-30
KR102660608B1 (ko) 2024-04-26
WO2020156453A1 (zh) 2020-08-06
KR20210123360A (ko) 2021-10-13
EP3919492A4 (en) 2022-11-09

Similar Documents

Publication Publication Date Title
CN113365997B (zh) 作为c-Met抑制剂的含嘧啶基团的三并环类化合物
JP7233410B2 (ja) Ｅｇｆｒキナーゼ阻害薬としてのアリールホスフィンオキシド
EP3442977B1 (en) Inhibitors of activin receptor-like kinase
JP6976953B2 (ja) Ｒｏｃｋ阻害剤としてのスピロヘプタンサリチルアミドおよび関連性化合物
CN109563103B (zh) 用于治疗或预防与其相关的病症的β-3肾上腺素能受体的调节剂
TW202304911A (zh) 吡啶醯胺類化合物
EP3950685A1 (en) Pyrazolopyridine compound as ret inhibitor and application thereof
TW200951133A (en) P38 kinase inhibiting agents
WO2023061294A1 (zh) 含氮杂环类衍生物调节剂、其制备方法及应用
EP4129996A1 (en) Novel aminopyrimidine egfr inhibitor
CN111094267B (zh) 作为RORγ抑制剂的磺酰基取代的双环化合物
EP3527570A1 (en) Five-membered heteroaryl ring bridged ring derivative, preparation method therefor and medical use thereof
JP2022510628A (ja) ヘモグロビンの調節薬としてのピラゾール
WO2022194192A1 (zh) 一类杂芳环化合物、其制备方法及用途
JP6977038B2 (ja) Ｇｓｋ−３阻害剤
JP2024511614A (ja) フッ素置換ピリドピラゾール系化合物の結晶形及びその製造方法
WO2017161145A1 (en) Triazolopyridine inhibitors of myeloperoxidase and/or epx
JP2019518032A (ja) Ｐｉ３ｋ ｂｅｔａ阻害薬としての二環式ピリジン、ピラジンおよびピリミジン誘導体
EP4155304A1 (en) Compound used as ret kinase inhibitor and application thereof
JP7440710B1 (ja) Ｇ１２ｄ変異ｋｒａｓタンパクに作用する複素環化合物
CN112142731B (zh) 一种2，4-二取代嘧啶衍生物及其制备方法和用途
WO2024066986A1 (zh) 2-氨基嘧啶类化合物及其应用、药用组合物
CN116143805A (zh) 一类含氮杂环联芳基类化合物、制备方法和用途
CN117800976A (zh) 一类含氮杂环类化合物、制备方法和用途
WO2023155886A1 (en) Pyrazolopyridine compounds as tam inhibitors

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20240409

Address after: 211112, No. 699, Jian Lu, Science Park, Jiangning, Jiangsu, Nanjing

Patentee after: JIANGSU AOSAIKANG PHARMACEUTICAL Co.,Ltd.

Country or region after: China

Address before: 210032 room 218, business office building, No.9 Gaoxin Road, Jiangbei new district, Nanjing City, Jiangsu Province

Patentee before: Nanjing Mingde New Drug Development Co.,Ltd.

Country or region before: China