BR0314883A - Derivados de piridoindolona substituìdos em -3 por uma fenila, seu preparo e sua aplicação em terapêutica - Google Patents
Derivados de piridoindolona substituìdos em -3 por uma fenila, seu preparo e sua aplicação em terapêuticaInfo
- Publication number
- BR0314883A BR0314883A BR0314883-1A BR0314883A BR0314883A BR 0314883 A BR0314883 A BR 0314883A BR 0314883 A BR0314883 A BR 0314883A BR 0314883 A BR0314883 A BR 0314883A
- Authority
- BR
- Brazil
- Prior art keywords
- group
- phenyl
- alkyl
- preparation
- conr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"DERIVADOS DE PIRIDOINDOLONA SUBSTITUìDOS EM -3 POR UMA FENILA, SEU PREPARO E SUA APLICAçãO EM TERAPêUTICA". A presente invenção refere-se a compostos que têm uma atividade anti-cancerígena, correspondendo à fórmula (I), na qual: R~ 1~, representa um átomo de hidrogênio, um grupo (C~ 1~-C~ 4~)alquila ou um grupamento (CH~ 2~)~ n~OH, (CH~ 2~)~ n~-O-tetrahidropiran-2-ila, (CH~ 2~)~ n~ NR<39>~ 6~R<39>~ 7~, (CH~ 2~)~ n~ CN, (CH~ 2~)~ n~ C0~ 2~(C~ 1~-C~ 4~)Alq ou (CH~ 2~)~ n~ CONR~ 6~R~ 7~; R~ 2~ representa um átomo de hidrogênio ou um grupo (C~ 1~-C~ 4~)alquila; ou R~ 1~, e R~ 2~ juntos formam um grupo (CH~ 2~)~ 3~; R~ 3~ representa uma fenila monossubstituída por um grupo hidroxila, hidroximetila, carbóxi, (C~ 1~-C~ 4~)alcanoíla, azido, (C~ 1~-C~ 4~)alcoxicarbonila, hidroxiiminometila, (C~ 1~-C~ 4~)alquisulfonila, trifluorometila, tiol, (C~ 1~-C~ 4~)alquiltio, ciano ou por um grupamento (CH~ 2~)~ m~NR<39>~ 7~R~ 10~, CONR~ 6~R~ 8~ ou O(CH~ 2~)~ n~R~ 9~; uma fenila substituída por de 2 a 5 substituintes idênticos ou diferentes escolhidos dentre um átomo de halogênio, um grupo (C~ 1~-C~ 4~)alquila, trifluorometila, hidroxila, hidroximetila, (C~ 1~-C~ 4~)alcóxi, carbóxi, (C~ 1~-C~ 4~)alcanoíla, azido, (C~ 1~-C~ 4~)alcoxicarbonila, hidroxiiminometila, tiol,(C~ 1~-C~ 4~)alquiltio, (C~ 1~-C~ 4~)alquilsulfonila, uma fenila, ciano ou por um grupamento (CH~ 2~)~ m~NR<39>~ 7~R~ 10~, CONR~ 6~R~ 8~ ou O(CH~ 2~)~ n~R~ 9~; ou R~ 3~ representa um grupo benzodioxolila não substituído ou substituído sobre a fenila por um átomo de halogênio; R~ 4~ e R~ 5~ são idênticos ou diferentes e representam, cada um independentemente, um átomo de hidrogênio ou de halogênio, ou um grupo hidroxila, (C~ 1~-C~ 4~)alquila, trifluorometila, fenila, ciano, (C~ 1~-C~ 4~)alcóxi, (C~ 1~-C~ 4~)alcoxicarbonila, (C~ 1~-C~ 4~)alquilsulfonila ou um grupamento 0-(CH~ 2~)~ n~NR~ 6~R~ 7~ ou (CH~ 2~)~ n~ NR~ 6~R~ 7~.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0213264A FR2846329B1 (fr) | 2002-10-23 | 2002-10-23 | Derives de pyridoindolone substitues en -3 par un phenyle, leur preparation et leur application en therapeutique |
| PCT/FR2003/003110 WO2004041817A1 (fr) | 2002-10-23 | 2003-10-21 | Derives de pyridoindolone substitues en -3 par un phenyle, leur preparation et leur application en therapeutique. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0314883A true BR0314883A (pt) | 2005-08-02 |
Family
ID=32088223
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0314883-1A Pending BR0314883A (pt) | 2002-10-23 | 2003-10-21 | Derivados de piridoindolona substituìdos em -3 por uma fenila, seu preparo e sua aplicação em terapêutica |
Country Status (33)
| Country | Link |
|---|---|
| US (2) | US7390818B2 (pt) |
| EP (1) | EP1556382B1 (pt) |
| JP (1) | JP4488899B2 (pt) |
| KR (1) | KR101051859B1 (pt) |
| CN (1) | CN100345850C (pt) |
| AR (1) | AR041689A1 (pt) |
| AT (1) | ATE396994T1 (pt) |
| AU (1) | AU2003296769B2 (pt) |
| BR (1) | BR0314883A (pt) |
| CA (1) | CA2502769C (pt) |
| CY (1) | CY1109785T1 (pt) |
| DE (1) | DE60321372D1 (pt) |
| DK (1) | DK1556382T3 (pt) |
| EA (1) | EA010833B1 (pt) |
| ES (1) | ES2304546T3 (pt) |
| FR (1) | FR2846329B1 (pt) |
| HK (1) | HK1074446A1 (pt) |
| HR (1) | HRP20050362B1 (pt) |
| IL (1) | IL168133A (pt) |
| IS (1) | IS2641B (pt) |
| MA (1) | MA27455A1 (pt) |
| ME (1) | ME00102B (pt) |
| MX (1) | MXPA05004349A (pt) |
| NO (1) | NO331297B1 (pt) |
| NZ (1) | NZ539866A (pt) |
| PL (1) | PL214867B1 (pt) |
| PT (1) | PT1556382E (pt) |
| RS (1) | RS51605B (pt) |
| SI (1) | SI1556382T1 (pt) |
| TW (1) | TWI325864B (pt) |
| UA (1) | UA79317C2 (pt) |
| WO (1) | WO2004041817A1 (pt) |
| ZA (1) | ZA200503231B (pt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2823975B1 (fr) | 2001-04-27 | 2003-05-30 | Sanofi Synthelabo | Nouvelle utilisation de pyridoindolone |
| US7456193B2 (en) | 2002-10-23 | 2008-11-25 | Sanofi-Aventis | Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics |
| US8512727B2 (en) * | 2003-03-03 | 2013-08-20 | Alkermes Pharma Ireland Limited | Nanoparticulate meloxicam formulations |
| US20100297252A1 (en) * | 2003-03-03 | 2010-11-25 | Elan Pharma International Ltd. | Nanoparticulate meloxicam formulations |
| FR2869316B1 (fr) | 2004-04-21 | 2006-06-02 | Sanofi Synthelabo | Derives de pyridoindolone substitues en -6, leur preparation et leur application en therapeutique. |
| FR2876377B1 (fr) * | 2004-10-11 | 2007-03-16 | Univ Claude Bernard Lyon | Nouveaux derives de 9h-pyrido[2,3-b]indole, leur procede de preparation, ainsi que les compositions pharmaceutiques contenant de tels composes |
| FR2892416B1 (fr) * | 2005-10-20 | 2008-06-27 | Sanofi Aventis Sa | Derives de 6-heteroarylpyridoindolone, leur preparation et leur application en therapeutique |
| FR2945950A1 (fr) | 2009-05-27 | 2010-12-03 | Elan Pharma Int Ltd | Compositions de nanoparticules anticancereuses et procedes pour les preparer |
| HUE032426T2 (en) | 2009-05-27 | 2017-09-28 | Alkermes Pharma Ireland Ltd | Inhibition of flake aggregation in nanoparticulate meloxicam formulations |
| FR2959133A1 (fr) | 2010-04-22 | 2011-10-28 | Sanofi Aventis | Formulation pharmaceutique anticancereuse |
| CN107459481A (zh) * | 2017-07-25 | 2017-12-12 | 广州大学 | 一种3‑（4‑甲氧基苯基）‑6‑甲氧基‑4‑氯‑5,7‑二溴喹啉的合成方法 |
| US12122780B2 (en) * | 2019-02-01 | 2024-10-22 | Jiangsu Aosaikang Pharmaceutical Co., Ltd. | Pyrimidinyl group-containing tricyclic compound serving as c-Met inhibitor |
| CN113329276B (zh) | 2020-02-28 | 2022-10-28 | 华为技术有限公司 | 数据传输方法、装置、网关、芯片及存储介质 |
| CN116171156A (zh) * | 2020-07-31 | 2023-05-26 | 南京明德新药研发有限公司 | 含嘧啶基团的三并环类化合物的盐型、晶型及其制备方法 |
| US20240132446A1 (en) * | 2021-05-26 | 2024-04-25 | Refined Technologies, Inc. | Compositions and methods for removal of n-methyl-2-pyrrolidone (nmp) degradation products and other foulants from nmp purification systems |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1268772A (en) | 1968-03-15 | 1972-03-29 | Glaxo Lab Ltd | NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME |
| US4263304A (en) | 1978-06-05 | 1981-04-21 | Sumitomo Chemical Company, Limited | 7 H-indolo[2,3-c]isoquinolines |
| SU833971A1 (ru) | 1979-07-10 | 1981-05-30 | Ленинградский Химико-Фармацевтическийинститут | Способ получени 3-фенил-2-оксо- - КАРбОлиНОВ |
| FR2595701B1 (fr) | 1986-03-17 | 1988-07-01 | Sanofi Sa | Derives du pyrido-indole, leur application a titre de medicaments et les compositions les renfermant |
| EP0755454B1 (en) | 1994-04-13 | 2008-02-13 | The Rockefeller University | Aav-mediated delivery of dna to cells of the nervous system |
| DE19502753A1 (de) * | 1995-01-23 | 1996-07-25 | Schering Ag | Neue 9H-Pyrido[3,4-b]indol-Derivate |
| FR2765581B1 (fr) * | 1997-07-03 | 1999-08-06 | Synthelabo | Derives de 3-aryl-1,9-dihydro-2h-pyrido[2,3-b]indol-2-one, leur preparation et leur application en therapeutique |
| FR2765582B1 (fr) | 1997-07-03 | 1999-08-06 | Synthelabo | Derives de 3-alkyl-1,9-dihydro-2h-pyrido[2,3-b]indol-2-one leur preparation et leur application en therapeutique |
| CA2326319A1 (en) | 1998-04-02 | 1999-10-14 | Neurogen Corporation | Aminoalkyl substituted 5,6,7,8-tetrahydro-9h pyrimidino[2,3-b]indole and 5,6,7,8-tetrahydro-9h-pyrimidino[4,5-b]indole derivatives: crf1 specific ligands |
| IT1313592B1 (it) * | 1999-08-03 | 2002-09-09 | Novuspharma Spa | Derivati di 1h-pirido 3,4-b indol-1-one. |
| US20020156016A1 (en) | 2001-03-30 | 2002-10-24 | Gerald Minuk | Control of cell growth by altering cell membrane potentials |
| FR2823975B1 (fr) | 2001-04-27 | 2003-05-30 | Sanofi Synthelabo | Nouvelle utilisation de pyridoindolone |
| FR2846330B1 (fr) | 2002-10-23 | 2004-12-03 | Sanofi Synthelabo | Derives de pyridoindolone substitues en -3 par groupe heterocyclique, leur preparation et leur application en therapeutique |
| US7456193B2 (en) | 2002-10-23 | 2008-11-25 | Sanofi-Aventis | Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics |
| FR2869316B1 (fr) | 2004-04-21 | 2006-06-02 | Sanofi Synthelabo | Derives de pyridoindolone substitues en -6, leur preparation et leur application en therapeutique. |
| FR2892416B1 (fr) | 2005-10-20 | 2008-06-27 | Sanofi Aventis Sa | Derives de 6-heteroarylpyridoindolone, leur preparation et leur application en therapeutique |
-
2002
- 2002-10-23 FR FR0213264A patent/FR2846329B1/fr not_active Expired - Fee Related
-
2003
- 2003-10-21 UA UAA200503772A patent/UA79317C2/uk unknown
- 2003-10-21 KR KR20057006949A patent/KR101051859B1/ko not_active IP Right Cessation
- 2003-10-21 WO PCT/FR2003/003110 patent/WO2004041817A1/fr active IP Right Grant
- 2003-10-21 SI SI200331333T patent/SI1556382T1/sl unknown
- 2003-10-21 DE DE60321372T patent/DE60321372D1/de not_active Expired - Lifetime
- 2003-10-21 AU AU2003296769A patent/AU2003296769B2/en not_active Ceased
- 2003-10-21 ME MEP-2008-222A patent/ME00102B/me unknown
- 2003-10-21 BR BR0314883-1A patent/BR0314883A/pt active Pending
- 2003-10-21 NZ NZ539866A patent/NZ539866A/en not_active IP Right Cessation
- 2003-10-21 EA EA200500521A patent/EA010833B1/ru not_active IP Right Cessation
- 2003-10-21 MX MXPA05004349A patent/MXPA05004349A/es active IP Right Grant
- 2003-10-21 CN CNB2003801072280A patent/CN100345850C/zh not_active Expired - Fee Related
- 2003-10-21 ES ES03810495T patent/ES2304546T3/es not_active Expired - Lifetime
- 2003-10-21 AT AT03810495T patent/ATE396994T1/de active
- 2003-10-21 PT PT03810495T patent/PT1556382E/pt unknown
- 2003-10-21 JP JP2004549256A patent/JP4488899B2/ja not_active Expired - Fee Related
- 2003-10-21 EP EP03810495A patent/EP1556382B1/fr not_active Expired - Lifetime
- 2003-10-21 CA CA2502769A patent/CA2502769C/en not_active Expired - Fee Related
- 2003-10-21 RS YU20050362A patent/RS51605B/en unknown
- 2003-10-21 DK DK03810495T patent/DK1556382T3/da active
- 2003-10-21 PL PL376790A patent/PL214867B1/pl unknown
- 2003-10-22 AR ARP030103840A patent/AR041689A1/es unknown
- 2003-10-23 TW TW092129440A patent/TWI325864B/zh not_active IP Right Cessation
-
2005
- 2005-04-19 IL IL168133A patent/IL168133A/en not_active IP Right Cessation
- 2005-04-19 US US11/109,068 patent/US7390818B2/en not_active Expired - Lifetime
- 2005-04-19 MA MA28228A patent/MA27455A1/fr unknown
- 2005-04-20 IS IS7815A patent/IS2641B/is unknown
- 2005-04-21 HR HRP20050362AA patent/HRP20050362B1/hr not_active IP Right Cessation
- 2005-04-21 ZA ZA200503231A patent/ZA200503231B/en unknown
- 2005-04-22 NO NO20051983A patent/NO331297B1/no not_active IP Right Cessation
- 2005-09-23 HK HK05108402A patent/HK1074446A1/xx not_active IP Right Cessation
-
2008
- 2008-05-12 US US12/118,920 patent/US8012991B2/en active Active
- 2008-07-29 CY CY20081100788T patent/CY1109785T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR0314883A (pt) | Derivados de piridoindolona substituìdos em -3 por uma fenila, seu preparo e sua aplicação em terapêutica | |
| UY29886A1 (es) | Derivados de pirazol novedosos, composiciones farmaccuticas que los contienen, procedimientos para la preparacinn de los mismos y aplicaciones | |
| BRPI0606845A2 (pt) | derivados de (1,5-difenil-1h-pirazol-3-il)oxadiazol, o respectivo preparo e a respectiva aplicação em terapêutica | |
| BRPI0508098A (pt) | compostos, composições farmacêuticas e métodos para uso no tratamento de distúrbios metabólicos | |
| BRPI0518068A (pt) | composto ou um éster ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, inibidor seletivo de aurora a, agente anti-tumor, e, preparação combinada | |
| TR200201156T2 (tr) | 4-Fenilpiperidin bileşimleri. | |
| UY29360A1 (es) | Nuevos derivados de pirazol, composiciones farmacéuticas que los contienen, procedimientos de preparación y aplicaciones. | |
| ATE433981T1 (de) | Heterocyclische verbindungen | |
| TW200612920A (en) | Novel imidazolidine derivatives | |
| DK1767535T3 (da) | Syntese af epothiloner, mellemprodukter deraf, analoge og deres anvendelse | |
| BRPI1007456A2 (pt) | derivados de azaespiranil-alquilcarbamatos de compostos heterocíclicos com 5 membros, o respectivo preparo e a respectiva aplicação em terapêutica | |
| NO20054787L (no) | Indenderivater som farmasotiske midler | |
| DE602007004740D1 (de) | Antibiotische spiroderivate | |
| ECSP066304A (es) | Compuestos | |
| NO20062491L (no) | Benzoksazinderivter og deres anvendelse | |
| DE602006020295D1 (de) | Azabenzimidalzolderivate, ihre herstellung und ihre verwendung als antikrebsmittel | |
| NO20076680L (no) | Utvalgte CGRP-antagonister, metoder for fremstilling av disse og deres anvendelse som medikamenter | |
| IL177887A0 (en) | Synthetic multiple quaternary ammonium salts | |
| BRPI0714885B8 (pt) | compostos terapêuticos e seu uso | |
| MA32192B1 (fr) | Composés dérivés d'azétidines, leur préparation et leur application en thérapeutique | |
| BRPI0411723A (pt) | agente redutor de colesterol no soro ou agente preventivo ou terapêutico para aterosclerose, e, método de dosagem de um agente redutor de colesterol no soro ou agente preventivo ou terapêutico para aterosclerose | |
| DK1643984T3 (da) | Anvendelse af parthenolidderivater som antileukæmiske og cytotoksske midler | |
| BRPI0601766A (pt) | composições contendo aminas e seu uso | |
| NO20055167L (no) | Nye benzotiadiazinforbindelser, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende dem | |
| PA8605101A1 (es) | 4-(aminometil)-piperidin benzamidas como antagonista de 5ht4 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 12A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2328 DE 18-08-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |