TR200201156T2 - 4-Fenilpiperidin bileşimleri. - Google Patents

4-Fenilpiperidin bileşimleri.

Info

Publication number
TR200201156T2
TR200201156T2 TR2002/01156T TR200201156T TR200201156T2 TR 200201156 T2 TR200201156 T2 TR 200201156T2 TR 2002/01156 T TR2002/01156 T TR 2002/01156T TR 200201156 T TR200201156 T TR 200201156T TR 200201156 T2 TR200201156 T2 TR 200201156T2
Authority
TR
Turkey
Prior art keywords
group
alkyl
halogen
alkoxy
optionally substituted
Prior art date
Application number
TR2002/01156T
Other languages
English (en)
Inventor
Bernardus Gemma Benneker Franciscus
Van Dalen Frans
Maria Lemmens Jacobus
Hendricus Antonium Peters Theodorus
Picha Frantisek
Original Assignee
Synthon B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26647319&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TR200201156(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Synthon B.V. filed Critical Synthon B.V.
Publication of TR200201156T2 publication Critical patent/TR200201156T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms

Abstract

Bu bulus bir bilesime ve ilaç imaline uygun tuzlara iliskin olup, formül I'e sahiptirler; burada R bir alkil ya da alkinil grubunu temsil etmekte olup, 1-4 karbon atomuna sahiptir, ya da bir fenil grubu olup, istege göre C1-4 alkil, alkiltio, alkoksi, halojen, nitro, asilamino, metilsülfonil ya da metilenedioksi ile yerdegisimi yapilmaktadir, ya da tetrahidronaftili temsil etmektedir; R hidrojen, trifloro (C1-4) alkil, alkil ya da alkinili temsil etmektedir; X hidrojen, 1-4 karbon atomlu alkil, alkoksi, trifloroalkil, hidroksi, halojen, metiltio ya da aralkoksiyi temsil etmektedir; R ise sunlari temsil etmektedir: bir C1-C10 alkil grubu, bir fenil grubu olup, istege göre asagidaki gruplarin bir ya da daha fazlasiyla yerdegisimi yapilmaktadir; bir C1-C10 alkil grubu, bir halojen grubu, bir nitro grubu, hidroksi grubu, ve/veya bir alkoksi grubu.
TR2002/01156T 1997-06-10 1997-06-10 4-Fenilpiperidin bileşimleri. TR200201156T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/NL1997/000328 WO1998056787A1 (en) 1997-06-10 1997-06-10 4-Phenylpiperidine compounds
US08/872,023 US5874447A (en) 1997-06-10 1997-06-10 4-Phenylpiperidine compounds for treating depression

Publications (1)

Publication Number Publication Date
TR200201156T2 true TR200201156T2 (tr) 2002-07-22

Family

ID=26647319

Family Applications (2)

Application Number Title Priority Date Filing Date
TR1999/03025T TR199903025T2 (tr) 1997-06-10 1997-06-10 4-Fenilpiperidin bilesimleri.
TR2002/01156T TR200201156T2 (tr) 1997-06-10 1997-06-10 4-Fenilpiperidin bileşimleri.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
TR1999/03025T TR199903025T2 (tr) 1997-06-10 1997-06-10 4-Fenilpiperidin bilesimleri.

Country Status (26)

Country Link
US (4) US5874447A (tr)
EP (2) EP1078925A1 (tr)
JP (1) JP2002503248A (tr)
KR (1) KR100543614B1 (tr)
AT (1) ATE200781T1 (tr)
AU (1) AU3108097A (tr)
BG (1) BG64315B1 (tr)
BR (1) BR9714787A (tr)
CA (1) CA2293247C (tr)
CZ (1) CZ295301B6 (tr)
DE (2) DE69704679T2 (tr)
DK (1) DK0994872T3 (tr)
EE (2) EE200200633A (tr)
ES (1) ES2155995T3 (tr)
GR (1) GR3035784T3 (tr)
HK (1) HK1027352A1 (tr)
HU (1) HUP0003141A3 (tr)
IL (1) IL133366A (tr)
IS (2) IS1927B (tr)
NO (3) NO317371B1 (tr)
PL (1) PL188450B1 (tr)
PT (1) PT994872E (tr)
SI (1) SI0994872T1 (tr)
SK (1) SK283394B6 (tr)
TR (2) TR199903025T2 (tr)
WO (1) WO1998056787A1 (tr)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU221921B1 (hu) * 1996-07-08 2003-02-28 Richter Gedeon Vegyészeti Gyár Rt. N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására
CA2327450A1 (en) * 1998-04-09 1999-10-21 Victor Witold Jacewicz Paroxetine maleate
CH689805A8 (fr) * 1998-07-02 2000-02-29 Smithkline Beecham Plc Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant.
GB9814316D0 (en) * 1998-07-02 1998-09-02 Smithkline Beecham Plc Novel compounds
AU724845B3 (en) * 1998-07-02 2000-09-28 Smithkline Beecham Plc Novel compound
US20010023252A1 (en) * 1998-07-02 2001-09-20 Smithkline Beecham Plc Novel compound
EP1102764A1 (en) * 1998-08-08 2001-05-30 Smithkline Beecham Plc Paroxetine salts
GB9827431D0 (en) * 1998-12-11 1999-02-03 Smithkline Beecham Plc Novel compound
GB9828781D0 (en) * 1998-12-29 1999-02-17 Smithkline Beecham Plc Novel process
GB9828779D0 (en) * 1998-12-29 1999-02-17 Smithkline Beecham Plc Novel process
GB9828780D0 (en) * 1998-12-29 1999-02-17 Smithkline Beecham Plc Novel process
ES2159260B1 (es) * 1999-06-22 2002-05-01 Smithkline Beechan Plc Nueva composicion de metanosulfonato de paroxetina
AU5078700A (en) * 1999-06-22 2001-01-09 Smithkline Beecham Plc Novel composition
GB9914585D0 (en) * 1999-06-22 1999-08-25 Smithkline Beecham Plc Novel process
KR100759159B1 (ko) * 1999-07-01 2007-09-14 이탈파마코 에스.피.에이. 파록세틴과 사이클로덱스트린 또는 사이클로덱스트린유도체의 컴플렉스
GB9919052D0 (en) * 1999-08-12 1999-10-13 Smithkline Beecham Plc Novel compound composition and process
US6503927B1 (en) * 1999-10-28 2003-01-07 Pentech Pharmaceuticals, Inc. Amorphous paroxetine composition
USRE46117E1 (en) 1999-12-22 2016-08-23 Teva Pharmaceuticals International Gmbh Modulators of dopamine neurotransmission
SI1286965T1 (en) * 2000-05-12 2004-04-30 Synthon B.V. Piperidine compounds and process for providing such
CZ20023694A3 (cs) * 2000-05-12 2003-05-14 Synthon B. V. Tosylátové soli 4-(p-fluorfenyl)-piperidin-3-methanolů
NZ523902A (en) * 2000-08-28 2004-05-28 Synthon Bv Paroxetine compositions and processes for making the same
WO2002022609A1 (fr) * 2000-09-14 2002-03-21 Asahi Glass Company, Limited Procede de production de sel de paroxetine sensiblement exempt de solvant organique
DE20100529U1 (de) * 2001-01-11 2001-05-10 Synthon Bv Pharmazeutische Tablette umfassend Paroxetinmesylat
US6720003B2 (en) * 2001-02-16 2004-04-13 Andrx Corporation Serotonin reuptake inhibitor formulations
NL1017421C2 (nl) * 2001-02-21 2002-01-15 Synthon Bv Werkwijze voor het vervaardigen van paroxetine.
US20030032809A1 (en) * 2001-04-25 2003-02-13 Subhash P. Upadhyaya Optimized procedures for the manufacture of paroxetine salts
US6930186B2 (en) * 2001-06-13 2005-08-16 Teva Pharmacetical Industries Ltd. Process for the preparation of paroxetine substantially free of alkoxy impurities
IL159280A0 (en) * 2001-06-14 2004-06-01 Teva Pharma A process for preparing paroxetine hcl which limits formation of pink colored compounds
WO2003020717A1 (en) * 2001-08-02 2003-03-13 Spurcourt Limited Paroxetine isethionate salt, process of preparation and use in the treatment of depression
US20030181488A1 (en) 2002-03-07 2003-09-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester and the salts thereof
AR039163A1 (es) * 2002-03-28 2005-02-09 Synthon Bv Besilato de venlafaxina
US20040220153A1 (en) * 2002-09-24 2004-11-04 Jost-Price Edward Roydon Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines
US7202259B2 (en) * 2002-11-18 2007-04-10 Euro-Celtique S.A. Therapeutic agents useful for treating pain
PT1691811E (pt) 2003-12-11 2014-10-30 Sunovion Pharmaceuticals Inc Combinação de um sedativo e de um modulador de neurotransmissores e métodos para melhorar a qualidade do sono e tratamento da depressão
US20060063737A1 (en) * 2004-08-18 2006-03-23 Holmdahl Lisa K Liquid paroxetine compositions
EP1791531A1 (en) * 2004-08-20 2007-06-06 Alpharma, Inc. Paroxetine formulations
BRPI0615973A2 (pt) * 2005-07-29 2011-05-31 Concert Pharmaceuticals Inc novos derivados de benzo [d] [1,3] - dioxol
US20080033011A1 (en) * 2005-07-29 2008-02-07 Concert Pharmaceuticals Inc. Novel benzo[d][1,3]-dioxol derivatives
US20070112031A1 (en) * 2005-11-14 2007-05-17 Gant Thomas G Substituted phenylpiperidines with serotoninergic activity and enhanced therapeutic properties
SE529246C2 (sv) 2005-10-13 2007-06-12 Neurosearch Sweden Ab Nya disubstituerade fenyl-piperidiner som modulatorer för dopaminneurotransmission
US20080033050A1 (en) 2006-08-04 2008-02-07 Richards Patricia Allison Tewe Method of treating thermoregulatory disfunction with paroxetine
WO2009035652A1 (en) 2007-09-13 2009-03-19 Concert Pharmaceuticals, Inc. Synthesis of deuterated catechols and benzo[d][1,3] dioxoles and derivatives thereof
US9138430B2 (en) * 2007-12-27 2015-09-22 Mylan Specialty L.P. Formulation and method for the release of paroxetine in the large intestine
JP6038128B2 (ja) 2011-06-03 2016-12-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 レンバチニブ化合物に対する甲状腺癌対象及び腎臓癌対象の反応性を予測及び評価するためのバイオマーカー
KR101950057B1 (ko) * 2012-01-31 2019-02-19 에자이 알앤드디 매니지먼트 가부시키가이샤 파록세틴 유도체
MX2014011971A (es) 2012-04-04 2015-01-16 Ivax Int Gmbh Composiciones farmaceuticas para terapia de combinacion.
HRP20221047T1 (hr) 2014-08-28 2022-11-11 Eisai R&D Management Co., Ltd. Derivat kinolina visoke čistoće i postupak za njegovu proizvodnju
JP6792546B2 (ja) 2015-02-25 2020-11-25 エーザイ・アール・アンド・ディー・マネジメント株式会社 キノリン誘導体の苦味抑制方法
CN107801379B (zh) 2015-06-16 2021-05-25 卫材R&D管理有限公司 抗癌剂

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT99678B (de) * 1921-09-21 1925-04-10 Hoechst Ag Verfahren zur Darstellung arzneilich wirksamer Quecksilberverbindungen.
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
US4585777A (en) * 1984-02-07 1986-04-29 A/S Ferrosan (-)-Trans-4-(4-fluorophenyl)-3-(4-methoxyphenoxy)methylpiperidine for potentiating 5-HT
GB8430581D0 (en) * 1984-12-04 1985-01-09 Ferrosan As Treatment
EP0190496A3 (en) * 1984-12-13 1987-05-27 Beecham Group Plc Piperidine derivatives having a gastro-intestinal activity
DE3680184D1 (de) * 1985-08-10 1991-08-14 Beecham Group Plc Verfahren zur herstellung von arylpiperidincarbinol.
GB8520154D0 (en) * 1985-08-10 1985-09-18 Beecham Group Plc Chemical process
EP0223403B1 (en) * 1985-10-25 1993-08-04 Beecham Group Plc Piperidine derivative, its preparation, and its use as medicament
US5258388A (en) 1986-03-17 1993-11-02 University Of Florida Anticholinergic compounds, compositions and methods of treatment
IE66332B1 (en) * 1986-11-03 1995-12-27 Novo Nordisk As Piperidine compounds and their preparation and use
GB8626936D0 (en) * 1986-11-11 1986-12-10 Ferrosan As Treatment
GB8714707D0 (en) * 1987-06-23 1987-07-29 Beecham Group Plc Chemical process
DK716088D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Reduktion af piperidin-dion-derivater samt intermediat
DK715988D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Etherifikation og dealkylering af piperidin-derivater samt intermediater
KR930702000A (ko) 1990-11-24 1993-09-08 데이빗 로버츠 노년기 치매, 식용항진, 편두통, 또는 식용불량의 치료를 위한 파로세틴의 사용
GB9209687D0 (en) * 1992-05-06 1992-06-17 Smithkline Beecham Plc Novel process
US5258517A (en) * 1992-08-06 1993-11-02 Sepracor, Inc. Method of preparing optically pure precursors of paroxetine
JP2773587B2 (ja) * 1992-11-30 1998-07-09 東レ株式会社 Ｏ，ｏ´−ジアシル酒石酸無水物の製造法
US5276042A (en) 1993-04-16 1994-01-04 Crenshaw Roger T Treatment of premature ejaculation
US5546683A (en) * 1993-09-29 1996-08-20 Clark; George J. Bucket attachment device with remote controlled retractable pins
IT1274241B (it) * 1993-12-03 1997-07-15 Smithkline Beecham Farma Complessi agente terapeutico/matrice polimerica dotati di migliorate caratteristiche di sapore e composizioni farmaceutiche che li contengono
GB9325644D0 (en) 1993-12-15 1994-02-16 Smithkline Beecham Plc Novel formulation
US5668134A (en) * 1994-01-28 1997-09-16 G. D. Searle & Co. Method for preventing or reducing photosensitivity and/or phototoxicity reactions to medications
GB9402029D0 (en) * 1994-02-03 1994-03-30 Smithkline Beecham Plc Novel formulation
CA2143070C (en) * 1994-02-22 2001-12-18 Pankaj Modi Oral controlled release liquid suspension pharmaceutical formulation
EP0714663A3 (en) * 1994-11-28 1997-01-15 Lilly Co Eli Potentiation of drug responses by serotonin 1A receptor antagonists
JPH08220486A (ja) * 1994-12-14 1996-08-30 Kato Kogei:Kk 眼鏡フレーム
AR001982A1 (es) * 1995-02-06 1998-01-07 Smithkline Beecham Plc Clorhidrato de paroxetina anhidratado, y procedimiento para su preparacion
US5856493A (en) * 1995-02-06 1999-01-05 Smithkline Beecham Corporation Process for making novel form of paroxeting hydrochloride anhydrate
GB2297550C2 (en) * 1995-02-06 1997-04-09 Smithkline Beecham Plc Paroxetine hydrochloride anhydrate substantially free of bound organic solvent
EP0818990A1 (en) * 1995-04-03 1998-01-21 Abbott Laboratories Homogeneous mixtures of low temperature-melting drugs and additives for controlled release
EP0828735A1 (en) * 1995-05-17 1998-03-18 Novo Nordisk A/S Process for preparing 4-aryl-piperidine derivatives
JP2813768B2 (ja) * 1995-05-24 1998-10-22 農林水産省家畜衛生試験場長 口蹄疫診断用ペプチドおよび当該ペプチドを含有する口蹄疫診断用抗原
GB9514842D0 (en) * 1995-07-20 1995-09-20 Smithkline Beecham Plc Novel formulation
WO1997016448A1 (en) * 1995-10-31 1997-05-09 Merck & Co., Inc. Process for preparing substituted azetidinones
IT1276160B1 (it) * 1995-11-22 1997-10-27 Recordati Chem Pharm Composizioni farmaceutiche orali a pronto rilascio per sospensioni estemporanee
GB9526645D0 (en) * 1995-12-28 1996-02-28 Chiroscience Ltd Stereoselective synthesis
ES2117557B1 (es) * 1996-02-29 1999-07-01 Ferrer Int Nuevo procedimiento de obtencion de (-)-trans -n-p-fluorobenzoilmetil-4-(p-fluorofenil)-3- ((3,4-(metilendioxi)fenoxi ) metil)-piperidina.
JP3446468B2 (ja) * 1996-04-15 2003-09-16 旭硝子株式会社 ピペリジンカルビノール類の製造方法
CA2206592A1 (en) * 1996-05-30 1997-11-30 Shu-Zhong Wang Method of producing amorphous paroxetine hydrochloride
JP3882224B2 (ja) * 1996-05-31 2007-02-14 旭硝子株式会社 パロキセチンの製造方法
ES2331937T3 (es) * 1996-06-13 2010-01-20 Sumitomo Chemical Company, Limited Derivados de piperidina como intermediarios para la preparacion de paroxetina y procedimiento de preparacion de los mismos.
HU221921B1 (hu) * 1996-07-08 2003-02-28 Richter Gedeon Vegyészeti Gyár Rt. N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására
US5672609A (en) * 1996-07-18 1997-09-30 Eli Lilly And Company Pyridine compounds, intermediates compositions and methods of use
CA2187128A1 (en) * 1996-10-04 1997-06-26 K. S. Keshava Murthy New and useful polymorph of anhydrous paroxetine hydrochloride
US5955475A (en) * 1997-06-30 1999-09-21 Endo Pharmaceuticals Inc. Process for manufacturing paroxetine solid dispersions
CH689805A8 (fr) 1998-07-02 2000-02-29 Smithkline Beecham Plc Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant.

Also Published As

Publication number Publication date
EE200200633A (et) 2003-02-17
HK1027352A1 (en) 2001-01-12
WO1998056787A1 (en) 1998-12-17
NO20033766L (no) 2000-02-09
DE69704679T2 (de) 2001-09-13
US20010031767A1 (en) 2001-10-18
IL133366A (en) 2005-11-20
EP0994872B1 (en) 2001-04-25
ATE200781T1 (de) 2001-05-15
TR199903025T2 (tr) 2000-07-21
US20090326233A1 (en) 2009-12-31
AU3108097A (en) 1998-12-30
SK161999A3 (en) 2000-08-14
IS7098A (is) 2004-01-08
BG64315B1 (bg) 2004-09-30
CZ295301B6 (cs) 2005-07-13
EP1078925A1 (en) 2001-02-28
US6900327B2 (en) 2005-05-31
HUP0003141A3 (en) 2001-04-28
KR100543614B1 (ko) 2006-01-20
BG103980A (en) 2000-07-31
IL133366A0 (en) 2001-04-30
HUP0003141A2 (en) 2001-03-28
CA2293247A1 (en) 1998-12-17
NO995455L (no) 2000-02-09
NO317371B1 (no) 2004-10-18
EP0994872B9 (en) 2001-12-05
NO20033766D0 (no) 2003-08-25
BR9714787A (pt) 2000-07-18
GR3035784T3 (en) 2001-07-31
CA2293247C (en) 2005-04-12
JP2002503248A (ja) 2002-01-29
DE69704679D1 (de) 2001-05-31
EE9900570A (et) 2000-08-15
IS5249A (is) 1999-11-16
US5874447A (en) 1999-02-23
NO995455D0 (no) 1999-11-08
NO20033765L (no) 2000-02-09
SK283394B6 (sk) 2003-07-01
PL336895A1 (en) 2000-07-17
CZ429599A3 (cs) 2000-04-12
IS1927B (is) 2004-04-15
SI0994872T1 (tr) 2001-08-31
ES2155995T3 (es) 2001-06-01
EP0994872A1 (en) 2000-04-26
DK0994872T3 (da) 2001-05-28
PT994872E (pt) 2001-09-28
US7598271B1 (en) 2009-10-06
PL188450B1 (pl) 2005-02-28
KR20010013615A (ko) 2001-02-26
EE03970B1 (et) 2003-02-17
DE29724281U1 (de) 2000-08-10
NO20033765D0 (no) 2003-08-25

Similar Documents

Publication Publication Date Title
TR200201156T2 (tr) 4-Fenilpiperidin bileşimleri.
BR0005866A (pt) Composição de resina fotossensìvel
DE3781716T2 (de) Mittel zur ortsspezifischen alkylierung.
IL160304A (en) Compounds and composition for activating peroxisome proliferators-responsive receptor ??
HUP0402235A2 (hu) 4,4-Difluor-1,2,3,4-tetrahidro-5H-1-benzazepin-származékok és ezek sói és ezeket tartalmazó gyógyszerkészítmények
DE69815302D1 (de) Glaszusammensetzung zur vermeidung der alkali-kiesel-kieselsäure reaktion
DE68904792D1 (de) Biozide zusammensetzung.
NO990578L (no) Diesel-brennstoff inneholdende oksygenerte forbindelser
FI971227A0 (fi) Pyramidinyylipyratsolijohdannaisia
ATE9336T1 (de) 3,1-benzoxazin-2-one, ihre herstellung und verwendung.
TW427979B (en) A condensed piperidine compound
ES2054806T3 (es) Cicloalquilamidas de (8beta)-1-alquil-6-(sustituido)-ergolinas.
ES8706690A1 (es) Un procedimiento para la preparacion de nuevos derivados de penem.
TR200002851T2 (tr) MRP1'i inhibe etmek için yöntemler.
BR9609991A (pt) Carbamoilcarboxamida composição adequada para controlar fungos nocivos processos para a preparação de uma carbamoilcarboxamida para preparação da composição e para controle de fungos nocivos e uso de um composto ou de uma composição
DK0963998T3 (da) Azasteroidforbindelse til behandling eller prævention af prostatacancer
DK1312608T3 (da) Discodermolid-analoge samt deres farmaceutiske anvendelse
DE3766863D1 (de) Fungizide.
BR0113907A (pt) Derivados bifenilas substituìdos, o respectivo processo de preparação e as composições farmacêuticas que os contêm
ATE189813T1 (de) Prostaglandin-i-analoga
EP0273357A3 (en) Fluorine-containing macrolide compounds, pharmaceutical compositions comprising the same and their use for the manufacture of medicaments