SI0994872T1 - - Google Patents

Info

Publication number
SI0994872T1
SI0994872T1 SI9730138T SI9730138T SI0994872T1 SI 0994872 T1 SI0994872 T1 SI 0994872T1 SI 9730138 T SI9730138 T SI 9730138T SI 9730138 T SI9730138 T SI 9730138T SI 0994872 T1 SI0994872 T1 SI 0994872T1
Authority
SI
Slovenia
Prior art keywords
alkyl
halo
alkoxy
trifluoroalkyl
alkynyl
Prior art date
Application number
SI9730138T
Other languages
English (en)
Inventor
Franciscus Bernardus Benneker
Dalen Frans Van
Jacobus Maria Lemmens
Theodorus Hendricus Ant Peters
Frantisek Picha
Original Assignee
Synthon Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26647319&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI0994872(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Synthon Bv filed Critical Synthon Bv
Publication of SI0994872T1 publication Critical patent/SI0994872T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
SI9730138T 1997-06-10 1997-06-10 SI0994872T1 (xx)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/NL1997/000328 WO1998056787A1 (en) 1997-06-10 1997-06-10 4-Phenylpiperidine compounds
EP97926276A EP0994872B9 (en) 1997-06-10 1997-06-10 4-phenylpiperidine compounds
US08/872,023 US5874447A (en) 1997-06-10 1997-06-10 4-Phenylpiperidine compounds for treating depression

Publications (1)

Publication Number Publication Date
SI0994872T1 true SI0994872T1 (xx) 2001-08-31

Family

ID=26647319

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9730138T SI0994872T1 (xx) 1997-06-10 1997-06-10

Country Status (26)

Country Link
US (4) US5874447A (xx)
EP (2) EP1078925A1 (xx)
JP (1) JP2002503248A (xx)
KR (1) KR100543614B1 (xx)
AT (1) ATE200781T1 (xx)
AU (1) AU3108097A (xx)
BG (1) BG64315B1 (xx)
BR (1) BR9714787A (xx)
CA (1) CA2293247C (xx)
CZ (1) CZ295301B6 (xx)
DE (2) DE69704679T2 (xx)
DK (1) DK0994872T3 (xx)
EE (2) EE03970B1 (xx)
ES (1) ES2155995T3 (xx)
GR (1) GR3035784T3 (xx)
HK (1) HK1027352A1 (xx)
HU (1) HUP0003141A3 (xx)
IL (1) IL133366A (xx)
IS (2) IS1927B (xx)
NO (3) NO317371B1 (xx)
PL (1) PL188450B1 (xx)
PT (1) PT994872E (xx)
SI (1) SI0994872T1 (xx)
SK (1) SK283394B6 (xx)
TR (2) TR200201156T2 (xx)
WO (1) WO1998056787A1 (xx)

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WO1999052901A1 (en) * 1998-04-09 1999-10-21 Smithkline Beecham Plc Paroxetine maleate
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AU724845B3 (en) * 1998-07-02 2000-09-28 Smithkline Beecham Plc Novel compound
GB9814316D0 (en) * 1998-07-02 1998-09-02 Smithkline Beecham Plc Novel compounds
US20010023252A1 (en) * 1998-07-02 2001-09-20 Smithkline Beecham Plc Novel compound
EP1102764A1 (en) * 1998-08-08 2001-05-30 Smithkline Beecham Plc Paroxetine salts
GB9827431D0 (en) * 1998-12-11 1999-02-03 Smithkline Beecham Plc Novel compound
GB9828779D0 (en) * 1998-12-29 1999-02-17 Smithkline Beecham Plc Novel process
GB9828780D0 (en) * 1998-12-29 1999-02-17 Smithkline Beecham Plc Novel process
GB9828781D0 (en) * 1998-12-29 1999-02-17 Smithkline Beecham Plc Novel process
ES2159260B1 (es) * 1999-06-22 2002-05-01 Smithkline Beechan Plc Nueva composicion de metanosulfonato de paroxetina
AU5078700A (en) * 1999-06-22 2001-01-09 Smithkline Beecham Plc Novel composition
GB9914585D0 (en) * 1999-06-22 1999-08-25 Smithkline Beecham Plc Novel process
EP1109806B8 (en) * 1999-07-01 2003-10-29 Italfarmaco S.p.A. Complexes of paroxetine, with cyclodextrins or cyclodextrin derivates
GB9919052D0 (en) * 1999-08-12 1999-10-13 Smithkline Beecham Plc Novel compound composition and process
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USRE46117E1 (en) 1999-12-22 2016-08-23 Teva Pharmaceuticals International Gmbh Modulators of dopamine neurotransmission
CZ20023694A3 (cs) * 2000-05-12 2003-05-14 Synthon B. V. Tosylátové soli 4-(p-fluorfenyl)-piperidin-3-methanolů
EP1286965B1 (en) * 2000-05-12 2004-01-14 Synthon B.V. Piperidine compounds and process for providing such
NZ523902A (en) * 2000-08-28 2004-05-28 Synthon Bv Paroxetine compositions and processes for making the same
WO2002022609A1 (fr) * 2000-09-14 2002-03-21 Asahi Glass Company, Limited Procede de production de sel de paroxetine sensiblement exempt de solvant organique
DE20100529U1 (de) * 2001-01-11 2001-05-10 Synthon Bv Pharmazeutische Tablette umfassend Paroxetinmesylat
US6720003B2 (en) * 2001-02-16 2004-04-13 Andrx Corporation Serotonin reuptake inhibitor formulations
NL1017421C2 (nl) * 2001-02-21 2002-01-15 Synthon Bv Werkwijze voor het vervaardigen van paroxetine.
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IL159280A0 (en) * 2001-06-14 2004-06-01 Teva Pharma A process for preparing paroxetine hcl which limits formation of pink colored compounds
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US20030181488A1 (en) 2002-03-07 2003-09-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester and the salts thereof
AU2003221535A1 (en) * 2002-03-28 2003-10-13 Synthon B.V. Venlafaxine besylate
US20040220153A1 (en) * 2002-09-24 2004-11-04 Jost-Price Edward Roydon Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines
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DK1691811T3 (da) 2003-12-11 2014-10-20 Sunovion Pharmaceuticals Inc Kombination af et sedativ og en neurotransmittermodulator og fremgangsmåder til forbedring af søvnkvaliteten og behandling af depression
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CA2616383C (en) * 2005-07-29 2015-06-09 Concert Pharmaceuticals Inc. Novel benzo[d][1,3]-dioxol derivatives
SE529246C2 (sv) 2005-10-13 2007-06-12 Neurosearch Sweden Ab Nya disubstituerade fenyl-piperidiner som modulatorer för dopaminneurotransmission
EP1948646A2 (en) * 2005-11-14 2008-07-30 Auspex Pharmaceuticals Inc. Substituted phenylpiperidines with serotoninergic activity and enhanced therapeutic properties
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EP2200997B9 (en) * 2007-09-13 2016-01-13 Concert Pharmaceuticals Inc. Synthesis of deuterated benzodioxoles
US9138430B2 (en) * 2007-12-27 2015-09-22 Mylan Specialty L.P. Formulation and method for the release of paroxetine in the large intestine
ES2705950T3 (es) 2011-06-03 2019-03-27 Eisai R&D Man Co Ltd Biomarcadores para predecir y valorar la capacidad de respuesta de sujetos con cáncer de tiroides y de riñón a compuestos de lenvatinib
AR089837A1 (es) * 2012-01-31 2014-09-17 Eisai R&D Man Co Ltd Derivado de paroxetina
ES2776678T3 (es) 2012-04-04 2020-07-31 Prilenia Neurotherapeutics Ltd Composiciones farmacéuticas para terapia de combinación
MX2017001980A (es) 2014-08-28 2017-05-04 Eisai R&D Man Co Ltd Derivado de quinolina muy puro y metodo para su produccion.
LT3263106T (lt) 2015-02-25 2024-01-10 Eisai R&D Management Co., Ltd. Chinolino darinių kartumo sumažinimo būdas
CN107801379B (zh) 2015-06-16 2021-05-25 卫材R&D管理有限公司 抗癌剂

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Also Published As

Publication number Publication date
US20010031767A1 (en) 2001-10-18
EE9900570A (et) 2000-08-15
NO20033766D0 (no) 2003-08-25
CZ295301B6 (cs) 2005-07-13
HK1027352A1 (en) 2001-01-12
NO20033765D0 (no) 2003-08-25
JP2002503248A (ja) 2002-01-29
PL188450B1 (pl) 2005-02-28
SK283394B6 (sk) 2003-07-01
NO317371B1 (no) 2004-10-18
GR3035784T3 (en) 2001-07-31
IS7098A (is) 2004-01-08
CZ429599A3 (cs) 2000-04-12
CA2293247C (en) 2005-04-12
DK0994872T3 (da) 2001-05-28
NO20033766L (no) 2000-02-09
CA2293247A1 (en) 1998-12-17
ATE200781T1 (de) 2001-05-15
BG64315B1 (bg) 2004-09-30
DE29724281U1 (de) 2000-08-10
US20090326233A1 (en) 2009-12-31
US7598271B1 (en) 2009-10-06
SK161999A3 (en) 2000-08-14
EE200200633A (et) 2003-02-17
BR9714787A (pt) 2000-07-18
EE03970B1 (et) 2003-02-17
TR199903025T2 (xx) 2000-07-21
WO1998056787A1 (en) 1998-12-17
BG103980A (en) 2000-07-31
KR20010013615A (ko) 2001-02-26
HUP0003141A2 (en) 2001-03-28
EP0994872B9 (en) 2001-12-05
ES2155995T3 (es) 2001-06-01
IS1927B (is) 2004-04-15
NO995455D0 (no) 1999-11-08
US6900327B2 (en) 2005-05-31
IL133366A (en) 2005-11-20
IL133366A0 (en) 2001-04-30
EP1078925A1 (en) 2001-02-28
EP0994872B1 (en) 2001-04-25
PT994872E (pt) 2001-09-28
NO20033765L (no) 2000-02-09
PL336895A1 (en) 2000-07-17
KR100543614B1 (ko) 2006-01-20
AU3108097A (en) 1998-12-30
TR200201156T2 (tr) 2002-07-22
NO995455L (no) 2000-02-09
DE69704679T2 (de) 2001-09-13
EP0994872A1 (en) 2000-04-26
US5874447A (en) 1999-02-23
IS5249A (is) 1999-11-16
DE69704679D1 (de) 2001-05-31
HUP0003141A3 (en) 2001-04-28

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