BRPI0411723A - agente redutor de colesterol no soro ou agente preventivo ou terapêutico para aterosclerose, e, método de dosagem de um agente redutor de colesterol no soro ou agente preventivo ou terapêutico para aterosclerose - Google Patents
agente redutor de colesterol no soro ou agente preventivo ou terapêutico para aterosclerose, e, método de dosagem de um agente redutor de colesterol no soro ou agente preventivo ou terapêutico para ateroscleroseInfo
- Publication number
- BRPI0411723A BRPI0411723A BRPI0411723-9A BRPI0411723A BRPI0411723A BR PI0411723 A BRPI0411723 A BR PI0411723A BR PI0411723 A BRPI0411723 A BR PI0411723A BR PI0411723 A BRPI0411723 A BR PI0411723A
- Authority
- BR
- Brazil
- Prior art keywords
- atherosclerosis
- preventive
- agent
- therapeutic agent
- cholesterol lowering
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"AGENTE REDUTOR DE COLESTEROL NO SORO OU AGENTE PREVENTIVO OU TERAPêUTICO PARA ATEROSCLEROSE, E, MéTODO DE DOSAGEM DE UM AGENTE REDUTOR DE COLESTEROL NO SORO OU AGENTE PREVENTIVO OU TERAPêUTICO PARA ATEROSCLEROSE". A invenção refere-se a um agente redutor de colesterol no soro ou a um agente preventivo ou terapêutico para aterosclerose, em que cada um compreende uma combinação de um composto representado pela seguinte fórmula geral (I) ou sais farmaceuticamente aceitáveis com um agente inibidor de biossíntese de colesterol e/ou agente redutor de colesterol do tipo fibrato. ¢Na fórmula, A~ 1~, A~ 2~, A~ 3~ e A~ 4~, cada um, é hidrogênio, um grupo representado pela fórmula (b), ou um grupo representado pela fórmula (a), contanto que pelo menos um destes seja um grupo representado pela fórmula (a): A2 é alquila C~ 1~-C~ 5~ etc; e n, p, q e r, cada um, é um número inteiro de 0, 1 ou 2.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003185171A JP2005015434A (ja) | 2003-06-27 | 2003-06-27 | 血清コレステロール低下剤或はアテローム性硬化症の予防又は治療剤 |
PCT/JP2004/008678 WO2005000353A1 (ja) | 2003-06-27 | 2004-06-15 | 血清コレステロール低下剤或はアテローム性動脈硬化症の予防又は治療剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
BRPI0411723A true BRPI0411723A (pt) | 2006-08-08 |
BRPI0411723B1 BRPI0411723B1 (pt) | 2016-08-02 |
Family
ID=33549648
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0411723A BRPI0411723B1 (pt) | 2003-06-27 | 2004-06-15 | agente redutor de colesterol no soro ou agente preventivo ou terapêutico para aterosclerose, e, kit |
Country Status (16)
Country | Link |
---|---|
US (1) | US7795229B2 (pt) |
EP (1) | EP1655037B1 (pt) |
JP (1) | JP2005015434A (pt) |
KR (1) | KR100792098B1 (pt) |
CN (1) | CN1812812B (pt) |
AU (1) | AU2004251536B2 (pt) |
BR (1) | BRPI0411723B1 (pt) |
CA (1) | CA2529452C (pt) |
DK (1) | DK1655037T3 (pt) |
ES (1) | ES2545667T3 (pt) |
HK (1) | HK1095733A1 (pt) |
MX (1) | MXPA05014084A (pt) |
NO (1) | NO335222B1 (pt) |
PT (1) | PT1655037E (pt) |
RU (1) | RU2328307C2 (pt) |
WO (1) | WO2005000353A1 (pt) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0215579D0 (en) | 2002-07-05 | 2002-08-14 | Astrazeneca Ab | Chemical compounds |
US7871998B2 (en) | 2003-12-23 | 2011-01-18 | Astrazeneca Ab | Diphenylazetidinone derivatives possessing cholesterol absorption inhibitory activity |
WO2007001975A1 (en) | 2005-06-20 | 2007-01-04 | Schering Corporation | Piperidine derivatives useful as histamine h3 antagonists |
UY29607A1 (es) | 2005-06-20 | 2007-01-31 | Astrazeneca Ab | Compuestos quimicos |
SA06270191B1 (ar) | 2005-06-22 | 2010-03-29 | استرازينيكا ايه بي | مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم |
MY148538A (en) | 2005-06-22 | 2013-04-30 | Astrazeneca Ab | Novel 2-azetidinone derivatives as cholesterol absorption inhibitors for the treatment of hyperlipidaemic conditions |
TW200806623A (en) * | 2005-10-05 | 2008-02-01 | Merck & Co Inc | Anti-hypercholesterolemic compounds |
TW200811098A (en) | 2006-04-27 | 2008-03-01 | Astrazeneca Ab | Chemical compounds |
RU2009108280A (ru) | 2006-08-08 | 2010-09-20 | Санофи-Авентис (Fr) | Ариламиноарилалкилзамещенные имидазолидин-2,4-дионы, способы их получения, содержащие эти соединения лекарственные средства и их применение |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
DE102007054497B3 (de) | 2007-11-13 | 2009-07-23 | Sanofi-Aventis Deutschland Gmbh | Neue kristalline Diphenylazetidinonhydrate und Verfahren zu deren Herstellung |
UY31968A (es) | 2008-07-09 | 2010-01-29 | Sanofi Aventis | Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos |
WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
SG178880A1 (en) | 2009-08-26 | 2012-04-27 | Sanofi Sa | Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use |
WO2011157827A1 (de) | 2010-06-18 | 2011-12-22 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
EP2683699B1 (de) | 2011-03-08 | 2015-06-24 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
WO2012120054A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LT3300B (en) * | 1992-12-23 | 1995-06-26 | Schering Corp | Combination of a cholesterol biosynhtesis inhibitor and a beta- lactam cholesterol absorbtion inhibitor |
LT3595B (en) * | 1993-01-21 | 1995-12-27 | Schering Corp | Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents |
US5627176A (en) * | 1994-03-25 | 1997-05-06 | Schering Corporation | Substituted azetidinone compounds useful as hypocholesterolemic agents |
HU226822B1 (en) | 1995-10-31 | 2009-11-30 | Schering Corp | Hypocholesterolemic sugar-substituted 2-azetidinones, and pharmaceutical compns. contg. them |
US5756470A (en) * | 1996-10-29 | 1998-05-26 | Schering Corporation | Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents |
CZ302193B6 (cs) | 2000-12-20 | 2010-12-08 | Schering Corporation | 2-azetidinonové deriváty, substituované zbytkem cukru |
ES2290562T3 (es) * | 2001-01-26 | 2008-02-16 | Schering Corporation | Combinaciones del activador del receptor activado por el proliferador de los peroxisomas (ppar) fenofibrato con el inhibidor de la absorcion de esteroles ezetimiba para indicaciones vasculares. |
CZ20032031A3 (cs) * | 2001-01-26 | 2003-12-17 | Schering Corporation | Farmaceutický prostředek |
TWI291957B (en) * | 2001-02-23 | 2008-01-01 | Kotobuki Pharmaceutical Co Ltd | Beta-lactam compounds, process for repoducing the same and serum cholesterol-lowering agents containing the same |
-
2003
- 2003-06-27 JP JP2003185171A patent/JP2005015434A/ja active Pending
-
2004
- 2004-06-15 PT PT47461538T patent/PT1655037E/pt unknown
- 2004-06-15 CA CA2529452A patent/CA2529452C/en not_active Expired - Fee Related
- 2004-06-15 US US10/560,357 patent/US7795229B2/en active Active
- 2004-06-15 DK DK04746153.8T patent/DK1655037T3/en active
- 2004-06-15 RU RU2006102355/15A patent/RU2328307C2/ru not_active IP Right Cessation
- 2004-06-15 EP EP04746153.8A patent/EP1655037B1/en not_active Expired - Lifetime
- 2004-06-15 AU AU2004251536A patent/AU2004251536B2/en not_active Ceased
- 2004-06-15 WO PCT/JP2004/008678 patent/WO2005000353A1/ja active Application Filing
- 2004-06-15 KR KR1020057024565A patent/KR100792098B1/ko not_active IP Right Cessation
- 2004-06-15 CN CN2004800179552A patent/CN1812812B/zh not_active Expired - Fee Related
- 2004-06-15 ES ES04746153.8T patent/ES2545667T3/es not_active Expired - Lifetime
- 2004-06-15 MX MXPA05014084A patent/MXPA05014084A/es active IP Right Grant
- 2004-06-15 BR BRPI0411723A patent/BRPI0411723B1/pt not_active IP Right Cessation
-
2006
- 2006-01-23 NO NO20060366A patent/NO335222B1/no not_active IP Right Cessation
-
2007
- 2007-01-30 HK HK07101052.6A patent/HK1095733A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
MXPA05014084A (es) | 2006-03-17 |
EP1655037A1 (en) | 2006-05-10 |
CN1812812B (zh) | 2010-11-03 |
HK1095733A1 (en) | 2007-05-18 |
DK1655037T3 (en) | 2015-08-24 |
RU2328307C2 (ru) | 2008-07-10 |
PT1655037E (pt) | 2015-10-19 |
EP1655037A4 (en) | 2010-04-28 |
WO2005000353A1 (ja) | 2005-01-06 |
BRPI0411723B1 (pt) | 2016-08-02 |
AU2004251536A1 (en) | 2005-01-06 |
RU2006102355A (ru) | 2006-07-27 |
JP2005015434A (ja) | 2005-01-20 |
US20060154876A1 (en) | 2006-07-13 |
NO20060366L (no) | 2006-01-23 |
EP1655037B1 (en) | 2015-08-05 |
CA2529452A1 (en) | 2005-01-06 |
KR100792098B1 (ko) | 2008-01-04 |
NO335222B1 (no) | 2014-10-20 |
ES2545667T3 (es) | 2015-09-14 |
KR20060012032A (ko) | 2006-02-06 |
CN1812812A (zh) | 2006-08-02 |
CA2529452C (en) | 2011-02-15 |
US7795229B2 (en) | 2010-09-14 |
AU2004251536B2 (en) | 2007-11-15 |
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Legal Events
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
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B07A | Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 02/08/2016, OBSERVADAS AS CONDICOES LEGAIS. |
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B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time | ||
B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |