BRPI0408902A - composições de inibidores seletivos da ciclooxigenase-2 e agonistas de 5-ht 1b/1d para o tratamento e a prevenção de enxaqueca - Google Patents
composições de inibidores seletivos da ciclooxigenase-2 e agonistas de 5-ht 1b/1d para o tratamento e a prevenção de enxaquecaInfo
- Publication number
- BRPI0408902A BRPI0408902A BRPI0408902-2A BRPI0408902A BRPI0408902A BR PI0408902 A BRPI0408902 A BR PI0408902A BR PI0408902 A BRPI0408902 A BR PI0408902A BR PI0408902 A BRPI0408902 A BR PI0408902A
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- migraine
- agonists
- prevention
- selective cyclooxygenase
- Prior art date
Links
- 208000019695 Migraine disease Diseases 0.000 title abstract 3
- 239000000556 agonist Substances 0.000 title abstract 3
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 title abstract 3
- 206010027599 migraine Diseases 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 229940093444 Cyclooxygenase 2 inhibitor Drugs 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title abstract 2
- 238000002648 combination therapy Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
"COMPOSIçõES DE INIBIDORES SELETIVOS DA CICLOOXIGENASE-2 E AGONISTAS DE 5-HT~ 1B/1D~ PARA O TRATAMENTO E A PREVENçãO DE ENXAQUECA". A presente invenção refere-se a composições e métodos para o tratamento de enxaqueca. Mais particularmente, a invenção proporciona uma terapia de combinação para o tratamento de enxaqueca compreendendo a administração a um indivíduo de um agonista de 5-HT~ 1B/1D~ em combinação com um inibidor seletivo da ciclooxigenase-2.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45886803P | 2003-03-28 | 2003-03-28 | |
| PCT/US2004/007559 WO2004093826A2 (en) | 2003-03-28 | 2004-03-12 | Compositions of cyclooxygenase-2 selective inhibitors and 5-ht1b/1d agonists for the treatment and prevention of migraine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0408902A true BRPI0408902A (pt) | 2006-03-28 |
Family
ID=33310695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0408902-2A BRPI0408902A (pt) | 2003-03-28 | 2004-03-12 | composições de inibidores seletivos da ciclooxigenase-2 e agonistas de 5-ht 1b/1d para o tratamento e a prevenção de enxaqueca |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20040214861A1 (pt) |
| EP (1) | EP1608361A4 (pt) |
| JP (1) | JP2006521353A (pt) |
| BR (1) | BRPI0408902A (pt) |
| CA (1) | CA2520527A1 (pt) |
| CL (1) | CL2004000643A1 (pt) |
| MX (1) | MXPA05010476A (pt) |
| TW (1) | TW200509924A (pt) |
| WO (1) | WO2004093826A2 (pt) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008115586A1 (en) * | 2007-03-21 | 2008-09-25 | Alza Corporation | Apparatus and method for transdermal delivery of a triptan agonist |
| US8680134B2 (en) * | 2009-10-23 | 2014-03-25 | Avi Dascalu | Triptans for the treatment of psoriasis |
| US11013805B2 (en) | 2015-02-10 | 2021-05-25 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11607456B2 (en) | 2015-02-10 | 2023-03-21 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11013806B2 (en) | 2015-02-10 | 2021-05-25 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11738085B2 (en) | 2015-02-10 | 2023-08-29 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11602563B2 (en) | 2015-02-10 | 2023-03-14 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US12485176B2 (en) | 2015-02-10 | 2025-12-02 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11045549B2 (en) | 2015-02-10 | 2021-06-29 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US10933136B2 (en) | 2015-02-10 | 2021-03-02 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11433079B2 (en) | 2017-01-04 | 2022-09-06 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11617755B2 (en) | 2017-01-04 | 2023-04-04 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US10905693B2 (en) | 2017-01-04 | 2021-02-02 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US10940153B2 (en) | 2017-01-04 | 2021-03-09 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11806354B2 (en) | 2017-01-04 | 2023-11-07 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| KR102493541B1 (ko) * | 2017-01-04 | 2023-01-30 | 액섬 테라퓨틱스, 인크. | 멜록시캄을 포함하는 약학적 조성물 |
| US11266657B2 (en) * | 2017-01-04 | 2022-03-08 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11433078B2 (en) | 2017-01-04 | 2022-09-06 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US10821182B2 (en) | 2017-06-29 | 2020-11-03 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11801250B2 (en) | 2017-01-04 | 2023-10-31 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11471465B2 (en) | 2017-01-04 | 2022-10-18 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11207327B2 (en) | 2017-01-04 | 2021-12-28 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| HUE070065T2 (hu) * | 2017-05-10 | 2025-05-28 | Axsome Therapeutics Inc | Gyógyszerkészítmények, amelyek meloxikámot tartalmaznak |
| US11617791B2 (en) | 2017-06-29 | 2023-04-04 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11865117B2 (en) | 2017-06-29 | 2024-01-09 | Axsome Therapeutics, Inc | Pharmaceutical compositions comprising meloxicam |
| US11185550B2 (en) | 2017-06-29 | 2021-11-30 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US10918722B2 (en) | 2017-06-29 | 2021-02-16 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11759522B2 (en) | 2017-06-29 | 2023-09-19 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11617756B2 (en) | 2017-06-29 | 2023-04-04 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11510927B2 (en) | 2017-06-29 | 2022-11-29 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| AU2019297360B2 (en) * | 2018-07-03 | 2022-07-21 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| MX2021009435A (es) * | 2019-02-06 | 2021-09-10 | Axsome Therapeutics Inc | Composiciones farmaceuticas que comprenden meloxicam. |
| US20240058354A1 (en) | 2020-04-06 | 2024-02-22 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US12128052B2 (en) | 2020-05-28 | 2024-10-29 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US12370196B2 (en) | 2020-12-31 | 2025-07-29 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| WO2022147155A1 (en) | 2020-12-31 | 2022-07-07 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US12005118B2 (en) | 2022-05-19 | 2024-06-11 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5466823A (en) * | 1993-11-30 | 1995-11-14 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides |
| US5633272A (en) * | 1995-02-13 | 1997-05-27 | Talley; John J. | Substituted isoxazoles for the treatment of inflammation |
| PT892791E (pt) * | 1996-04-12 | 2003-06-30 | Searle & Co | N-¬¬4-(5-metil-3-fenilisoxazol-4-il|fenil|sulfonil-propilamida e seu sal de sodio como pro-farmacos de inibidores de cox-2 |
| US6586458B1 (en) * | 1996-08-16 | 2003-07-01 | Pozen Inc. | Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs |
| US6034256A (en) * | 1997-04-21 | 2000-03-07 | G.D. Searle & Co. | Substituted benzopyran derivatives for the treatment of inflammation |
| US6077850A (en) * | 1997-04-21 | 2000-06-20 | G.D. Searle & Co. | Substituted benzopyran analogs for the treatment of inflammation |
| WO2000025779A1 (en) * | 1998-11-02 | 2000-05-11 | Merck & Co., Inc. | Method of treating migraines and pharmaceutical compositions |
| CO5190664A1 (es) * | 1999-06-30 | 2002-08-29 | Pfizer Prod Inc | Terapia de combinacion para el tratamiento de migrana administracion de un receptor 5ht, cafeina y un inhibidor de ciclooxigenasa-2 |
| GB9929040D0 (en) * | 1999-12-08 | 2000-02-02 | Glaxo Group Ltd | Medicaments |
| WO2001091856A2 (en) * | 2000-06-01 | 2001-12-06 | Pharmacia Corporation | Use of cox2 inhibitors for treating skin injury from exposure to ultraviolet radiation |
| JP2004503588A (ja) * | 2000-07-13 | 2004-02-05 | ファルマシア・コーポレーション | 全身性疼痛および頭痛に対する選択的シクロオキシゲナーゼ−2阻害薬および血管調節化合物 |
-
2004
- 2004-03-05 US US10/794,041 patent/US20040214861A1/en not_active Abandoned
- 2004-03-12 EP EP04720385A patent/EP1608361A4/en not_active Withdrawn
- 2004-03-12 MX MXPA05010476A patent/MXPA05010476A/es unknown
- 2004-03-12 WO PCT/US2004/007559 patent/WO2004093826A2/en not_active Ceased
- 2004-03-12 BR BRPI0408902-2A patent/BRPI0408902A/pt not_active IP Right Cessation
- 2004-03-12 JP JP2006507115A patent/JP2006521353A/ja not_active Withdrawn
- 2004-03-12 CA CA002520527A patent/CA2520527A1/en not_active Abandoned
- 2004-03-26 TW TW093108301A patent/TW200509924A/zh unknown
- 2004-03-26 CL CL200400643A patent/CL2004000643A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2006521353A (ja) | 2006-09-21 |
| US20040214861A1 (en) | 2004-10-28 |
| CL2004000643A1 (es) | 2005-03-18 |
| EP1608361A2 (en) | 2005-12-28 |
| MXPA05010476A (es) | 2005-11-16 |
| TW200509924A (en) | 2005-03-16 |
| WO2004093826A2 (en) | 2004-11-04 |
| WO2004093826A3 (en) | 2005-10-27 |
| CA2520527A1 (en) | 2004-11-04 |
| EP1608361A4 (en) | 2006-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 4A , 5A , 6A E 7A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2129 DE 25/10/2011. |