CN100343670C - 用于测量微阵列上磁性纳米粒子面密度的传感器和方法 - Google Patents

用于测量微阵列上磁性纳米粒子面密度的传感器和方法 Download PDF

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CN100343670C
CN100343670C CNB02825869XA CN02825869A CN100343670C CN 100343670 C CN100343670 C CN 100343670C CN B02825869X A CNB02825869X A CN B02825869XA CN 02825869 A CN02825869 A CN 02825869A CN 100343670 C CN100343670 C CN 100343670C
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magnetic
particle
magnetoresistive transducer
transducer device
nano
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CN1608206A (zh
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R·科胡恩
M·W·J·普林斯
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Koninklijke Philips NV
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
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    • G—PHYSICS
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    • G01R33/12—Measuring magnetic properties of articles or specimens of solids or fluids
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G—PHYSICS
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/493—Physical analysis of biological material of liquid biological material urine
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/02—Measuring direction or magnitude of magnetic fields or magnetic flux
    • G01R33/06—Measuring direction or magnitude of magnetic fields or magnetic flux using galvano-magnetic devices
    • G01R33/09—Magnetoresistive devices
    • G01R33/093—Magnetoresistive devices using multilayer structures, e.g. giant magnetoresistance sensors
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    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/02—Measuring direction or magnitude of magnetic fields or magnetic flux
    • G01R33/06—Measuring direction or magnitude of magnetic fields or magnetic flux using galvano-magnetic devices
    • G01R33/09—Magnetoresistive devices
    • G01R33/096—Magnetoresistive devices anisotropic magnetoresistance sensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/12—Measuring magnetic properties of articles or specimens of solids or fluids
    • G01R33/1269—Measuring magnetic properties of articles or specimens of solids or fluids of molecules labeled with magnetic beads
    • C—CHEMISTRY; METALLURGY
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    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
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    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/155—Particles of a defined size, e.g. nanoparticles
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    • G01N2446/00—Magnetic particle immunoreagent carriers
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  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Measuring Magnetic Variables (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CNB02825869XA 2001-12-21 2002-12-17 用于测量微阵列上磁性纳米粒子面密度的传感器和方法 Expired - Fee Related CN100343670C (zh)

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EP01205152 2001-12-21
EP01205152.0 2001-12-21

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CN1608206A CN1608206A (zh) 2005-04-20
CN100343670C true CN100343670C (zh) 2007-10-17

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US (2) US7048890B2 (de)
EP (1) EP1456658B1 (de)
JP (1) JP2005513475A (de)
KR (1) KR20040068968A (de)
CN (1) CN100343670C (de)
AT (1) ATE326697T1 (de)
AU (1) AU2002366904A1 (de)
DE (1) DE60211555T2 (de)
TW (1) TWI295323B (de)
WO (1) WO2003054523A2 (de)

Cited By (3)

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CN103987654A (zh) * 2011-10-19 2014-08-13 明尼苏达大学董事会 用于高吞吐量生物分子测试的磁性生物医学传感器和感测系统
US9927431B2 (en) 2011-09-14 2018-03-27 Regents Of The University Of Minnesota External field—free magnetic biosensor
US10725126B2 (en) 2016-09-05 2020-07-28 Industrial Technology Research Institute Biomolecule magnetic sensor

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