DE60211555D1 - Sensor und methode zur messung der flächendichte von magnetischen nanopartikeln auf einem mikroarray - Google Patents
Sensor und methode zur messung der flächendichte von magnetischen nanopartikeln auf einem mikroarrayInfo
- Publication number
- DE60211555D1 DE60211555D1 DE60211555T DE60211555T DE60211555D1 DE 60211555 D1 DE60211555 D1 DE 60211555D1 DE 60211555 T DE60211555 T DE 60211555T DE 60211555 T DE60211555 T DE 60211555T DE 60211555 D1 DE60211555 D1 DE 60211555D1
- Authority
- DE
- Germany
- Prior art keywords
- nanoparticles
- magnetoresistive sensor
- measuring
- magnetic nanoparticles
- target sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002122 magnetic nanoparticle Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 238000002493 microarray Methods 0.000 title abstract 2
- 239000002105 nanoparticle Substances 0.000 abstract 2
- 238000000018 DNA microarray Methods 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/12—Measuring magnetic properties of articles or specimens of solids or fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y25/00—Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6825—Nucleic acid detection involving sensors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/06—Investigating concentration of particle suspensions
- G01N15/0656—Investigating concentration of particle suspensions using electric, e.g. electrostatic methods or magnetic methods
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
- G01N27/74—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
- G01N27/745—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids for detecting magnetic beads used in biochemical assays
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/493—Physical analysis of biological material of liquid biological material urine
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/02—Measuring direction or magnitude of magnetic fields or magnetic flux
- G01R33/06—Measuring direction or magnitude of magnetic fields or magnetic flux using galvano-magnetic devices
- G01R33/09—Magnetoresistive devices
- G01R33/093—Magnetoresistive devices using multilayer structures, e.g. giant magnetoresistance sensors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/02—Measuring direction or magnitude of magnetic fields or magnetic flux
- G01R33/06—Measuring direction or magnitude of magnetic fields or magnetic flux using galvano-magnetic devices
- G01R33/09—Magnetoresistive devices
- G01R33/096—Magnetoresistive devices anisotropic magnetoresistance sensors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/12—Measuring magnetic properties of articles or specimens of solids or fluids
- G01R33/1269—Measuring magnetic properties of articles or specimens of solids or fluids of molecules labeled with magnetic beads
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/143—Magnetism, e.g. magnetic label
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/155—Particles of a defined size, e.g. nanoparticles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2446/00—Magnetic particle immunoreagent carriers
-
- H—ELECTRICITY
- H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
- H10N—ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
- H10N50/00—Galvanomagnetic devices
- H10N50/10—Magnetoresistive devices
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Pathology (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Nanotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Electrochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Ecology (AREA)
- Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
- Measuring Magnetic Variables (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01205152 | 2001-12-21 | ||
EP01205152 | 2001-12-21 | ||
PCT/IB2002/005567 WO2003054523A2 (en) | 2001-12-21 | 2002-12-17 | Sensor and method for measuring the areal density of magnetic nanoparticles on a micro-array |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60211555D1 true DE60211555D1 (de) | 2006-06-22 |
DE60211555T2 DE60211555T2 (de) | 2007-02-22 |
Family
ID=8181541
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60211555T Expired - Lifetime DE60211555T2 (de) | 2001-12-21 | 2002-12-17 | Sensor und methode zur messung der flächendichte von magnetischen nanopartikeln auf einem mikroarray |
Country Status (10)
Country | Link |
---|---|
US (2) | US7048890B2 (de) |
EP (1) | EP1456658B1 (de) |
JP (1) | JP2005513475A (de) |
KR (1) | KR20040068968A (de) |
CN (1) | CN100343670C (de) |
AT (1) | ATE326697T1 (de) |
AU (1) | AU2002366904A1 (de) |
DE (1) | DE60211555T2 (de) |
TW (1) | TWI295323B (de) |
WO (1) | WO2003054523A2 (de) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112924906A (zh) * | 2021-01-26 | 2021-06-08 | 西安交通大学 | 基于磁热效应的无线柔性磁传感器及制备方法和检测方法 |
Families Citing this family (148)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100516879C (zh) * | 2002-01-29 | 2009-07-22 | 旭化成株式会社 | 生物传感器、用于磁性分子以及待测量目标的测量方法 |
US20080309329A1 (en) * | 2003-07-30 | 2008-12-18 | Koninklike Philips Electronics N.V. | On-Chip Magnetic Sensor Device with Suppressed Cross-Talk |
WO2005010542A2 (en) * | 2003-07-30 | 2005-02-03 | Koninklijke Philips Electronics N.V. | On-chip magnetic particle sensor with improved snr |
JP4392429B2 (ja) * | 2003-07-30 | 2010-01-06 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 磁気抵抗ナノ粒子センサの集積された1/fノイズ除去方法 |
US7906345B2 (en) * | 2003-11-12 | 2011-03-15 | The Board Of Trustees Of The Leland Stanford Junior University | Magnetic nanoparticles, magnetic detector arrays, and methods for their use in detecting biological molecules |
US7432714B2 (en) * | 2004-01-26 | 2008-10-07 | Koninklijke Philips Electronics N.V. | Method and device for on-chip magnetic resonance spectroscopy |
JP4433820B2 (ja) * | 2004-02-20 | 2010-03-17 | Tdk株式会社 | 磁気検出素子およびその形成方法ならびに磁気センサ、電流計 |
JP2005315678A (ja) * | 2004-04-28 | 2005-11-10 | Canon Inc | 検出方法、検出デバイス及び検出用キット |
GB0410980D0 (en) * | 2004-05-17 | 2004-06-16 | Randox Lab Ltd | Magnetic particle detector system and method of performing binding assay |
GB0410976D0 (en) * | 2004-05-17 | 2004-06-16 | Randox Lab Ltd | Magnetic particle detector system |
US7892817B2 (en) * | 2004-05-18 | 2011-02-22 | Koninklijke Philips Electronics, N.V. | Magnetic rotation to improve signal-over-background in biosensing |
EP1754063A1 (de) * | 2004-05-24 | 2007-02-21 | Koninklijke Philips Electronics N.V. | Magnetoresistiver sensor zur hochsensitiven tiefensondierung |
PT1781820T (pt) * | 2004-08-20 | 2018-07-10 | Magnomics Sa | Um dispositivo bioeletrónico |
CA2520670A1 (en) * | 2004-09-23 | 2006-03-23 | National Research Council Of Canada | Nanocrystal coated surfaces |
CN101069094A (zh) | 2004-11-30 | 2007-11-07 | 皇家飞利浦电子股份有限公司 | 用于降低生物传感器中的磁串扰的装置和方法 |
JP4731927B2 (ja) * | 2005-01-31 | 2011-07-27 | キヤノン株式会社 | 磁性体センサおよび検出キット |
US8828740B2 (en) | 2005-01-31 | 2014-09-09 | Koninklijke Philips N.V. | Rapid and sensitive biosensing |
JP4756868B2 (ja) * | 2005-01-31 | 2011-08-24 | キヤノン株式会社 | 検出方法 |
JP4728012B2 (ja) * | 2005-02-28 | 2011-07-20 | 旭化成株式会社 | バイオセンサ |
CN100360939C (zh) * | 2005-05-26 | 2008-01-09 | 上海交通大学 | 利用生物磁控压电传感芯片探针探测癌细胞 |
WO2006131892A2 (en) * | 2005-06-09 | 2006-12-14 | Koninklijke Philips Electronics N.V. | Amplification of nucleic acids with magnetic detection |
US20080206104A1 (en) * | 2005-06-17 | 2008-08-28 | Koninklijke Philips Electronics, N.V. | Accurate Magnetic Biosensor |
JP2009501929A (ja) * | 2005-07-21 | 2009-01-22 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 短距離相互作用を有するマイクロチップアセンブリ |
US8456157B2 (en) * | 2005-07-27 | 2013-06-04 | University Of Houston | Nanomagnetic detector array for biomolecular recognition |
DE102006037739B4 (de) * | 2005-08-12 | 2011-09-15 | Siemens Ag | Vorrichtung zur Durchführung eines Analyseverfahrens, insbesondere zur Erkennung biochemischer Moleküle, und mit dieser Vorrichtung ausführbare Analyseverfahren |
US8143073B2 (en) * | 2005-08-12 | 2012-03-27 | Siemens Aktiengesellschaft | Apparatus for carrying out an analysis process, in particular for identification of biochemical molecules, and analysis processes which can be carried out using this apparatus |
DE102006042044B4 (de) * | 2005-09-21 | 2020-02-06 | Siemens Aktiengesellschaft | Verfahren zum Messen kleinster lokaler Magnetfelder, insbesondere zur Messung von durch magnetische Beads erzeugten lokalen magnetischen Streufeldern, und zugehörige Einrichtung zur Durchführung des Verfahrens |
US8283184B2 (en) * | 2005-09-21 | 2012-10-09 | Siemens Aktiengesellschaft | Method for measurement of very small local magnetic fields, in particular for measurement of local magnetic stray fields produced by magnetic beads, and an associated device for carrying out the method |
WO2007042959A2 (en) * | 2005-10-12 | 2007-04-19 | Koninklijke Philips Electronics N.V. | Magnetic sensor device with different internal operating frequencies |
US20080311598A1 (en) * | 2005-11-25 | 2008-12-18 | Koninklijke Philips Electronics, N.V. | Magnetic Biosensor For Determination of Enzymic Activity |
DE102006003177A1 (de) * | 2006-01-23 | 2007-08-02 | Siemens Ag | Vorrichtung und Verfahren zum Nachweis eines Analyten |
AU2007225038B2 (en) | 2006-03-15 | 2013-08-29 | Perkinelmer Health Sciences, Inc. | Integrated nucleic acid assays |
EP1999272B1 (de) | 2006-03-21 | 2017-11-01 | Koninklijke Philips N.V. | Mikroelektronische sensorvorrichtung mit sensoranordnung |
JP4837410B2 (ja) * | 2006-03-22 | 2011-12-14 | 富士フイルム株式会社 | 標的化合物の検出方法 |
US8945946B2 (en) * | 2006-03-31 | 2015-02-03 | Canon Kabushiki Kaisha | Sensor element and detection method of magnetic particles using this element, and detection method of target substance |
DE102006016334B4 (de) * | 2006-04-06 | 2018-11-15 | Boehringer Ingelheim Vetmedica Gmbh | Verfahren und Vorrichtung zur Detektion magnetisierbarer Partikel |
FI121248B (fi) * | 2006-04-21 | 2010-08-31 | Magnasense Technologies Oy | Laite magneettisten partikkelien mittaamiseksi ja vastaava menetelmä |
US20090102472A1 (en) | 2006-05-09 | 2009-04-23 | Koninklijke Philips Electronics N.V. | Magnetic sensor device with field generators and sensors |
WO2007132366A2 (en) * | 2006-05-09 | 2007-11-22 | Koninklijke Philips Electronics N. V. | Microelectronic sensor device for concentration measurements |
EP2018574A1 (de) * | 2006-05-09 | 2009-01-28 | Koninklijke Philips Electronics N.V. | Magnetsensoreinrichtung und verfahren zum erfassen von magnetischen teilchen |
JP2009536348A (ja) * | 2006-05-10 | 2009-10-08 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 高速磁気バイオセンサ |
CN101443674A (zh) | 2006-05-10 | 2009-05-27 | 皇家飞利浦电子股份有限公司 | 用于激励磁阻传感器的系统和方法 |
CN101479617A (zh) * | 2006-06-28 | 2009-07-08 | 皇家飞利浦电子股份有限公司 | 具有场发生器和传感器元件的磁传感器设备 |
WO2008091364A2 (en) * | 2006-06-30 | 2008-07-31 | Intel Corporation | Nanoparticles as tags for bioanalyte detection by nuclear magnetic resonance or electron spin resonance |
WO2008007291A2 (en) * | 2006-07-11 | 2008-01-17 | Koninklijke Philips Electronics N. V. | Magnetic sensor device |
US8133439B2 (en) * | 2006-08-01 | 2012-03-13 | Magic Technologies, Inc. | GMR biosensor with enhanced sensitivity |
JP2010500547A (ja) * | 2006-08-09 | 2010-01-07 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | マイクロチップの磁気センサー装置 |
EP2082231A2 (de) * | 2006-10-09 | 2009-07-29 | Koninklijke Philips Electronics N.V. | Magnetsensorvorrichtung mit paaren von erfassungseinheiten |
US8372344B2 (en) | 2006-10-11 | 2013-02-12 | University Of South Carolina | Nanoscale spintronic chemical sensor |
CN101523215B (zh) * | 2006-10-12 | 2014-07-30 | 皇家飞利浦电子股份有限公司 | 磁性和/或电子标签辅助检测系统和方法 |
JP2010508404A (ja) * | 2006-10-30 | 2010-03-18 | エスティーシー. ユーエヌエム | 磁気感受性粒子およびその混合装置 |
EP2115467A1 (de) * | 2007-02-23 | 2009-11-11 | Koninklijke Philips Electronics N.V. | Magnetsensorvorrichtung mit feldgenerator und sensorelement |
US8114683B2 (en) * | 2007-03-05 | 2012-02-14 | Headway Technologies, Inc. | Low temperature method to enhance detection of magnetic beads |
EP3059583B1 (de) * | 2007-03-06 | 2019-05-15 | Koninklijke Philips N.V. | Elektromagnetisches system für biosensoren |
EP1967855A1 (de) * | 2007-03-08 | 2008-09-10 | Koninklijke Philips Electronics N.V. | Magnetsensorvorrichtung |
DE102007015543A1 (de) * | 2007-03-30 | 2008-10-09 | Siemens Ag | Verfahren und Anordnung zur Detektion biologischer Reaktionsprodukte |
WO2008120169A1 (en) | 2007-04-03 | 2008-10-09 | Koninklijke Philips Electronics N. V. | Sensor device with magnetic washing means |
US7705591B2 (en) * | 2007-06-29 | 2010-04-27 | The Boeing Company | Radio frequency sensor systems, electromagnetic sensor arrays, and methods of manufacture |
EP2017619A1 (de) * | 2007-07-20 | 2009-01-21 | Koninklijke Philips Electronics N.V. | Magnetsensorvorrichtung |
FR2919390B1 (fr) * | 2007-07-27 | 2009-10-30 | Bertin Technologies Soc Par Ac | Procede de dosage d'un analyte dans un milieu liquide |
CN101868286A (zh) * | 2007-09-20 | 2010-10-20 | 马格雷股份有限公司 | 采用磁性传感器进行的分析物检测 |
CN101802614B (zh) * | 2007-09-21 | 2013-08-07 | 皇家飞利浦电子股份有限公司 | 具有高频交流磁场的传感器及描述流体样本特征的方法 |
EP2060637A1 (de) * | 2007-11-14 | 2009-05-20 | Koninklijke Philips Electronics N.V. | Mittel und Verfahren zum Erkennen von Nukleinsäuren |
CN101952725B (zh) * | 2007-12-03 | 2014-12-10 | 多摩川精机株式会社 | 使用了包覆磁性微粒的生物传感方法以及用于该方法的生物传感装置 |
US9656271B2 (en) * | 2007-12-04 | 2017-05-23 | Headway Technologies, Inc. | Guided transport of magnetically labeled biological molecules and cells |
CN101889208A (zh) * | 2007-12-07 | 2010-11-17 | 皇家飞利浦电子股份有限公司 | 用于生物传感器的磁清洗 |
KR100949804B1 (ko) * | 2007-12-14 | 2010-03-30 | 한국전자통신연구원 | 자기장 감지소자 |
KR100952468B1 (ko) * | 2007-12-14 | 2010-04-13 | 한국전자통신연구원 | 자기장 감지소자의 제조방법 |
WO2009081309A2 (en) * | 2007-12-18 | 2009-07-02 | Koninklijke Philips Electronics N. V. | A magnetic sensor device |
EP2073016A1 (de) * | 2007-12-20 | 2009-06-24 | Koninklijke Philips Electronics N.V. | Magnetetikett-basierte Detektion |
EP2235504A1 (de) * | 2007-12-20 | 2010-10-06 | Koninklijke Philips Electronics N.V. | Positionierung magnetischer spulen in einer sensorvorrichtung |
KR20100115744A (ko) * | 2008-01-17 | 2010-10-28 | 더 리전츠 오브 더 유니버시티 오브 캘리포니아 | 집적 자장 생성 및 검출 플랫폼 |
US8542009B2 (en) * | 2008-05-14 | 2013-09-24 | Koninklijke Philips N. V. | Oxygen concentration measurement with GMR |
JP2009031303A (ja) * | 2008-09-22 | 2009-02-12 | Canon Inc | 検出デバイス及び検出用キット |
WO2010044005A2 (en) * | 2008-10-16 | 2010-04-22 | Koninklijke Philips Electronics N.V. | Method and device for determining the amount of magnetically labeled target components |
RU2520607C2 (ru) | 2008-10-17 | 2014-06-27 | Конинклейке Филипс Электроникс Н.В. | Приведение в действие импульсным магнитным полем для чувствительных анализов |
CN102300800A (zh) * | 2008-11-03 | 2011-12-28 | 曳达研究和发展有限公司 | 磁构图方法和系统 |
KR101181697B1 (ko) * | 2008-12-22 | 2012-09-19 | 한국전자통신연구원 | 정십자형 자기비드 감지 어레이 소자 |
EP2401625B1 (de) | 2009-02-26 | 2014-01-22 | Regents of the University of Minnesota | Detektion von teilchen mit hohem magnetischem moment |
US8993236B2 (en) * | 2009-04-17 | 2015-03-31 | California Institute Of Technology | Electromagnetic molecular sensors and methods of using same |
US9599591B2 (en) | 2009-03-06 | 2017-03-21 | California Institute Of Technology | Low cost, portable sensor for molecular assays |
JP5662357B2 (ja) * | 2009-03-10 | 2015-01-28 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 磁気抵抗センサにおける温度及びドリフト補償 |
KR101034273B1 (ko) * | 2009-04-07 | 2011-05-16 | 최철원 | 마그네틱 비드를 이용한 마이크로어레이 분석 방법 및 시스템 |
JP2012523576A (ja) * | 2009-04-13 | 2012-10-04 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | 試料中の分析物の存在を検出するための方法および装置 |
KR101009802B1 (ko) * | 2009-05-11 | 2011-01-19 | 금오공과대학교 산학협력단 | 입자밀도 측정 시스템 및 방법 |
JP5671527B2 (ja) * | 2009-05-25 | 2015-02-18 | インスプリオン エービー | 局在表面プラズモン共鳴(lspr)を使用するセンサ |
EP2449382B8 (de) * | 2009-06-30 | 2019-06-19 | Koninklijke Philips N.V. | Magnetsensorvorrichtung, verfahren für den betrieb einer derartigen vorrichtung und probe |
EP2454020B1 (de) | 2009-07-17 | 2019-05-15 | Koninklijke Philips N.V. | Vorrichtung und verfahren zur anreicherung von magnetpartikeln |
JP5643825B2 (ja) | 2009-09-28 | 2014-12-17 | コーニンクレッカ フィリップス エヌ ヴェ | 物質決定装置 |
US9081004B2 (en) * | 2009-09-28 | 2015-07-14 | International Business Machines Corporation | Circuit for detecting analytes via nanoparticle-labeled substances with electromagnetic read-write heads |
AU2010315007B2 (en) * | 2009-11-06 | 2015-05-21 | Imagion Biosystems, Inc. | Detection, measurement, and imaging of cells such as cancer and other biologic substances using targeted nanoparticles and magnetic properties thereof |
JP5765907B2 (ja) | 2009-11-09 | 2015-08-19 | 株式会社フェローテック | 磁性部材および電子部品 |
KR101851117B1 (ko) | 2010-01-29 | 2018-04-23 | 마이크로닉스 인코포레이티드. | 샘플-투-앤서 마이크로유체 카트리지 |
WO2011112929A2 (en) * | 2010-03-12 | 2011-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Magnetic sensor based quantitative binding kinetics analysis |
DE102010020784A1 (de) * | 2010-05-18 | 2011-11-24 | Siemens Aktiengesellschaft | Verfahren zum Erkennen von magnetisch gekennzeichneten Objekten sowie entsprechende Vorrichtung |
KR101157997B1 (ko) * | 2010-08-19 | 2012-06-25 | 주식회사 엘지생명과학 | 자기저항센서를 이용한 검출시스템 |
DE102010040391B4 (de) * | 2010-09-08 | 2015-11-19 | Siemens Aktiengesellschaft | Magnetische Durchflusszytometrie zur Einzelzelldetektion |
GB201016484D0 (en) | 2010-09-30 | 2010-11-17 | Geneseque As | Method |
US8815610B2 (en) * | 2010-10-15 | 2014-08-26 | International Business Machines Corporation | Magnetic nanoparticle detection across a membrane |
US20140099663A1 (en) * | 2010-11-15 | 2014-04-10 | Regents Of The University Of Minnesota | Gmr sensor |
CN102487118B (zh) * | 2010-12-05 | 2014-04-30 | 北京德锐磁星科技有限公司 | 一种磁性生物传感器及其制备方法 |
US9304130B2 (en) | 2010-12-16 | 2016-04-05 | International Business Machines Corporation | Trenched sample assembly for detection of analytes with electromagnetic read-write heads |
EP2684036B1 (de) | 2011-03-09 | 2018-04-25 | Magarray, Inc. | Systeme und verfahren zum nachweis von analyten in einer probe mit hohem durchsatz |
US8855957B2 (en) | 2011-05-03 | 2014-10-07 | International Business Machines Corporation | Method for calibrating read sensors of electromagnetic read-write heads |
US9040311B2 (en) | 2011-05-03 | 2015-05-26 | International Business Machines Corporation | Calibration assembly for aide in detection of analytes with electromagnetic read-write heads |
US9229071B2 (en) * | 2011-06-01 | 2016-01-05 | International Business Machines Corporation | Identification of molecules based on frequency responses using electromagnetic write-heads and magneto-resistive sensors |
DE102011080945A1 (de) * | 2011-08-15 | 2013-02-21 | Siemens Aktiengesellschaft | Dynamische Zustandsbestimmung von Analyten mittels magnetischer Durchflussmessung |
CN102393453B (zh) * | 2011-08-22 | 2013-09-18 | 中国科学院宁波材料技术与工程研究所 | 一种磁标记生物传感器、其制备方法以及检测方法 |
WO2013040489A1 (en) * | 2011-09-14 | 2013-03-21 | Regents Of The University Of Minnesota | External field-free magnetic biosensor |
WO2013059692A1 (en) * | 2011-10-19 | 2013-04-25 | Regents Of The University Of Minnesota | Magnetic biomedical sensors and sensing system for high-throughput biomolecule testing |
WO2013102850A1 (en) | 2012-01-04 | 2013-07-11 | Insituto De Engenharia De Sistemas E Computadores Para Os Microsistemas E As Nanotecnologias | Monolithic device combining cmos with magnetoresistive sensors |
US9435800B2 (en) | 2012-09-14 | 2016-09-06 | International Business Machines Corporation | Sample assembly with an electromagnetic field to accelerate the bonding of target antigens and nanoparticles |
JP6935167B2 (ja) | 2012-12-21 | 2021-09-15 | ペルキネルマー ヘルス サイエンシーズ, インコーポレイテッド | マイクロ流体使用のための低弾性フィルム |
CN104919035B (zh) | 2012-12-21 | 2017-08-11 | 精密公司 | 便携式荧光检测系统和微测定盒 |
EP2935908B1 (de) | 2012-12-21 | 2019-08-14 | PerkinElmer Health Sciences, Inc. | Fluidkreisläufe und zugehörige herstellungsverfahren |
US10267871B2 (en) | 2013-03-15 | 2019-04-23 | Magarray, Inc. | Magnetic tunnel junction sensors and methods for using the same |
EP2994543B1 (de) | 2013-05-07 | 2018-08-15 | Micronics, Inc. | Vorrichtung zur herstellung und analyse von nukleinsäuren |
WO2014182844A1 (en) | 2013-05-07 | 2014-11-13 | Micronics, Inc. | Microfluidic devices and methods for performing serum separation and blood cross-matching |
US10190153B2 (en) | 2013-05-07 | 2019-01-29 | Micronics, Inc. | Methods for preparation of nucleic acid-containing samples using clay minerals and alkaline solutions |
US9767943B2 (en) | 2013-11-07 | 2017-09-19 | University Of South Carolina | Patterned nanoparticle assembly methodology |
CN106461741B (zh) * | 2014-01-31 | 2019-11-01 | 南澳大利亚大学 | 用于检测磁粒子的传感器 |
US9678169B2 (en) * | 2014-07-09 | 2017-06-13 | Voltafield Technology Corp. | Testing assembly for testing magnetic sensor and method for testing magnetic sensor |
US20160011182A1 (en) * | 2014-07-09 | 2016-01-14 | Zepto Life Technology, LLC | Method and system for substance detection with a magnetic sensor |
GB201413929D0 (en) | 2014-08-06 | 2014-09-17 | Geneseque As | Method |
WO2016029943A1 (en) * | 2014-08-27 | 2016-03-03 | Siemens Aktiengesellschaft | Method for determining at least one physiological parameter of a biological sample |
CN105092879B (zh) * | 2015-08-06 | 2019-08-13 | 德惠市北方汽车底盘零部件有限公司 | 复合电子元件 |
WO2017082227A1 (ja) * | 2015-11-10 | 2017-05-18 | Tdk株式会社 | バイオセンサ、生体分子の検出方法、及びバイオチップ |
CN108780067A (zh) * | 2016-03-28 | 2018-11-09 | Tdk株式会社 | 生物传感器和生物芯片 |
JP6860007B2 (ja) | 2016-03-28 | 2021-04-14 | Tdk株式会社 | 化学センサ |
JPWO2017170236A1 (ja) * | 2016-03-28 | 2019-02-14 | Tdk株式会社 | バイオセンサ及びバイオチップ |
JP6668176B2 (ja) * | 2016-06-16 | 2020-03-18 | 株式会社東芝 | センサ |
CN107796865B (zh) | 2016-09-05 | 2021-05-25 | 财团法人工业技术研究院 | 生物分子磁传感器 |
US10060880B2 (en) | 2016-09-15 | 2018-08-28 | Qualcomm Incorporated | Magnetoresistive (MR) sensors employing dual MR devices for differential MR sensing |
US20200243230A1 (en) * | 2017-02-24 | 2020-07-30 | Nano Theranostics, Inc | Doped magnetic nanoparticles |
DE102017114537A1 (de) * | 2017-06-29 | 2019-01-03 | Endress+Hauser Conducta Gmbh+Co. Kg | Sensormembran, Sensorkappe und optischer Sensor |
CN107394062B (zh) * | 2017-07-20 | 2019-02-05 | 京东方科技集团股份有限公司 | 一种有机发光二极管显示面板及其制作方法、显示装置 |
US10738342B2 (en) | 2018-08-30 | 2020-08-11 | Urinary Technologies, Inc. | System for microbial species detection, quantification and antibiotic susceptibility identification |
US10978376B2 (en) * | 2019-01-18 | 2021-04-13 | Electronics And Telecommunications Research Institute | Sensing device and method for fabricating the same |
US11112468B2 (en) * | 2019-04-12 | 2021-09-07 | Western Digital Technologies, Inc. | Magnetoresistive sensor array for molecule detection and related detection schemes |
US11609208B2 (en) * | 2019-04-12 | 2023-03-21 | Western Digital Technologies, Inc. | Devices and methods for molecule detection based on thermal stabilities of magnetic nanoparticles |
CN110274951A (zh) * | 2019-05-20 | 2019-09-24 | 青岛大学 | 一种磁标签及其检测系统、检测方法、制备方法 |
CN112082901B (zh) * | 2019-06-13 | 2022-02-22 | 宁德时代新能源科技股份有限公司 | 面密度测量补偿系统 |
CN110302838B (zh) * | 2019-06-20 | 2022-04-15 | 苏州大学 | 表面修饰PNH的磁性Fe2O3纳米小球及其在水处理中的应用 |
JP7136137B2 (ja) * | 2020-01-29 | 2022-09-13 | Tdk株式会社 | 磁気センサ、磁気検出装置及び磁気検出システム |
WO2022203904A1 (en) | 2021-03-22 | 2022-09-29 | NearField Atomics Inc. | Systems and methods for measuring magnetic fields from solvated target molecules using a magnetoresistive sensor |
DE102021115952A1 (de) * | 2021-06-21 | 2022-12-22 | Universidad Complutense Madrid | Sensorvorrichtungen, elektrische Verbindungssysteme und Verfahren zum Detektieren eines genetischen Materials |
US20230243778A1 (en) * | 2022-01-28 | 2023-08-03 | Western Digital Technologies, Inc. | Self-aligned surface modification for magnetochemical sensors |
WO2023208697A1 (en) * | 2022-04-29 | 2023-11-02 | Analog Devices International Unlimited Company | Comparative measurement using particles within one or more compartments |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5252459A (en) * | 1988-09-23 | 1993-10-12 | Abbott Laboratories | Indicator reagents, diagnostic assays and test kits employing organic polymer latex particles |
US5021736A (en) * | 1989-09-19 | 1991-06-04 | Texas Instruments Incorporated | Speed/position sensor calibration method with angular adjustment of a magnetoresistive element |
US5412087A (en) * | 1992-04-24 | 1995-05-02 | Affymax Technologies N.V. | Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces |
JPH06220609A (ja) * | 1992-07-31 | 1994-08-09 | Sony Corp | 磁気抵抗効果膜及びその製造方法並びにそれを用いた磁気抵抗効果素子、磁気抵抗効果型磁気ヘッド |
US5569544A (en) * | 1992-11-16 | 1996-10-29 | Nonvolatile Electronics, Incorporated | Magnetoresistive structure comprising ferromagnetic thin films and intermediate layers of less than 30 angstroms formed of alloys having immiscible components |
CN1076784A (zh) * | 1993-03-10 | 1993-09-29 | 北京放射医学研究所 | 磁性微颗粒免疫分离剂及制备 |
US5411814A (en) * | 1994-01-26 | 1995-05-02 | At&T Corp. | Article comprising magnetoresistive oxide of La, Ca, Mn additionally containing either of both of Sr and Ba |
US5739990A (en) * | 1996-11-13 | 1998-04-14 | Read-Rite Corporation | Spin-valve GMR sensor with inbound exchange stabilization |
US5981297A (en) * | 1997-02-05 | 1999-11-09 | The United States Of America As Represented By The Secretary Of The Navy | Biosensor using magnetically-detected label |
US6592820B1 (en) * | 1998-11-05 | 2003-07-15 | Bio-Spectrum Technologies, Inc. | System and method for biochemical assay |
AU4244300A (en) * | 1999-04-13 | 2000-11-14 | Nanogen, Inc. | Magnetic bead-based array for genetic detection |
CA2381732A1 (en) * | 1999-08-21 | 2001-03-01 | John S. Fox | High sensitivity biomolecule detection with magnetic particles |
US6743639B1 (en) * | 1999-10-13 | 2004-06-01 | Nve Corporation | Magnetizable bead detector |
US6468809B1 (en) * | 2000-02-04 | 2002-10-22 | The United States Of America As Represented By The Secretary Of The Navy | High efficiency magnetic sensor for magnetic particles |
US20040219695A1 (en) * | 2002-01-19 | 2004-11-04 | Fox John Stewart | High sensitivity detection of and manipulation of biomolecules and cells with magnetic particles |
AU2003239963A1 (en) * | 2002-05-31 | 2003-12-19 | The Regents Of The University Of California | Method and apparatus for detecting substances of interest |
-
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- 2002-12-17 CN CNB02825869XA patent/CN100343670C/zh not_active Expired - Fee Related
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- 2002-12-17 EP EP02790607A patent/EP1456658B1/de not_active Expired - Lifetime
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112924906A (zh) * | 2021-01-26 | 2021-06-08 | 西安交通大学 | 基于磁热效应的无线柔性磁传感器及制备方法和检测方法 |
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AU2002366904A8 (en) | 2003-07-09 |
US7048890B2 (en) | 2006-05-23 |
CN1608206A (zh) | 2005-04-20 |
JP2005513475A (ja) | 2005-05-12 |
US20060128035A1 (en) | 2006-06-15 |
WO2003054523A2 (en) | 2003-07-03 |
TWI295323B (en) | 2008-04-01 |
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