DE69928747D1 - Verfahen und Zusammensetzungen zur Vermehrung von feststellbaren Signalen in spezifischen Bindungstests - Google Patents

Verfahen und Zusammensetzungen zur Vermehrung von feststellbaren Signalen in spezifischen Bindungstests

Info

Publication number
DE69928747D1
DE69928747D1 DE69928747T DE69928747T DE69928747D1 DE 69928747 D1 DE69928747 D1 DE 69928747D1 DE 69928747 T DE69928747 T DE 69928747T DE 69928747 T DE69928747 T DE 69928747T DE 69928747 D1 DE69928747 D1 DE 69928747D1
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DE
Germany
Prior art keywords
receptor
amplification reagent
nucleic acid
binding
target
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69928747T
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English (en)
Other versions
DE69928747T2 (de
Inventor
Martin J Goldberg
Govinda Rao S Yelagalawadi
Eugen Yuji Tanimoto
Huu Minh Tran
Helin Dong
David Lockhart
Thomas B Ryder
Janet A Warrington
Jody Beecher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Affymetrix Inc
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Affymetrix Inc
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Publication date
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Publication of DE69928747D1 publication Critical patent/DE69928747D1/de
Application granted granted Critical
Publication of DE69928747T2 publication Critical patent/DE69928747T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/682Signal amplification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804Nucleic acid analysis using immunogens
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/807Apparatus included in process claim, e.g. physical support structures

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE69928747T 1998-09-30 1999-09-22 Verfahen und Zusammensetzungen zur Vermehrung von feststellbaren Signalen in spezifischen Bindungstests Expired - Lifetime DE69928747T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10257798P 1998-09-30 1998-09-30
US102577P 1998-09-30
US09/276,774 US6203989B1 (en) 1998-09-30 1999-03-25 Methods and compositions for amplifying detectable signals in specific binding assays
US276774 1999-03-25

Publications (2)

Publication Number Publication Date
DE69928747D1 true DE69928747D1 (de) 2006-01-12
DE69928747T2 DE69928747T2 (de) 2006-09-07

Family

ID=26799529

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69928747T Expired - Lifetime DE69928747T2 (de) 1998-09-30 1999-09-22 Verfahen und Zusammensetzungen zur Vermehrung von feststellbaren Signalen in spezifischen Bindungstests

Country Status (7)

Country Link
US (3) US6203989B1 (de)
EP (1) EP0999285B1 (de)
JP (2) JP2000106876A (de)
AT (1) ATE312199T1 (de)
AU (1) AU6275099A (de)
DE (1) DE69928747T2 (de)
WO (1) WO2000018962A1 (de)

Families Citing this family (149)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6750016B2 (en) * 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6506564B1 (en) 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US7169556B2 (en) 1996-07-29 2007-01-30 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US7098320B1 (en) 1996-07-29 2006-08-29 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
CA2262018C (en) 1996-07-29 2007-10-02 Nanosphere Llc Nanoparticles having oligonucleotides attached thereto and uses therefor
US6582921B2 (en) 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US6984491B2 (en) * 1996-07-29 2006-01-10 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US20050037397A1 (en) * 2001-03-28 2005-02-17 Nanosphere, Inc. Bio-barcode based detection of target analytes
US6974669B2 (en) * 2000-03-28 2005-12-13 Nanosphere, Inc. Bio-barcodes based on oligonucleotide-modified nanoparticles
US7348181B2 (en) 1997-10-06 2008-03-25 Trustees Of Tufts College Self-encoding sensor with microspheres
US6203989B1 (en) * 1998-09-30 2001-03-20 Affymetrix, Inc. Methods and compositions for amplifying detectable signals in specific binding assays
AU768535B2 (en) 1998-11-30 2003-12-18 Nanosphere, Inc. Nanoparticles with polymer shells
WO2000068434A2 (en) * 1999-05-07 2000-11-16 Yale University Multiple tag analysis
US6921638B2 (en) * 1999-06-25 2005-07-26 Amersham Biosciences Ab Hydrogel-based microarray signal amplification methods and devices therefor
EP1192448B1 (de) 1999-07-05 2006-09-27 Novartis AG Verfahren zur anwendung einer sensoreinheit
US6771376B2 (en) * 1999-07-05 2004-08-03 Novartis Ag Sensor platform, apparatus incorporating the platform, and process using the platform
US7244559B2 (en) * 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
ATE321886T1 (de) * 1999-11-29 2006-04-15 Diasorin S P A Oligonukleotide und diese enthaltende komplexe zur detektion der anwesenheit oder abwesenheit einer zielnukleinsäure in einer probe
AU774593C (en) 2000-01-13 2005-06-23 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US20020094538A1 (en) * 2001-01-13 2002-07-18 Getts Robert C. Methods for detecting and assaying nucleic acid sequences using temperature cycling
JP2003528625A (ja) * 2000-03-31 2003-09-30 メモレック シュトッフェル ゲゼルシャフト ミット ベシュレンクテル ハフツング メディツィニッシューモレクラー エントヴィクルンク,ケルン シグナル発生特性と、標識核酸に対する親和性を有する少なくとも1種類の基とを有する粒子の使用
DE60119170T2 (de) * 2000-07-11 2007-05-24 Northwestern University, Evanston Nachweismethode mittels verstärkter silberfärbung
US20020019792A1 (en) * 2000-08-11 2002-02-14 Robert Maerz Method and system for offering television pilots as a security
JP2004506900A (ja) * 2000-08-11 2004-03-04 アジリックス・コーポレイション 超高感度検出システム
EP1186671A3 (de) * 2000-09-05 2003-12-17 Agilent Technologies, Inc. (a Delaware corporation) Methode zur Hybridisierung von Arrays auf Silikonoberflächen
US7494817B2 (en) * 2000-09-06 2009-02-24 Transnet Yx, Inc. Methods for genotype screening using magnetic particles
US20050239125A1 (en) * 2000-09-06 2005-10-27 Hodge Timothy A Methods for genotype screening
US20050272085A1 (en) * 2000-09-06 2005-12-08 Hodge Timothy A Methods for forensic and congenic screening
US7011943B2 (en) * 2000-09-06 2006-03-14 Transnetyx, Inc. Method for detecting a designated genetic sequence in murine genomic DNA
US20050266494A1 (en) * 2000-09-06 2005-12-01 Hodge Timothy A System and method for computer network ordering of biological testing
US6803196B1 (en) * 2000-10-13 2004-10-12 Affymetrix, Inc. Methods and compositions for detecting signals in binding assays using microparticles
GB0029154D0 (en) * 2000-11-30 2001-01-17 Lee Helen Signal enhancement with multiple labelled-antibodies
US20020165675A1 (en) * 2001-03-03 2002-11-07 Golovlev Valeri V. Method and microelectronic device for multi-site molecule detection
EP1373573B1 (de) * 2001-03-09 2013-10-02 TrovaGene, Inc. Konjugatsonden und optischer nachweis von analyten
US20060040286A1 (en) * 2001-03-28 2006-02-23 Nanosphere, Inc. Bio-barcode based detection of target analytes
JP2004532404A (ja) * 2001-03-28 2004-10-21 ジェネテック・バイオテクノロジー・(シャンハイ)・カンパニー・リミテッド 多数のアナライトを検出するための装置および方法
US7147687B2 (en) * 2001-05-25 2006-12-12 Nanosphere, Inc. Non-alloying core shell nanoparticles
US7238472B2 (en) * 2001-05-25 2007-07-03 Nanosphere, Inc. Non-alloying core shell nanoparticles
JP2003014746A (ja) * 2001-06-27 2003-01-15 Fuji Photo Film Co Ltd 生物学的素材が固定された構造体及びその製造方法
US6662091B2 (en) * 2001-06-29 2003-12-09 Battelle Memorial Institute Diagnostics/prognostics using wireless links
US6753145B2 (en) * 2001-07-05 2004-06-22 Agilent Technologies, Inc. Buffer composition and method for hybridization of microarrays on adsorbed polymer siliceous surfaces
US20030096268A1 (en) * 2001-07-06 2003-05-22 Michael Weiner Method for isolation of independent, parallel chemical micro-reactions using a porous filter
US7297553B2 (en) * 2002-05-28 2007-11-20 Nanosphere, Inc. Method for attachment of silylated molecules to glass surfaces
US7687437B2 (en) * 2001-07-13 2010-03-30 Nanosphere, Inc. Method for immobilizing molecules onto surfaces
AU2002365115A1 (en) * 2001-07-20 2003-09-02 North Carolina State University Light addressable electrochemical detection of duplex structures
US20060014186A1 (en) * 2001-09-04 2006-01-19 Hodge Timothy A Methods for genotype screening of a strain disposed on an adsorbent carrier
US20030054396A1 (en) * 2001-09-07 2003-03-20 Weiner Michael P. Enzymatic light amplification
WO2003027678A1 (en) * 2001-09-26 2003-04-03 Psychiatric Genomics, Inc. Fluorescence proximity assay
US7132236B2 (en) * 2001-10-25 2006-11-07 Agilent Technologies, Inc. Composition and method for optimized hybridization using modified solutions
US6902921B2 (en) 2001-10-30 2005-06-07 454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US20050124022A1 (en) * 2001-10-30 2005-06-09 Maithreyan Srinivasan Novel sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US6956114B2 (en) 2001-10-30 2005-10-18 '454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
WO2003081202A2 (en) 2001-11-09 2003-10-02 Nanosphere, Inc. Bioconjugate-nanoparticle probes
WO2003050242A2 (en) * 2001-11-13 2003-06-19 Rubicon Genomics Inc. Dna amplification and sequencing using dna molecules generated by random fragmentation
NZ535044A (en) * 2002-03-01 2008-12-24 Ravgen Inc Non-invasive method to determine the genetic sequence of foetal DNA from a sample from a pregnant female thereby detecting any alternation in gene sequence as compared with the wild type sequence
US6977162B2 (en) * 2002-03-01 2005-12-20 Ravgen, Inc. Rapid analysis of variations in a genome
US20050266455A1 (en) * 2002-03-02 2005-12-01 Sci Tec, Inc. Method and microelectronic device for multi-site molecule detection
US20030175828A1 (en) * 2002-03-15 2003-09-18 Lazar James G. Signal amplification by Hybrid Capture
US20030211488A1 (en) 2002-05-07 2003-11-13 Northwestern University Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection
US7442506B2 (en) * 2002-05-08 2008-10-28 Ravgen, Inc. Methods for detection of genetic disorders
US7727720B2 (en) * 2002-05-08 2010-06-01 Ravgen, Inc. Methods for detection of genetic disorders
US20070178478A1 (en) * 2002-05-08 2007-08-02 Dhallan Ravinder S Methods for detection of genetic disorders
EP1540006B1 (de) * 2002-07-02 2009-01-07 Nanosphere, Inc. Nanopartikel-polyanion-konjugate sowie verfahren zur verwendung davon beim nachweis von analyten
US20040101444A1 (en) * 2002-07-15 2004-05-27 Xeotron Corporation Apparatus and method for fluid delivery to a hybridization station
ATE534748T1 (de) * 2002-12-12 2011-12-15 Nanosphere Inc Direkter snp-nachweis mit nichtamplifizierter dna
WO2004076683A2 (en) * 2003-02-26 2004-09-10 Callida Genomics, Inc. Random array dna analysis by hybridization
US20040180369A1 (en) * 2003-01-16 2004-09-16 North Carolina State University Photothermal detection of nucleic acid hybridization
WO2005003375A2 (en) 2003-01-29 2005-01-13 454 Corporation Methods of amplifying and sequencing nucleic acids
US7575865B2 (en) * 2003-01-29 2009-08-18 454 Life Sciences Corporation Methods of amplifying and sequencing nucleic acids
US7192703B2 (en) 2003-02-14 2007-03-20 Intel Corporation, Inc. Biomolecule analysis by rolling circle amplification and SERS detection
US20050130174A1 (en) * 2003-02-27 2005-06-16 Nanosphere, Inc. Label-free gene expression profiling with universal nanoparticle probes in microarray assay format
AU2003268333A1 (en) * 2003-02-28 2004-09-28 Ravgen, Inc. Methods for detection of genetic disorders
US20050250094A1 (en) * 2003-05-30 2005-11-10 Nanosphere, Inc. Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes
US20040259100A1 (en) 2003-06-20 2004-12-23 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US9045796B2 (en) 2003-06-20 2015-06-02 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US20050181394A1 (en) * 2003-06-20 2005-08-18 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US7642064B2 (en) 2003-06-24 2010-01-05 Ventana Medical Systems, Inc. Enzyme-catalyzed metal deposition for the enhanced detection of analytes of interest
JP3899407B2 (ja) * 2003-06-26 2007-03-28 国立大学法人 鹿児島大学 免疫組織化学的染色方法による抗原の検出方法
US20090163375A1 (en) 2003-09-09 2009-06-25 Bowman Christopher N Use of Photopolymerization for Amplification and Detection of a Molecular Recognition Event
WO2005024386A2 (en) * 2003-09-09 2005-03-17 The Regents Of The University Of Colorado, A Body Corporate Use of photopolymerization for amplification and detection of a molecular recognition event
US7354706B2 (en) * 2003-09-09 2008-04-08 The Regents Of The University Of Colorado, A Body Corporate Use of photopolymerization for amplification and detection of a molecular recognition event
KR100571817B1 (ko) * 2003-09-19 2006-04-17 삼성전자주식회사 태그 서열에 혼성화하는 검출 프로브를 이용하는 표적핵산의 검출방법
US20050089874A1 (en) * 2003-10-24 2005-04-28 Torontali Suzanne M. Amplification of signal using a bead-based oligonucleotide assay
US20050214796A1 (en) * 2003-10-29 2005-09-29 Hanna Michelle M Compositions, methods and detection technologies for reiterative oligonucleotide synthesis
WO2005042783A1 (en) * 2003-10-30 2005-05-12 North Carolina State University Temperature-jump enhanced electrochemical detection of nucleic acid hybridization
WO2005042785A1 (en) * 2003-10-30 2005-05-12 North Carolina State University Electrochemical detection of nucleic acid hybridization
GB0404187D0 (en) * 2004-02-25 2004-03-31 Biotransformations Ltd Binding agents
US20050266432A1 (en) * 2004-02-26 2005-12-01 Illumina, Inc. Haplotype markers for diagnosing susceptibility to immunological conditions
JP4476050B2 (ja) * 2004-06-30 2010-06-09 株式会社ニデック 視野計
JP2008529035A (ja) * 2005-02-03 2008-07-31 パーキンエルマー エルエーエス,インク. 多次元シグナルを用いる超高感度検出システム
US20070154903A1 (en) * 2005-06-23 2007-07-05 Nanosphere, Inc. Selective isolation and concentration of nucleic acids from complex samples
US7368246B2 (en) * 2005-09-15 2008-05-06 Primera Biosystems, Inc. Quantitative gene expression profiling
US20070275388A1 (en) * 2006-05-25 2007-11-29 Daniel Ryan Dendrimers that possess a single target annealing site and uses thereof
US20090002703A1 (en) * 2006-08-16 2009-01-01 Craig Edward Parman Methods and systems for quantifying isobaric labels and peptides
US20080153135A1 (en) * 2006-12-20 2008-06-26 Liu Timothy Z Methods and apparatus for conducting amplification reactions on high density hydrophilic patterned microplates
US20080153134A1 (en) * 2006-12-22 2008-06-26 Willy Wiyatno Methods and apparatus for generating hydrophilic patterning of high density microplates using an amphiphilic polymer
US20080241831A1 (en) * 2007-03-28 2008-10-02 Jian-Bing Fan Methods for detecting small RNA species
US20080268440A1 (en) * 2007-04-26 2008-10-30 Liu Timothy Z Biomolecule immobilization on surface via hydrophobic interactions
CA2697032C (en) 2007-08-22 2021-09-14 The Regents Of The University Of California Activatable binding polypeptides and methods of identification and use thereof
US20090137405A1 (en) * 2007-11-16 2009-05-28 Christopher Bowman Detection of nucleic acid biomarkers using polymerization-based amplification
US20090162863A1 (en) * 2007-12-13 2009-06-25 Hitachi High-Technologies Corporation Nucleic acid detection probe
JP5504587B2 (ja) * 2008-05-27 2014-05-28 東レ株式会社 分析用チップ
GB0814570D0 (en) 2008-08-08 2008-09-17 Diagnostics For The Real World Isolation of nucleic acid
US20110159499A1 (en) * 2009-11-25 2011-06-30 Quantalife, Inc. Methods and compositions for detecting genetic material
US8309306B2 (en) * 2008-11-12 2012-11-13 Nodality, Inc. Detection composition
ATE523603T1 (de) * 2008-11-21 2011-09-15 Chimera Biotec Gmbh Konjugatkomplexe zum analytnachweis
CA2749339A1 (en) 2009-01-12 2010-07-15 Cytomx Therapeutics, Llc Modified antibody compositions, methods of making and using thereof
RU2011138951A (ru) 2009-02-23 2013-03-27 Сайтомкс Терапьютикс, Инк. Пропротеины и способы их применения
WO2010107825A2 (en) 2009-03-16 2010-09-23 Pangu Biopharma Limited Compositions and methods comprising histidyl-trna synthetase splice variants having non-canonical biological activities
US9464319B2 (en) 2009-03-24 2016-10-11 California Institute Of Technology Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes
CN104722342B (zh) 2009-03-24 2017-01-11 芝加哥大学 滑动式芯片装置和方法
US10196700B2 (en) 2009-03-24 2019-02-05 University Of Chicago Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes
US9447461B2 (en) 2009-03-24 2016-09-20 California Institute Of Technology Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes
AU2010236913B2 (en) 2009-03-31 2016-03-24 Atyr Pharma, Inc. Compositions and methods comprising aspartyl-tRNA synthetases having non-canonical biological activities
WO2011139714A2 (en) 2010-04-26 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-trna synthetase
EP2563381B1 (de) 2010-04-27 2017-08-09 aTyr Pharma, Inc. Innovative entdeckung therapeutischer, diagnostischer und antikörperhaltiger zusammensetzungen im zusammenhang mit proteinfragmenten von isoleucyl-trna-synthetasen
EP2563911B1 (de) 2010-04-28 2021-07-21 aTyr Pharma, Inc. Innovative entdeckung therapeutischer, diagnostischer und antikörperhaltiger zusammensetzungen im zusammenhang mit proteinfragmenten von alanyl-trna-synthetasen
US9034320B2 (en) 2010-04-29 2015-05-19 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Valyl-tRNA synthetases
US9598734B2 (en) 2010-04-29 2017-03-21 Medical Prognosis Institute A/S Methods and devices for predicting treatment efficacy
AU2011248490B2 (en) 2010-04-29 2016-11-10 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Asparaginyl tRNA synthetases
EP2566495B1 (de) 2010-05-03 2017-03-01 aTyr Pharma, Inc. Innovative entdeckung therapeutischer, diagnostischer und antikörperhaltiger zusammensetzungen im zusammenhang mit proteinfragmenten von phenylalanyl-alpha-trna-synthetasen
CA2797277C (en) 2010-05-03 2021-02-23 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of arginyl-trna synthetases
EP2566496B1 (de) 2010-05-03 2018-02-28 aTyr Pharma, Inc. Innovative entdeckung therapeutischer, diagnostischer und antikörperhaltiger zusammensetzungen im zusammenhang mit proteinfragmenten von methionyl-trna-synthetasen
AU2011248101B2 (en) 2010-05-04 2016-10-20 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-tRNA synthetase complex
AU2011252990B2 (en) 2010-05-14 2017-04-20 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-tRNA synthetases
AU2011256366C1 (en) 2010-05-17 2017-06-15 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-tRNA synthetases
JP6046607B2 (ja) 2010-05-27 2016-12-21 エータイアー ファーマ, インコーポレイテッド グルタミニルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
CA2800281C (en) 2010-06-01 2021-01-12 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of lysyl-trna synthetases
JP6116479B2 (ja) 2010-07-12 2017-04-19 エータイアー ファーマ, インコーポレイテッド グリシルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
US9029506B2 (en) 2010-08-25 2015-05-12 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tyrosyl-tRNA synthetases
WO2012109500A2 (en) 2011-02-09 2012-08-16 Bio-Rad Laboratories, Inc. Analysis of nucleic acids
JP2014515094A (ja) * 2011-03-04 2014-06-26 バイオ−ラッド ラボラトリーズ,インコーポレイティド アビジン−ビオチン結合の利用によるイムノアッセイのためのシグナル増幅
CN103930563B (zh) 2011-06-01 2016-11-09 医学预后研究所 用于预测癌症复发的方法和装置
CN103733047B (zh) 2011-08-11 2016-03-30 奥林巴斯株式会社 目标粒子的检测方法
EP2752655A4 (de) 2011-08-30 2015-06-17 Olympus Corp Verfahren zum nachweis von zielpartikeln
CN104334196B (zh) 2012-02-16 2018-04-10 Atyr 医药公司 用于治疗自身免疫疾病和炎性疾病的组氨酰‑tRNA合成酶
EP2818850B1 (de) 2012-02-22 2016-08-03 Olympus Corporation Verfahren zum nachweis eines zielpartikels
WO2013140890A1 (ja) 2012-03-21 2013-09-26 オリンパス株式会社 標的核酸分子の検出方法
NZ709167A (en) 2012-11-27 2020-03-27 Univ Pontificia Catolica Chile Compositions and methods for diagnosing thyroid tumors
US20140308205A1 (en) * 2013-04-12 2014-10-16 University Of Massachusetts Medical School Trifunctional and completely clearable specific targeting agents and methods thereof
WO2014195032A1 (en) 2013-06-07 2014-12-11 Medical Prognosis Institute A/S Methods and devices for predicting treatment efficacy of fulvestrant in cancer patients
CN105555972B (zh) 2013-07-25 2020-07-31 伯乐生命医学产品有限公司 遗传测定
CA2954764A1 (en) 2014-07-15 2016-01-21 Ontario Institute For Cancer Research Methods and devices for predicting anthracycline treatment efficacy
WO2016141040A1 (en) * 2015-03-02 2016-09-09 The Regents Of The University Of California Homogenous entropy-driven biomolecular assay (heba)
US11230732B2 (en) 2017-03-31 2022-01-25 Marcella Chiari Genotyping of mutations by combination of in-tube hybridization and universal tag-microarray
US10655168B2 (en) * 2017-12-22 2020-05-19 Pacific Biosciences Of California, Inc. Modified biotin-binding proteins for immobilization
WO2019200326A1 (en) 2018-04-13 2019-10-17 Rarecyte, Inc. Kits for labeling of biomarkers and methods of using the same
CN116298265A (zh) * 2023-04-12 2023-06-23 上海品峰医疗科技有限公司 一种应用了多级信号放大技术的hs-cTnT化学发光测定试剂盒

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
US4748111A (en) 1984-03-12 1988-05-31 Molecular Diagnostics, Inc. Nucleic acid-protein conjugate used in immunoassay
US4910300A (en) 1985-12-11 1990-03-20 Chiron Corporation Method for making nucleic acid probes
US4882269A (en) 1985-12-13 1989-11-21 Princeton University Amplified hybridization assay
US5175270A (en) 1986-09-10 1992-12-29 Polyprobe, Inc. Reagents for detecting and assaying nucleic acid sequences
US5124246A (en) 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
CA1339351C (en) 1987-10-15 1997-08-26 Michael S. Urdea Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5359100A (en) 1987-10-15 1994-10-25 Chiron Corporation Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers
US5656731A (en) 1987-10-15 1997-08-12 Chiron Corporation Nucleic acid-amplified immunoassay probes
WO1990004786A1 (en) 1988-10-17 1990-05-03 Molecular Devices Corporation Hapten derivatized capture membrane and diagnostic assays using such membrane
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5527681A (en) 1989-06-07 1996-06-18 Affymax Technologies N.V. Immobilized molecular synthesis of systematically substituted compounds
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
EP0405913B1 (de) 1989-06-30 1998-12-23 Chiron Corporation Hydrophobe Nukleinsäure-Sonde
US5252743A (en) 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
US5629153A (en) 1990-01-10 1997-05-13 Chiron Corporation Use of DNA-dependent RNA polymerase transcripts as reporter molecules for signal amplification in nucleic acid hybridization assays
AU8050591A (en) 1990-06-15 1992-01-07 Chiron Corporation Self-contained assay assembly and apparatus
AU8412991A (en) 1990-07-27 1992-03-02 Chiron Corporation Large comb-type branched polynucleotides
US5849481A (en) 1990-07-27 1998-12-15 Chiron Corporation Nucleic acid hybridization assays employing large comb-type branched polynucleotides
EP1046421B8 (de) 1990-12-06 2006-01-11 Affymetrix, Inc. (a Delaware Corporation) Verfahren und Reagenzien für immobilisierten Polymersynthese in sehr grossem Masstab
GB9114180D0 (en) * 1991-07-01 1991-08-21 Amersham Int Plc Enhancement of polynucleotide hybridisation
US5412087A (en) 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
US5677195A (en) 1991-11-22 1997-10-14 Affymax Technologies N.V. Combinatorial strategies for polymer synthesis
US5384261A (en) 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
EP0618924B1 (de) 1991-12-23 2001-02-14 Bayer Corporation Hbv amplifizierungssonden zur verwendung in hybridisierungssandwichassay in der lösungsphase
AU4596893A (en) 1992-05-29 1993-12-30 Gen Trak, Inc. Signal amplification probe and methods of use
US5681697A (en) 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
US5561043A (en) 1994-01-31 1996-10-01 Trustees Of Boston University Self-assembling multimeric nucleic acid constructs
US5631734A (en) 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US5578832A (en) 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
US5571639A (en) 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
US5876924A (en) 1994-06-22 1999-03-02 Mount Sinai School Of Medicine Nucleic acid amplification method hybridization signal amplification method (HSAM)
US5597909A (en) 1994-08-25 1997-01-28 Chiron Corporation Polynucleotide reagents containing modified deoxyribose moieties, and associated methods of synthesis and use
US5580731A (en) 1994-08-25 1996-12-03 Chiron Corporation N-4 modified pyrimidine deoxynucleotides and oligonucleotide probes synthesized therewith
US5710000A (en) 1994-09-16 1998-01-20 Affymetrix, Inc. Capturing sequences adjacent to Type-IIs restriction sites for genomic library mapping
US5599695A (en) 1995-02-27 1997-02-04 Affymetrix, Inc. Printing molecular library arrays using deprotection agents solely in the vapor phase
US5624711A (en) 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
JP2000504575A (ja) 1996-02-08 2000-04-18 アフィメトリックス,インコーポレイテッド 微生物のチップベースの種分化および表現型特徴付け
WO1997042211A1 (en) 1996-05-06 1997-11-13 Chiron Corporation Mammalian sex comb on midleg (mammalian scm) acts as a tumor suppressor
AU2936497A (en) 1996-05-08 1997-11-26 Chiron Corporation Mammalian additional sex combs (mammalian asx) acts as a tumor suppressor
US6072043A (en) 1996-06-04 2000-06-06 Polyprobe, Inc. Optimally fluorescent oligonucleotides
US6117631A (en) 1996-10-29 2000-09-12 Polyprobe, Inc. Detection of antigens via oligonucleotide antibody conjugates
US5804384A (en) * 1996-12-06 1998-09-08 Vysis, Inc. Devices and methods for detecting multiple analytes in samples
US6203989B1 (en) * 1998-09-30 2001-03-20 Affymetrix, Inc. Methods and compositions for amplifying detectable signals in specific binding assays

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US20010041335A1 (en) 2001-11-15
EP0999285A1 (de) 2000-05-10
US6806047B2 (en) 2004-10-19
JP2000106876A (ja) 2000-04-18
AU6275099A (en) 2000-04-17
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US6203989B1 (en) 2001-03-20
DE69928747T2 (de) 2006-09-07

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