ATE312199T1 - Verfahen und zusammensetzungen zur vermehrung von feststellbaren signalen in spezifischen bindungstests - Google Patents

Verfahen und zusammensetzungen zur vermehrung von feststellbaren signalen in spezifischen bindungstests

Info

Publication number
ATE312199T1
ATE312199T1 AT99250336T AT99250336T ATE312199T1 AT E312199 T1 ATE312199 T1 AT E312199T1 AT 99250336 T AT99250336 T AT 99250336T AT 99250336 T AT99250336 T AT 99250336T AT E312199 T1 ATE312199 T1 AT E312199T1
Authority
AT
Austria
Prior art keywords
receptor
amplification reagent
nucleic acid
binding
target
Prior art date
Application number
AT99250336T
Other languages
English (en)
Inventor
Martin J Goldberg
Govinda Rao S Yelagalawadi
Eugen Yuji Tanimoto
Huu Minh Tran
Helin Dong
David Lockhart
Thomas B Ryder
Janet A Warrington
Jody Beecher
Original Assignee
Affymetrix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affymetrix Inc filed Critical Affymetrix Inc
Application granted granted Critical
Publication of ATE312199T1 publication Critical patent/ATE312199T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/682Signal amplification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804Nucleic acid analysis using immunogens
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/807Apparatus included in process claim, e.g. physical support structures
AT99250336T 1998-09-30 1999-09-22 Verfahen und zusammensetzungen zur vermehrung von feststellbaren signalen in spezifischen bindungstests ATE312199T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10257798P 1998-09-30 1998-09-30
US09/276,774 US6203989B1 (en) 1998-09-30 1999-03-25 Methods and compositions for amplifying detectable signals in specific binding assays

Publications (1)

Publication Number Publication Date
ATE312199T1 true ATE312199T1 (de) 2005-12-15

Family

ID=26799529

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99250336T ATE312199T1 (de) 1998-09-30 1999-09-22 Verfahen und zusammensetzungen zur vermehrung von feststellbaren signalen in spezifischen bindungstests

Country Status (7)

Country Link
US (3) US6203989B1 (de)
EP (1) EP0999285B1 (de)
JP (2) JP2000106876A (de)
AT (1) ATE312199T1 (de)
AU (1) AU6275099A (de)
DE (1) DE69928747T2 (de)
WO (1) WO2000018962A1 (de)

Families Citing this family (149)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6506564B1 (en) 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
EP1818417B1 (de) 1996-07-29 2014-02-12 Nanosphere, Inc. Nanopartikel mit angehängten Oligonukleotiden und ihre Verwendungen
US6582921B2 (en) 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US6750016B2 (en) 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US7169556B2 (en) 1996-07-29 2007-01-30 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US7098320B1 (en) 1996-07-29 2006-08-29 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6984491B2 (en) 1996-07-29 2006-01-10 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6974669B2 (en) * 2000-03-28 2005-12-13 Nanosphere, Inc. Bio-barcodes based on oligonucleotide-modified nanoparticles
US20050037397A1 (en) * 2001-03-28 2005-02-17 Nanosphere, Inc. Bio-barcode based detection of target analytes
US7348181B2 (en) 1997-10-06 2008-03-25 Trustees Of Tufts College Self-encoding sensor with microspheres
US6203989B1 (en) * 1998-09-30 2001-03-20 Affymetrix, Inc. Methods and compositions for amplifying detectable signals in specific binding assays
EP1135682B1 (de) 1998-11-30 2007-07-11 Nanosphere, Inc. Nanopartikel mit polymerschalen
WO2000068434A2 (en) * 1999-05-07 2000-11-16 Yale University Multiple tag analysis
US6921638B2 (en) * 1999-06-25 2005-07-26 Amersham Biosciences Ab Hydrogel-based microarray signal amplification methods and devices therefor
US6771376B2 (en) * 1999-07-05 2004-08-03 Novartis Ag Sensor platform, apparatus incorporating the platform, and process using the platform
JP4684507B2 (ja) 1999-07-05 2011-05-18 ノバルティス アーゲー センサープラットホームを使用する方法
US7244559B2 (en) * 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
WO2001038570A1 (en) * 1999-11-29 2001-05-31 Gamida Sense Diagnostics Ltd. Oligonucleotides and assemblies thereof useful in the detection of the presence or absence of target nucleic acid sequences in a sample
WO2001051665A2 (en) 2000-01-13 2001-07-19 Nanosphere Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US20020094538A1 (en) * 2001-01-13 2002-07-18 Getts Robert C. Methods for detecting and assaying nucleic acid sequences using temperature cycling
EP1268858A1 (de) * 2000-03-31 2003-01-02 Memorec Stoffel GmbH Medizinisch-Molekulare Entwicklung Verwendung von partikeln, die signalgebende eigenschaften und mindestens eine affinitätsgruppierung für markierte nukleinsäuren besitzen
AU2001276870B2 (en) * 2000-07-11 2006-07-20 Northwestern University Method of detection by enhancement of silver staining
WO2002014867A2 (en) * 2000-08-11 2002-02-21 Agilix Corporation Ultra-sensitive detection systems
US20020019792A1 (en) * 2000-08-11 2002-02-14 Robert Maerz Method and system for offering television pilots as a security
EP1186671A3 (de) * 2000-09-05 2003-12-17 Agilent Technologies, Inc. (a Delaware corporation) Methode zur Hybridisierung von Arrays auf Silikonoberflächen
US20050239125A1 (en) * 2000-09-06 2005-10-27 Hodge Timothy A Methods for genotype screening
US7494817B2 (en) * 2000-09-06 2009-02-24 Transnet Yx, Inc. Methods for genotype screening using magnetic particles
US20050272085A1 (en) * 2000-09-06 2005-12-08 Hodge Timothy A Methods for forensic and congenic screening
US20050266494A1 (en) * 2000-09-06 2005-12-01 Hodge Timothy A System and method for computer network ordering of biological testing
EP1978110B1 (de) * 2000-09-06 2010-05-26 Transnetyx, Inc. Computer-basiertes Verfahren und System zum Screenen von genomischer DNS
US6803196B1 (en) * 2000-10-13 2004-10-12 Affymetrix, Inc. Methods and compositions for detecting signals in binding assays using microparticles
GB0029154D0 (en) 2000-11-30 2001-01-17 Lee Helen Signal enhancement with multiple labelled-antibodies
US20020165675A1 (en) * 2001-03-03 2002-11-07 Golovlev Valeri V. Method and microelectronic device for multi-site molecule detection
CA2440656A1 (en) * 2001-03-09 2002-09-19 Apollo Biotechnology, Inc. Conjugate probes and optical detection of analytes
US20060040286A1 (en) * 2001-03-28 2006-02-23 Nanosphere, Inc. Bio-barcode based detection of target analytes
US20040091939A1 (en) * 2001-03-28 2004-05-13 To Cheung Device and method for detection of multiple analytes
US7147687B2 (en) * 2001-05-25 2006-12-12 Nanosphere, Inc. Non-alloying core shell nanoparticles
AU2002239726A1 (en) 2001-05-25 2002-12-09 Northwestern University Non-alloying core shell nanoparticles
JP2003014746A (ja) * 2001-06-27 2003-01-15 Fuji Photo Film Co Ltd 生物学的素材が固定された構造体及びその製造方法
US6662091B2 (en) * 2001-06-29 2003-12-09 Battelle Memorial Institute Diagnostics/prognostics using wireless links
US6753145B2 (en) * 2001-07-05 2004-06-22 Agilent Technologies, Inc. Buffer composition and method for hybridization of microarrays on adsorbed polymer siliceous surfaces
US20050009022A1 (en) * 2001-07-06 2005-01-13 Weiner Michael P. Method for isolation of independent, parallel chemical micro-reactions using a porous filter
US7297553B2 (en) * 2002-05-28 2007-11-20 Nanosphere, Inc. Method for attachment of silylated molecules to glass surfaces
US7687437B2 (en) * 2001-07-13 2010-03-30 Nanosphere, Inc. Method for immobilizing molecules onto surfaces
WO2003062783A2 (en) * 2001-07-20 2003-07-31 North Carolina State University Light addressable electrochemical detection of duplex structures
US20060014186A1 (en) * 2001-09-04 2006-01-19 Hodge Timothy A Methods for genotype screening of a strain disposed on an adsorbent carrier
US20030054396A1 (en) * 2001-09-07 2003-03-20 Weiner Michael P. Enzymatic light amplification
WO2003027678A1 (en) * 2001-09-26 2003-04-03 Psychiatric Genomics, Inc. Fluorescence proximity assay
US7132236B2 (en) * 2001-10-25 2006-11-07 Agilent Technologies, Inc. Composition and method for optimized hybridization using modified solutions
US6956114B2 (en) 2001-10-30 2005-10-18 '454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US20050124022A1 (en) * 2001-10-30 2005-06-09 Maithreyan Srinivasan Novel sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US6902921B2 (en) * 2001-10-30 2005-06-07 454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
AU2002367817B2 (en) 2001-11-09 2008-05-29 Nanosphere, Inc. Bioconjugate-nanoparticle probes
EP1451365A4 (de) 2001-11-13 2006-09-13 Rubicon Genomics Inc Dna-amplifikation und -sequenzierung mit durch zufallsfragmentierung erzeugten dna-molekülen
MXPA04008477A (es) 2002-03-01 2005-10-26 Ravgen Inc Metodos para deteccion de trastornos geneticos.
US6977162B2 (en) * 2002-03-01 2005-12-20 Ravgen, Inc. Rapid analysis of variations in a genome
US20050266455A1 (en) * 2002-03-02 2005-12-01 Sci Tec, Inc. Method and microelectronic device for multi-site molecule detection
US20030175828A1 (en) * 2002-03-15 2003-09-18 Lazar James G. Signal amplification by Hybrid Capture
US20030211488A1 (en) 2002-05-07 2003-11-13 Northwestern University Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection
US20070178478A1 (en) * 2002-05-08 2007-08-02 Dhallan Ravinder S Methods for detection of genetic disorders
US7442506B2 (en) * 2002-05-08 2008-10-28 Ravgen, Inc. Methods for detection of genetic disorders
US7727720B2 (en) * 2002-05-08 2010-06-01 Ravgen, Inc. Methods for detection of genetic disorders
ATE420357T1 (de) * 2002-07-02 2009-01-15 Nanosphere Inc Nanopartikel-polyanion-konjugate sowie verfahren zur verwendung davon beim nachweis von analyten
US20040101444A1 (en) * 2002-07-15 2004-05-27 Xeotron Corporation Apparatus and method for fluid delivery to a hybridization station
ATE534748T1 (de) * 2002-12-12 2011-12-15 Nanosphere Inc Direkter snp-nachweis mit nichtamplifizierter dna
US20040180369A1 (en) * 2003-01-16 2004-09-16 North Carolina State University Photothermal detection of nucleic acid hybridization
DE602004024034D1 (de) 2003-01-29 2009-12-24 454 Corp Nukleinsäureamplifikation auf basis von kügelchenemulsion
US7575865B2 (en) * 2003-01-29 2009-08-18 454 Life Sciences Corporation Methods of amplifying and sequencing nucleic acids
US7192703B2 (en) 2003-02-14 2007-03-20 Intel Corporation, Inc. Biomolecule analysis by rolling circle amplification and SERS detection
CN1791682B (zh) * 2003-02-26 2013-05-22 凯利达基因组股份有限公司 通过杂交进行的随机阵列dna分析
EP1597399A2 (de) * 2003-02-27 2005-11-23 Nanosphere, Inc. Markierungsfreie erstellung von genexpressionsprofilen mittels universeller nanopartikelsonden im mikroarray-testformat
JP2006521086A (ja) * 2003-02-28 2006-09-21 ラブジェン, インコーポレイテッド 遺伝子疾患の検出方法
US20050250094A1 (en) * 2003-05-30 2005-11-10 Nanosphere, Inc. Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes
WO2005003304A2 (en) 2003-06-20 2005-01-13 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US20050181394A1 (en) * 2003-06-20 2005-08-18 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US20040259100A1 (en) 2003-06-20 2004-12-23 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US7642064B2 (en) * 2003-06-24 2010-01-05 Ventana Medical Systems, Inc. Enzyme-catalyzed metal deposition for the enhanced detection of analytes of interest
JP3899407B2 (ja) * 2003-06-26 2007-03-28 国立大学法人 鹿児島大学 免疫組織化学的染色方法による抗原の検出方法
EP1673480B1 (de) * 2003-09-09 2010-04-14 The Regents Of The University Of Colorado, A Body Corporate Verwendung der photopolymerisierung zur amplifikation und zum nachweis eines molekularen erkennungsereignisses
US7354706B2 (en) * 2003-09-09 2008-04-08 The Regents Of The University Of Colorado, A Body Corporate Use of photopolymerization for amplification and detection of a molecular recognition event
US20090163375A1 (en) 2003-09-09 2009-06-25 Bowman Christopher N Use of Photopolymerization for Amplification and Detection of a Molecular Recognition Event
KR100571817B1 (ko) * 2003-09-19 2006-04-17 삼성전자주식회사 태그 서열에 혼성화하는 검출 프로브를 이용하는 표적핵산의 검출방법
US20050089874A1 (en) * 2003-10-24 2005-04-28 Torontali Suzanne M. Amplification of signal using a bead-based oligonucleotide assay
EP1692263A4 (de) * 2003-10-29 2008-01-02 Ribomed Biotechnologies Inc Zusammensetzungen, verfahren und nachweistechnologien zur reiterativen oligonukleotidsynthese
WO2005042785A1 (en) * 2003-10-30 2005-05-12 North Carolina State University Electrochemical detection of nucleic acid hybridization
WO2005042783A1 (en) * 2003-10-30 2005-05-12 North Carolina State University Temperature-jump enhanced electrochemical detection of nucleic acid hybridization
GB0404187D0 (en) * 2004-02-25 2004-03-31 Biotransformations Ltd Binding agents
WO2005082110A2 (en) * 2004-02-26 2005-09-09 Illumina Inc. Haplotype markers for diagnosing susceptibility to immunological conditions
JP4476050B2 (ja) * 2004-06-30 2010-06-09 株式会社ニデック 視野計
US20070207555A1 (en) * 2005-02-03 2007-09-06 Cesar Guerra Ultra-sensitive detection systems using multidimension signals
US20070154903A1 (en) * 2005-06-23 2007-07-05 Nanosphere, Inc. Selective isolation and concentration of nucleic acids from complex samples
US7368246B2 (en) * 2005-09-15 2008-05-06 Primera Biosystems, Inc. Quantitative gene expression profiling
US20070275388A1 (en) * 2006-05-25 2007-11-29 Daniel Ryan Dendrimers that possess a single target annealing site and uses thereof
US20090002703A1 (en) * 2006-08-16 2009-01-01 Craig Edward Parman Methods and systems for quantifying isobaric labels and peptides
US20080153135A1 (en) * 2006-12-20 2008-06-26 Liu Timothy Z Methods and apparatus for conducting amplification reactions on high density hydrophilic patterned microplates
US20080153134A1 (en) * 2006-12-22 2008-06-26 Willy Wiyatno Methods and apparatus for generating hydrophilic patterning of high density microplates using an amphiphilic polymer
US20080241831A1 (en) * 2007-03-28 2008-10-02 Jian-Bing Fan Methods for detecting small RNA species
US20080268440A1 (en) * 2007-04-26 2008-10-30 Liu Timothy Z Biomolecule immobilization on surface via hydrophobic interactions
CA3128656A1 (en) 2007-08-22 2009-02-26 The Regents Of The University Of California Activatable binding polypeptides and methods of identification and use thereof
US20090137405A1 (en) * 2007-11-16 2009-05-28 Christopher Bowman Detection of nucleic acid biomarkers using polymerization-based amplification
US20090162863A1 (en) * 2007-12-13 2009-06-25 Hitachi High-Technologies Corporation Nucleic acid detection probe
JP5504587B2 (ja) * 2008-05-27 2014-05-28 東レ株式会社 分析用チップ
GB0814570D0 (en) 2008-08-08 2008-09-17 Diagnostics For The Real World Isolation of nucleic acid
US8309306B2 (en) * 2008-11-12 2012-11-13 Nodality, Inc. Detection composition
ATE523603T1 (de) * 2008-11-21 2011-09-15 Chimera Biotec Gmbh Konjugatkomplexe zum analytnachweis
EP2385955B1 (de) 2009-01-12 2020-08-12 CytomX Therapeutics, Inc. Modifizierte antikörperzusammensetzungen, verfahren zu ihrer herstellung und verwendung
AU2010215761B2 (en) 2009-02-23 2017-04-06 Cytomx Therapeutics, Inc Proproteins and methods of use thereof
DK3255146T3 (da) 2009-03-16 2019-08-19 Pangu Biopharma Ltd Præparater og fremgangsmåder omfattende histidyl-tRNA-synthetasesplejsningsvarianter med ikke-kanoniske biologiske aktiviteter
US9464319B2 (en) 2009-03-24 2016-10-11 California Institute Of Technology Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes
US9447461B2 (en) 2009-03-24 2016-09-20 California Institute Of Technology Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes
US10196700B2 (en) 2009-03-24 2019-02-05 University Of Chicago Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes
EP2412020B1 (de) 2009-03-24 2020-09-30 University Of Chicago Schiebe- und schneidevorrichtung und entsprechende verfahren
AU2010236913B2 (en) 2009-03-31 2016-03-24 Atyr Pharma, Inc. Compositions and methods comprising aspartyl-tRNA synthetases having non-canonical biological activities
EP2504448B1 (de) * 2009-11-25 2016-10-19 Bio-Rad Laboratories, Inc. Verfahren und zusammensetzung zur erkennung von genetischem material
AU2011248625B2 (en) 2010-04-26 2017-01-05 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-tRNA synthetase
JP6294074B2 (ja) 2010-04-27 2018-03-14 エータイアー ファーマ, インコーポレイテッド イソロイシルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
CA2797271C (en) 2010-04-28 2021-05-25 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl trna synthetases
CN103097523B (zh) 2010-04-29 2016-09-28 Atyr医药公司 与天冬酰胺酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
EP2563936B1 (de) 2010-04-29 2018-03-14 Medical Prognosis Institute A/S Verfahren und vorrichtungen zur vorhersage der behandlungswirksamkeit
CA2797393C (en) 2010-04-29 2020-03-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl trna synthetases
CN103096925A (zh) 2010-05-03 2013-05-08 Atyr医药公司 与精氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
ES2668207T3 (es) 2010-05-03 2018-05-17 Atyr Pharma, Inc. Descubrimiento innovador de composiciones terapéuticas, de diagnóstico y de anticuerpos relacionadas con fragmentos de proteínas de metionil-ARNt sintetasas
AU2011248227B2 (en) 2010-05-03 2016-12-01 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-tRNA synthetases
CN102985103A (zh) 2010-05-04 2013-03-20 Atyr医药公司 与p38多-tRNA合成酶复合物相关的治疗、诊断和抗体组合物的创新发现
US8945541B2 (en) 2010-05-14 2015-02-03 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-tRNA synthetases
CA2799480C (en) 2010-05-17 2020-12-15 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-trna synthetases
EP2575856B1 (de) 2010-05-27 2017-08-16 aTyr Pharma, Inc. Therapeutische, diagnostische und antikörperhaltige zusammensetzungen in zusammenhang mit proteinfragmenten von glutaminyl-trna-synthetasen
EP2575857B1 (de) 2010-06-01 2018-01-24 aTyr Pharma, Inc. Innovative erkennung therapeutischer, diagnostischer und antikörperhaltiger zusammensetzungen in zusammenhang mit proteinfragmenten von lysyl-trna-synthetasen
WO2012021247A2 (en) 2010-07-12 2012-02-16 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-trna synthetases
CA2808539C (en) 2010-08-25 2021-05-25 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tyrosyl-trna synthetases
WO2012109500A2 (en) 2011-02-09 2012-08-16 Bio-Rad Laboratories, Inc. Analysis of nucleic acids
JP2014515094A (ja) * 2011-03-04 2014-06-26 バイオ−ラッド ラボラトリーズ,インコーポレイティド アビジン−ビオチン結合の利用によるイムノアッセイのためのシグナル増幅
JP6039656B2 (ja) 2011-06-01 2016-12-07 メディカル プログノシス インスティテュート エー/エス 癌再発の予後予測のための方法および装置
CN103733047B (zh) 2011-08-11 2016-03-30 奥林巴斯株式会社 目标粒子的检测方法
WO2013031365A1 (ja) 2011-08-30 2013-03-07 オリンパス株式会社 標的粒子の検出方法
US8835387B2 (en) 2012-02-16 2014-09-16 Atyr Pharma, Inc. Histidyl-tRNA synthetases for treating autoimmune and inflammatory diseases
JP5940644B2 (ja) 2012-02-22 2016-06-29 オリンパス株式会社 標的粒子の検出方法
EP2829614A4 (de) 2012-03-21 2016-03-16 Olympus Corp Verfahren zur detektion eines zielnucleinsäuremoleküls
CA2892822C (en) 2012-11-27 2023-08-08 Pontificia Universidad Catolica De Chile Compositions and methods for diagnosing thyroid tumors
US20140308205A1 (en) * 2013-04-12 2014-10-16 University Of Massachusetts Medical School Trifunctional and completely clearable specific targeting agents and methods thereof
US10392667B2 (en) 2013-06-07 2019-08-27 Medical Prognosis Institute A/S Methods and devices for predicting treatment efficacy of fulvestrant in cancer patients
CN105555972B (zh) 2013-07-25 2020-07-31 伯乐生命医学产品有限公司 遗传测定
WO2016008048A1 (en) 2014-07-15 2016-01-21 Ontario Institute For Cancer Research Methods and devices for predicting anthracycline treatment efficacy
EP3265587A4 (de) * 2015-03-02 2018-08-08 The Regents of the University of California Homogener entropiegesteuerter biomolekulartest (heba)
EP3577233B1 (de) 2017-03-31 2021-07-14 Marcella Chiari Genotypisierung von mutationen durch kombination von in-tube-hybridisierung und universellem tag-mikroarray
WO2019126734A1 (en) * 2017-12-22 2019-06-27 Pacific Biosciences Of California, Inc. Modified biotin-binding proteins for immobilization
US10871485B2 (en) 2018-04-13 2020-12-22 Rarecyte, Inc. Kits for labeling of biomarkers and methods of using the same
CN116298265A (zh) * 2023-04-12 2023-06-23 上海品峰医疗科技有限公司 一种应用了多级信号放大技术的hs-cTnT化学发光测定试剂盒

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
US4748111A (en) 1984-03-12 1988-05-31 Molecular Diagnostics, Inc. Nucleic acid-protein conjugate used in immunoassay
US4910300A (en) 1985-12-11 1990-03-20 Chiron Corporation Method for making nucleic acid probes
US4882269A (en) 1985-12-13 1989-11-21 Princeton University Amplified hybridization assay
US5175270A (en) * 1986-09-10 1992-12-29 Polyprobe, Inc. Reagents for detecting and assaying nucleic acid sequences
US5124246A (en) 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5359100A (en) 1987-10-15 1994-10-25 Chiron Corporation Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers
US5656731A (en) 1987-10-15 1997-08-12 Chiron Corporation Nucleic acid-amplified immunoassay probes
CA1339351C (en) 1987-10-15 1997-08-26 Michael S. Urdea Nucleic acid multimers and amplified nucleic acid hybridization assays using same
WO1990004786A1 (en) 1988-10-17 1990-05-03 Molecular Devices Corporation Hapten derivatized capture membrane and diagnostic assays using such membrane
US5527681A (en) 1989-06-07 1996-06-18 Affymax Technologies N.V. Immobilized molecular synthesis of systematically substituted compounds
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
EP0405913B1 (de) 1989-06-30 1998-12-23 Chiron Corporation Hydrophobe Nukleinsäure-Sonde
US5252743A (en) 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
US5629153A (en) 1990-01-10 1997-05-13 Chiron Corporation Use of DNA-dependent RNA polymerase transcripts as reporter molecules for signal amplification in nucleic acid hybridization assays
CA2084342A1 (en) 1990-06-15 1991-12-16 Rich T. Smethers Self-contained assay assembly and apparatus
US5849481A (en) 1990-07-27 1998-12-15 Chiron Corporation Nucleic acid hybridization assays employing large comb-type branched polynucleotides
EP0541693B1 (de) 1990-07-27 1998-12-09 Chiron Corporation Grosse kammförmig verzweigte polynukleotide
DE69132531T2 (de) 1990-12-06 2001-09-13 Affymetrix Inc Verbindungen und ihre Verwendung in einer binären Synthesestrategie
GB9114180D0 (en) * 1991-07-01 1991-08-21 Amersham Int Plc Enhancement of polynucleotide hybridisation
US5384261A (en) 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
US5412087A (en) 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
WO1993009668A1 (en) 1991-11-22 1993-05-27 Affymax Technology N.V. Combinatorial strategies for polymer synthesis
ATE199158T1 (de) 1991-12-23 2001-02-15 Bayer Ag Hbv amplifizierungssonden zur verwendung in hybridisierungssandwichassay in der lösungsphase
AU4596893A (en) 1992-05-29 1993-12-30 Gen Trak, Inc. Signal amplification probe and methods of use
US5681697A (en) 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
US5561043A (en) 1994-01-31 1996-10-01 Trustees Of Boston University Self-assembling multimeric nucleic acid constructs
US5578832A (en) 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
US5631734A (en) 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US5571639A (en) 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
US5876924A (en) 1994-06-22 1999-03-02 Mount Sinai School Of Medicine Nucleic acid amplification method hybridization signal amplification method (HSAM)
US5597909A (en) 1994-08-25 1997-01-28 Chiron Corporation Polynucleotide reagents containing modified deoxyribose moieties, and associated methods of synthesis and use
US5580731A (en) 1994-08-25 1996-12-03 Chiron Corporation N-4 modified pyrimidine deoxynucleotides and oligonucleotide probes synthesized therewith
US5710000A (en) 1994-09-16 1998-01-20 Affymetrix, Inc. Capturing sequences adjacent to Type-IIs restriction sites for genomic library mapping
US5599695A (en) 1995-02-27 1997-02-04 Affymetrix, Inc. Printing molecular library arrays using deprotection agents solely in the vapor phase
US5624711A (en) 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
EP0937159A4 (de) 1996-02-08 2004-10-20 Affymetrix Inc Speziesbestimmung und phenotypische charakterisierung von mikroorganismen auf der basis eines chips
AU3117597A (en) 1996-05-06 1997-11-26 Chiron Corporation Mammalian sex comb on midleg (mammalian (scm)) acts as a tumor suppressor
US5948640A (en) 1996-05-08 1999-09-07 Chiron Corporation Mammalian additional sex combs (mammalian Asx) acts as a tumor suppressor
US6072043A (en) 1996-06-04 2000-06-06 Polyprobe, Inc. Optimally fluorescent oligonucleotides
US6117631A (en) 1996-10-29 2000-09-12 Polyprobe, Inc. Detection of antigens via oligonucleotide antibody conjugates
US5804384A (en) * 1996-12-06 1998-09-08 Vysis, Inc. Devices and methods for detecting multiple analytes in samples
US6203989B1 (en) * 1998-09-30 2001-03-20 Affymetrix, Inc. Methods and compositions for amplifying detectable signals in specific binding assays

Also Published As

Publication number Publication date
US6203989B1 (en) 2001-03-20
US20040137493A1 (en) 2004-07-15
EP0999285B1 (de) 2005-12-07
US6806047B2 (en) 2004-10-19
WO2000018962A1 (en) 2000-04-06
AU6275099A (en) 2000-04-17
DE69928747T2 (de) 2006-09-07
JP2006042831A (ja) 2006-02-16
JP2000106876A (ja) 2000-04-18
EP0999285A1 (de) 2000-05-10
US20010041335A1 (en) 2001-11-15
DE69928747D1 (de) 2006-01-12
WO2000018962A9 (en) 2000-08-24

Similar Documents

Publication Publication Date Title
ATE312199T1 (de) Verfahen und zusammensetzungen zur vermehrung von feststellbaren signalen in spezifischen bindungstests
US20220099678A1 (en) Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US7858396B2 (en) Lateral flow assay device with multiple equidistant capture zones
US6929944B2 (en) Analysis using a distributed sample
ATE118824T1 (de) Immobilisierte oligonukleotidsonden und ihre verwendungen.
DE60133111D1 (de) Verfahren zur erkennung und zum assay von nukleinsäuresequenzen
US20020119470A1 (en) Magnetic bead-based array for genetic detection
CA2306907A1 (en) Dna base mismatch detection using flow cytometry
WO2001094635A3 (en) Integrated active flux microfluidic devices and methods
WO2001059161A3 (en) Analyte assays employing universal arrays
DE60023539D1 (de) Immunologischer nachweis von rna:dna hybriden auf mikroarrays
BR9004881A (pt) Processo para detectar uma sequencia de acido nucleico,processo para determinar quantitativamente a extensao de hibridizacao,ensaio de hibridizacao,estojo,bases,sondas,processo para detectar chlamydia trachomatis e lamina de microtitulacao
US20190293655A1 (en) Methods and arrays for target analyte detection and determination of target analyte concentration in solution
EP1431398A1 (de) Verfahren zum Nachweis die Menge eines Analyten in einer Mischung
EP2278334A1 (de) Membranbasierte Mikroarray-Vorrichtung zur Erkennung eines hohen Multianalyt-Durchlaufs
US6399299B1 (en) Amplified array analysis system
US20040043398A1 (en) Use of the multipin platform as anchor device
DE60306328D1 (de) Verfahren zur integrierten Integritätsbewertung und Analyse von Nukleinsäuren
US20060084101A1 (en) Two-color chemiluminescent microarray system
US20080096767A1 (en) Method For Expanding The Dynamic Detection Range In Microarrays
Smith et al. The development of single molecule environmental sensors
KR970015747A (ko) 표지에 대한 수용체를 사용하는 동종 유전자 프로브 테스트
US20100240147A1 (en) High sensitivity nanotechnology-based multiplexed bioassay method and device
WO2001036585A1 (en) Sequence tag microarray and method for detection of multiple proteins through dna methods
Kimball Corstjens et al.(45) Date of Patent: Dec. 28, 2010

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties