ATE521883T1 - Verfahren zur verwendung eines beugungsbasierten sensors, der etikettenlose bindungserkennung und fluoreszenz-verstärkung kombiniert - Google Patents

Verfahren zur verwendung eines beugungsbasierten sensors, der etikettenlose bindungserkennung und fluoreszenz-verstärkung kombiniert

Info

Publication number
ATE521883T1
ATE521883T1 AT08768116T AT08768116T ATE521883T1 AT E521883 T1 ATE521883 T1 AT E521883T1 AT 08768116 T AT08768116 T AT 08768116T AT 08768116 T AT08768116 T AT 08768116T AT E521883 T1 ATE521883 T1 AT E521883T1
Authority
AT
Austria
Prior art keywords
labelless
diffraction
based sensor
binding detection
fluorescence amplification
Prior art date
Application number
AT08768116T
Other languages
English (en)
Inventor
Brian Cunningham
Peter Li
Lance Laing
Gangadhar Jogikalmath
Brant Binder
Original Assignee
Sru Biosystems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sru Biosystems Inc filed Critical Sru Biosystems Inc
Application granted granted Critical
Publication of ATE521883T1 publication Critical patent/ATE521883T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N21/774—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure
    • G01N21/7743—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure the reagent-coated grating coupling light in or out of the waveguide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Plasma & Fusion (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Geophysics And Detection Of Objects (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT08768116T 2007-06-15 2008-06-03 Verfahren zur verwendung eines beugungsbasierten sensors, der etikettenlose bindungserkennung und fluoreszenz-verstärkung kombiniert ATE521883T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/818,742 US7790406B2 (en) 2005-08-11 2007-06-15 Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor
PCT/US2008/007031 WO2008156560A1 (en) 2007-06-15 2008-06-03 Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor

Publications (1)

Publication Number Publication Date
ATE521883T1 true ATE521883T1 (de) 2011-09-15

Family

ID=39720303

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08768116T ATE521883T1 (de) 2007-06-15 2008-06-03 Verfahren zur verwendung eines beugungsbasierten sensors, der etikettenlose bindungserkennung und fluoreszenz-verstärkung kombiniert

Country Status (10)

Country Link
US (3) US7790406B2 (de)
EP (2) EP2158474B1 (de)
JP (1) JP2010530069A (de)
KR (1) KR20100023961A (de)
AT (1) ATE521883T1 (de)
AU (1) AU2008267068B2 (de)
CA (1) CA2686968A1 (de)
IL (1) IL201657A0 (de)
NZ (1) NZ580398A (de)
WO (1) WO2008156560A1 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
US8111401B2 (en) 1999-11-05 2012-02-07 Robert Magnusson Guided-mode resonance sensors employing angular, spectral, modal, and polarization diversity for high-precision sensing in compact formats
US7118710B2 (en) 2000-10-30 2006-10-10 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US7371562B2 (en) * 2000-10-30 2008-05-13 Sru Biosystems, Inc. Guided mode resonant filter biosensor using a linear grating surface structure
US7524625B2 (en) * 2000-10-30 2009-04-28 Sru Biosystems, Inc. Real time binding analysis of antigens on a biosensor surface
US7575939B2 (en) 2000-10-30 2009-08-18 Sru Biosystems, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
US7927822B2 (en) 2002-09-09 2011-04-19 Sru Biosystems, Inc. Methods for screening cells and antibodies
US7309614B1 (en) 2002-12-04 2007-12-18 Sru Biosystems, Inc. Self-referencing biodetection method and patterned bioassays
US8298780B2 (en) 2003-09-22 2012-10-30 X-Body, Inc. Methods of detection of changes in cells
ATE475886T1 (de) * 2005-04-12 2010-08-15 Sru Biosystems Inc Proteolipidmembran und lipidmembranen-biosensor
US7854505B2 (en) * 2006-03-15 2010-12-21 The Board Of Trustees Of The University Of Illinois Passive and active photonic crystal structures and devices
US7768640B2 (en) * 2007-05-07 2010-08-03 The Board Of Trustees Of The University Of Illinois Fluorescence detection enhancement using photonic crystal extraction
US9778267B2 (en) 2007-07-11 2017-10-03 X-Body, Inc. Methods for identifying modulators of ion channels
US9134307B2 (en) 2007-07-11 2015-09-15 X-Body, Inc. Method for determining ion channel modulating properties of a test reagent
US8759013B2 (en) 2008-03-05 2014-06-24 Corning Incorporated Dual-target biosensor cell assays
US8846575B2 (en) 2008-03-05 2014-09-30 Corning Incorporated High-throughput high-information content label-free cell biology screening methods
US8257936B2 (en) 2008-04-09 2012-09-04 X-Body Inc. High resolution label free analysis of cellular properties
US9842004B2 (en) * 2008-08-22 2017-12-12 Red Hat, Inc. Adjusting resource usage for cloud-based networks
US7999944B2 (en) * 2008-10-23 2011-08-16 Corning Incorporated Multi-channel swept wavelength optical interrogation system and method for using same
US10203320B2 (en) 2008-11-11 2019-02-12 Corning Incorporated Label free method for assessing chemical cardiotoxicity
US9134301B2 (en) 2010-11-22 2015-09-15 Bio-Rad Laboratories, Inc. Sorting of adherent cells by selective transformation of labels
CA2835847A1 (en) * 2011-05-13 2012-11-22 The Regents Of The University Of Michigan Focusing luminescent and thermal radiation concentrators
DE102011101635A1 (de) 2011-05-16 2012-11-22 Giesecke & Devrient Gmbh Zweidimensional periodisches, farbfilterndes Gitter
US8981318B1 (en) 2011-12-30 2015-03-17 Gene Capture, Inc. Multi-dimensional scanner for nano-second time scale signal detection
US20130330761A1 (en) 2012-06-12 2013-12-12 Celcuity, LLC Whole cell assays and methods
US20140072959A1 (en) 2012-09-12 2014-03-13 Force Diagnostics, Inc. Rapid tests for insurance underwriting
WO2015089380A2 (en) 2013-12-12 2015-06-18 Celcuity Llc Assays and methods for determining the responsiveness of an individual subject to a therapeutic agent
WO2016003936A1 (en) 2014-06-30 2016-01-07 Biodesy, Inc. Systems and methods for high throughput analysis of conformation in biological entities
EP3237906B8 (de) 2014-12-23 2020-10-28 Bluelight Therapeutics, Inc. Befestigung von proteinen an schnittstellen zur verwendung in nicht-linearer optischer detektion
EP3133386B1 (de) 2015-07-27 2023-03-15 Personal Genomics, Inc. Messmodul und messverfahren
CA3037799A1 (en) * 2017-01-26 2018-08-02 Azure Biosystems, Inc. Devices and methods for imaging biomolecules
AU2018239989A1 (en) 2017-03-20 2019-08-08 Celcuity Inc. Methods of measuring signaling pathway activity for selection of therapeutic agents
US10436655B2 (en) 2017-07-14 2019-10-08 Saudi Arabian Oil Company Fluorophore enhanced multidimensional photonic sensors
US10571334B2 (en) 2017-12-15 2020-02-25 Horiba Instruments Incorporated System and method for selective resolution for concave grating spectrometer
EP3832292B1 (de) * 2018-07-31 2023-08-30 Sekisui Chemical Co., Ltd. Inspektionsverfahren, inspektionsinstrument und inspektionsvorrichtung
WO2021118982A1 (en) * 2019-12-10 2021-06-17 Trustees Of Boston University Apparatus and method for biomolecular analysis
US11378444B2 (en) * 2020-08-05 2022-07-05 Visera Technologies Company Limited Biosensor and bio detection system

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4815843A (en) * 1985-05-29 1989-03-28 Oerlikon-Buhrle Holding Ag Optical sensor for selective detection of substances and/or for the detection of refractive index changes in gaseous, liquid, solid and porous samples
US4952056A (en) * 1988-05-17 1990-08-28 Entwicklungsgemeinschaft Asi Method of determining the autocollimation angle of a grating coupler
GB8916764D0 (en) * 1989-07-21 1989-09-06 Sambles John R Surface plasmon optical sensor
EP0552241B1 (de) * 1990-10-10 2000-06-28 The University Of Maryland Verfahren und vorrichtung zur bestimmung von lebensdauer von fluoreszenz in der durchflusscytometrie
US5216680A (en) * 1991-07-11 1993-06-01 Board Of Regents, The University Of Texas System Optical guided-mode resonance filter
EP0824684B1 (de) * 1995-05-12 2007-11-07 Novartis AG Verfahren zur parallelen bestimmung mehrerer analyten mittels evaneszent angeregter lumineszenz
US5598300A (en) * 1995-06-05 1997-01-28 Board Of Regents, The University Of Texas System Efficient bandpass reflection and transmission filters with low sidebands based on guided-mode resonance effects
JP2000502450A (ja) * 1995-12-22 2000-02-29 アボツト・ラボラトリーズ 蛍光偏光免疫アッセイによる診断法
US6207397B1 (en) * 1996-04-18 2001-03-27 Ariad Pharmaceuticals, Inc. In vitro fluorescence polarization assay
DE19615366B4 (de) 1996-04-19 2006-02-09 Carl Zeiss Jena Gmbh Verfahren und Einrichtung zum Nachweis physikalischer, chemischer, biologischer oder biochemischer Reaktionen und Wechselwirkungen
FR2749955B1 (fr) * 1996-06-14 1998-09-11 Thomson Csf Systeme de lecture d'empreintes digitales
JP2001504213A (ja) 1996-08-29 2001-03-27 ツェプトゼンス アクチエンゲゼルシャフト 化学的／生化学的な光センサ
DE19715483A1 (de) * 1997-04-14 1998-10-15 Boehringer Mannheim Gmbh Methode zur gleichzeitigen Bestimmung von biomolekularen Wechselwirkungen mittels Plasmonenresonanz undFluoreszenzdetektion
US6035089A (en) * 1997-06-11 2000-03-07 Lockheed Martin Energy Research Corporation Integrated narrowband optical filter based on embedded subwavelength resonant grating structures
US5955378A (en) * 1997-08-20 1999-09-21 Challener; William A. Near normal incidence optical assaying method and system having wavelength and angle sensitivity
US5925878A (en) * 1997-08-20 1999-07-20 Imation Corp. Diffraction anomaly sensor having grating coated with protective dielectric layer
ATE317122T1 (de) * 1997-09-05 2006-02-15 Matsushita Electric Ind Co Ltd Fluoreszierende polarisation
US5994150A (en) * 1997-11-19 1999-11-30 Imation Corp. Optical assaying method and system having rotatable sensor disk with multiple sensing regions
JP3416532B2 (ja) * 1998-06-15 2003-06-16 富士通カンタムデバイス株式会社 化合物半導体装置及びその製造方法
US5986762A (en) * 1998-06-15 1999-11-16 Imation Corp. Optical sensor having optimized surface profile
JP3437094B2 (ja) * 1998-07-03 2003-08-18 松下電器産業株式会社 多波長蛍光偏光法
US6320991B1 (en) * 1998-10-16 2001-11-20 Imation Corp. Optical sensor having dielectric film stack
US6455861B1 (en) * 1998-11-24 2002-09-24 Cambridge Research & Instrumentation, Inc. Fluorescence polarization assay system and method
JP4684507B2 (ja) * 1999-07-05 2011-05-18 ノバルティス アーゲー センサープラットホームを使用する方法
US6771376B2 (en) * 1999-07-05 2004-08-03 Novartis Ag Sensor platform, apparatus incorporating the platform, and process using the platform
US7167615B1 (en) * 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
WO2001063262A1 (en) * 2000-02-25 2001-08-30 Cambridge Research & Instrumentation Inc. Multiple label fluorescence polarization assay system and method
AU2001261094A1 (en) * 2000-04-28 2001-11-12 Edgelight Biosciences, Inc. Micro-array evanescent wave fluorescence detection device
US7142296B2 (en) * 2000-10-30 2006-11-28 Sru Biosystems, Inc. Method and apparatus for detecting biomolecular interactions
US7023544B2 (en) * 2000-10-30 2006-04-04 Sru Biosystems, Inc. Method and instrument for detecting biomolecular interactions
US6951715B2 (en) * 2000-10-30 2005-10-04 Sru Biosystems, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
US7217574B2 (en) * 2000-10-30 2007-05-15 Sru Biosystems, Inc. Method and apparatus for biosensor spectral shift detection
US7118710B2 (en) * 2000-10-30 2006-10-10 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US7306827B2 (en) * 2000-10-30 2007-12-11 Sru Biosystems, Inc. Method and machine for replicating holographic gratings on a substrate
US7070987B2 (en) * 2000-10-30 2006-07-04 Sru Biosystems, Inc. Guided mode resonant filter biosensor using a linear grating surface structure
US7004863B2 (en) * 2002-05-15 2006-02-28 The Gates Corporation Damping mechanism
JP2004170195A (ja) 2002-11-19 2004-06-17 Reverse Proteomics Research Institute Co Ltd タンパク質の固定化方法
KR20050084016A (ko) * 2002-12-19 2005-08-26 어낵시스 발처스 악티엔게젤샤프트 전자기장 분포 발생 방법
US7497992B2 (en) * 2003-05-08 2009-03-03 Sru Biosystems, Inc. Detection of biochemical interactions on a biosensor using tunable filters and tunable lasers
US20050053974A1 (en) * 2003-05-20 2005-03-10 University Of Maryland Apparatus and methods for surface plasmon-coupled directional emission
US6985664B2 (en) * 2003-08-01 2006-01-10 Corning Incorporated Substrate index modification for increasing the sensitivity of grating-coupled waveguides
ATE470849T1 (de) 2005-08-11 2010-06-15 Sru Biosystems Inc Beugungsbasierter sensor, der markierungsfreie bindungserkennung und fluoreszenz-verstärkung kombiniert

Also Published As

Publication number Publication date
US20090226950A1 (en) 2009-09-10
US20100202923A1 (en) 2010-08-12
KR20100023961A (ko) 2010-03-04
US20100143959A1 (en) 2010-06-10
CA2686968A1 (en) 2008-12-24
AU2008267068A1 (en) 2008-12-24
EP2158474B1 (de) 2011-08-24
NZ580398A (en) 2011-09-30
WO2008156560A1 (en) 2008-12-24
IL201657A0 (en) 2010-05-31
EP2343532A3 (de) 2012-01-04
JP2010530069A (ja) 2010-09-02
US7790406B2 (en) 2010-09-07
AU2008267068B2 (en) 2011-04-28
EP2343532A2 (de) 2011-07-13
EP2158474A1 (de) 2010-03-03

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