CL2016000030A1 - Bencil-1h-pirazolo[3,4-b]piridinas y su uso - Google Patents
Bencil-1h-pirazolo[3,4-b]piridinas y su usoInfo
- Publication number
- CL2016000030A1 CL2016000030A1 CL2016000030A CL2016000030A CL2016000030A1 CL 2016000030 A1 CL2016000030 A1 CL 2016000030A1 CL 2016000030 A CL2016000030 A CL 2016000030A CL 2016000030 A CL2016000030 A CL 2016000030A CL 2016000030 A1 CL2016000030 A1 CL 2016000030A1
- Authority
- CL
- Chile
- Prior art keywords
- disorders
- pyrazolo
- pyridines
- benzyl
- hypertension
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Gynecology & Obstetrics (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
COMPUESTOS DERIVADOS DE BENCIL-1H-PIRAZOLO[3,4-B]PIRIDINAS; MEDICAMENTO; Y SU USO PARA EL Tratamiento y/o profilaxis de falla cardiaca, angina pectoris, hipertensión, hipertensiOn pulmonar, isquemias, trastornos vasculares, insuficiencia renal. trastornos tromboembolicos, trastornos fibroticos, arteriosclerosis, trastornos de demencia y disfuncio erectil
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13175892 | 2013-07-10 | ||
EP13175895 | 2013-07-10 | ||
EP13175899 | 2013-07-10 | ||
EP13175890 | 2013-07-10 | ||
EP13175898 | 2013-07-10 | ||
EP13175894 | 2013-07-10 | ||
EP13175896 | 2013-07-10 | ||
EP13175903 | 2013-07-10 | ||
EP13175889 | 2013-07-10 | ||
EP13175904 | 2013-07-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2016000030A1 true CL2016000030A1 (es) | 2016-08-19 |
Family
ID=51162805
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2016000030A CL2016000030A1 (es) | 2013-07-10 | 2016-01-08 | Bencil-1h-pirazolo[3,4-b]piridinas y su uso |
Country Status (22)
Country | Link |
---|---|
US (1) | US9605008B2 (es) |
EP (1) | EP3019506A1 (es) |
JP (1) | JP2016523944A (es) |
KR (1) | KR20160030541A (es) |
CN (1) | CN105745215A (es) |
AP (1) | AP2016008970A0 (es) |
AU (1) | AU2014289312A1 (es) |
CA (1) | CA2917682A1 (es) |
CL (1) | CL2016000030A1 (es) |
CU (1) | CU20160004A7 (es) |
DO (1) | DOP2016000006A (es) |
EA (1) | EA201600096A1 (es) |
GT (1) | GT201600002A (es) |
IL (1) | IL243525A0 (es) |
MX (1) | MX2016000258A (es) |
PE (1) | PE20160201A1 (es) |
PH (1) | PH12016500065A1 (es) |
SG (1) | SG11201600038UA (es) |
TN (1) | TN2016000006A1 (es) |
TW (1) | TW201542569A (es) |
UY (1) | UY35652A (es) |
WO (1) | WO2015004105A1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102012200349A1 (de) | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Substituierte annellierte Pyrimidine und Triazine und ihre Verwendung |
CN107580495A (zh) | 2015-05-06 | 2018-01-12 | 拜耳制药股份公司 | 单独和与PDE5抑制剂组合的sGC刺激剂、sGC活化剂用于治疗伴随系统性硬化症(SSc)的指溃疡(DU)的用途 |
LT3325013T (lt) | 2015-07-23 | 2020-11-10 | Bayer Pharma Aktiengesellschaft | Tirpios guanilatciklazės (sgc) stimuliatoriai/aktyvatoriai derinyje su nep inhibitoriumi ir (arba) angiotenzino aii antagonistu ir jų naudojimas |
WO2017107052A1 (en) | 2015-12-22 | 2017-06-29 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase stimulators |
WO2017121692A1 (de) | 2016-01-15 | 2017-07-20 | Bayer Pharma Aktiengesellschaft | Substituierte sulfamide und ihre verwendung |
WO2017121700A1 (de) | 2016-01-15 | 2017-07-20 | Bayer Pharma Aktiengesellschaft | 1,3-disubstituierte 1h-pyrazolo[3,4-b]pyridin- derivate und ihre verwendung als stimulatoren der löslichen guanylatcyclase |
EP3525779A1 (de) | 2016-10-11 | 2019-08-21 | Bayer Pharma Aktiengesellschaft | Kombination enthaltend sgc stimulatoren und mineralocorticoid-rezeptor-antagonisten |
JP7237823B2 (ja) | 2016-10-11 | 2023-03-13 | バイエル ファーマ アクチエンゲゼルシャフト | Sgcアクチベーターとミネラルコルチコイド受容体アンタゴニストとを含む組合せ |
CA3056501A1 (en) | 2017-04-11 | 2018-10-18 | Sunshine Lake Pharma Co., Ltd. | Fluorine-substituted indazole compounds and uses thereof |
WO2018234488A1 (en) | 2017-06-23 | 2018-12-27 | Basf Se | SUBSTITUTED CYCLOPROPYL DERIVATIVES |
JP2021523201A (ja) | 2018-05-15 | 2021-09-02 | バイエル アクチェンゲゼルシャフトBayer Aktiengesellschaft | 神経線維感作に関連する疾患を治療するための1,3−チアゾール−2−イル置換ベンズアミド |
WO2020164008A1 (en) | 2019-02-13 | 2020-08-20 | Bayer Aktiengesellschaft | Process for the preparation of porous microparticles |
Family Cites Families (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES8601208A1 (es) | 1984-11-26 | 1985-11-01 | Fordonal Sa | Procedimiento de preparacion de un derivado de piracina. |
JPS63139949A (ja) | 1986-12-02 | 1988-06-11 | Fuji Photo Film Co Ltd | 新規ピラゾロン染料 |
SE8704248D0 (sv) | 1987-10-30 | 1987-10-30 | Haessle Ab | Medical use |
GB9314412D0 (en) | 1993-07-13 | 1993-08-25 | Rhone Poulenc Agriculture | New compositions of matter |
AU5348396A (en) | 1995-05-01 | 1996-11-21 | Fujisawa Pharmaceutical Co., Ltd. | Imidazo 1,2-a pyridine and imidazo 1,2-a pyridezine derivati ves and their use as bone resorption inhibitors |
EP0743066A3 (en) | 1995-05-16 | 1998-09-30 | Mitsui Pharmaceuticals, Inc. | Wound-healing agent |
TR199901174T2 (xx) | 1996-10-14 | 1999-08-23 | Bayer Aktiengesellschaft | Yeni heterosiklilmetil-ikameli pirazol t�revleri. |
DE19642255A1 (de) | 1996-10-14 | 1998-04-16 | Bayer Ag | Verwendung von 1-Benzyl-3-(substituierten-hetaryl) -kondensierten Pyrazol-Derivaten |
US6451805B1 (en) | 1997-11-14 | 2002-09-17 | Bayer Aktiengesellschaft | Substituted pyrazole derivatives for the treatment of cardiocirculatory diseases |
DE19834044A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Neue substituierte Pyrazolderivate |
DE19834047A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Substituierte Pyrazolderivate |
DE10021069A1 (de) | 2000-04-28 | 2001-10-31 | Bayer Ag | Substituiertes Pyrazolderivat |
CZ20031125A3 (cs) | 2000-10-23 | 2003-10-15 | Smithkline Beecham Corporation | Nové sloučeniny |
AU2002221827A1 (en) | 2000-11-22 | 2002-06-03 | Bayer Aktiengesellschaft | Novel lactame-substituted pyrazolopyridine derivatives |
DE10132416A1 (de) | 2001-07-04 | 2003-01-16 | Bayer Ag | Neue Morpholin-überbrückte Pyrazolopyridinderivate |
DE10220570A1 (de) | 2002-05-08 | 2003-11-20 | Bayer Ag | Carbamat-substituierte Pyrazolopyridine |
DE10232571A1 (de) | 2002-07-18 | 2004-02-05 | Bayer Ag | 4-Aminosubstituierte Pyrimidinderivate |
WO2004099149A1 (ja) | 2003-05-09 | 2004-11-18 | Asahi Glass Company, Limited | 2-クロロ-5-フルオロ-3-置換ピリジンまたはその塩の製造方法 |
CN100355732C (zh) | 2003-11-03 | 2007-12-19 | 上海药明康德新药开发有限公司 | 2-氯-5-氟-烟酸酯及酸的制备方法 |
EP1871765B1 (en) | 2005-01-26 | 2009-12-09 | Schering Corporation | 3-(indazol-5-yl)-(1,2,4)triazine derivatives and related compounds as protein kinase inhibitors for the treatment of cancer |
US7541367B2 (en) | 2005-05-31 | 2009-06-02 | Janssen Pharmaceutica, N.V. | 3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders |
CN101277960A (zh) | 2005-09-29 | 2008-10-01 | 默克公司 | 作为黑皮质素-4受体调节剂的酰化螺哌啶衍生物 |
DE102006043443A1 (de) | 2006-09-15 | 2008-03-27 | Bayer Healthcare Ag | Neue aza-bicyclische Verbindungen und ihre Verwendung |
WO2009018415A1 (en) | 2007-07-31 | 2009-02-05 | Vertex Pharmaceuticals Incorporated | Process for preparing 5-fluoro-1h-pyrazolo [3, 4-b] pyridin-3-amine and derivatives thereof |
JP2011513483A (ja) | 2008-03-10 | 2011-04-28 | バーテックス ファーマシューティカルズ インコーポレイテッド | タンパク質キナーゼの阻害剤として有用なピリミジンおよびピリジン |
CA2743864A1 (en) * | 2008-11-25 | 2010-06-10 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
DE102009004245A1 (de) | 2009-01-09 | 2010-07-15 | Bayer Schering Pharma Aktiengesellschaft | Neue anellierte, Heteroatom-verbrückte Pyrazol- und Imidazol-Derivate und ihre Verwendung |
WO2010132999A1 (en) | 2009-05-21 | 2010-11-25 | Chlorion Pharma, Inc. | Methyl sulfanyl pyrmidmes useful as antiinflammatories, analgesics, and antiepileptics |
US20130178475A1 (en) | 2010-03-17 | 2013-07-11 | Ironwood Pharmaceuticals, Inc. | sGC STIMULATORS |
DE102010021637A1 (de) | 2010-05-26 | 2011-12-01 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung |
PE20130222A1 (es) | 2010-05-27 | 2013-03-14 | Merck Sharp & Dohme | Activadores de guanilato ciclasa soluble |
EP2585055A1 (de) | 2010-06-25 | 2013-05-01 | Bayer Intellectual Property GmbH | Verwendung von stimulatoren und aktivatoren der löslichen guanylatzyklase zur behandlung von sichelzellanämie und konservierung von blutersatzstoffen |
ES2572638T3 (es) | 2010-07-09 | 2016-06-01 | Bayer Intellectual Property Gmbh | 4-Aminopirimidinas condensadas y su uso como estimuladores de la guanilatociclasa soluble |
CN103097387B (zh) | 2010-07-09 | 2016-11-02 | 拜耳知识产权有限责任公司 | 环稠合的嘧啶和三嗪以及其用于治疗和/或预防心血管疾病的用途 |
KR101802004B1 (ko) | 2010-08-31 | 2017-11-27 | 다우 아그로사이언시즈 엘엘씨 | 살충제 조성물 |
DE102010040233A1 (de) | 2010-09-03 | 2012-03-08 | Bayer Schering Pharma Aktiengesellschaft | Bicyclische Aza-Heterocyclen und ihre Verwendung |
DE102010040234A1 (de) | 2010-09-03 | 2012-03-08 | Bayer Schering Pharma Aktiengesellschaft | Verfahren zur Herstellung von 5-Flour-1H-pyrazolo[3,4-b]pyridin-3-carbonitril |
DE102010043380A1 (de) | 2010-11-04 | 2012-05-10 | Bayer Schering Pharma Aktiengesellschaft | Benzyl-substituierte Carbamate und ihre Verwendung |
ES2583086T3 (es) | 2011-04-21 | 2016-09-19 | Bayer Intellectual Property Gmbh | Pirazolopiridinas sustituidas con fluoroalquilo y su uso |
ES2592267T3 (es) * | 2011-05-06 | 2016-11-29 | Bayer Intellectual Property Gmbh | Imidazopiridinas e imidazopiridazinas sustituidas y su uso |
PT2716642T (pt) | 2011-05-30 | 2016-10-17 | Astellas Pharma Inc | Composto de imidazopiridina |
BR112014000268A2 (pt) | 2011-07-06 | 2017-04-25 | Bayer Ip Gmbh | pirazolopiridinas com substituinte heteroarilo e utilização destas |
KR20140074912A (ko) | 2011-09-01 | 2014-06-18 | 에프. 호프만-라 로슈 아게 | 피롤로피라진 키나아제 억제제 |
EP2751106B1 (de) * | 2011-09-02 | 2017-10-18 | Bayer Intellectual Property GmbH | Substituierte annellierte pyrimidine und ihre verwendung |
DE102012200360A1 (de) | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Substituierte Triazine und ihre Verwendung |
DE102012200352A1 (de) * | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Substituierte, annellierte Imidazole und Pyrazole und ihre Verwendung |
DE102012200349A1 (de) * | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Substituierte annellierte Pyrimidine und Triazine und ihre Verwendung |
WO2013131923A1 (de) | 2012-03-06 | 2013-09-12 | Bayer Intellectual Property Gmbh | Substituierte azabicyclen und ihre verwendung |
ES2616042T3 (es) | 2013-03-01 | 2017-06-09 | Bayer Pharma Aktiengesellschaft | Pirazolopiridinas sustituidas con bencilo y su uso |
KR20150121007A (ko) | 2013-03-01 | 2015-10-28 | 바이엘 파마 악티엔게젤샤프트 | 트리플루오르메틸-치환된 고리-융합된 피리미딘 및 그의 용도 |
CA2920559A1 (en) | 2013-08-08 | 2015-02-12 | Bayer Pharma Aktiengesellschaft | Substituted imidazo[1,2-a]pyrazinecarboxamides and use thereof |
-
2014
- 2014-07-08 UY UY0001035652A patent/UY35652A/es not_active Application Discontinuation
- 2014-07-08 TW TW103123391A patent/TW201542569A/zh unknown
- 2014-07-08 AU AU2014289312A patent/AU2014289312A1/en not_active Abandoned
- 2014-07-08 CA CA2917682A patent/CA2917682A1/en not_active Abandoned
- 2014-07-08 SG SG11201600038UA patent/SG11201600038UA/en unknown
- 2014-07-08 AP AP2016008970A patent/AP2016008970A0/xx unknown
- 2014-07-08 EP EP14736803.9A patent/EP3019506A1/de not_active Withdrawn
- 2014-07-08 JP JP2016524789A patent/JP2016523944A/ja active Pending
- 2014-07-08 EA EA201600096A patent/EA201600096A1/ru unknown
- 2014-07-08 PE PE2016000026A patent/PE20160201A1/es not_active Application Discontinuation
- 2014-07-08 MX MX2016000258A patent/MX2016000258A/es unknown
- 2014-07-08 KR KR1020167003065A patent/KR20160030541A/ko not_active Application Discontinuation
- 2014-07-08 US US14/903,347 patent/US9605008B2/en not_active Expired - Fee Related
- 2014-07-08 CN CN201480049852.8A patent/CN105745215A/zh active Pending
- 2014-07-08 WO PCT/EP2014/064547 patent/WO2015004105A1/de active Application Filing
- 2014-07-08 TN TN2016000006A patent/TN2016000006A1/en unknown
-
2016
- 2016-01-07 DO DO2016000006A patent/DOP2016000006A/es unknown
- 2016-01-08 PH PH12016500065A patent/PH12016500065A1/en unknown
- 2016-01-08 GT GT201600002A patent/GT201600002A/es unknown
- 2016-01-08 CL CL2016000030A patent/CL2016000030A1/es unknown
- 2016-01-10 IL IL243525A patent/IL243525A0/en unknown
- 2016-01-11 CU CUP2016000004A patent/CU20160004A7/es unknown
Also Published As
Publication number | Publication date |
---|---|
AP2016008970A0 (en) | 2016-01-31 |
GT201600002A (es) | 2018-12-19 |
JP2016523944A (ja) | 2016-08-12 |
PH12016500065A1 (en) | 2016-07-04 |
PE20160201A1 (es) | 2016-05-06 |
DOP2016000006A (es) | 2016-02-15 |
CU20160004A7 (es) | 2016-06-29 |
TN2016000006A1 (en) | 2017-07-05 |
EP3019506A1 (de) | 2016-05-18 |
WO2015004105A1 (de) | 2015-01-15 |
US20160145271A1 (en) | 2016-05-26 |
CN105745215A (zh) | 2016-07-06 |
CA2917682A1 (en) | 2015-01-15 |
MX2016000258A (es) | 2016-04-28 |
TW201542569A (zh) | 2015-11-16 |
AU2014289312A1 (en) | 2016-02-11 |
UY35652A (es) | 2015-01-30 |
KR20160030541A (ko) | 2016-03-18 |
SG11201600038UA (en) | 2016-02-26 |
US9605008B2 (en) | 2017-03-28 |
IL243525A0 (en) | 2016-02-29 |
EA201600096A1 (ru) | 2016-10-31 |
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