WO2015004105A1 - Benzyl-1h-pyrazolo[3,4-b]pyridine und ihre verwendung - Google Patents
Benzyl-1h-pyrazolo[3,4-b]pyridine und ihre verwendung Download PDFInfo
- Publication number
- WO2015004105A1 WO2015004105A1 PCT/EP2014/064547 EP2014064547W WO2015004105A1 WO 2015004105 A1 WO2015004105 A1 WO 2015004105A1 EP 2014064547 W EP2014064547 W EP 2014064547W WO 2015004105 A1 WO2015004105 A1 WO 2015004105A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methyl
- salts
- oxides
- pyrazolo
- solvates
- Prior art date
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- YNVRFTUDHPLHJD-UHFFFAOYSA-N 1-benzylpyrazolo[3,4-b]pyridine Chemical class N1=CC2=CC=CN=C2N1CC1=CC=CC=C1 YNVRFTUDHPLHJD-UHFFFAOYSA-N 0.000 title abstract description 3
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- 150000001875 compounds Chemical class 0.000 claims description 225
- 150000003839 salts Chemical class 0.000 claims description 112
- 150000001204 N-oxides Chemical class 0.000 claims description 96
- -1 3-[5-fluoro-6-methyl-l-(2,3, 6-trifluorobenzyl)- 1 H-pyrrolo [3,4-b]pyridin-3 -yl] -7,7-dimethyl-5,7-dihydro-6H-pyrrolo [2,3 -e] [1,2, 4]triazin-6-one Chemical compound 0.000 claims description 80
- 239000012453 solvate Substances 0.000 claims description 75
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims description 44
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- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims description 3
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- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
Abstract
Description
Claims
Priority Applications (16)
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KR1020167003065A KR20160030541A (ko) | 2013-07-10 | 2014-07-08 | 벤질-1H-피라졸로[3,4-b]피리딘 및 그의 용도 |
CA2917682A CA2917682A1 (en) | 2013-07-10 | 2014-07-08 | Benzyl-1h-pyrazolo[3,4-b]pyridines and use thereof |
MA38775A MA38775A1 (fr) | 2013-07-10 | 2014-07-08 | Benzyl-1h-pyrazolo[3,4-b]pyridine et utilisation de cette dernière |
AU2014289312A AU2014289312A1 (en) | 2013-07-10 | 2014-07-08 | Benzyl-1H-pyrazolo(3,4-b)pyridines and use thereof |
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EP14736803.9A EP3019506A1 (de) | 2013-07-10 | 2014-07-08 | Benzyl-1h-pyrazolo[3,4-b]pyridine und ihre verwendung |
CN201480049852.8A CN105745215A (zh) | 2013-07-10 | 2014-07-08 | 苯甲基-1H-吡唑并[3,4-b]吡啶及其用途 |
TN2016000006A TN2016000006A1 (en) | 2013-07-10 | 2014-07-08 | Benzyl-1h-pyrazolo[3,4-b]pyridines and use thereof |
PH12016500065A PH12016500065A1 (en) | 2013-07-10 | 2016-01-08 | Benzyl-1h-pyrazolo[3,4-b]pyridines and use thereof |
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CUP2016000004A CU20160004A7 (es) | 2013-07-10 | 2016-01-11 | Bencil-1 h-pirazolo[3,4-b]piridinas |
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WO2016177660A1 (en) | 2015-05-06 | 2016-11-10 | Bayer Pharma Aktiengesellschaft | The use of sgc stimulators, sgc activators, alone and combinations with pde5 inhibitors for the treatment of digital ulcers (du) concomitant to systemic sclerosis (ssc) |
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US11166932B2 (en) | 2015-07-23 | 2021-11-09 | Bayer Pharma Aktiengesellschaft | Stimulators and/or activators of soluble guanylate cyclase (sGC) in combination with an inhibitor of neutral endopeptidase (NEP inhibitor) and/or an angiotensin AII antagonist and the use thereof |
WO2017112617A1 (en) | 2015-12-22 | 2017-06-29 | Merck Sharp & Dohme Corp. | 4-amino-2-(1h-pyrazolo[3,4-b]pyridin-3-yl)-6-oxo-6,7-dihydro-5h-pyrrolo[2,3-d]pyrimidine derivatives and the respective (1h-indazol-3-yl) derivatives as cgmp modulators for treating cardiovascular diseases |
WO2017121700A1 (de) | 2016-01-15 | 2017-07-20 | Bayer Pharma Aktiengesellschaft | 1,3-disubstituierte 1h-pyrazolo[3,4-b]pyridin- derivate und ihre verwendung als stimulatoren der löslichen guanylatcyclase |
WO2017121692A1 (de) | 2016-01-15 | 2017-07-20 | Bayer Pharma Aktiengesellschaft | Substituierte sulfamide und ihre verwendung |
WO2018069126A1 (de) | 2016-10-11 | 2018-04-19 | Bayer Pharma Aktiengesellschaft | Kombination enthaltend sgc stimulatoren und mineralocorticoid-rezeptor-antagonisten |
US10918639B2 (en) | 2016-10-11 | 2021-02-16 | Bayer Pharma Aktiengesellschaft | Combination containing SGC stimulators and mineralocorticoid receptor antagonists |
US11331308B2 (en) | 2016-10-11 | 2022-05-17 | Bayer Pharma Aktiengesellschaft | Combination containing sGC activators and mineralocorticoid receptor antagonists |
US11684621B2 (en) | 2016-10-11 | 2023-06-27 | Bayer Pharma Aktiengesellschaft | Combination containing sGC stimulators and mineralocorticoid receptor antagonists |
WO2019219672A1 (en) | 2018-05-15 | 2019-11-21 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization |
WO2020165010A1 (en) | 2019-02-13 | 2020-08-20 | Bayer Aktiengesellschaft | Process for the preparation of porous microparticles |
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AP2016008970A0 (en) | 2016-01-31 |
US20160145271A1 (en) | 2016-05-26 |
PE20160201A1 (es) | 2016-05-06 |
GT201600002A (es) | 2018-12-19 |
CU20160004A7 (es) | 2016-06-29 |
SG11201600038UA (en) | 2016-02-26 |
CN105745215A (zh) | 2016-07-06 |
TW201542569A (zh) | 2015-11-16 |
PH12016500065A1 (en) | 2016-07-04 |
KR20160030541A (ko) | 2016-03-18 |
AU2014289312A1 (en) | 2016-02-11 |
CA2917682A1 (en) | 2015-01-15 |
CL2016000030A1 (es) | 2016-08-19 |
EP3019506A1 (de) | 2016-05-18 |
EA201600096A1 (ru) | 2016-10-31 |
UY35652A (es) | 2015-01-30 |
TN2016000006A1 (en) | 2017-07-05 |
DOP2016000006A (es) | 2016-02-15 |
MX2016000258A (es) | 2016-04-28 |
US9605008B2 (en) | 2017-03-28 |
IL243525A0 (en) | 2016-02-29 |
JP2016523944A (ja) | 2016-08-12 |
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