AR076601A1 - Pirimidinas como agentes terapeuticos - Google Patents
Pirimidinas como agentes terapeuticosInfo
- Publication number
- AR076601A1 AR076601A1 ARP100101785A ARP100101785A AR076601A1 AR 076601 A1 AR076601 A1 AR 076601A1 AR P100101785 A ARP100101785 A AR P100101785A AR P100101785 A ARP100101785 A AR P100101785A AR 076601 A1 AR076601 A1 AR 076601A1
- Authority
- AR
- Argentina
- Prior art keywords
- aromatic
- nhc
- unsubstituted
- alkyl
- independently
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto de cualquiera de las Formulas ((1a-2)-(1a-21)), incluyendo otros tautomeros, estereoisomeros, estereoisomeros E/Z, profármacos, sales farmacéuticamente aceptables, y también caracteriza composiciones, métodos para tratar o prevenir dolor (por ej., dolor neuropático), inflamacion, o epilepsia y como anticonvulsivos. Reivindicacion 1: Un compuesto que tiene la siguiente estructura (1a) y sus tautomeros (1b), incluyendo otros tautomeros, estereoisomeros, estereoisomeros E/Z, profármacos y sus sales farmacéuticamente aceptables, donde Q1 es -O-, -S-, -SO-, -SO2-, -CH2-, -CH2CH2-, -CH=CH-, -OCH2-, -SCH2-, -SOCH2-, o -SO2CH2-; V es O, S, NH, o NZ, o amino ácido ligado a N-terminal, halogeno, o H cuando R1 está ausente; R1 está ausente, -H, alquilo C1-8, alquenillo C2-8, alquinilo C2-8, cicloalquilo C3-12, arilo C6-12, arilalquilo C7-14, -(CH2)nOZ, -C(O)Z, -C(O)OZ, -C(O)NHZ, -C(O)N(Z)2, -(CR1AR1B)r2OPO(OZ)2, -(CR2AR2B)r3PO(OZ)2, o aminoácido ligado a C-terminal; cada R1A, R1B, R2A y R2B es, de manera independiente, H o alquilo C1-5; cada Z es, de manera independiente, -H, alquilo C1-8, alqcicloalquilo C4-12, alqheterociclilo C3-9, donde el heterociclilo es de 3 a 9 miembros, cicloalquilo C3-12, arilo C6-12, arilalquilo C7-14, heterociclilo 3 a 9 miembros aromático o no aromático, alquenilo C2-8, o alquinilo C2-8, o dos Z, junto con el átomo(s) al cual cada uno está adherido, se juntan para formar un heterociclo de 3 a 7 miembros aromático o no aromático; cada n es 1 o 2; cada r2 es un numero entero entre 1-3; cada r3 es un numero entero entre 0-2; R2 y R3 son cada uno, de manera independiente, -H, -D, -OH, -halogeno, -CN, -NO2, -SH, -CF3, alquilo C1-8, alquenilo C2-8, alquinilo C2-8, cicloalquilo C3-12, arilo C6-12, arilalquilo C7-14, heterociclilo de 3 a 9 miembros aromático o no aromático, -OZ, -N(Z)2, -C(NH)N(Z)2, -O(CH2)nOZ, -C(O)Z, -OC(O)Z, -OC(O)OZ, -OC(O)N(Z)2, -C(O)N(Z)2, -C(O)OZ, -SZ, -SOZ, -S(O)2Z, -NHC(O)Z, -NHS(O)2Z, -NHC(NH)N(Z)2, -NZC(NH)N(Z)2, - NHC(NCN)N(Z)2, -NZC(NCN)N(Z)2, o -PO(OZ)2, o R2 y R3, junto con el átomo al cual cada uno está adherido, se juntan para formar un carbociclo o heterociclo de 5 o 6 miembros aromático o no aromático; A1 y A2 son cada uno, de manera independiente, -H, -D, -halogeno, alquilo C1-8, alquenilo C2-8, alquinilo C2-8, cicloalquilo C3-12, -arilo C6-12, o arilalquilo C7-14; A3 es un anillo heterocíclico aromático seleccionado entre el grupo integrado por los fragmentos A-1 a A-4; Q2, Q5 y Q6 son cada uno, de manera independiente, N, N+-O-, o C; Q3 y Q4 son cada uno, de manera independiente, N, N+-O-, C, O, o S, donde solamente uno de Q3 y Q4 puede ser O u S; donde Q2, Q3, Q4, Q5 y Q6 simultáneamente son C solo si R4 y R5, R5 y R6, R6 y R7, o R7 y R8, junto con los átomos al cual cada uno está adherido, se unen para formar un heterociclilo de 5 a 6 miembros aromático o no aromático; y R4, R5, R6, R7 y R8 son cada uno, de manera independiente, ausente, -H, -D, -OH, -O, -halogeno, -CN, -NO2, -SH, alquilo C1-8, alquenilo C2-8, alquinilo C2-8, cicloalquilo C3-12, arilo C6-12, arilalquilo C7-14, heterociclilo de 3 a 9 miembros aromático o no aromático, -OZ, -N(Z)2, -C(NH)N(Z)2, -O(CH2)nOZ, -C(O)Z, -OC(O)Z, -OC(O)OZ, -OC(O)N(Z)2, -C(O)N(Z)2, -C(O)OZ, -SZ, -SOZ, -S(O)2Z, -NHC(O)Z, -NHS(O)2Z, -NHC(NH)N(Z)2, -NZC(NH)N(Z)2, -NHC(NCN)N(Z)2, -NZC(NCN)N(Z)2, -PO(OZ)2, o R4 y R5, o R5 y R6, o R6 y R7, o R7 y R8, junto con los átomos al cual cada uno está adherido, se unen para formar un carbociclo o heterociclo de 5 a 6 miembros aromático o no aromático siempre y cuando el sistema anular resultante no esté sustituido o bencimidazol no sustituido, no sustituido benzotiazol, imidazo[1,2-a]piridina no sustituido, 5- o 6- cloro-imidazo[1,2-a]piridina, indol cuando R2 es C(O)OCH2CH3, quinolina no sustituido, quinolina 8-sustituida, quinoxalina no sustituido, 2- o 4-cloro-quinolina, 2-cloro-7-metil-quinolina o 2-piperidin-1-il-quinolina cuando R3 es NH2, o 4-hidroxi-1,3-quinazolina, donde cuando A3 es piridina-2-il no sustituido y A1, y A2 son cada uno -H, R3 no es -H, -OH, -NH2, -CF3, alquilo C1-3, fenilo, difluorobencil, -NHC(O)furan, -NHC(O)CH3, o -NHC(O)CH2CH3; donde cuando A3 es piridina-4-il no sustituido y A1 y A2 son cada uno -H, R3 no es -H, -OH, -NH2, -CH3, -CH2CH2CH3, o difluorobencil; donde cuando A3 es no sustituido, 6-cloro, o 2,6-dicloro piridina-3-il y A1 y A2 son cada uno -H, R3 no es -H, -OH, -NH2, -CF3, alquilo C1-3, fenilo, -C(O)OCH2CH3, o -NHC(O)CH3; donde cuando A3 es pirazol-1-il sustituido o no sustituido, R3 no es -OH; y donde A3 no es 4-NO2-imidazol-2-il.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18025309P | 2009-05-21 | 2009-05-21 | |
US28500309P | 2009-12-09 | 2009-12-09 | |
US28962809P | 2009-12-23 | 2009-12-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR076601A1 true AR076601A1 (es) | 2011-06-22 |
Family
ID=43124965
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100101785A AR076601A1 (es) | 2009-05-21 | 2010-05-21 | Pirimidinas como agentes terapeuticos |
Country Status (6)
Country | Link |
---|---|
US (2) | US9040538B2 (es) |
EP (1) | EP2432776B1 (es) |
AR (1) | AR076601A1 (es) |
CA (1) | CA2762680C (es) |
TW (1) | TW201100411A (es) |
WO (1) | WO2010132999A1 (es) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
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US9040538B2 (en) | 2009-05-21 | 2015-05-26 | Universite Laval | Pyrimidines as novel therapeutic agents |
RS56080B1 (sr) | 2010-01-15 | 2017-10-31 | Inserm (Institut Nat De La Santé Et De La Rech Médicale) | Inhibitori nkcc za lečenje autizma |
MX351368B (es) | 2010-05-26 | 2017-10-12 | Sunovion Pharmaceuticals Inc | Compuestos heteroarilo y metodos para utilizarlos. |
CN102070553B (zh) * | 2010-12-17 | 2013-08-07 | 西安瑞联近代电子材料有限责任公司 | 一种噻唑-4-甲醛的合成方法 |
BR112013028895A2 (pt) | 2011-05-10 | 2016-08-09 | Bayer Ip Gmbh | (tio)carbonilamidinas bicíclicas |
DE102012200354A1 (de) | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Heteroaryl-substituierte Pyrazolopyridine und ihre Verwendung |
JP6109161B2 (ja) | 2011-07-06 | 2017-04-05 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH | ヘテロアリール置換ピラゾロピリジン類およびその使用 |
DK2746265T3 (da) | 2011-08-18 | 2016-02-01 | Nippon Shinyaku Co Ltd | Heterocyclisk derivat som mikrosomal prostaglandin-E-syntase-(mPGEs)-inhibitor |
DE102012200349A1 (de) | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Substituierte annellierte Pyrimidine und Triazine und ihre Verwendung |
DE102012200360A1 (de) | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Substituierte Triazine und ihre Verwendung |
JP6140738B2 (ja) | 2012-03-06 | 2017-05-31 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH | 置換アザ二環およびその使用 |
EP2732815A1 (en) | 2012-11-16 | 2014-05-21 | Neurochlore | Modulators of intracellular chloride concentration for treating fragile X syndrome |
WO2014139983A1 (en) | 2013-03-13 | 2014-09-18 | H. Lundbeck A/S | [1,2,4]triazolo[4,3-a]quinoxalines as dual pde2/pde10 inhibitors |
KR20150140381A (ko) | 2013-04-12 | 2015-12-15 | 바이엘 크롭사이언스 악티엔게젤샤프트 | 신규 트리아졸 유도체 |
MX2015014365A (es) | 2013-04-12 | 2015-12-07 | Bayer Cropscience Ag | Derivados de triazol novedosos. |
BR112015025331A2 (pt) | 2013-04-12 | 2017-07-18 | Bayer Cropscience Ag | novos derivados de triazolintiona |
BR112015027395A2 (pt) | 2013-05-14 | 2017-08-29 | Active Biotech Ab | Composto, composição farmacêutica, e, método para tratar uma doença ou condição |
UY35652A (es) | 2013-07-10 | 2015-01-30 | Bayer Pharma AG | Bencil-1h-pirazolo[3,4-b]piridinas y su uso |
CN104693114B (zh) * | 2013-12-10 | 2019-08-16 | 四川海思科制药有限公司 | 一种贝曲西班的改进的制备方法 |
RU2537848C1 (ru) * | 2013-12-10 | 2015-01-10 | Федеральное государственное казенное учреждение "33 Центральный научно-исследовательский испытательный институт Министерства обороны Российской Федерации" | Способ получения 2-хлор-5-гидроксиметилпиридина |
CN106255414A (zh) * | 2014-01-17 | 2016-12-21 | 瓦伦特生物科学公司 | S‑苄硫尿嘧啶化合物以及增强植物根部生长的方法 |
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WO2010132999A1 (en) | 2010-11-25 |
WO2010132999A8 (en) | 2011-06-30 |
CA2762680A1 (en) | 2010-11-25 |
EP2432776B1 (en) | 2019-09-11 |
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