CL2011002482A1 - Anticuerpo biespecificos que se une especificamente a las proteinas erbb-3 humana y c-met humana; acido nucleico que lo codifica; composicion farmaceutica que lo comprende; y su uso para tratar cancer - Google Patents
Anticuerpo biespecificos que se une especificamente a las proteinas erbb-3 humana y c-met humana; acido nucleico que lo codifica; composicion farmaceutica que lo comprende; y su uso para tratar cancerInfo
- Publication number
- CL2011002482A1 CL2011002482A1 CL2011002482A CL2011002482A CL2011002482A1 CL 2011002482 A1 CL2011002482 A1 CL 2011002482A1 CL 2011002482 A CL2011002482 A CL 2011002482A CL 2011002482 A CL2011002482 A CL 2011002482A CL 2011002482 A1 CL2011002482 A1 CL 2011002482A1
- Authority
- CL
- Chile
- Prior art keywords
- human
- nucleic acid
- pharmaceutical composition
- specifically binds
- acid encoding
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 102000008022 Proto-Oncogene Proteins c-met Human genes 0.000 title abstract 2
- 108010089836 Proto-Oncogene Proteins c-met Proteins 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
Anticuerpo biespecíficos que se une específicamente a las proteínas erbb-3 humana y c-met humana; ácido nucleico que lo codifica; composición farmacéutica que lo comprende; y su uso para tratar cáncer.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09005110 | 2009-04-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2011002482A1 true CL2011002482A1 (es) | 2012-03-30 |
Family
ID=40942420
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2011002482A CL2011002482A1 (es) | 2009-04-07 | 2011-10-06 | Anticuerpo biespecificos que se une especificamente a las proteinas erbb-3 humana y c-met humana; acido nucleico que lo codifica; composicion farmaceutica que lo comprende; y su uso para tratar cancer |
Country Status (20)
Country | Link |
---|---|
US (2) | US20100256339A1 (es) |
EP (1) | EP2417159A1 (es) |
JP (1) | JP5587975B2 (es) |
KR (1) | KR20110124369A (es) |
CN (1) | CN102378768A (es) |
AR (1) | AR076196A1 (es) |
AU (1) | AU2010233994A1 (es) |
BR (1) | BRPI1012589A2 (es) |
CA (1) | CA2757531A1 (es) |
CL (1) | CL2011002482A1 (es) |
CO (1) | CO6420355A2 (es) |
CR (1) | CR20110466A (es) |
EC (1) | ECSP11011387A (es) |
IL (1) | IL215062A0 (es) |
MX (1) | MX2011010166A (es) |
PE (1) | PE20120550A1 (es) |
RU (1) | RU2011144312A (es) |
SG (1) | SG175081A1 (es) |
TW (1) | TW201039851A (es) |
WO (1) | WO2010115552A1 (es) |
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CN102369215B (zh) | 2009-04-02 | 2015-01-21 | 罗切格利卡特公司 | 包含全长抗体和单链Fab片段的多特异性抗体 |
PT2417156E (pt) | 2009-04-07 | 2015-04-29 | Roche Glycart Ag | Anticorpos trivalentes, biespecíficos |
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US9493578B2 (en) | 2009-09-02 | 2016-11-15 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
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BR112013001847A2 (pt) | 2010-08-24 | 2016-05-31 | Hoffmann La Roche | anticorpo biespecífico, método de preparação do anticorpo biespecífico, do anticorpo biespecífico trivalente, métodos e composição farmacêutica |
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2010
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- 2010-03-30 JP JP2012503896A patent/JP5587975B2/ja not_active Expired - Fee Related
- 2010-03-30 CA CA2757531A patent/CA2757531A1/en not_active Abandoned
- 2010-03-30 MX MX2011010166A patent/MX2011010166A/es not_active Application Discontinuation
- 2010-03-30 CN CN2010800150723A patent/CN102378768A/zh active Pending
- 2010-03-30 SG SG2011072642A patent/SG175081A1/en unknown
- 2010-03-30 RU RU2011144312/10A patent/RU2011144312A/ru not_active Application Discontinuation
- 2010-03-30 BR BRPI1012589A patent/BRPI1012589A2/pt not_active IP Right Cessation
- 2010-03-30 EP EP10711590A patent/EP2417159A1/en not_active Withdrawn
- 2010-03-30 WO PCT/EP2010/002005 patent/WO2010115552A1/en active Application Filing
- 2010-03-30 AU AU2010233994A patent/AU2010233994A1/en not_active Abandoned
- 2010-03-30 KR KR1020117023708A patent/KR20110124369A/ko not_active Application Discontinuation
- 2010-04-01 US US12/752,196 patent/US20100256339A1/en not_active Abandoned
- 2010-04-05 AR ARP100101125A patent/AR076196A1/es not_active Application Discontinuation
- 2010-04-06 TW TW099110644A patent/TW201039851A/zh unknown
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2011
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- 2011-08-30 CR CR20110466A patent/CR20110466A/es unknown
- 2011-08-31 CO CO11111960A patent/CO6420355A2/es not_active Application Discontinuation
- 2011-09-08 IL IL215062A patent/IL215062A0/en unknown
- 2011-10-06 CL CL2011002482A patent/CL2011002482A1/es unknown
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2014
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CR20110466A (es) | 2011-09-21 |
TW201039851A (en) | 2010-11-16 |
IL215062A0 (en) | 2011-11-30 |
ECSP11011387A (es) | 2011-11-30 |
CA2757531A1 (en) | 2010-10-14 |
AR076196A1 (es) | 2011-05-26 |
JP5587975B2 (ja) | 2014-09-10 |
MX2011010166A (es) | 2011-10-11 |
RU2011144312A (ru) | 2013-05-20 |
BRPI1012589A2 (pt) | 2016-03-22 |
PE20120550A1 (es) | 2012-05-21 |
JP2012522524A (ja) | 2012-09-27 |
SG175081A1 (en) | 2011-11-28 |
EP2417159A1 (en) | 2012-02-15 |
AU2010233994A1 (en) | 2011-09-22 |
CO6420355A2 (es) | 2012-04-16 |
WO2010115552A1 (en) | 2010-10-14 |
CN102378768A (zh) | 2012-03-14 |
US20140135482A1 (en) | 2014-05-15 |
KR20110124369A (ko) | 2011-11-16 |
US20100256339A1 (en) | 2010-10-07 |
WO2010115552A8 (en) | 2011-11-03 |
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