CL2008002861A1 - Polipeptido aislado de m. ruminantium; vector, molecula conjugada y celula huesped que comprenden dicho polipeptido; anticuerpo o fragmento que se une al polipeptido; composicion farmaceutica que comprende la molecula conjugada; metodo para dirigir una celula metanogena para identificacion, aislamiento o inhibicion. - Google Patents

Polipeptido aislado de m. ruminantium; vector, molecula conjugada y celula huesped que comprenden dicho polipeptido; anticuerpo o fragmento que se une al polipeptido; composicion farmaceutica que comprende la molecula conjugada; metodo para dirigir una celula metanogena para identificacion, aislamiento o inhibicion.

Info

Publication number
CL2008002861A1
CL2008002861A1 CL2008002861A CL2008002861A CL2008002861A1 CL 2008002861 A1 CL2008002861 A1 CL 2008002861A1 CL 2008002861 A CL2008002861 A CL 2008002861A CL 2008002861 A CL2008002861 A CL 2008002861A CL 2008002861 A1 CL2008002861 A1 CL 2008002861A1
Authority
CL
Chile
Prior art keywords
polypeptide
conjugated molecule
cell
polypeptides
peptides
Prior art date
Application number
CL2008002861A
Other languages
English (en)
Spanish (es)
Inventor
John Kelly Eric Heinz Altermann Sinead Leahy Zhanhao Kong Graeme Trevor Attwood William
Dong Li
Original Assignee
Pastoral Greenhouse Gas Res Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pastoral Greenhouse Gas Res Limited filed Critical Pastoral Greenhouse Gas Res Limited
Publication of CL2008002861A1 publication Critical patent/CL2008002861A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6405—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
    • C12N9/641—Cysteine endopeptidases (3.4.22)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/13—Tumour cells, irrespective of tissue of origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
    • Y02P60/20—Reduction of greenhouse gas [GHG] emissions in agriculture, e.g. CO2
    • Y02P60/22—Methane [CH4], e.g. from rice paddies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
CL2008002861A 2007-09-25 2008-09-25 Polipeptido aislado de m. ruminantium; vector, molecula conjugada y celula huesped que comprenden dicho polipeptido; anticuerpo o fragmento que se une al polipeptido; composicion farmaceutica que comprende la molecula conjugada; metodo para dirigir una celula metanogena para identificacion, aislamiento o inhibicion. CL2008002861A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97510407P 2007-09-25 2007-09-25
US98984107P 2007-11-22 2007-11-22
US98984007P 2007-11-22 2007-11-22

Publications (1)

Publication Number Publication Date
CL2008002861A1 true CL2008002861A1 (es) 2009-03-06

Family

ID=40511642

Family Applications (3)

Application Number Title Priority Date Filing Date
CL2008002861A CL2008002861A1 (es) 2007-09-25 2008-09-25 Polipeptido aislado de m. ruminantium; vector, molecula conjugada y celula huesped que comprenden dicho polipeptido; anticuerpo o fragmento que se une al polipeptido; composicion farmaceutica que comprende la molecula conjugada; metodo para dirigir una celula metanogena para identificacion, aislamiento o inhibicion.
CL2008002859A CL2008002859A1 (es) 2007-09-25 2008-09-25 Péptido señal con actividad de permeabilización de células microbianas; vector; célula huésped; molécula conjugada que lo comprende; y método para permeabilizar una célula microbiana.
CL2008002860A CL2008002860A1 (es) 2007-09-25 2008-09-25 Polipeptido; polinucleotido que lo codifica; vector y fago aislado que comprenda este polinucleotido; anticuerpo que se une a este polipeptido; molecula de fusion que comprende este polipeptido; celula huesped metanogena que comprende el vector; composicion farmaceutica que comprende el polinucleotido.

Family Applications After (2)

Application Number Title Priority Date Filing Date
CL2008002859A CL2008002859A1 (es) 2007-09-25 2008-09-25 Péptido señal con actividad de permeabilización de células microbianas; vector; célula huésped; molécula conjugada que lo comprende; y método para permeabilizar una célula microbiana.
CL2008002860A CL2008002860A1 (es) 2007-09-25 2008-09-25 Polipeptido; polinucleotido que lo codifica; vector y fago aislado que comprenda este polinucleotido; anticuerpo que se une a este polipeptido; molecula de fusion que comprende este polipeptido; celula huesped metanogena que comprende el vector; composicion farmaceutica que comprende el polinucleotido.

Country Status (17)

Country Link
US (7) US9296789B2 (cg-RX-API-DMAC7.html)
EP (5) EP3327030B1 (cg-RX-API-DMAC7.html)
JP (5) JP5558356B2 (cg-RX-API-DMAC7.html)
CN (4) CN101918431B (cg-RX-API-DMAC7.html)
AR (3) AR068553A1 (cg-RX-API-DMAC7.html)
AU (4) AU2008304018A1 (cg-RX-API-DMAC7.html)
BR (5) BRPI0817312B1 (cg-RX-API-DMAC7.html)
CA (3) CA2700129C (cg-RX-API-DMAC7.html)
CL (3) CL2008002861A1 (cg-RX-API-DMAC7.html)
DK (3) DK2203467T3 (cg-RX-API-DMAC7.html)
ES (3) ES2625144T3 (cg-RX-API-DMAC7.html)
MX (3) MX2010003321A (cg-RX-API-DMAC7.html)
NZ (1) NZ745324A (cg-RX-API-DMAC7.html)
RU (1) RU2528854C2 (cg-RX-API-DMAC7.html)
UY (3) UY31359A1 (cg-RX-API-DMAC7.html)
WO (3) WO2009041832A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA201001933B (cg-RX-API-DMAC7.html)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3327030B1 (en) 2007-09-25 2021-07-21 Pastoral Greenhouse Gas Research LTD Vaccines and vaccine components for inhibition of microbial cells
GB0815484D0 (en) 2008-08-26 2008-10-01 Univ Leuven Kath Antibacterial agents
KR101701890B1 (ko) * 2009-06-26 2017-02-02 뤼산도 아게 항균제
DK2445515T3 (en) 2009-06-26 2016-07-04 Univ Leuven Kath antimicrobial agents
US9441016B2 (en) * 2009-08-27 2016-09-13 Pastoral Greenhouse Gas Research Ltd. Complete genome sequence of the methanogen Methanobrevibacter ruminantium
BR112012026880B1 (pt) * 2010-04-27 2021-03-16 Lysando Ag método para eliminação ou redução de um biofilme bacteriano, variante de endolisina ou variante de bacteriocina e seus usos
ES2802253T3 (es) * 2012-09-19 2021-01-18 Gemvax & Kael Co Ltd Péptido de penetración celular, conjugado que comprende el mismo y composición que comprende el conjugado
KR20150105635A (ko) * 2012-12-12 2015-09-17 더 브로드 인스티튜트, 인코퍼레이티드 서열 조작을 위한 crispr-cas 성분 시스템, 방법 및 조성물
WO2014204578A1 (en) 2013-06-21 2014-12-24 The General Hospital Corporation Using rna-guided foki nucleases (rfns) to increase specificity for rna-guided genome editing
KR102874079B1 (ko) 2013-03-15 2025-10-22 더 제너럴 하스피탈 코포레이션 Rna-안내 게놈 편집을 위해 특이성을 증가시키기 위한 절단된 안내 rna(tru-grnas)의 이용
US10760064B2 (en) 2013-03-15 2020-09-01 The General Hospital Corporation RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
CN111218447B (zh) 2013-11-07 2024-10-11 爱迪塔斯医药有限公司 使用统治型gRNA的CRISPR相关方法和组合物
CN107406838A (zh) * 2014-11-06 2017-11-28 纳幕尔杜邦公司 Rna引导的内切核酸酶向细胞中的肽介导的递送
CN104789675A (zh) * 2015-04-15 2015-07-22 江苏师范大学 一种检测荷斯坦奶牛瘤胃微生物的方法
EP3292219B9 (en) * 2015-05-04 2022-05-18 Ramot at Tel-Aviv University Ltd. Methods and kits for fragmenting dna
US9926546B2 (en) 2015-08-28 2018-03-27 The General Hospital Corporation Engineered CRISPR-Cas9 nucleases
US9512446B1 (en) 2015-08-28 2016-12-06 The General Hospital Corporation Engineered CRISPR-Cas9 nucleases
MX2019000621A (es) * 2016-07-14 2019-08-01 Basf Se Medio de fermentacion que comprende agente quelante.
WO2018125982A1 (en) * 2016-12-29 2018-07-05 Illumina, Inc. Analysis system for orthogonal access to and tagging of biomolecules in cellular compartments
US12473535B2 (en) 2017-01-05 2025-11-18 Shenzhen Mindray Bio-Medical Electronics Co., Ltd. Method for preparing reticulocyte simulating particles and platelet simulating particles, and reference control
US10745439B2 (en) * 2017-03-20 2020-08-18 Regents Of The University Of Minnesota Kinase substrates and methods of use thereof
WO2019147743A1 (en) 2018-01-26 2019-08-01 Massachusetts Institute Of Technology Structure-guided chemical modification of guide rna and its applications
WO2019183123A1 (en) * 2018-03-19 2019-09-26 Regeneron Pharmaceuticals, Inc. Transcription modulation in animals using crispr/cas systems
CN113677359A (zh) 2018-11-14 2021-11-19 鲁比克治疗股份有限公司 Cd25抗体
WO2020102603A1 (en) 2018-11-14 2020-05-22 Rubryc Therapeutics, Inc. Engineered cd25 polypeptides and uses thereof
CN109627301B (zh) * 2019-02-18 2022-08-05 浙江新银象生物工程有限公司 Nisin固体稳定剂开发及应用
CA3171721A1 (en) * 2020-03-19 2021-09-23 Fritz Eichenseher A stabilized protein of interest
WO2021207687A1 (en) * 2020-04-10 2021-10-14 Liberty Biosecurity Llc Polypeptide compositions and uses thereof
CN112143747B (zh) * 2020-09-09 2022-09-13 昆明理工大学 一种噬菌体裂解酶及其基因、基因重组表达载体与应用
US11529310B2 (en) 2020-12-08 2022-12-20 Ruminant Biotech Corp Limited Devices and methods for delivery of substances to animals
CN112961217B (zh) * 2021-03-19 2022-11-08 江苏元本生物科技有限公司 一种靶向Siglec-15的噬菌体多肽
CN113121705B (zh) * 2021-04-19 2023-03-24 成都英普博集生物科技有限公司 用于制备短肽混合物的融合蛋白、目的多肽、短肽混合物的制备方法及应用
US20240009291A1 (en) * 2022-07-11 2024-01-11 Arkea Bio Corp. Compositions and methods for reducing methane emissions in ruminant populations
CN115417927A (zh) * 2022-09-08 2022-12-02 南京松天盛科生物科技有限公司 小鼠腹水致敏物及其应用
CA3269329A1 (en) * 2022-11-03 2024-05-10 Helix Nanotechnologies Inc Vaccines for Ruminants Against Methogens and Their Uses
CN115938486B (zh) * 2022-12-06 2023-11-10 内蒙古农业大学 基于图神经网络的抗菌性乳酸菌株筛选方法
WO2025219570A1 (en) 2024-04-17 2025-10-23 Johannes Kepler Universität Linz Composition for inhibiting protein translocation and methods using the same
WO2025233675A1 (en) * 2024-05-10 2025-11-13 Institut Pasteur Use of talosaminidase to regulate populations of archaeal methanogens in industrial, agricultural and medical settings

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US159861A (en) * 1875-02-16 Improvement in brooms
NZ207394A (en) 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
EP0150186A1 (fr) * 1983-05-03 1985-08-07 S.S.M. International Chemical Company Limited Composition a activite pharmaceutique amelioree et utilisation decelle-ci pour des usages veterinaires
GB8815968D0 (en) * 1988-07-05 1988-08-10 Pfizer Ltd Veterinary devices
JPH05219927A (ja) * 1992-02-14 1993-08-31 Gumma Pref Gov 飼料の混合装置及び混合飼料の製造方法
JP3651915B2 (ja) * 1993-06-30 2005-05-25 財団法人神奈川科学技術アカデミー シグナル配列ペプチドをコードするｄｎａ断片の探索法及びそのためのベクター
ZA948204B (en) 1993-10-19 1995-06-12 Commw Scient Ind Res Org Method for improving utilisation of nutrients by ruminant or ruminant-like animals
JPH09507121A (ja) 1993-10-26 1997-07-22 アフィマックス テクノロジーズ ナームロゼ ベノートスハップ 生物学的チップ上の核酸プローブアレー
PT739198E (pt) 1994-01-20 2004-02-27 Agres Ltd Dispositivo para administracao de substancias beneficas a ruminantes
NZ278977A (en) 1994-01-20 1997-03-24 Pastoral Agric Res Inst Nz Ltd Sustained release bolus for ruminants
US6015880A (en) 1994-03-16 2000-01-18 California Institute Of Technology Method and substrate for performing multiple sequential reactions on a matrix
AUPN353695A0 (en) 1995-06-14 1995-07-06 Commonwealth Scientific And Industrial Research Organisation Immunogenic preparation and method for improving the productivity of ruminant animals
WO1998007830A2 (en) * 1996-08-22 1998-02-26 The Institute For Genomic Research COMPLETE GENOME SEQUENCE OF THE METHANOGENIC ARCHAEON, $i(METHANOCOCCUS JANNASCHII)
US5985907A (en) * 1998-08-12 1999-11-16 Health Research, Inc. Method for inhibiting growth of methanogens
AU2002306849A1 (en) 2001-03-21 2002-10-08 Elitra Pharmaceuticals, Inc. Identification of essential genes in microorganisms
US20030219467A1 (en) * 2001-09-18 2003-11-27 The Board Of Regents Of The University Of Nebraska Method for the inhibition of methanogensis
US7314974B2 (en) * 2002-02-21 2008-01-01 Monsanto Technology, Llc Expression of microbial proteins in plants for production of plants with improved properties
US20060068386A1 (en) * 2002-03-04 2006-03-30 Alexei Slesarev Complete genome and protein sequence of the hyperthermophile methanopyrus kandleri av19 and monophyly of archael methanogens and methods of use thereof
SE523209C2 (sv) * 2002-05-14 2004-04-06 Akzo Nobel Nv Förfarande för att reducera metanbildningen från matspjälkningsaktiviteter hos djur
WO2006102350A1 (en) 2005-03-23 2006-09-28 Washington University In St. Louis The use of archaea to modulate the nutrient harvesting functions of the gastrointestinal microbiota
EP3327030B1 (en) * 2007-09-25 2021-07-21 Pastoral Greenhouse Gas Research LTD Vaccines and vaccine components for inhibition of microbial cells
CN101434924A (zh) * 2008-12-17 2009-05-20 中南大学 一种分离严格厌氧产甲烷古菌的方法
US9441016B2 (en) * 2009-08-27 2016-09-13 Pastoral Greenhouse Gas Research Ltd. Complete genome sequence of the methanogen Methanobrevibacter ruminantium
CN101864362B (zh) * 2010-05-19 2012-05-09 江苏加德绿色能源有限公司 一种复合微生物菌剂及其应用
DE102011119230B4 (de) * 2011-11-23 2013-07-11 Audi Ag Kraftwagen-Blinkleuchte und Verfahren zum Betreiben einer Blinkleuchte
WO2014100726A2 (en) * 2012-12-21 2014-06-26 Danisco Us Inc. Production of isoprene, isoprenoid, and isoprenoid precursors using an alternative lower mevalonate pathway

Also Published As

Publication number Publication date
CA2700162C (en) 2018-08-14
NZ780936A (en) 2024-08-30
EP2203466A4 (en) 2011-04-13
US20100209998A1 (en) 2010-08-19
US20100221185A1 (en) 2010-09-02
AU2014210649B2 (en) 2016-09-08
MX340736B (es) 2016-07-22
EP3327030B1 (en) 2021-07-21
US8592556B2 (en) 2013-11-26
US10590170B2 (en) 2020-03-17
MX2010003328A (es) 2010-08-16
UY31361A1 (es) 2009-04-30
JP5558356B2 (ja) 2014-07-23
EP2203466B1 (en) 2016-04-06
CL2008002859A1 (es) 2009-03-06
CN102015755A (zh) 2011-04-13
WO2009041831A9 (en) 2009-11-05
US10995120B2 (en) 2021-05-04
CN101918431B (zh) 2014-10-08
EP3936516A1 (en) 2022-01-12
AU2008304018A1 (en) 2009-04-02
JP5552053B2 (ja) 2014-07-16
CA2700162A1 (en) 2009-04-02
RU2528854C2 (ru) 2014-09-20
DK2203467T3 (en) 2017-03-27
ES2895908T3 (es) 2022-02-23
US20100209999A1 (en) 2010-08-19
WO2009041832A2 (en) 2009-04-02
BRPI0817299A8 (pt) 2019-01-29
US11926647B2 (en) 2024-03-12
BRPI0817299A2 (pt) 2015-06-16
WO2009041830A3 (en) 2009-07-02
ES2625144T3 (es) 2017-07-18
WO2009041832A3 (en) 2009-06-11
BR122020023381B1 (pt) 2021-09-08
US20200325180A1 (en) 2020-10-15
US20140220636A1 (en) 2014-08-07
JP2010539927A (ja) 2010-12-24
CA2700129A1 (en) 2009-04-02
CL2008002860A1 (es) 2009-06-05
WO2009041830A2 (en) 2009-04-02
US9296789B2 (en) 2016-03-29
JP2017046704A (ja) 2017-03-09
NZ745324A (en) 2023-02-24
BRPI0817312B1 (pt) 2018-05-29
CN101932595B (zh) 2016-02-10
US8586709B2 (en) 2013-11-19
EP2203470A4 (en) 2011-04-13
UY31359A1 (es) 2009-04-30
EP3327030A1 (en) 2018-05-30
CN101918431A (zh) 2010-12-15
MX2010003319A (es) 2010-09-10
UY31360A1 (es) 2009-04-30
CA2700164A1 (en) 2009-04-02
CN107129524B (zh) 2023-11-21
DK3327030T3 (da) 2021-10-04
AR068552A1 (es) 2009-11-18
JP2015042166A (ja) 2015-03-05
WO2009041831A1 (en) 2009-04-02
BRPI0817312A2 (pt) 2015-03-17
ES2587595T3 (es) 2016-10-25
BR122021010737B1 (pt) 2021-09-21
EP2203467B1 (en) 2016-12-14
AU2014210649A1 (en) 2014-09-04
JP6067209B2 (ja) 2017-01-25
AR068551A1 (es) 2009-11-18
US20170342112A1 (en) 2017-11-30
BR122021010729B1 (pt) 2022-02-15
DK2203466T3 (en) 2016-07-25
WO2009041830A9 (en) 2009-08-27
CA2700164C (en) 2018-05-29
EP2203467A4 (en) 2011-04-13
AR068553A1 (es) 2009-11-18
JP2010539926A (ja) 2010-12-24
WO2009041832A9 (en) 2009-10-22
RU2010116163A (ru) 2011-11-10
ZA201001933B (en) 2013-10-30
MX2010003321A (es) 2010-08-03
CN107129524A (zh) 2017-09-05
AU2008305846A1 (en) 2009-04-02
AU2008304019A1 (en) 2009-04-02
EP2203466A2 (en) 2010-07-07
EP2203470A2 (en) 2010-07-07
CN101932595A (zh) 2010-12-29
US20210332087A1 (en) 2021-10-28
CA2700129C (en) 2021-07-20
JP2010539928A (ja) 2010-12-24
EP2203467A1 (en) 2010-07-07

Similar Documents

Publication Publication Date Title
CL2008002861A1 (es) Polipeptido aislado de m. ruminantium; vector, molecula conjugada y celula huesped que comprenden dicho polipeptido; anticuerpo o fragmento que se une al polipeptido; composicion farmaceutica que comprende la molecula conjugada; metodo para dirigir una celula metanogena para identificacion, aislamiento o inhibicion.
CL2024002235A1 (es) Anticuerpo anti-cd73 humano; método de producción; composición farmacéutica; y su uso.
BR112012011740A2 (pt) polipeptídeo, composição compreendendo o referido polipeptídeo, complexo de proteína, seqüência de nucleotídeo, vetor de expressão célula, e métodos para a preparação do complexo de proteína, para a preparação de um fviii, e para intensificar uma propriedade farmacocinética no plasma de um fviii
BR112012009854B8 (pt) proteína de ligação de antígeno isolada recombinante que liga il-23, composição farmacêutica, molécula de ácido nucleico isolada recombinante, vetor recombinante, método de confecção da referida proteína de ligação e uso da mesma
PE20091382A1 (es) Anticuerpos que se une a il-4 y/o a il-13
PE20091713A1 (es) Inhibicion del receptor para la proteina estimulante del macrofago (ron), composiciones y metodos
CR9969A (es) Anticuerpos anti-globulomero ab, porciones de union a antigeno de estos, hibridomas correspondientes, acidos nucleicos, vectores, celulas huesped, metodos para producir dichos anticuerpos, composiciones que comprenden dichos anticuerpos
MX347291B (es) Inmunoglobulinas portadoras y usos de las mismas.
CA2848209C (en) T cell receptors recognizing hla-a1- or hla-cw7-restricted mage
CL2008001814A1 (es) Anticuerpos anti-factor de crecimiento 1 y 2 semejantes a insulina (igf-1, igf-2); molecula de adn que los codifica; vector y celula huesped; metodo de produccion; composicion farmaceutica que los comprende; y su uso para tratar cancer.
AR071874A1 (es) Proteinas de dominio de armazon basadas en fibronectina multivalentes
UA97516C2 (ru) Полностью человеческое моноклональное антитело против vap-1
NZ595707A (en) Cancer antigen helper peptide
CO6280541A2 (es) Anticuerpos monoclonales o fragmentos del mismo que se unen al recptor humano ox40
CL2013002888A1 (es) Anticuerpo que se une peptido antigenico que se obtiene a partir de una proteina tau; composicion farmaceutica que comprende; uso para tratar trastorno o enfermedad neurodegenerativa;kit de ensayo, linea celular (div 2457-2011).
CL2010001457A1 (es) Molecula de acido nucleico que codifica delta endotoxinas de bacillus thuringiensis; constituciones moleculares quer comprenden dichos polinucleotifdos, anticuerpos que se asocian especificamente a las endotoxinas, y procedimiento para el control de plagas de insectos.
CR11282A (es) Proteinas enlazadas al antigeno de celula de cepa mcdonough de felino humanas
DE602005026219D1 (de) Gegen das säugetier-eag1-ionenkanalprotein gerichtete antikörper
BR112012026766A2 (pt) métodos in vitro para gerar uma proteína heterodimérica, para a seleção de um anticorpo biespecífico e para inibir o crescimento, vetor de expressão, célula hospedeira, proteína heterodimérica, composição farmacêutica.
AR047729A1 (es) Anticuerpos terapeuticos que se unen a la apolipoproteina e (apoe)
ES2674567T3 (es) Proteínas de fusión biespecíficas
SG10201807877TA (en) Hybrid immunoglobulin containing non-peptidyl linkage
AU2011353197A8 (en) A cross linking polypeptide comprising an hexameric single chain antibody binding MHC-MAGE complex that induces apoptosis
AR079340A1 (es) Anticuerpos anti-c4.4a y usos de los mismos
CL2009000862A1 (es) Anticuerpo aislado, derivados o fragmentos aislados del mismo capaz de unirse a la proteina cd151, composición que lo comprende; ácido nucleico que lo codifica, vector y célula huesped que lo comprenden; procedimiento para preparar dicho anticuerpo; util como medicamento para prevenir o tratar el cáncer.