CH693625A5 - Composizioni farmaceutiche contenenti composti ad attività promotrice di assorbimento di principi attivi. - Google Patents

Composizioni farmaceutiche contenenti composti ad attività promotrice di assorbimento di principi attivi. Download PDF

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CH693625A5
CH693625A5 CH00311/99A CH31199A CH693625A5 CH 693625 A5 CH693625 A5 CH 693625A5 CH 00311/99 A CH00311/99 A CH 00311/99A CH 31199 A CH31199 A CH 31199A CH 693625 A5 CH693625 A5 CH 693625A5
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sep
acid
bromide
sodium
compounds
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CH00311/99A
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Norberto Festoe
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Inpharma Sa
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Priority to CH00311/99A priority Critical patent/CH693625A5/it
Priority to EP00902827A priority patent/EP1073470B1/en
Priority to JP2000599426A priority patent/JP2002537417A/ja
Priority to PT00902827T priority patent/PT1073470E/pt
Priority to KR1020007011308A priority patent/KR100689686B1/ko
Priority to CA002326756A priority patent/CA2326756C/en
Priority to US09/673,411 priority patent/US7026360B1/en
Priority to CNB008001715A priority patent/CN1178699C/zh
Priority to PCT/IB2000/000167 priority patent/WO2000048636A1/en
Priority to ES00902827T priority patent/ES2241575T3/es
Priority to DE60019693T priority patent/DE60019693T2/de
Priority to AT00902827T priority patent/ATE293995T1/de
Priority to HK01107391A priority patent/HK1036931A1/xx
Publication of CH693625A5 publication Critical patent/CH693625A5/it

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/002—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from unsaturated compounds
    • C08G65/005—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from unsaturated compounds containing halogens
    • C08G65/007—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from unsaturated compounds containing halogens containing fluorine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polyethers (AREA)

Description


  



   L'invenzione qui descritta si riferisce a delle composizioni farmaceutiche,  a l'utilizzazione di composti  come agenti  ad attività promitrice di assorbimento di  principi  attivi ed a composti  specifici, tutto secondo le parti generali delle rivendicazione 1, 2, 5, 6 e 10 seguenti. 



  Problemi legati all'assorbimento cutaneo dei p.a. in forme farmaceutiche topiche e transdermali (drug delivery systems) è noto ed oggetto di brevettazione [1]. Percutaneous absorption: mechanisms-methodology-drug delivery, 2 Ed., Bronaugh Maibach, MARCEL DEKKER, INC. 



  Tra i più significativi esempi riportati nella letteratura scientifica possiamo menzionare l'attività enhancer del decilmetilsolfossido per incrementare la permeazione cutanea dell'idoxuridina [2] Touitou, E. (1988). lnt. J. Pharm. 43:1.  L'effetto del dodecilazacicloeptan-2-one (laurocapram  Azone)  di promuovere l'assorbimento di varie molecole è stato indagato da Stoughton [3] Stoughton, R.B. (1982) Arch. Dermatol. 118:474. e da Sugibayashi [4] Sugibayashi, K., Hosoya, K., Morimoto,Y., and Higuchi, W. I. (1985). J. Pharm. Pharmacol. 37:578. 



  II mercato ha messo a disposizione sostanze inizialmente con un utilizzo in campi differenti dal farmaceutico che poi si sono rivelati di notevole importanza nel campo farmaceutico. Tra queste, possiamo trovare una classe di composti Perfluoropolieteri (PFPE)  [5] ottenuti dalla polimerizzazione di esafluoropropene con ossigeno attivato dalle radiazioni UV e successivamente trattato per ottenere un prodotto di grado cosmetico [6] quale eccipiente per preparati atti alla preparazione i prodotti ad effetto barriera [7]. 


 Riassunto dell'invenzione 
 



  La  seguente invenzione consiste nell'utilizzare i  PFPE quali promotori di  assorbimento di  PA farmacologicamente attivi  in forme farmaceutiche topiche e/o in formulazioni transdermali (drug delivery systems) contenenti miscele 0 almeno un PA per promuoverne l'assorbimento. 



  Questi composti se  inclusi in formulazioni farmaceutiche contenenti una associazione o almeno un PA possono modificare la capacità di permeazione dei PA attraverso la cute, evidenziando una sorprendente e inaspettata capacità di promuovere la penetrazione dei PA. 



  In accordo con il primo aspetto dell'invenzione, l'inclusione di una quantità di PFPE può essere applicata in formulazioni topiche convenzionali, quali ad esempio, ma non esclusivamente: creme, emulsioni liquide, unguenti, lozioni, microemulsioni, schiume, gel, polveri aspersonrie; ed in formulazioni  transdermali (drug delivery systems). 



  Con il termine di PFPE si intende molecole con struttura chimica 
EMI2.1
 



  Con pesi molecolari compresi tra i 650 e 6250, 



  C.A.S. Name: 1-Propene,1,1,2,3,3,3-hexafluoro-, oxidized and polymerized
 C.A.S. number: 69 991-67-9 



  È stato sorprendemente trovato che l'inclusione di una quantità di PFPE in concentrazioni comprese tra lo 0,01% p/p e il 60% p/p, in formulazioni topiche e/o transdermali (drug delivery systems) riesce ad incrementare la permeabilità cutanea di PA a oltre 5-20 volte la loro capacità naturale, permettendo cosÌ di migliorarne l'assorbimento e ottimizzarne l'effetto sistemico attraverso adatte forme farmaceutiche. 


 Descrizione dettagliata dell'invenzione 
 



  La comprensione dell'invenzione è facilitata dalla descrizione di alcune valutazioni della permeabilità cutanea di alcune formulazioni contenenti differenti PA. 



  Nell'esempio A viene evidenziato l'aumento della permeabilità di circa 10 volte di una formulazione a base di troxerutina contenente il 3% di PFPE rispetto alla formulazione base. 



  Nell'esempio B viene dimostrata la correlazione concentrazione PFPE-permeazione cutanea di formulazioni contenenti Nimesulide e concentrazioni crescenti di PFPE. 



  Nell'esempio C vengono comparate le velocità di permeazione di formulazioni contenenti alcuni antinfiammatori non steroidei versus formulazioni addizionate del 3% di PFPE. 


 Esempio A 
 



  Verifica del passaggio di TROXERUTINA attraverso cute porcina di differenti formulazioni contenenti diversi tipi di promotori di assorbimento. In particolare è stato studiato il profilo di rilascio della TROXERUTINA da formulazioni contenenti PFPE, Acido nor-chenodesossicolico e transcutol, verso una formulazione di riferimento. 



  Parte sperimentale: 



  Apparecchiature: Celle di Franz (produttore: Crown Glass Company Inc. New Jersey). Le celle di diffusione di Franz sono uno dei sistemi principali per gli studi di permeazione in ex-vivo. In questo studio si sono utilizzate tre celle aventi ciascuna un compartimento donatore di 9 mm di diametro corrispondente ad un'area di diffusione di 64 mm<2>.
 Il compartimento ricevente ha una capienza di 4,8 ml. La camera recettoriale è ermostatata a 37 DEG C +/-1. 



  Sistema Analitico: H.P.L.C. Gilson Mod. 305 con roòevatore Spectra physics Mod Spectra 200 



   Formulazioni: 



   
<tb><TABLE> Columns=5 AL=L>Troxerutina<SEP>3<SEP>3<SEP>3<SEP>3
<tb><SEP>Fosfatidilcolina<SEP>7<SEP>7<SEP>7<CEL AL=L>7
<tb><SEP>Tocoferolo acetato<SEP>0,5<SEP>0,5<SEP>0,5<SEP>0,5
<tb><SEP>Sepigel 305<CEL AL=L>4<CEL AL=L>4<SEP>4<SEP>4
<tb><SEP>Metile-p-idrossibenzoato<SEP>0,15<SEP>0,15<SEP>0,15<CEL AL=L>0,15
<tb><CEL AL=L>Propile-p-idrossibenzoato<SEP>0,05<SEP>0,05<SEP>0,05<SEP>0,05
<tb><SEP>Fenossietanolo<SEP>1<CEL AL=L>1<SEP>1<SEP>1
<tb><SEP>PFPE<SEP>3<SEP>-<SEP>- (SEP)<->(TB><SEP>Ac. nor-chenodesossicolico<SEP>-<SEP>0,4<SEP>- (SEP)<->(TB><SEP>Transcutol<SEP>-<SEP>-<CEL CB=4 AL=L>15 (SEP)<->(TB><SEP>Acqua depurata<SEP>q.b.a 100<SEP>q.b.a 100<SEP>q.b.a 100<SEP>q.b.a 100 
<tb></TABLE> 



  Preparazione della cute 



  I campioni di cute porcina sono stati prelevati dall'orecchiointerno di maiale appea sacrificato.
 I campioni vengono immersi per 24 ore a 4 DEG C in una soluzione di tampone a pH 7,4.
 Sucessivamente vengono asportate le parti connettivali e muscolari della cute, quindi viene sucessivamente tagliata in pezzi quadrati quadrati da 2 cm di lato.
 I campioni di cute vengono conservati ad una temperatura di -20 DEG C. 



  Condizioni operative di analisi HPLC 



  Colonna: KP18, 5 micron Licrospher 100
 Fase mobile: 20% acetonitrile 80% tampone fosfato a pH 6,6
 Flusso 1 ml/min
 Pressione 1,52 Kpsi
 Lunghezza d'onda: 245 nm
 TR: 8,51 



  Modalità di esecuzione 



  Si posiziona la cute porcina tra il compartimento donatore e la camera recettrice con la superficie cutanea esterna rivolta verso il compartimento superiore. Si inserisce la formulazione da testare all'interno del compartimento donatore.
 La camera ricevente viene riempita con soluzione tampone fosfato a pH 7,4, e ad intervalli di tempo compresi tra 0,5 ore e 8 ore, si prelevano dalla camera recettoriale 2 ml di soluzione. Ad ogni prelievo si ripristina il volume iniziale con soluzione tampone fresca, termostatata a 37 DEG C. I campioni vengono quindi analizzati mediante metodica HPLC. Ogni prova viene effettuata in triplicato. 



  Risultati 



  I risultati della permeazione sono riassunti nella tabella 



   
<tb><TABLE> Columns=5 troxerutina permeati<SEP>CMcg troxerutnia permeati<SEP>DMcg troxerutina permeati
<tb><SEP>0,5<SEP>18,89<CEL AL=L>13,26<SEP>8,29<SEP>13,7
<tb><SEP>1<SEP>77,48<SEP>43,04<SEP>17,17<SEP>50,51
<tb><CEL AL=L>2<SEP>345,29<SEP>102,6<SEP>58,19<SEP>232,84
<tb><SEP>4<SEP>1.289,11<SEP>390,80<CEL AL=L>229,46<SEP>636,68
<tb><SEP>6<SEP>3.999,07<SEP>614,95<SEP>530<SEP>1.053,09
<tb><SEP>8<CEL AL=L>12.042<SEP>1.090<SEP>714,6<SEP>1.434,90 
<tb></TABLE> 



   Conclusioni:
 Le formulazioni B,C,D non hanno evidenziato alcuna differenza di permeabilità, mentre la formulazione A, contenente PFPE ha evidenziato all'ottava ora, una permeabilità di circa 9-10 volte maggiore della formulazione base D. 


 Esempio B 
 



  Verifica del passaggio di NIMESULIDE mediante celle di Franz, come descritto nell'esempio A, attraverso cute porcina di differenti formulazioni contenenti diversi concentrazioni di PFPE verso una formulazione di riferimento. 



  Formulazioni: 



   
<tb><TABLE> Columns=5 AL=L>Nimesulide<SEP>5<SEP>5<SEP>5<SEP>5
<tb><SEP>Acido lattico<SEP>2<SEP>2<SEP>2<CEL AL=L>2
<tb><SEP>Alcool etilico 95<SEP>4<SEP>4<SEP>4<SEP>4
<tb><SEP>Glicerina<SEP>5<CEL AL=L>5<CEL AL=L>5<SEP>5
<tb><SEP>PFPE<SEP>1,5<SEP>3<SEP>4,5
<tb><SEP>Sepigel 305<SEP>4<SEP>4<CEL AL=L>4<SEP>4
<tb><SEP>Fosfatidil colina<SEP>2<SEP>2<SEP>2<SEP>2
<tb><SEP>Metile-p-idrossi benzoato<SEP>0,15<SEP>0,15<SEP>0,15<SEP>0,15
<tb><SEP>Propile-p-idrossibenzoato<SEP>0,05<CEL AL=L>0,05<SEP>0,05<SEP>0,05
<tb><SEP>Acqua depurata<SEP>q.b. a 100%<SEP>q.b. a 100%<SEP>q.b. a 100%<SEP>q.b. a 100% 
<tb></TABLE> 



  Risultati:
 I risultati della permeazione sono riassunti nella tabella e dal grafico 



   
<tb><TABLE> Columns=5 nimesulide permeati<SEP>CMcg nimesulide permeati<SEP>DMcg nimesulide permeati
<tb><SEP>0,5<SEP>0,15<CEL AL=L>0,16<SEP>0,59<SEP>0,83
<tb><SEP>1<SEP>0,27<SEP>0,39<SEP>0,59<SEP>1,21
<tb><SEP>2<CEL AL=L>0,35<SEP>0,72<SEP>0,97<SEP>1,70
<tb><SEP>4<SEP>0,86<SEP>1,14<SEP>1,24<CEL AL=L>1,91
<tb><CEL AL=L>6<SEP>1,15<SEP>1,54<SEP>2,21<SEP>2,38
<tb><SEP>8<SEP>1,54<SEP>2.24<SEP>3,21<CEL AL=L>3,73
<tb><SEP>24<SEP>3,53<SEP>6,00<SEP>9,71<SEP>9,86 
<tb></TABLE> 



  Conclusioni:
 Le formulazioni B,C,D hanno evidenziato crescenti capacità di permeare la cute, questa capacità permeante risulta essere correlata alla dose crescente di PFPE. 


 Esempio C 
 



  Valutazione della velocità di permeazione di formulazioni topiche a base di antinflammatori versus formulazioni addizionate con il 3% di PFPE, mediante celle di Franz, come descritto nell'esempio A, attraverso cute porcina dopo 8 ore. 



   
<tb><TABLE> Columns=3 di PA
 Permeati dopo 8 ore<SEP>Formula base +3% PFPEMcg di PA
 Permeati dopo 8 ore
<tb><SEP>Ketoprofene<SEP>0,64<SEP>5,33
<tb><SEP>Didofenac sodico<SEP>1,82<CEL AL=L>8,66
<tb><SEP>Ibuprofene<SEP>0,21<SEP>6,84
<tb><SEP>Acido etodolico<SEP>0,53<SEP>9,93
<tb><CEL AL=L>Piroxicam<SEP>1,19<SEP>7,94 
<tb></TABLE> 



  L'invenzione e caratterizzata nelle rivendicazioni alla fine di questa descrizione. 



  Siccome l'effetto secondo l'invenzione è inerente per principio ai composti di formula I dovrebbe anche effettuarsi sulle molecole ad attività farmacologiche seguenti: 



   1.  alpha -Adrenergic agonists such as Adrafinil.  Adrenolone.  Amidephrine.  Apraclonidine. Budralazine. Clonidine. Cyclopentamine. Detomidine. Dimetofrine. Dipivefrin. Ephedrine. Epinephrine. Fenoxazoline.  Guanabenz.  Guanfacine. Hydroxyamphetamine. Ibopamine. Indanazoline. Isometheptene. Mephentermine. Metaraminol. Methoxamine Hydrochloride. Methylhexaneamine. Metizolene. Midodrine. Naphazoline. Norepinephrine. Norfenefrine. Octodrine. Octopamine. Oxymetazoline. Phenylephrine Hydrochloride. Phenylpropanolamine Hydrochloride. Phenylpropylmethylamine. Pholedrine. Propylhexedrine. Pseudo-ephedrine. Rilmenidine. Synephrine. Tetrahydrozoline. Tiamenidine. Tramazoline. Tuaminoheptane. Tymazoline. Tyramine and Xylometazoline. 



  2.  beta -Adrenergic agonists such as Albuterol. Bambuterol. Bitolterol. Carbuterol. Clenbuterol. Clorprenaline. Denopamine. Dioxethedrine. Dopexamine. Ephedrine. Epinephrine. Etafedrine. Ethylnorepinephrine. Fenoterol. Formoterol. Hexoprenaline. Ibopamine. Isoetharine. Isoproterenol. Mabuterol. Metaproterenol. Methoxyphenamine. Oxyfedrine. Pirbuterol. Prenalterol. Procaterol. Protokylol. Reproterol. Rimiterol. Ritodrine. Soterenol. Terbuterol and Xamoterol. 



  3.  alpha -Adrenergic blockers such as Amosulalol. Arotinolol. Dapiprazole. Doxazosin. Ergoloid Mesylates. Fenspiride. Indoramin. Labetalol. Nicergoline. Prazosin. Terazosin. Tolazoline. Trimazosin and Yohimbine. 



  4.  beta -Adrenergic blockers such as Acebutolol. Alprenolol. Amosulalol. Arotinolol. Atenolol. Befunolol. Betaxolol. Bevantolol. Bisoprolol. Bopindolol. Bucumolol. Bufetolol. Bufuralol. Bunitrolol. Bupranolol. Butidrine Hydrochloride. Butofilolol. Carazolol. Carteolol. Carvedilol. Celiprolol. Cetamolol. Cloranolol. Dilevalol. Epanolol. Esmolol. Indenolol. Labetalol. Levobunolol.  Mepindolol.  Metipranolol.  Metoprolol.  Moprolol. Nadoxolol. Nifenalol. Nipradilol. Oxprenolol. Penbutolol. Pindolol. Practolol. Pronethalol. Propranolol. Sotalol. Sulfinalol. Talinolol. Tertatolol. Timolol. Toliprolol and Xibenolol. 



  5. Alcohol  deterrents such  as  Calcium  Cyanamide  Citrated. Disulfiram.  Nadide  and Nitrefazole. 



  6. Aldose reductase inhibitors such as Epalrestat. Ponalrestat. Sorbinil and Tolrestat. 



  7. Anabolics such as Androisoxazole. Androstenediol. Bolandiol. Bolasterone. Clostebol. Ethylestrenol. Formyldienolone. 4-Hydroxy-19-nortestosterone. Methandriol. Methenolone. Methyltrienolone. Nandrolone. Nandrolone Decanoate. Nandrolone p-Hexyloxyphenylpropionate. Nandrolone Phenpropionate.   Norbolethone. Oxymesterone. Pizotyline. Quinbolone. Stenbolone and Trenbolone. 



  8. Analgesics (dental) such as Chlorobutanol. Clove and Eugenol. 



  9. Analgesics   (narcotic)   such   as   Alfentanil.   Allylprodine.  Alphaprodine.   Anileridine. Benzylmorphine. Bezitramide. Buprenorphine. Butorphanol. Clonitazene. Codeine. Codeine Methyl Bromide. Codeine Phosphate. Codeine Sulfate. Desomorphine. Dextromoramide. Dezocine. Diampromide.      Dihydrocodeine. Dihydrocodeinone Enol Acetate. Dihydromorphine. Dimenoxadol. Dimepheptanol. Dimethylthiambutene. Dioxaphetyl Butyrate. Dipipanone. Eptazocine. Ethoheptazine. Ethylmethylthiambutene. Ethylmorphine. Etonitazene. Fentanyl. Hydrocodone. Hydromorphone. Hydroxypethidine. Isomethadone. Ketobemidone. Levorphanol. Lofentanil. Meperidine. Meptazinol. Metazocine. Methadone Hydrochloride. Metopon. Morphine. Morphine Derivatives. Myrophine. Nalbuphine. Narceine. Nicomorphine.   Norlevorphanol. Normethadone. Normorphine. Norpipanone. Opium. Oxycodone. Oxymorphone. Papaveretum. Pentazocine.

   Phenadoxone. Phenazocine. Phenoperidine. Piminodine. Piritramide. Proheptazine. Promedol. Properidine. Propiram. Propoxyphene. Sufentanil and Tilidine. 



  10. Analgesics (non-narcotic) such as Acetaminophen. Acetaminosalol. Acetanilide. Acetylsalicylsalicylic Acid. Alclofenac. Alminoprofen. Aloxiprin. Aluminum Bis(acetylsalicylate). Aminochlorthenoxazin. 2-Amino-4-picoline. Aminopropylon. Aminopyrine. Ammonium Salicylate. Antipyrine. Antipyrine Salicylate.   Antrafenine. Apazone. Aspirin. Benorylate. Benoxaprofen. Benzpiperylon. Benzydamine. p-Bromoacetanilide. 5-Bromosalicylic Acid Acetate. Bucetin. Bufexamac. Bumadizon. Butacetin. Calcium Acetylsalicylate. Carbamazepine. Carbetidine. Carbiphene. Carsalam. Chloralantipyrine. Chlorthenoxazin(e). Choline    Salicylate. Cinchophen. Ciramadol. Clometacin. Cropropamide. Crotethamide. Dexoxadrol. Difenamizole.    Diflunisal. Dihydroxyaluminum Acetylsalicylate. Dipyrocetyl. Dipyrone. Emorfazone. Enfenamic Acid. Epirizole. Etersalate. Ethenzamide. Ethoxazene. Etodolac. Felbinac. Fenoprofen.

   Floctafenine. Flufenamic Acid. Fluoresone. Flupirtine. Fluproquazone. Flurbiprofen. Fosfosal. Gentisic Acid. Glafenine. Ibufenac. Imidazole Salicylate. Indomethacin. Indoprofen. Isofezolac. Isoladol. Isonixin. Ketoprofen. Ketorolac.   p-Lactophenetide. Lefetamine. Loxoprofen. Lysine Acetylsalicylate. Magnesium Acetylsalicylate. Methotrimeprazine. Metofoline. Miroprofen. Morazone. Morpholine Salicylate. Naproxen. Nefopam. Nifenazone. 5¾Nitro-2¾propoxyacetanilide. Parsalmide. Perisoxal. Phenacetin. Phenazopyridine Hydrochloride. Phenocoll. Phenopyrazone. Phenyl Acetylsalicylate. Phenyl Salicylate. Phenyramidol. Pipebuzone. Piperylone.    Prodilidine. Propacetamol. Propyphenazone. Proxazole. Quinine Salicylate. Ramifenazone. Rimazolium Metilsulfate. Salacetamide. Salicin. Salicylamide. Salicylamide O-Acetic Acid. Salicylsulfuric Acid. Salsalate. Salverine. Simetride.

   Sodium Salicylate. Sulfamipyrine. Suprofen. Talniflumate. Tenoxicam. Terofenamate. Tetradrine. Tinoridine. Tolfenamic Acid. Tolpronine. Tramadol. Viminol. Xenbucin and Zomepirac. 



  11. Androgens such as Boldenone. Fluoxymesterone. Mestanolone. Mesterolone. Methandrostenolone. 17-Methyltestosterone. Methyltestosterone. 17 alpha -Methyltestosterone 3-Cyclopentyl Enol Ether. Norethandrolone. Normethandrone. Oxandrolone. Oxymesterone. Oxymetholone. Prasterone. Stanolone. Stanozolol. Testosterone. Testosterone 17-Chloral Hemiacetal. Testosterone 17 beta -Cypionate. Testosterone Enanthate. Testosterone Nicotinate. Testosterone Phenyl Acetate. Testosterone Propionate and Tiomesterone. 



  12. Anesthetics (intravenous) such as Acetamidoeugenol. Alfadolone Acetate. Alfaxalone. Ambucaine. Amolanone. Amylocaine Hydrochloride. Benoxinate. Betoxycaine. Biphenamine. Bupivacaine. Butacaine.   Butamben. Butanilicaine. Butethamine. Buthalital Sodium. Butoxycaine. Carticaine. 2-Chloroprocaine    Hydrochloride. Cocaethylene. Cocaine. Cyclomethycaine. Dibucaine Hydrochloride. Dimethisoquin. Dimethocaine. Diperodon Hydrochloride. Dyclonine. Ecgonidine. Ecgonine. Ethyl Aminobenzoate. Ethyl Chloride. Etidocaine. Etoxadrol.  beta -Eucaine. Euprocin. Fenalcomine. Fomocaine. Hexobarbital. Hexylcaine Hydrochloride. Hydroxydione Sodium. Hydroxyprocaine. Hydroxytetracaine. Isobutyl  p-Aminobenzoate. Kentamine. Leucinocaine Mesylate. Levoxadrol. Lidocaine. Mepivacaine. Meprylcaine Hydrochloride. Metabutoxycaine Hydrochloride. Methohexital Sodium. Methyl Chloride. Midazolam. Myrtecaine.

   Naepaine. Octacaine. Orthocaine. Oxethazaine. Parethoxycaine. Phenacaine Hydrochloride. Phencyclidine. Phenol. Piperocaine. Piridocaine. Polidocanol. Pramoxine. Prilocaine. Procaine. Propanidid. Propanocaine. Proparacaine. Propipocaine. Propofol. Propoxycaine Hydrochloride. Pseudococaine. Pyrrocaine.    Quinine Urea Hydrochloride. Risocaine. Salicyl Alcohol. Tetracaine Hydrochloride. Thialbarbital. Thimylal. Thiobutabarbital. Thiopental Sodium. Tolycaine. Trimecaine and Zolamine. 



  13. Anorectics such as Aminorex. Amphecloral. Amphetamine. Benzphetamine. Chlorphentermine. Clobenzorex. Cloforex. Clortermine. Cyclexedrine. Dextroamphetamine Sulfate. Diethylpropion. Diphemethoxidine. N-Ethylamphetamine. Fenbutrazate. Fenfluramine. Fenproporex. Furfurylmethylamphetamine.  Levophacetoperate. Mazindol. Mefenorex. Metamfepramone. Methamphetamine. Norpseudoephedrine. Phendimetrazine. Phenmetrazine. Phenpentermine. Phenylpropanolamine Hydrochloride and Picilorex. 



  14. Anthelmintics (Cestodes) such as Arecoline. Aspidin. Aspidinol. Dichlorophen(e). Embelin. Kosin. Napthalene. Niclosamide. Pellertierine. Pellertierine Tannate and Quinacrine. 



  15. Anthelmintics (Nematodes) such as Alantolactone. Amoscanate. Ascaridole. Bephenium. Bitoscanate. Carbon Tetrachloride. Carvacrol. Cyclobendazole. Diethylcarbamazine. Diphenane. Dithiazanine Iodide. Dymanthine. Gentian Violet. 4-Hexylresorcinol. Kainic Acid. Mebendazole. 2-Napthol. Oxantel. Papain. Piperazine. Piperazine Adipate. Piperazine Citrate. Piperazine Edetate Calcium. Piperazine Tartrate. Pyrantel. Pyrvinium Pamoate.  alpha -Santonin. Stilbazium Iodide. Tetrachloroethylene. Tetramisole. Thiabendazole. Thymol. Thymyl N-Isoamylcarbamate. Triclofenol Piperazine and Urea Stibamine. 



  16. Anthelmintics (Onchocerca) such as Ivermectin and Suramin Sodium. 



  17. Anthelmintics (Schistosoma) such as Amoscanate. Amphotalide. Antimony Potassium Tartrate. Antimony Sodium Gluconate. Antimony Sodium Tartrate. Antimony Sodium Thioglycollate. Antimony    Thioglycollamide. Becanthone. Hycanthone. Lucanthone Hydrochloride. Niridazole. Oxamniquine. Praziquantel. Stibocaptate. Stibophen and Urea Stibamine. 



  18. Anthelmintics (Trematodes) such as Anthiolimine and Tetrachloroethylene. 



  19. Antiacne drugs such as Algestone Acetophenide. Azelaic Acid. Benzoyl Peroxide. Cyoctol. Cyproterone. Motretinide. Resorcinol. Retinoic Acid and Tetroquinone. 



   20. Antiallergics such as   Amlexanox. Astemizole. Azelastine. Cromolyn. Fenpiprane. Histamine. Ibudilast. Nedocromil. Oxatomide. Pentigetide. Poison Ivy Extract. Poison Oak Extract. Poison Sumac Extract. Repirinast. Tranilast. Traxanox and Urushiol. 



  21. Antiamebics such as Arsthinol. Bialamicol. Carbarsone. Cephaeline. Chlorbetamide. Chloroquine. Chlorphenoxamide. Chlortetracycline. Dehydroemetine. Dibromopropamidine. Diloxanide. Diphetarsone. Emetine. Fumagillin. Glaucarubin. Glycobiarsol. 8-Hydroxy-7-iodo-5-quinolinesulfonic Add. Iodochlorhydroxyquin. Iodoquinol. Paromomycin. Phanquinone. Phenarsone Sulfoxylate. Polybenzarsol. Propamidine. Quinfamide. Secnidazole. Sulfarside. Teclozan. Tetracycline. Thiocarbamizine. Thiocarbarsone and Tinidazole. 



  22. Antiandrogens such as Bifluranol. Cyoctol. Cyproterone. Delmadinone Acetate. Flutamide. Nilutamide and Oxendolone. 



  23. Antianginals  such as Acebutolol. Alprenolol. Amiodarone. Amlodipine. Arotinolol. Atenolol. Bepridil. Bevantolol. Bucumolol. Bufetolol. Bufuralol. Bunitrolol. Bupranolol. Carozolol. Carteolol. Carvedilol Celiprolol. Cinepazet Maleate. Diltiazem. Epanolol. Felodipine. Gallopamil. Imolamine. Indenolol. Isosorbide Dinitrate. Isradipine. Limaprost. Mepindolol. Metoprolol. Molsidomine. Nadolol. Nicardipine. Nifedipine. Nifenalol. Nilvadipine. Nipradilol. Nisoldipine. Nitroglycerin. Oxprenolol. Oxyfedrine. Ozagrel. Penbutolol.   Pentaerythritol Tetranitrate. Pindolol. Pronethalol. Propranolol. Sotalol. Terodiline. Timolol. Toliprolol and Verapamil. 



  24. Antiarrhythmics such as Acebutolol. Acecainide Adenosine. Ajmaline. Alprenolol. Amiodarone. Amoproxan. Aprindine. Arotinolol. Atenolol. Bevantolol. Bretylium Tosylate. Bucumolol. Bufetolol. Bunaftine. Bunitrolol. Bupranolol. Butidrine Hydrochloride Butobendine. Capobenic Acid. Carazolol. Carteolol. Cifenline. Cloranolol. Disopyramide. Encainide. Esmolol. Flecainide. Gallopamil. Hydroquinidine. Indecainide. Indenolol. Ipratropium Bromide. Lidocaine. Lorajmine. Lorcainide. Meobentine. Metipranolol. Mexiletine. Moricizine. Nadoxolol. Nifenalol. Oxprenolol. Penbutolol. Pindolol. Pirmenol. Practolol. Prajmaline. Procainamide Hydrochloride. Pronethalol. Propafenone. Propranolol. Pyrinoline. Quinidine Sulfate. Quinidine. Sotalol. Talinolol. Timolol. Tocainide. Verapamil. Viquidil and Xibenolol. 



  25. Antiarteriosclerotics such as Pyridinol Carbamate. 



  26. Antiarthritic/Antirheumatics such as Allocupreide Sodium. Auranofin. Aurothioglucose. Aurothioglycanide. Azathioprine. Calcium 3-Aurothio-2-propanol-1-sulfonate. Chloroquine. Clobuzarit. Cuproxoline. Diacerein. Glucosamine. Gold Sodium Thiomalate. Gold Sodium Thiosulfate. Hydroxychloroquine. Kebuzone. Lobenzarit. Melittin. Methotrexate. Myoral and Penicillamine. 



  27. Antibacterial (antibiotic) drugs, including: Aminoglycosides such as Amikacin. Apramycin. Arbekacin. Bambermycins. Butirosin. Dibekacin. Dihydrostreptomycin. Fortimicin(s). Gentamicin. Isepamicin.  Kanamycin. Micronomicin. Neomycin. Neomycin Undecylenate. Netilmicin. Paromomycin. Ribostamycin. Sisomicin. Spectinomycin. Streptomycin. Streptonicozid and Tobramycin; Amphenicols such as Azidamfenicol. Chloramphenicol. Chloramphenicol Palmitate. Chloramphenicol Pantothenate. Florfenicol and Thiamphenicol; Ansamycins such as Rifamide. Rifampin. Rifamycin and Rifaximin.  beta -Lactams including: Carbapenems such as Imipenem; Cephalosporins such as Cefaclor. Cefadroxil. Cefamandole. Cefatrizine. Cefazedone. Cefazolin. Cefixime. Cefmenoxime Cefodizime. Cefonicid. Cefoperazone.  Ceforanide. Cefotaxime. Cefotiam. Cefpimizole. Cefpiramide. Cefpodoxime Proxetil. Cefroxadine. Cefsulodin.

   Ceftazidime. Cefteram. Ceftezole. Ceftibuten. Ceftizoxime. Ceftriaxone. Cefuroxime. Cefuzonam. Cephacetrile Sodium. Cephalexin. Cephaloglycin. Cephaloridie. Cephalosporin. Cephalothin. Cephapirin Sodium. Cephradine and Pivcefalexin; Cephamycins such as Cefbuperazone. Cefmetazole. Cefminox. Cefotetan and Cefoxitin; Monobactams such as Aztreonam. Carumonam and Tigemonam; Oxacephems such as Flomoxef and Moxolactam; Penicillins such as Amidinocillin. Amdinocillin Pivoxil. Amoxicillin. Ampicillin. Apalcillin. Aspoxicillin. Azidocillin. Azlocillin. Bacampicillin. Benzylpenicillinic Acid. Benzylpenicillin Sodium.   Carbenicillin. Carfecillin Sodium. Carindacillin. Clometocillin. Cloxacillin. Cyclacillin. Dicloxacillin. Diphenicillin Sodium. Epicillin. Fenbenicillin. Floxacillin. Hetacillin. Lenampicillin. Metampicillin. Methicillin Sodium. Mezlocillin. Nafcillin Sodium. Oxacillin.

   Penamecillin. Penethamate Hydriodide. Penicillin G Benethamine. Penicillin G Benzathine. Penicillin G Benzhydrylamine. Penicillin G Calcium. Penicillin G Hydrabamine. Penicillin G Potassium. Penicillin G Procaine. Penicillin N. Penicillin O. Penicillin V. Penicillin V Benzathine. Penicillin V Hydrabamine. Penimepicycline. Phenethicillin Potassium. Piperacillin. Pivampicillin. Propicillin. Quinacillin. Sulbenicillin. Talampicillin. Temocillin and Ticarcillin; Lincosamides such as Clindamycin and Lincomycin; Macrolides such as Azithromycin. Carbomycin. Clarithromycin. Erythromycin. Erythromycin Acistrate. Erythromycin Estolate. Erythromycin Glucoheptonate. Erythromycin Lactobionate. Erythromycin Propionate. Erythromycin Stearate. Josamycin. Leucomycins. Midecamycins. Miokamycin. Oleandomycin. Primycin. Rokitamycin. Rosaramicin. Roxithromycin.

   Spiramycin and Troleandomycin; Polypeptides such as Amphomycin. Bacitracin. Capreomycin. Colistin.    Enduracidin. Enviomycin. Fusafungine. Gramicidin(s). Gramicidin S. Mikamycin. Polymyxin. Polymyxin B-Methanesulfonic Acid. Pristinamycin. Ristocetin. Teicoplanin. Thiostrepton. Tuberactinomycin. Tyrocidine. Tyrothricin. Vancomycin. Viomycin. Viomycin Pantothenate. Virginiamycin and Zinc Bacitracin; Tet-racyclines such as Apicycline. Chlortetracycline. Clomocycline. Demeclocycline. Doxycycline.   Guamecycline. Lymecycline. Meclocycline. Methacycline Minocycline. Oxytetracycline. Penimepicycline. Pipacycline. Rolitetracycline. Sancycline. Senociclin and Tetracycline; and other antibiotics such as Cycloserine. Mupirocin and Tuberin. 



  28. Antibacterial drugs (synthetic), including: 2.4-Diaminopyrimidines such as Brodimoprim. Tetroxoprim and Trimethoprim; Nitrofurans such as Furaltadone. Furazolium Chloride. Nifuradene.  Nifuratel.  Nifurfoline. Nifurpirinol. Nifurprazine. Nifurtoinol and Nitrofurantoin; Quinolones and Analogs such as Amifloxacin. Cinoxacin. Ciprofloxacin. Difloxacin. Enoxacin. Fleroxacin. Flumequine. Lomefloxacin. Miloxacin. Nalidixic Acid. Norfloxacin. Ofloxacin. Oxolinic Acid. Pefloxacin. Pipemidic Acid. Piromidic Acid. Rosoxacin. Temafloxacin and Tosufloxacin; Sulfonamides such  as Acetyl Sulfamethoxypyrazine. Acetyl  Sulfisoxazole. Azosulfamide. Benzylsulfamide. Chloramine-B. Chloramine-T. Dichloramine T. Formosulfathiazole. N<2>Formylsulfisomidine. N<2>- beta -D-Glucosylsulfanilamide. Mafenide. 4¾-(Methylsulfamoyl) sulfanil-anilide. p-Nitrosulfathiazole. Noprylsulfamide.

   Phthalylsulfacetamide. Phthalylsulfathiazole. Salazosulfadimidine. Succinylsulfathiazole. Sulfabenzamide. Sulfacetamide. Sulfachlorpyridazine. Sulfachrysoidine. Sulfacytine. Sulfadiazine. Sulfadicramide. Sulfadimethoxine. Sulfadoxine. Sulfaethidole. Sulfaguanidine. Sulfaguanol. Sulfalene. Sulfaloxic Acid. Sulfamerazine. Sulfameter. Sulfamethazine. Sulfamethizole. Sulfamethomidine. Sulfamethoxazole. Sulfamethoxypyridazine. Sulfametrole. Sulfamidochrysoidine.   Sulfamoxole. Sulfanilamide. Sulfanilamidomethanesulfonic Acid Triethanolamine Salt. 4-Sulfanilamidosalicylic Acid. N<4>-Sulfanilylsulfanilamide. Sulfanilylurea. N-Sulfanilyl-3,4-xylamide. Sulfanitran. Sulfaperine.    Sulfaphenazole. Sulfaproxyline. Sulfapyrazine. Sulfapyridine. Sulfasomizole. Sulfasymazine. Sulfathiazole. Sulfathiourea. Sulfatolamide. Sulfisomidine and Sulfisoxazole; Sulfones such as Acedapsone.

   Acediasulfone. Acetosulfone Sodium. Dapsone. Diathymosulfone. Glucosulfone Sodium. Solasulfone. Succisulfone. Sulfanilic Acid. p-Sulfanilylbenzylamine. p,p¾-Sulfonyldianiline-N,N¾digalactoside. Sulfoxone Sodium and Thiazolsulfone; and others such as Clofoctol. Hexedine. Methenamine. Methenamine Anhydromethylene-citrate. Methenamine Hippurate. Methenamine Mandelate. Methenamine Sulfosalicylate. Nitroxoline and Xibornol. 



  29. Anticholinergics such as Adiphenine Hydrochloride. Alverine. Ambutonomium Bromide. Aminopentamide. Amixetrine. Amprotropine Phosphate. Anisotropine Methylbromide. Apoatropine. Atropine. Atropine N-Oxide. Benactyzine. Benapryzine. Benzetimide. Benzilonium Bromide. Benztropine Mesylate.   Bevonium Methyl Sulfate. Biperiden. Butropium Bromide. N-Butylscopolammonium Bromide. Buzepide. Camylofine. Caramiphen Hydrochloride. Chlorbenzoxamine. Chlorphenoxamine. Cimetropium Bromide. Clidinium Bromide. Cyclodrine. Cyclonium Iodide. Cycrimine Hydrochloride. Deptropine. Dexetimide. Dibutoline Sulfate. Dicyclomine Hydrochloride. Diethazine. Difemerine. Dihexyverine. Diphemanil Methylsulfate. N-(1,2-Diphenylethyl)nicotinamide. Dipiproverine. Diponium Bromide. Emepronium Bromide. Endobenzyline Bromide. Ethopropazine. Ethybenztropine. Ethylbenzhydramine. Etomidoline. Eucatropine.

   Fenpiverinium Bromide. Fentonium Bromide. Flutropium Bromide. Glycopyrrolate. Heteronium Bromide. Hexocyclium Methyl Sulfate. Homatropine. Hyoscyamine. Ipratropium Bromide. Isopropamide. Levomepate. Mecloxamine. Mepenzolate Bromide. Metcaraphen. Methantheline Bromide. Methixene. Methscopolamine Bromide. Octamylamine. Oxybutynin Chloride. Oxyphencyclimine. Oxyphenonium Bromide. Pentapiperide. Penthienate Bromide. Phencarbamide. Phenglutarimide. Pipenzolate Bromide. Piperidolate. Piperilate. Poldine Methysulfate. Pridinol. Prifinium Bromide. Procyclidine. Propantheline Bromide. Propenzolate. Propyromazine. Scopolamine. Scopolamine N-Oxide. Stilonium Iodide. Stramonium. Sultroponium. Thihexinol. Thiphenamil. Tiemonium Iodide. Timepidium Bromide. Tiquizium Bromide. Tridihexethyl Iodide. Trihexyphenidyl Hydrochloride. Tropacine. Tropenzile. Tropicamide. Trospium Chloride.

   Valethamate Bromide and Xenytropium Bromide. 



  30. Anticonvulsants such as Acetylpheneturide. Albutoin. Aloxidone. Aminoglutethimide. 4-Amino-3-hydroxybutyric Acid. Atrolactamide. Beclamide. Buramate. Calcium Bromide. Carbamazepine.    Cinromide. Clomethiazole. Clonazepam. Decimemide. Diethadione. Dimethadione. Doxenitoin. Eterobarb. Ethadione, Ethosuximide. Ethotoin. Fluoresone. 5-Hydroxytryptophan. Lamotrigine. Magnesium Bromide. Magnesium Sulfate. Mephenytoin. Mephobarbital. Metharbital. Methetoin. Methsuximide. 5-Methyl-5-(3-phenanthryl)hydantoin. 3-Methyl-5-phenylhydantoin. Narcobarbital. Nimetazepam. Nitrazepam. Paramethadione.  Phenacemide.  Phenetharbital.  Pheneturide. Phenobarbital. Phenobarbital Sodium. Phensuximide. Phenylmethylbarbituric Acid. Phenytoin. Phethenylate Sodium. Potassium Bromide. Primidone. Progabide. Sodium Bromide. Solanum. Strontium Bromide. Suclofenide. Sulthiame. Tetrantoin. Trimethadione.

   Valproic Acid. Valpromide. Vigabatrin and Zonisamide. 



  31. Antidepressants, including: Bicyclics such as Binedaline. Caroxazone. Citalopram. Dimethazan. Indalpine. Fencamine. Indeloxazine Hydrochloride. Nefopam. Nomifensine. Oxitriptan. Oxypertine. Paroxetine. Sertraline. Thiazesim. Trazodone and Zometapine; Hydrazides/Hydrazines such as Benmoxine. Iproclozide. Iproniazid. Isocarboxazid. Nialamide. Octamoxin and Phenelzine; Pyrrolidones such as Cotinine. Rolicyprine and Rolipram; Tetracyclics such as Maprotiline. Metralindole. Mianserin and Oxaprotiline; Tricyclics such as Adinazolam. Amitriptyline. Amitriptylinoxide. Amoxapine. Butriptyline. Clomipramine. Demexiptiline. Desipramine. Dibenzepin. Dimetacrine. Dothiepin. Doxepin. Fluacizine. Imipramine.    Imipramine N-Oxide. Iprindole. Lofepramine. Melitracen. Metapramine. Nortriptyline. Noxiptilin. Opipramol. Pizotyline. Propizepine. Protriptyline. Quinupramine.

   Tianeptine and Trimipramine; and others such as Adrafinil. Benactyzine. Bupropion. Butacetin. Deanol. Deanol Aceglumate. Deanol Acetamidobenzoate. Dioxadrol. Etoperidone. Febarbamate. Femoxetine. Fenpentadiol. Fluoxetine. Fluvoxamine. Hematoporphyrin. Hypercinin. Levophacetoperane. Medifoxamine. Minaprine. Moclobemide. Oxaflozane. Piberaline. Prolintane. Pyrisuccideanol. Rubidium Chloride. Sulpiride. Sultopride. Teniloxazine. Thozalinone.   Tofenacin. Toloxatone. Tranylcypromine. L-Tryptophan. Viloxazine and Zimeldine. 



  32. Antidiabetics, including: Biguanides such as Buformin. Metformin and Phenformin; Hormones such as Glucagon. Insulin. Insulin Injection. Insulin Zinc Suspension. Isophane Insulin Suspension. Protamine Zinc Insulin Suspension and Zinc Insulin Crystals; Sulfonylurea derivatives such as Acetohexamide.   1-Butyl-3-metanilylurea. Carbutamide. Chlorpropamide. Glibornuride. Gliclazide. Glipizide. Gliquidone. Glisoxepid. Glyburide. Glybuthiazo(e). Glybuzole. Glyhexamide. Glymidine. Glypinamide. Phenbutamide. Tolazamide. Tolbutamide and Tolcyclamide; and others such as Acarbose. Calcium Mesoxalate and Miglitol. 



  33. Antidiarrheal drugs such as Acetyltannic Acid. Albumin Tannate. Alkofanone. Aluminum Salicylates-Basic. Catechin. Difenoxin. Diphenoxylate. Lidamidine. Loperamide. Mebiquine.Trillium and Uzarin. 



  34. Antidiuretics such as Desmopressin. Felypressin. Lypressin. Ornipressin. Oxycinchophen. Pituitary-Posterior. Terlipressin and Vasopressin. 



   35. Antiestrogens such as Delmadinone Acetate. Ethamoxytriphetol. Tamoxifen and Toremifene. 



  36. Antifungal drugs (antibiotics), including: Polyenes such as Amphotericin-B. Candicidin. Dermostatin. Filipin. Fungichromin. Hachimycin. Hamycin. Lucensomycin. Mepartricin. Natamycin. Nystatin. Pecilocin and Perimycin; and others such as Azaserine. Griseofulvin. Oligomycins. Neomycin Undecylenate. Pyrrolnitrin. Siccanin. Tubercidin and Viridin. 



  37. Antifungal drugs (synthetic), including: Allylamines such as Naftifine and Terbinafine; Imidazoles such as Bifonazole. Butoconazole. Chlordantoin. Chlormidazole. Cloconazole. Clotrimazole. Econazole. Enilconazole. Fenticonazole. Isoconazole. Ketoconazole. Miconazole. Omoconazole. Oxiconazole Nitrate. Sulconazole and Tioconazole; Triazoles such as Fluconazole. Itraconazole and Terconazole; and others such as Acrisorcin. Amorolfine. Biphenamine. Bromosalicylchloranilide. Buclosamide. Calcium Propionate. Chlorphenesin. Ciclopirox. Cloxyquin. Coparaffinate. Diamthazole Dihydrochloride. Exalamide. Flucytosine. Halethazole. Hexetidine. Loflucarban. Nifuratel. Potassium Iodide. Propionic Acid. Pyrithione. Salicylanilide. Sodium Propionate. Sulbentine.Tenonitrozole. Tolciclate. Tolindate. Tolnaftate. Triacetin. Ujothion. Undecylenic Acid and Zinc Propionate. 



  38. Antiglaucoma drugs such as Acetazolamide. Befunolol. Betaxolol. Bupranolol. Carteolol. Dapiprazole. Dichlorphenamide. Dipivefrin. Epinephrine, Levobunolol. Methazolamide. Metipranolol. Pilocarpine. Pindolol and Timolol. 



  39. Antigonadotropins such as Danazol. Gestrinone and Paroxypropione. 



  40. Antigout drugs such as Allopurinol. Carprofen. Colchicine. Probenecid and Sulfinpyrazone. 



  41. Antihistamines, including: Alkylamine derivatives such as Acrivastine. Bamipine. Brompheniramine. Chlorpheniramine. Dimethindene. Metron S. Pheniramine. Pyrrobutamine. Thenaldine. Tolpropamine and Triprolidine; Aminoalkyl ethers such as Bietanautine. Bromodiphenhydramine. Carbinoxamine. Clemastine. Diphenylpyraline. Doxylamine. Embramine. Medrylamine. Mephenhydramine. p-Methyldiphenhydramine. Orphenadrine. Phenyltoloxamine. Piprinhydrinate and Setasine; Ethylenediamine derivatives such as Alloclamide. p-Bromtripelennamine. Chloropyramine. Chlorothen. Histapyrrodine. Methafurylene. Methaphenilene. Methapyrilene. Phenbenzamine. Pyrilamine. Talastine. Thenyldiamine. Thonzylamine Hydrochloride. Tripelennamine and Zolamine; Piperazines such as Cetirizine. Chlorcyclizine. Cinnarizine. Clocinizine and Hydroxyzine; Tricyclics, including: Phenothiazines such as Ahistan. Etymemazine.

   Hydroxyzine. N-Hydroxyethylpromethazine Chloride. Isopromethazine. Mequitazine. Promethazine. Pyrathiazine and Thiazinamium Methyl Sulfate; and others such as Azatadine. Clobenzepam. Cyproheptadine. Deptropine. Isothipendyl. Loratadine and Prothipendyl; and other antihistamines such as Antazoline. Astemizole. Azelastine. Cetoxime. Clemizole. Clobenztropine. Diphenazoline. Diphenhydramine. Mebhydroline. Phenindamine. Terfenadine and Tritoqualine. 



  42. Antihyperlipoproteinemics, including: Aryloxyalkanoic acid derivatives such as Beclobrate. Bezafibrate. Binifibrate. Ciprofibrate. Clinofibrate. Clofibrate. Clofibric Acid. Etofibrate. Fenofibrate. Gemfibrozil. Nicofibrate. Pirifibrate. Ronifibrate. Simfibrate and Theofibrate; Bile acid sequesterants such as Cholestyramine Resin. Colestipol and Polidexide; HMG CoA reductase inhibitors such as Lovastatin. Pravastatin Sodium and Simvastatin; Nicotinic acid derivatives Aluminum Nicotinate. Acipimox. Niceritrol. Nicoclonate. Nicomol and Oxiniacic Acid; Thyroid hormones and analogs such as Etiroxate. Thyropropic Acid and Thyroxine; and others such as Acifran. Azacosterol. Benfluorex.  beta -Benzalbutyramide. Carnitine. Chondroitin Sulfate. Clomestrone. Detaxtran. Dextran Sulfate Sodium. 5,8,11,14,17-Eicosapentaenoic Acid. Eritadenine. Furazabol. Meglutol. Melinamide. Mytatrienediol.

   Ornithine.  gamma -Oryzanol. Pantethine.   Pentaerythritol Tetraacetate.  alpha -Phenylbutyramide. Pirozadil. Probucol.  alpha -Sitosterol. Sultosilic Acid. Piperazine Salt. Tiadenol. Triparanol and Xenbucin. 



  43. Antihypertensive drugs, including: Arylethanolamine derivatives such as Amosulalol. Bufuralol. Dilevalol. Labetalol. Pronethalol. Sotalol and Sulfinalol; Aryloxypropanolamine derivatives such as Acebutolol. Alprenolol. Arotinolol. Atenolol. Betaxolol. Bevantolol. Bisoprolol. Bopindolol. Bunitrolol. Bupranolol. Butofilolol. Carazolol. Carteolol. Carvedilol. Celiprolol. Cetamolol. Epanolol. Indenolol. Mepindolol. Metipranolol. Metoprolol. Moprolol. Nadolol. Nipradilol. Oxprenolol. Penbutolol. Pindolol. Propranolol. Talinolol. Tertatolol. Timolol and Toliprolol; Benzothiadiazine derivatives such as Althiazide. Bendroflumethia-zide. Benzthiazide. Benzylhydrochlorothiazide. Buthiazide. Chlorothiazide. Chlorthalidone. Cyclopen-thiazide. Cyclothiazide. Diazoxide. Epithiazide. Ethiazide. Fenquizone. Hydrochlorothiazide. Hydroflumethiazide. Methyclothiazide. Meticrane. Metolazone.

   Paraflutizide. Polythiazide. Tetrachlormethiazide and Trichlormethiazide; N-Carboxyalkyl (petide/lactam) derivatives such as Alacepril. Captopril. Cilazapril. Delapril. Enalapril. Enalaprilat. Fosinopril. Lisinopril. Moveltipril. Perindopril. Quinapril and Ramipril; Dihydropyridine derivatives such as Amlodipine. Felodipine. Isradipine. Nicardipine. Nifedipine. Nilvadipine. Nisoldipine and Nitrendipine; Guanidine derivatives such as Bethanidine. Debrisoquin. Guanabenz. Guanacline. Guanadrel. Guanazodine. Guanethidine. Guanfacine. Guanochlor. Guanoxabenz and Guanoxan; Hydrazines and phthalazines such as Budralazine. Cadralazine. Dihydralazine. Endralazine. Hydracarbazine. Hydralazine. Pheniprazine. Pildralazine and Todralazine; Imidazole derivatives such   as Clonidine. Lofexidine. Phentolamine. Tiamenidine and Tolonidine; Quaternary ammonium  com-pounds- Azamethonium Bromide.

   Chlorisondamine Chloride. Hexamethonium. Pentacynium Bis (methyl sulfate). Pentamethonium Bromide. Pentolinium Tartate. Phenactopinium Chloride and Trimethidinium Methosulfate; Quinazoline derivatives such as Alfuzosin. Bunazosin Doxazosin. Prazosin. Terazosin and Trimazosin; Reserpine derivatives such as Bietaserpine. Deserpidine. Rescinnamine. Reserpine   and Syrosingopine; Sulfonamide derivatives such as Ambuside. Clopamide. Furosemide. Indapamide. Quinethazone. Tripamide and Xipamide; and others such as  Ajmaline.   gamma -Aminobutyric Acid. Bufeniode. Chlorthalidone. Cicletanine. Ciclosidomine. Cryptenamine Tannates. Fenoldopam. Flosequinan. Indoramin. Ketanserin. Mebutamate. Mecamylamine. Methyldopa. Methyl 4-Pyridyl Ketone Thiosemicarbarzone. Metolazone. Minoxidil. Muzolimine. Pargyline. Pempidine. Pinacidil. Piperoxan. Primaperone. Protoveratrines. Raubasine. Rescimetol.

   Rilmenidene. Saralasin. Sodium Nitroprusside. Ticrynafen. Trimethaphan Camsylate. Tyrosinase and Urapidil. 



  44. Antihyperthyroids such as 2-Amino-4-methylthiazole. 2-Aminothiazole. Carbimazole. 3,5-Dibromo-L-tyrosine. 3,5-Diiodotyrosine. Hinderin. lodine. Iothiouracil. Methimazole. Methylthiouracil. Propylthiouracil. Sodium Perchlorate. Thibenzazoline. Thiobarbital and 2-Thiouracil. 



  45. Antihypotensive drugs such as Amezinium Methyl Sulfate. Angiotensin Amide. Dimetofrine. Dopamine. Etifelmin. Etilefrin. Gepefrine. Metaraminol. Midodrine. Norepinephrine. Pholedrine and Synephrine. 



  46. Antihypothyroid drugs such as Levothyroxine Sodium. Liothyronine. Thyroid. Thyroidin. Thyroxine. Tiratricol and TSH. 



  47. Anti-Inflammatory (non-steroidal) drugs, including: Aminoarylcarboxylic acid derivatives such as Enfenamic Acid. Etofenamate. Flufenamic Acid. Isonixin. Meclofenamic Acid. Mefenamic Acid. Niflumic Acid. Talniflumate. Terofenamate and Tolfenamic Acid; Arylacetic acid derivatives such as Acemetacin. Alclofenac. Amfenac. Bufexamac. Cinmetacin. Clopirac. Diclofenac Sodium. Etodolac. Felbinac. Fenclofenac. Fenclorac. Fenclozic Acid. Fentiazac. Glucametacin. Ibufenac. Indomethacin. Isofezolac Isoxepac. Lonazolac. Metiazinic Acid. Oxametacine. Proglumetacin. Sulindac. Tiaramide. Tolmetin and Zomepirac; Arylbutyric acid derivatives such as Bumadizon. Butibufen. Fenbufen and Xenbucin; Arylcarboxylic acid such as Clidanac. Ketorolac and Tinoridine; Arylpropionic acid derivatives such as Alminoprofen. Benoxaprofen. Bucloxic Acid. Carprofen. Fenoprofen. Flunoxaprofen. Flurbiprofen.

   Ibuprofen. Ibuproxam. Indoprofen. Ketoprofen. Loxoprofen. Miroprofen. Naproxen. Oxaprozin. Piketoprofen. Pirprofen. Pranoprofen. Protizinic Acid. Suprofen and Tiaprofenic Acid; Pyrazoles such as Difenamizole and Epirizole; Pyrazolones such as Apazone. Benzpiperylon. Feprazone. Mofebutazone. Morazone. Oxyphenbutazone. Phenylbutazone. Pipebuzone. Propyphenazone. Ramifenazone. Suxibuzone and Thiazolinobutazone; Salicylic acid derivatives such as Acetaminosalol. Aspirin. Benorylate. Bromosaligenin. Calcium Acetylsalicylate. Diflunisal. Etersalate. Fendosal. Gentisic Acid. Glycol Salicylate. Imidazole Salicylate. Lysine   Acetylsalicylate. Mesalamine. Morpholine Salicylate. 1-Naphthyl Salicylate. Olsalazine. Parsalmide. Phenyl Acetylsalicylate. Phenyl Salicylate. Salacetamide. Salicylarnine O-Acetic Acid. Salicylsulfuric Acid.

   Salsalate and Sulfasalazine; Thiazinecarboxamides such as Droxicam. Isoxicam. Piroxicam and Tenoxicam; and others such as  epsilon -Acetamidocaproic Acid. S-Adenosylmethionine. 3-Amino-4-hydroxybutyric Acid. Amixetrine. Bendazac. Benzydamine. Bucolome. Difenpiramide. Ditazol. Emorfazone. Guaiazulene. Nabumetone. Nimesulide. Orgotein. Oxaceprol. Paranyline. Perisoxal. Pifoxime. Proquazone. Proxazole and Tenidap. 



  48. Antimalarial drugs such as Acedapsone. Amodiaquin. Arteether. Artemether. Artemisinin. Artesunate.  Bebeerine. Berberine. Chirata. Chlorguanide. Chloroquine. Chlorproguanil. Cinchona. Cinchonidine. Cinchonine. Cycloguanil. Gentiopicrin. Halofantrine. Hydroxychloroquine. Mefloquine Hydrochloride. 3-Methylarsacetin. Pamaquine. Plasmocid. Primaquine. Pyrimethamine. Quinacrine. Quinine. Quinine Bisulfate. Quinine Carbonate. Quinine Dihydrobromide. Quinine Dihydrochloride. Quinine Ethylcarbonate. Quinine Formate. Quinine Gluconate. Quinine Hydriodide. Quinine Hydrochloride. Quinine Salicylate.  Quinine Sulfate. Quinine Tannate. Quinine Urea Hydrochloride. Quinocide. Quinoline and Sodium Arsenate Dibasic. 



  49. Antimigraine drugs such as Alpiropride. Dihydroergotamine. Ergocornine. Ergocorninine. Ergocryptine. Ergot. Ergotamine. Flumedroxone acetate. Fonazine. Lisuride. Methysergid(e). Oxetorone. Pizotyline and Sumatriptan. 



  50. Antinauseant drugs such as Acetylleucine Monoethanolamine. Alizapride. Benzquinamide. Bietanautine. Bromopride. Buclizine. Chlorpromazine. Clebopride. Cyclizine. Dimenhydrinate. Diphenidol.   Domperidone. Granisetron. Meclizine. Methallatal. Metoclopramide. Metopimazine. Nabilone. Ondansetron. Oxypendyl. Pipamazine. Piprinhydrinate. Prochlorperazine. Scopolamine. Tetrahydrocannabinols. Thiethylperazine. Thioproperazine and Trimethobenzamide. 



  51. Antineoplastic drugs, including: Alkylating agents, including: Alkyl sulfonates such as Busulfan. Improsulfan and Piposulfan; Aziridines such as Benzodepa. Carboquone. Meturedepa and Uredepa; Ethylenimines and methylmelamines such as Altretamine. Triethylenemelamine. Triethylenephosphoramide. Triethylenethiophosphoramide and Trimethylolmelamine; Nitrogen mustards such as Chlorambucil. Chlornaphazine. Cyclophosphamide Estramustine. Ifosfamide. Mechlorethamine. Mechlorethamine    Oxide Hydrochloride. Melphalan. Novembichin. Phenesterine. Prednimustine. Trofosfamide and Uracil Mustard; Nitrosoureas such as Carmustine. Chlorozotocin. Fotemustine. Lomustine. Nimustine and Ranimustine; and others such as Dacarbazine. Mannomustine. Mitobronitol. Mitolactol and Pipobroman; Antibiotics such as Aclacinomycins. Actinomycin F1.. Anthramycin. Azaserine. Bleomycins. Cactinomycin. Carubicin.

   Carzinophilin. Chromomycins. Dactinomycin. Daunorubicin. 6-Diazo-5-oxo-L-norleucine. Doxorubicin. Epirubicin. Mitomycins. Mycophenolic Acid. Nogalamycin. Olivomycins. Peplomycin. Plicamycin. Porfiromycin. Puromycin. Streptonigrin. Streptozocin. Tubercidin. Ubenimex. Zinostatin and Zorubicin; Antimetabolites, including: Folic acid analogs such as Denopterin. Methotrexate. Pteropterin and Trimetrexate; Purine analogs such as Fludarabine. 6-Mercaptopurine. Thiamiprine and Thioguanine; and Pirymidine analogs such as Ancitabine. Azacitidine. 6-Azauridine. Carmofur. Cytarabine. Doxifluridine. Enocitabine. Floxuridine. Fluorouracil and Tegafur; Enzymes such as L-Asparaginase; and others  such  as   Aceglatone. Amsacrine. Bestrabucil. Bisantrene. Carboplatin. Cisplatin. Defosfamide. Demecolcine. Diaziquone. Eflornithine. Elliptinium Acetate. Etoglucid. Etoposide. Gallium Nitrate.

   Hydroxyurea. Interferon- alpha . Interferon- beta . Interferon- gamma . Interleukin-2. Lentinan. Lonidamine. Mitoguazone. Mitoxantrone. Mopidamol. Nitracrine. Pentostatin. Phenamet. Pirarubicin. Podophyllinic Acid. 2-Ethylhydrazide. Procarbazine. PSK TM . Razoxane. Sizofiran. Spirogermanium. Taxol. Teniposide. Tenuazonic Acid. Triaziquone. 2,2¾, 2¾¾-Trichlorotriethylamine. Urethan. Vinblastine. Vincristine and Vindesine. 



  52. Antineoplastic (hormonal) drugs, including: Androgens such as Calusterone. Dromostanolone Propionate. Epitiostanol. Mepitiostane and Testolactone; Antiadrenals such as Aminoglutethimide. Mitotane and Trilostane; Antiandrogens such as Flutamide and Nilutamide; and Antiestrogens such as Tamoxifen and Toremifene. 



  53. Antineoplastic adjuncts including folic acid replenishers such as Folinic Acid. 



  54. Antiparkinsonian drugs such as Amantadine. Benserazide. Bietanautine. Biperiden. Bromocriptine.   Budipine. Carbidopa. Deprenyl. Dexetimide. Diethazine. Droxidopa. Ethopropazine. Ethylbenzhydramine. Levodopa. Naxagolide. Pergolide. Piroheptine. Pridinol. Prodipine. Terguride Tigloidine and Trihexyphenidyl Hydrochloride. 



  55. Antipheochromocytoma drugs such as Metyrosine. Phenoxybenzamine and Phentolamine. 



  56. Antipneumocystis drugs such as Eflornithine. Pentamidine and Sulfamethoxazole. 



  57. Antiprostatic hypertrophy drugs such as Gestonorone Caproate. Mepartricin. Oxendolone and Proscar TM . 



  58. Antiprotozoal drugs (Leshmania) such as Antimony Sodium Gluconate. Ethylstibamine. Hydroxystilbamidine. N-Methylglucamine. Pentamidine. Stilbamidine and Urea Stibamine. 



  59. Antiprotozoal drugs  (Trichomonas) such as Acetarsone. Aminitrozole. Anisomycin. Azanidazole. Forminitrazole. Furazolidone. Hachimycin. Lauroguadine. Mepartricin. Metronidazole. Nifuratel. Nifuroxime. Nimorazole. Secnidazole. Silver Picrate. Tenonitrozole and Tinidazole. 



  60. Antiprotozoal drugs (Trypanosma) such as Benznidazole. Eflornithine. Melarsoprol. Nifurtimox.    Oxophenarsine. Hydrochloride. Pentamidine. Propamidine. Puromycin. Quinapyramine. Stilbamidine. Suramin Sodium. Trypan Red and Tryparsamide. 



  61. Antipuritics such as Camphor. Cyproheptadine. Dichlorisone. Glycine. Halometasone. 3-Hydroxycamphor. Menthol. Mesulphen. Methdilazine. Phenol. Polidocanol. Risocaine. Spirit of Camphor. Thenaldine. Tolpropamine and Trimeprazine. 



  62. Antipsoriatic drugs such as Acitretin. Ammonium Salicylate. Anthralin. 6-Azauridine. Bergapten(e). Chrysarobin. Etretinate and Pyrogallol. 



  63. Antipsychotic drugs, including: Butyrophenones such as Benperidol. Bromperidol. Droperidol.   Fluanisone. Haloperidol. Melperone. Moperone. Pipamperone. Spiperone. Timiperone and Trifluperidol; Phenothiazines such as Acetophenazine. Butaperazine. Carphenazine. Chlorproethazine. Chlorpromazine. Clospirazine. Cyamemazine. Dixyrazine. Fluphenazine. Imiclopazine. Mepazine. Mesoridazine.   Methoxypromazine. Metofenazate. Oxaflumazine. Perazine. Pericyazine. Perimethazine. Perphenazine. Piperacetazine. Pipotiazine. Prochlorperazine. Promazine. Sulforidazine. Thiopropazate. Thioridazine. Trifluoperazine and Triflupromazine; Thioxanthenes such as Chlorprothixene. Clopenthixol. Flupentixol and Thiothixene; other tricyclics such as Benzquinamide. Carpipramine. Clocapramine. Clomacran. Clothiapine. Clozapine. Opipramol. Prothipendyl.

   Tetrabenazine and Zotepine; and others such as  Alizapride.  Amisulpride.  Buramate. Fluspirilene.  Molindone.   Penfluridol. Pimozide. Spirilene and Sulpiride. 



  64. Antipyretics such as Acetaminophen. Acetaminosalol. Acetanilide. Aconine. Aconite. Aconitine. Alclofenac. Aluminum Bis(acetylsalicylate). Aminochlorthenoxazin. Aminopyrine. Aspirin. Benorylate. Benzydamine. Berberine. p-Bromoacetanilide. Bufexamac. Bumadizon. Calcium Acetysalicylate. Chlorthenoxazin(e). Choline Salicyiate. Clidanac. Dihydroxyaluminum Acetylsalicylate. Dipyrocetyl. Dipyrone. Epirizole. Etersalate. Imidazole Salicylate. Indomethacin. Isofezolac. p-Lactophenetide. Lysine Acetylsalicylate. Magnesium Acetylsalicylate. Meclofenamic Acid. Morazone. Morpholine Salicylate. Naproxen. Nifenazone. 5¾-Nitro-2¾propoxyacetanilide. Propoxyacetanilide. Phenacetin. Phenicarbazide. Phenocoll. Phenopyrazone. Phenyl Acetylsalicylate. Phenyl Salicylate. Pipebuzone. Propacetamol. Propyphenazone. Ramifenazone. Salacetamide. Salicylamide O-Acetic Acid. Sodium Salicylate. Sulfamipyrine.

   Tetrandrine and Tinoridine. 



  65. Antirickettsial drugs such as p-Aminobenzoic Acid. Chloramphenicol. Chloramphenicol Palmitate. Chloramphenicol Pantothenate and Tetracycline. 



  66. Antiscborrheic drugs such as Chloroxine. 3-O-Lauroylpyridoxol Diacetate.  Piroctone. Pyrithione. Resorcinol. Selenium Sulfides and Tioxolone. 



  67. Antiseptics, including: Guanidines such as Alexidine. Ambazone. Chlorhexidine and Picloxydine; Halogens and halogen compounds such as Bismuth Iodide Oxide. Bismuth Iodosubgallate. Bismuth   Tribromophenate. Bornyl Chloride. Calcium Iodate. Chlorinated Lime. Cloflucarban. Flurosalan. Iodic Acid. lodine. lodine Monochloride. lodine Trichloride. Iodoform. Methenamine Tetraiodine. Oxychlorosene. Povidone-Iodine. Sodium Hypochlorite. Sodium Iodate. Symclosene. Thymol Iodide. Triclocarban. Triclosan and Troclosene Potassium; Mercurial compounds such as Hydrargaphen. Meralein Sodium. Merbromin. Mercurie Chloride. Mercuric Chloride Ammoniated. Mercuric Sodium p-Phenolsulfonate. Mercuric Succinimide. Mercuric Sulfide Red. Mercurophen. Mercurous Acetate. Mercurous Chloride. Mercurous Iodide. Nitromersol. Potassium Tetraiodomercurate(II). Potassium Triiodomercurate(II) Solution.

   Thimerfonate Sodium and Thimerosal; Nitrofurans such as Furazolidone. 2-(Methoxymethyl)-5-nitrofuran. Nidroxyzone. Nifuroxime. Nifurzide and Nitrofurazone; Phenols such as Acetomeroctol. Bithionol. Cadmium Salicylate. Carvacrol. Chloroxylenol. Clorophene. Creosote. Cresol(s). p-Cresol. Fenticlor. Hexachlorophene. 1-Naphthyl Salicylate. 2-Naphthyl Salicylate. 2,4,6-Tribromo-m-cresol and 3¾,4¾,5-Trichlorosalicylanilide; Quinolines such as Aminoquinuride. Benzoxiquine. Broxyquinoline. Chloroxine. Chlor-quinaldol. Cloxyquin. Ethylhydrocupreine. Euprocin. Halquinol. Hydrastine. 8-Hydroxquinoline. 8-Hydroxquinoline Sulfate and Iodochlorhydroxyquin; and others such as Aluminum Acetate Solution. Aluminum Subacetate Solution. Aluminum Sulfate. 3-Amino-4-hydroxybutyric Acid. Boric Acid. Chlorhexidine. Chloroazodin.   m-Cresyl Acetate. Cupric Sulfate. Dibromopropamidine. Ichthammol.

   Negatol TM . Noxytiolin. Ornidazole.  beta -Propiolactone.  alpha -Terpineol. 



  68. Antispasmodic drugs such as Alibendol. Ambucetamide. Aminopromazine. Apoatropine. Bevonium    Methyl Sulfate. Bietamiverine. Butaverine. Butropium Bromide. N-Butylscopolammonium Bromide. Caroverine. Cimetropium Bromide. Cinnamedrine. Clebopride. Coniine Hydrobromide. Coniine Hydrochloride. Cyclonium Iodide. Difemerine. Diisopromine. Dioxaphetyl Butyrate. Diponium Bromide. Drofenine. Emepronium Bromide. Ethaverine. Feclemine. Fenalamide. Fenoverine. Fenpiprane. Fenpiverinium Bromide. Fentonium Bromide. Flavoxate. Flopropione. Gluconic Acid. Guaiactamine. Hydramitrazine. Hymecromone. Leiopyrrole. Mebeverine. Moxaverine. Nafiverine. Octamylamine. Octaverine. Pentapiperide. Phenamacide Hydrochloride. Phloroglucinol. Pinaverium Bromide. Piperilate. Pipoxolan Hydrochloride. Pramiverin. Prifinium Bromide. Properidine. Propivane. Propyromazine. Prozapine. Racefemine. Rociverine.

     Spasmolytol. Stilonium Iodide. Sultroponium. Tiemonium Iodide. Tiquizium Bromide. Tiropramide. Trepibutone. Tricromyl. Trifolium. Trimebutine. N,N-1Trimethyl-3,3-diphenyl-propylamine. Tropenzile. Trospium Chloride and Xenytropium Bromide. 



  69. Antithrombotic drugs such as Anagrelide. Argatroban. Cilostazol. Daltroban. Defibrotide. Enoxaparin. Fraxiparine TM . Indobufen. Lamoparan. Ozagrel. Picotamide. Plafibride. Tedelparin. Ticlopidine and Triflusal. 



  70. Antitussive drugs such as Alloclamide. Amicibone. Benproperine. Benzonatate. Bibenzonium       Bromide. Bromoform. Butamirate. Butethamate. Caramiphen Ethanedisulfonate. Carbetapentane.   Chlophedianol. Clobutinol. Cloperastine. Codeine. Codeine Methyl Bromide. Codeine N-Oxide. Codeine   Phosphate. Codeine Sulfate. Cyclexanone. Dextromethorphan. Dibunate Sodium. Dihydrocodeine. Dihydrocodeinone Enol Acetate. Dimemorfan. Dimethoxanate.  alpha , alpha -Diphenyil-2-piperidinepropanol. Dropropizine. Drotebanol. Eprazinone. Ethyl Dibunate. Ethylmorphine. Fominoben. Guaiapate. Hydrocodone.    Isoaminile. Levopropoxyphene. Morclofone. Narceine. Normethadone. Noscapine. Oxeladin. Oxolamine.  Pholcodine. Picoperine. Pipazethate. Piperidione. Prenoxdiazine Hydrochloride. Racemethorphan. Taziprinone Hydrochloride. Tipepidine and Zipeprol. 



  71. Antiulcerative drugs such as Aceglutamide Aluminum Complex.  epsilon -Acetamidocaproic Acid Zinc Salt. Acetoxolone. Arbaprostil. Benexate Hydrochloride. Bismuth Subcitrate Sol (Dried). Carbenoxolone. Cetraxate. Cimetidine. Enprostil. Esaprazole. Famotidine. Ftaxilide. Gefarnate. Guaiazulene. Irsogladine. Misoprostol. Nizatidine. Omeprazole. Ornoprostil.  gamma -Oryzanol. Pifarnine. Pirenzepine. Plaunotol. Ranitidine. Rioprostil. Rosaprostol. Rotraxate. Roxatidine Acetate. Sofalcone. Spizofurone. Sucralfate. Teprenone. Trimoprostil. Trithiozine. Troxipide and Zolimidine. 



  72. Antiurolithic drugs such as Acetohydroxamic Acid. Allopurinol. Potassium Citrate and Succinimide. 



  73. Antivenin drugs such as Lyovac TM  Antivenin. 



  74. Antiviral drugs, including: Purines and pyrimidinones such as Acyclovir. Cytarabine. Dideoxyadenosine. Dideoxycytidine. Dideoxyinosine. Edoxudine. Floxuridine. Ganciclovir. Idoxuridine. Inosine Pranobex. MADU. Trifluridine. Vidarabine and Zidovudine; and others such as Acetylleucine Monoethanolamine. Amantadine. Amidinomycin. Cuminaldehyde Thiosemicarbazone. Foscarnet Sodium. Interferon- alpha . Interferon- beta . Interferon- gamma . Kethoxal. Lysozyme. Methisazone. Moroxydine. Podophyllotoxin. Ribavirin. Rimantadine. Stallimycin. Statolon. Tromantadine and Xenazoic Acid. 



  75. Anxiolytic drugs, including: Arylpiperazines such as Buspirone. Gepirone and Ipsapirone; Benzodiazepine derivatives such as Alprazolam. Bromazepam. Camazepam. Chlordiazepoxide. Clobazam. Clorazepate. Clotiazepam, Cloxazolam. Diazepam. Ethyl Loflazepate. Etizolam. Fludiazepam. Flutazolam. Flutoprazepam. Halazepam. Ketazolam. Lorazepam. Loxapine. Medazepam. Metaclazepam. Mexazolam. Nordazepam. Oxazepam. Oxazolam. Pinazepam. Prazepam and Tofisopam; Carbamates such as   Cyclarbamate. Emylcamate. Hydroxyphenamate. Meprobamate. Phenprobamate and Tybamate; and others such as Alpidem. Benzoctamine. Captodiamine. Chlormezanone. Etifoxine. Fluoresone. Glutamic Acid. Hydroxyzine. Mecloralurea. Mephenoxalone. Oxanamide. Phenaglycodol. Suriclone. 



  76. Benzodiazepine antagonists such as Flumazenil. 



  77. Bronchodilators, including: Ephedrine derivatives such as Albuterol. Bambuterol. Bitolterol.  Carbuterol. Clenbuterol. Clorprenaline. Dioxethedrine. Ephedrine. Epinephrine. Eprozinol. Etafedrine. Ethylnorepinephrine. Fenoterol. Hexoprenaline. Isoetharine. Isoproterenol. Mabuterol. Metaproterenol. N-Methyl-ephedrine. Pirbuterol. Procaterol. Protokylol. Reproterol. Rimiterol. Soterenol. Terbuterol and Tulobuterol; Quaternary ammonium compounds such as Bevonium Methyl Sulfate. Flutropium Bromide. Ipratropium Bromide and Oxitropium Bromide; Xanthine derivatives such as Acefylline. Acefylline Piperazine. Ambuphylline. Aminophylline. Bamifylline. Choline Theophyllinate. Doxofylline. Dyphylline. Enprofylline. Etamiphyllin. Etofylline. Guaithylline. Proxyphylline. Theobromine. 1-Theobromineacetic Acid and Theophylline; and others such as Fenspiride. Medibazine.

   Methoxyphenanime and Tretoquinol. 



  78. Calcium channel blockers, including: Arylalkylamines such as Bepridil. Diltiazem. Fendiline. Gallopanil. Prenylamine. Terodiline and Verapamil; Dihydropyridine derivatives such as Felodipine. Isradipine. Nicardipine. Nifedipine. Nilvadipine. Nimodipine. Nisoldipine and Nitrendipine; Piperazine derivatives such as Cinnarizine. Flunarizine and Lidoflazine; and others such as Bencyclane. Etafenone and Perhexiline. 



  79. Calcium regulators such as Calcifediol. Calcitonin. Calcitriol. Clodronic Acid. Dihydrotachysterol. Elcatonin. Etidronic Acid. Ipriflavone. Pamidronic Acid. Parathyroid Hormone and Teriparatide Acetate. 



  80. Cardiotonics such as Acefylline. Acetyldigititoxins. 2-Amino-4-picoline. Amrinone. Benfurodil Hemisuccinate. Bucladesine. Cerberoside. Camphotamide. Convallatoxin. Cymarin. Denopamine. Deslanoside. Digitalin. Digitalis. Digitoxin. Digoxin. Dobutamine. Dopamine. Dopexamine. Enoximone. Erythrophleine. Fenalcomine. Gitalin. Gitoxin. Glycocyamine. Heptaminol. Hydrastinine. Ibopamine. Lanatosides. Metamivam. Milrinone. Neriifolin. Oleandrin. Ouabain. Oxyfedrine. Prenalterol. Proscillaridin. Resibufogenin. Scillaren. Scillarenin. Strophanthin. Sulmazole. Theobromine and Xamoterol. 



  81. Chelating agente such as Deferoxamine. Ditiocarb Sodium. Edetate Calcium Disodium. Edetate Disodium. Edetate Sodium. Edetate Trisodium. Penicillamine. Pentetate Calcium Trisodium. Pentetic Acid. Succimer and Trientine. 



  82. Cholecystokinin antagonists such as Proglumide. 



  83. Cholelitholytic agents such as Chenodiol. Methyl tert-Butyl Ether. Monooctanoin and Ursodiol. 



  84. Choleretics such as Alibendol. Anethole Trithion. Azintamide. Cholic Acid. Cicrotoic Acid. Clanobutin. Cyclobutyrol. Cyclovalone. Cynarin(e). Dehydrocholic Acid. Deoxycholic Acid. Dimecrotic Acid.  alpha -Ethylbenzyl Alcohol. Exiproben. Feguprol. Fencibutirol. Fenipentol. Florantyrone. Hymecromone.  Menbutone. 3-(o-Methoxyphenyl)-2-phenylacrylic Acid. Metochalcone. Moquizone. Osalmid. Ox Bile Extract. 4,4¾-Oxydi-2-butanol. Piprozolin. Prozapine. 4-Salicyloylmorpholine. Sincalide. Taurocholic Acid. Timonacic. Tocamphyl. Trepibutone and Vanitiolide. 



  85. Cholinergic agents such as Aceclidine. Acetylcholine Bromide. Acetylcholine Chloride. Aclatonium   Napadisilate. Benzpyrinium Bromide. Bethanechol Chloride. Carbachol. Carpronium Chloride. Demecarium Bromide. Dexpanthenol. Diisopropyl Paraoxon. Echothiophate Iodide. Edrophomium Chloride. Eseridine. Furtrethonium. Isoflurophate. Methacholine Chloride. Muscarine. Neostigmine. Oxapropanium Iodide. Physostigmine and Pyridostigmine Bromide. 



  86. Cholinesterase  inhibitors  such  as  Ambenonium  Chloride.  Distigmine  Bromide  and Galanthamine. 



  87. Cholinesterase reactivators such as Obidoxime Chloride and Pralidoxime Chloride. 



  88. Central nervous System stimulants and agente such as Amineptine. Amphetamine. Amphetaminil.    Bemegride. Benzphetamine. Brucine. Caffeine. Chlorphentermine. Clofenciclan. Clortermine. Coca. Demanyl Phosphate. Dexoxadrol. Dextroamphetamine Sulfate. Diethylpropion. N-Ethytlamphetamine.    Ethamivan. Etifelmin. Etryptamine. Fencamfamine. Fenethylline. Fenozolone. Flurothyl. Hexacyclonate Sodium. Homocamfin. Mazindol. Mefexamide. Methamphetamine. Methylphenidate. Nikethamide. Pemoline. Pentylenetetrazole. Phendimetrazine. Phenmetrazine.  Phentermine. Picrotoxin. Pipradrol. Prolintane and Pyrovalerone. 



  89. Decongestants such as Amidephrine. Cafaminol. Cyclopentamine. Ephedrine. Epinephrine. Fe-noxazoline. Indanazoline. Metizoline. Naphazoline. Nordefrin Hydrochloride. Octodrine. Oxymetazoline. Phenylephrine Hydrochloride. Phenylpropanolamine Hydrochloride. Phenylpropylmethylamine. Propylhexedrine. Pseudoephedrine. Tetrahydrozoline. Tymazoline and Xylometazoline. 



  90. Dental caries prophylaxis such as Sodium Fluoride. 



  91. Depigmentors such as Hydroquinine. Hydroquinone and Monobenzone. 



  92. Diuretics, including: Organomercurials such as Chlormerodrin. Meralluride. Mercamphamide.   Mercaptomerin Sodium. Mercumallylic Acid. Mercumatilin Sodium. Mercurous Chloride and Mersalyl; Pteridines such as Furterene and Triamterene; Purines such as Acefylline. 7-Morpholinomethyltheophylline. Pamabrom. Protheobromine and Theobromine; Steroids such as Canrenone. Oleandrin and Spironolactone; Sulfonamide derivatives such as Acetazolamide. Ambuside. Azosemide. Bumetanide. Butazolamide. Chloraminophenamide. Clofenamide. Clopamide. Clorexolone. Diphenylmethane-4,4¾-disulfonamide. Disulfamide. Ethoxzolamide. Furosemide. Indapamide. Mefruside. Methazolamide. Piretanide. Quinethazone. Torasemide. Tripamide and Xipamide; Uracils such as Aminometradine and Amisometradine; others such as Amanozine. Amiloride.  Arbutin. Chlorazanil. Ethacrynic Acid. Etozolin. Hydracarbazine. Isosorbide.

   Mannitol. Metochalcone. Muzolimine. Perhexiline. Ticrynafen and Urea. 



  93. Dopamine receptor agonistes such as Bromocriptine. Dopexamine. Fenoldopam. Ibopamine. Lisuride. Naxagolide and Pergolide. 



  94. Ectoparasiticides such as Amitraz. Benzyl Benzoate. Carbaryl. Crotamiton. DDT. Dixanthogen. Isobornyl Thiocyanoacetate-Technical. Lime Sulfurated Solution.  Lindane. Malathion. Mercurie Oleate. Mesulphen and Sulphur-Pharmaceutical. 



  95. Enzymes, including: Digestive enzymes such as  alpha -Amylase (Swine Pancreas). Lipase. Pancrelipase. Pepsin and Rennin; Mucolytic enzymes such as Lysozyme; Penicillin inactivating enzymes such as Penicillinase; and Proteolytic enzymes such as Collagenase. Chymopapain. Chymotrypsins. Papain and Trypsin. 



  96. Enzyme inducers (hepatic) such as Flumecinol. 



  97. Estrogens, including: Nonsteroidal estrogens such as Benzestrol. Broparoestrol. Chlorotrianisene.   Dienestrol. Diethylstilbestrol. Diethylstilbestrol Dipropionate. Dimestrol. Fosfestrol. Hexestrol. Met-hallenes-tril and Methestrol; and Steroidal estrogens such as Colpormon. Conjugated Estrogenic Hormones. Equilenin. Equilin. Estradiol. Estradiol Benzoate. Estradiol 17 beta -Cypionate. Estriol. Estrone. Ethinyl Estradiol. Mestranol. Moxestrol. Mytatrienediol. Quinestradiol and Quinestrol. 



  98. Gastric secretion inhibitors such as Enterogastrone and Octreotide. 



  99. Glucocorticoids such as 21-Acetoxypregnenolone. Alclometasone. Algestone. Amcinonide. Beclomethasone. Betamethasone. Budesonide. Chloroprednisone. Clobetasol. Clobetasone. Clocortolone.   Cloprednol. Corticosterone. Cortisone. Cortivazol. Deflazacort. Desonide. Desoximetasone. Dexamethasone. Diflorasone. Diflucortolone. Difluprednate. Enoxolone. Fluazacort. Flucloronide. Flumethasone. Flunisolide. Fluocinolone Acetonide. Fluocinonide. Fluocortin Butyl. Fluocortolone. Fluorometholone. Fluperolone Acetate. Fluprednidene Acetate. Fluprednisolone. Flurandrenolide. Formocortal. Halcinonide.   Halometasone. Halopredone Acetate. Hydrocortamate. Hydrocortisone. Hydrocortisone Acetate. Hydrocortisone Phosphate. Hydrocortisone 21-Sodium Succinate. Hydrocortisone Tebutate. Mazipredone.   Medrysone. Meprednisone. Methylprednisolone. Mometasone Furoate. Paramethasone. Prednicarbate.

   Prednisolone. Prednisolone 21-Diethylaminoacetate. Prednisone Sodium Phosphate. Prednisolone Sodium Succinate. Prednisolone Sodium 21-m-Sulfobenzoate. Prednisolone 21-Stearoylglycolate. Prednisolone Tebutate. Prednisolone 21-Trimethylacetate. Prednisone. Prednival. Prednylidene. Prednylidene 21-Diethylaminoacetate.Tixocortal. Triamcinolone. Triamcinolone Acetonide. Triamcinolone Benetonide   and Triamcinolone Hexacetonide. 



  100. Gonad-Stimulating principles such as Buserelin. Clomiphene. Cyclofenil. Epimestrol. FSH. HCG and LH-RH. 



  101. Gonadotropic hormones such as LH and PMSG. 



  102. Growth hormone inhibitors such as Octreotide and Somatostatin. 



  103. Growth hormone releasing factors such as Semorelin. 



  104. Growth stimulants such as Somatotropin. 



  105. Hemolytic agents such as Phenylhydrazine and Phenylhydrazine Hydrochloride. 



  106. Heparin antagonists such as Hexadimethrine Bromide and Protamines. 



  107. Hepatoprotectants such as S-Adenosylmethionine. Betaine. Catechin. Citiolone. Malotilate. Orazamide. Phosphorylcholine. Protoporphyrin IX. Silymarin-Group. Thioctic Add and Tiopronin. 



  108. Immunomodulators such as Amiprilose. Bucillamine. Ditiocarb Sodium. Inosine Pranobex. Interferon- gamma . Interleukin-2. Lentinan. Muroctasin. Platonin. Procodazole. Tetramisole. Thymomodulin. Thymopentin and Ubenimex. 



  109. Immunosuppressants such as Azathioprine. Cyclosporins and Mizoribine. 



  110. Ion exchange  resins such as Carbacrylic  Resins.  Cholestyramine Resin.  Colestipol. Polidexide. Resodec and Sodium Polystyrene Sulfonate. 



  111. Lactation stimulating hormone such as Prolactin. 



  112. LH-RH agonists such as Buserelin. Goserelin. Leuprolide. Nafarelin and Triptorelin. 



  113. Lipotropic agents such as N-Acetylmethionine. Choline Chloride. Choline Dehydrocholate. Choline Dihydrogen Citrate. Inositol. Lecithin and Methionine. 



  114. Lupus erythematosus suppressants such as Bismuth Sodium Triglycollamate. Bismuth Subsalicylate. Chloroquine and Hydroxychloroquine. 



  115. Mineralcorticoids such as Aldosterone. Deoxycorticosterone. Deoxycorticosterone Acetate and Fludrocortisone. 



  116. Miotic drugs such as Carbachol. Physostigmine. Pilocarpine and Pilocarpus. 



  117. Monoamine oxidase inhibitors such as Deprenyl. Iproclozide. Iproniazid. Isocarboxazid.
 Moclobemide. Octamoxin. Pargyline. Phenelzine. Phenoxypropazine. Pivalylbenzhydrazine. Prodipine. Toloxatone and Tranylcypromine. 



  118. Mucolytic agents such as Acetylcysteine. Bromhexine. Carbocysteine. Domiodol. Letosteine. Lysozyme. Mecysteine Hydrochloride. Mesna. Sobrerol. Stepronin. Tiopronin and Tyloxapol. 



  119. Muscle relaxants (skeletal) such as Afloqualone. Alcuronium. Atracurium  Besylate. Baclofen. Benzoctamine. Benzoquinonium Chloride. C-Calebassine. Carisoprodol. Chlormezanone. Chlorphenesin   Carbamate. Chlorproethazine. Chlorzoxazone. Curare. Cyclarbamate. Cyclobenzaprine. Dantrolene.    Decamethonium Bromide. Diazepam. Eperisone. Fazadinium Bromide. Flumetramide. Gallamine Triethiodide. Hexacarbacholine Bromide. Hexafluorenium Bromide. Idrocilamide. Laudexium Methyl Sulfate. Leptodactyline. Memantine. Mephenesin. Mephenoxalone. Metaxalone. Methocarbamol. Metocurine Iodide. Nimetazepam. Orphenadrine. Pancuronium Bromide. Phenprobamate.   Phenyramidol. Pipecurium Bromide. Promoxolane. Quinine Sulfate. Styramate. Succinylcholine Bromide. Succinylcholine Chloride. Succinylcholine lodine. Suxethonium Bromide. Tetrazepam. Thiocolchicoside. Tizanidine. Tolperisone.

   Tubocurarine Chloride. Vecuronium Bromide and Zoxazolamine. 



  120. Narcotic antagonists such as Amiphenazole. Cyclazocine. Levallorphan. Nadide. Nalmefene. Nalorphine. Nalorphine Dinicotinate. Naloxone and Naltrexone. 



  121. Neuroprotective agents such as Dizocilpine. 



  122. Nootropic agents such as Aceglutamide. Acetylcarnitine. Aniracetam. Bifemelane. Exifone. Fipexide. Idebenone. Indeloxazine Hydrochloride. Nizofenone. Oxiracetam. Piracetam. Propentofylline. Pyritinol and Tacrine. 



  123. Ophthalmic agents such as 15-ketoprostaglandins. 



  124. Ovarian hormone such as Relaxin. 



  125. Oxytocic drugs such as Carboprost. Cargutocin. Deaminooxytocin. Ergonovine. Gemeprost. Methylergonovine. Oxytocin. Pituitary (Posterior). Prostaglandin E2. Prostaglandin F2 alpha  and Sparteine. 



  126. Pepsin inhibitors such as Sodium Amylosulfate. 



  127. Peristaltic stimulants such as Cisapride. 



  128. Progestogens such as Allylestrenol. Anagestone. Chlormadinone Acetate. Delmadinone Acetate.    Demegestone. Desogestrel. Dimethisterone. Dydrogesterone. Ethisterone. Ethynodiol. Flurogestone Acetate. Gestodene. Gestonorone Caproate. Haloprogesterone. 17-Hydroxy-16-methylene-progesterone.  17 alpha -Hydroxyprogesterone. 17 alpha -Hydroxyprogesterone Caproate. Lynestrenol. Medrogestone. Medroxyprogesterone. Megestrol Acetate. Melengestrol. Norethindrone. Norethynodrel. Norgesterone. Norgestimate.  Norgestrel. Norgestrienone. Norvinisterone. Pentagestrone. Progesterone. Promegestone. Quingestrone and Trengestone. 



  129. Prolactin inhibitors such as Metergoline. 



  130. Prostaglandins and prostaglandin analogs such as Arbaprostil. Carboprost. Enprostil. Gemeprost. Limaprost. Misoprostol. Ornoprostil. Prostacyclin. Prostaglandin E1. Prostaglandin E2. Prostaglandin F2 alpha . Rioprostil. Rosaprostol. Sulprostone and Trimoprostil. 



  131. Protease inhibitors such as Aprotinin. Camostat. Gabexate and Nafamostat. 



  132. Respiratory stimulants such as Almitrine. Bemegride. Carbon Dioxide. Cropropamide. Crotethamide. Dimefline. Dimorpholamine. Doxapram. Ethamivam. Fominoben. Lobeline. Mepixanox. Metamivam. Nikethamide. Picrotoxin. Pimeclone. Pyridofylline. Sodium Succinate and Tacrine. 



  133. Sclerosing agents such as Ethanolamine. Ethylamine. 2-Hexyldecanoic Acid. Polidocanol. Quinine Bisulfate. Quinine Urea Hydrochloride. Sodium Ricinoleate. Sodium Tetradecyl Sulfate and Tribenoside. 



  134. Sedatives and hypnotics, including: Acyclic ureides such as Acecarbromal. Apronalide. Bomisovalum. Capuride. Carbromal and Ectylurea; Alcohols such as Chlorhexadol. Ethchlorvynol. Meparfynol. 4-MethyI-5-thiazoleethanol. tert-Pentyl Alcohol and 2, 2, 2-Trichloroethanol; Amides such as Butoctamide. Diethylbromoacetamide. Ibrotamide. Isovaleryl Diethylamide. Niaprazine. Tricetamide. Trimetozine. Zolpidem and Zopiclone; Barbituric acid derivatives such as Allobarbital. Amobarbital. Aprobarbital.  Barbital. Brallobarbital. Butabarbital Sodium. Butalbital. Butallylonal. Butethal. Carbubarb. Cyclobarbital. Cyclopentobarbital. Enallylpropymal. 5-Ehtyl-5-(1-piperidyl) barbituric Acid. 5-Furfuryl-5-isopropylbarbituric  Acid. Heptabarbital. Hexethal Sodium. Hexobarbital. Mephobarbital. Methitural. Narcobarbital. Nealbarbital. Pentobarbital Sodium. Phenallymal. Phenobarbital.

   Phenobarbital Sodium. Phenylmethylbarbituric Acid. Probarbital. Propallylonal. Proxibarbal. Reposal. Secobarbital Sodium. Talbutal. Tetrabarbital. Vinbarbital Sodium and Vinylbital; Benzodiazepine derivatives such as Brotizolam. Doxefazepam. Estazolam. Flunitrazepam. Flurazepam. Haloxazolam. Loprazolam. Lormetazepam. Nitrazepam. Quazepam. Temazepam and Triazolam; Bromides such as Ammonium Bromide. Calcium Bromide. Calcium Bromolactobionate. Lithium Bromide. Magnesium Bromide. Potassium Bromide and Sodium Bromide; Carbamates  such as Amyl Carbamate-Tertiary. Ethinamate. Hexapropymate. Meparfynol Carbamate. Novonal and Trichlorourethan; Chloral derivatives such as Carbocloral. Chloral Betaine. Chloral Formamide. Chloral Hydrate. Chloralantipyrine. Dichloralphenazone. Pentaerythritol Chloral and Triclofos; Piperidinediones such as Glutethimide. Methyprylon. Piperidione.

   Pyrithyldione. Taglutimide and Thalidomide; Quinazolone derivatives such as Etaqualone. Mecloqualone and Methaqualone; and others such as Acetal. Acetophenone. Aldol. Ammonium Valerate. Amphenidone. d-Bornyl  alpha -Bromoisovalerate. d-Bornyl Isovalerate. Bromoform. Calcium 2-Ethylbutanoate. Carfinate.  alpha -Chloralose. Clomethiazole. Cypripedium. Doxylamine. Etodroxizine. Etomidate. Fenadiazole. Homofenazine. Hydrobromic Acid. Mecloxamine. Menthyl Valerate. Opium. Paraldehyde. Perlapine. Propiomazine. Rilmazafone. Sodium Oxybate. Sulfon-ethylmethane and Sulfonmethane. 



  135. Thrombolytic agents such as APSAC. Plasmin. Pro-Urokinase. Streptokinase. Tissue Plasminogen Activator and Urokinase. 



  136. Thyrotropic hormones such as TRH and TSH. 



  137. Uricosurics such as Benzbromarone. Ethebenecid. Orotic Acid. Oxycinchophen. Probenecid. Sulfinpyrazone. Ticrynafen and Zoxazolamine. 



  138. Vasodilators (cerebral) such as Bencyclane. Cinnarizine. Citicoline. Cyclandelate. Ciclonicate.   Diisopropylamine Dichloroacetate. Eburnamonine. Fenoxedil. Flunarizine. Ibudilast. Ifenprodil. Nafronyl. Nicametate. Nicergoline. Nimodipine. Papaverine. Pentifylline. Tinofedrine. Vincamine. Vinpocetine and Viquidil. 



  139. Vasodilators  (coronary)  such  as  Amotriphene.   Bendazol.  Benfurodil  Hemisuccinate. Benziodarone. Chloracizine. Chromonar. Clobenfurol. Clonitrate. Dilazep. Dipyridamole. Droprenilamine. Efloxate. Erythritol. Erythrityl Tetranitrate. Etafenone. Fendiline. Floredil. Ganglefene. Hexestrol Bis( beta -diethylaminoethyl ether). Hexobendine. Itramin Tosylate. Khellin. Lidoflazine. Mannitol Hexanitrate.    Medibazine. Nicorandil. Nitroglycerin. Pentaerythritol Tetranitrate. Pentrinitrol. Perhexiline. Pimefylline. Prenylamine. Propatyl Nitrate. Pyridofylline. Trapidil. Tricromyl. Trimetazidine. Trolnitrate Phosphate   and Visnadine. 



  140. Vasodilators (peripheral) such as Aluminum Nicotinate. Bamethan. Bencyclane. Betahistine.   Bradykinin. Brovincamine. Bufoniode. Buflomedil. Butalamine. Cetiedil. Ciclonicate. Cinepazide. Cinnarizine. Cyclandelate. Diisopropylamine Dichloracetate. Eledoisin. Fenoxedil. Flunarizine. Hepronicate. Ifenprodil. Inositol Niacinate. Isoxsuprine. Kallidin. Kallikrein. Moxisylyte. Nafronyl. Nicametate. Nicergoline. Nicofuranose. Nicotinyl Alcohol. Nylidrin. Pentifylline. Pentoxifylline. Piribedil. Prostaglandin E1. Suloctidil and Xanthinol Niacinate. 



  141. Vasoprotectants such as Benzarone. Bioflavonoids. Chromocarb. Clobenoside. Diosmin. Dobesilate Calcium. Escin. Folescutol. Leucocyanidin. Metescufylline. Quercetin. Rutin and Troxerutin. 



  142. Vitamins, vitamin sources and vitamin extracts such as Vitamins A, B, C, D, E and K and derivatives thereof. Calciferols. Glycyrrhiza and Mecobalamin. 



  143. Vulnerary agents such as Acetylcysteine. Allantoin. Asiaticoside. Cadexomer lodine. Chitin. Dextranomer and Oxaceprol. 



   Detta utilizzazione incrementa il transassorbimento dei farmaci fino a oltre 5 volte la loro capacit  naturale. 



  L'invenzione concerne, finalmente, anche i composti della classe dei Perfluoropolyeteri di formula I 



   
EMI21.1
 



   con n e m > 18 e < 46 e con pesi molecolari fra 600 e 8000, specialmente quelli con n e m > 24 e < 36 e con pesi molecolari fra 1000 e 4000 ed ottenuti mediante polimerizzazione di esafluoropropene 



   
EMI21.2
 



  con ossigeno attivato all'UV.

Claims (10)

1. Composizioni farmaceutiche, caratterizzate dal fatto di contenere, oltre il o i principio(i) attivo(i), - tra lo 0,01 ed il 60% p/p dei composti di formula I EMI22.1 - con n e m > 18 e < 46 e con pesi molecolari fra 600 e 8000- in combinazione con da 0,01 a 20% p/p di Fosfatidilcolina- come composti ad attività promotrice di assorbimento dei principi attivi.
2. Composizioni farmaceutiche secondo la rivendicazione 1 con 0,1 a 30% p/p dei composti di formula I con n e m > 24 e < 36 e con pesi molecolari fra 1000 e 4000 e con 0,1 a 10% p/p di Fosfatidilcolina.
3. Composizioni farmaceutiche secondo una delle rivendicazioni 1 o 2, contenenti altre componenti compatibili e presenti in forma di creme, emulsioni, unguenti, lozioni, schiume, gel e formulazioni trans-dermali.
4.
Utilizzazione dei composti di formula I EMI23.1 con n e m > 18 e < 46, preferibiImente > 24 e < 36, e con pesi molecolari fra 600 e 8000, preferibilmente fra 1000 e 4000, congiuntemente con la Fosfatidilcolina, in composizioni farmaceutiche ad uso topico esterno o interno per promuovere l'assorbimento di prinicpi attivi attraverso derma, cutis, mucosa, rectum, vagina e urethra.
5.
Utilizzazione secondo la rivendicazione 4, caratterizzata dal fatto che principi attivi usati hanno preferibilmente un effetto anabolico, analgesico, androgenico, anestetico, anoressico, antelmintico, antiallergico, antiamebico, antiandrogenico, anti-anginale, antiarritmico, antiarteriosclerotico, antiartritico e -reumatico, antibatterico, anticolinergico, anticonvulsivo, antidepressivo, antidiabetico, antidiarroico, antidiuretico, antiestrogenico, antibiotico, antiglaucomico, antigonatropico, antiistaminico, antiiperlipoproteico, antiipertireodico, antiipertensivo, antiinfiammatorico, antimalarico, antimigranico, antinauseante, antineoplastico, antiparkinsonico, antiprotozoico, antipruritico, antipsoriatico, antipsicotico, antipiretico, antisettico, antispasmodico, antitrombotico, antitussivo, antiulcerale, antivirale, ansiolitico, broncodilatatorio, CA-bloccante o -regolatorio,
cardiotonico, stimolante, decongestionante, diuretico o enzimatico.
6. Utilizzazione secondo la rivendicazione 5, caratterizzata dal fatto che i principi attivi sono la Troxerutina o il Nimesulide ed, inoltre, agenti antiinfiammatori non-steriodali come la Ketoprofene, il Diclofenac Sodio, 1¾Ibuprofene, l'acido Etodolico e il Piroxicam.
7. Utilizzazione secondo la rivendicazione 4, caratterizzata dal fatto che l'assorbimento dei farmaci è incrementato fino a oltre 5 volte la loro capacità naturale. EMI24.1
8. Composti della classe dei Perfluoropolieteri di formula I con n e m > 18 e < 46 e con pesi molecolari fra 600 e 8000.
9. Composti secondo la rivendicazione 8 con n e m > 24 e < 36 e con pesi molecolari fra 1000 e 4000.
10.
Composti secondo la rivendicazione 9, caratterizzati dal fatto che sono ottenuti mediante polimerizzazione di esafluoropropene EMI24.2 con ossigeno attivato all'UV.
CH00311/99A 1999-02-18 1999-02-18 Composizioni farmaceutiche contenenti composti ad attività promotrice di assorbimento di principi attivi. CH693625A5 (it)

Priority Applications (13)

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CH00311/99A CH693625A5 (it) 1999-02-18 1999-02-18 Composizioni farmaceutiche contenenti composti ad attività promotrice di assorbimento di principi attivi.
EP00902827A EP1073470B1 (en) 1999-02-18 2000-02-16 Pharmaceutical compositions containing compounds with activity for the enhancement of absorption of active ingredients
JP2000599426A JP2002537417A (ja) 1999-02-18 2000-02-16 有効成分の吸収促進に活性を示す化合物を含む薬剤組成物
PT00902827T PT1073470E (pt) 1999-02-18 2000-02-16 Composicoes farmaceuticas contendo compostos com actividade capaz de melhorar a absorcao de ingredientes activos
KR1020007011308A KR100689686B1 (ko) 1999-02-18 2000-02-16 활성 성분의 흡수 강화를 위한 활성을 갖는 화합물을함유하는 약학적 조성물
CA002326756A CA2326756C (en) 1999-02-18 2000-02-16 Pharmaceutical compositions containing compounds with activity for the enhancement of absorption of active ingredients
US09/673,411 US7026360B1 (en) 1999-02-18 2000-02-16 Pharmaceutical compositions containing compounds with activity for the enhancement of absorption of active ingredients
CNB008001715A CN1178699C (zh) 1999-02-18 2000-02-16 含有促进活性成分吸收活性的化合物的药物组合物
PCT/IB2000/000167 WO2000048636A1 (en) 1999-02-18 2000-02-16 Pharmaceutical compositions containing compounds with activity for the enhancement of absorption of active ingredients
ES00902827T ES2241575T3 (es) 1999-02-18 2000-02-16 Composiciones farmaceuticas que contienen compuestos con actividad para mejorar la absorcion de ingredientes.
DE60019693T DE60019693T2 (de) 1999-02-18 2000-02-16 Pharmazeutische zusammensetzungen, die wirkstoffabsorptionsfördernde verbindungen enthalten
AT00902827T ATE293995T1 (de) 1999-02-18 2000-02-16 Pharmazeutische zusammensetzungen, die wirkstoffabsorptionsfördernde verbindungen enthalten
HK01107391A HK1036931A1 (en) 1999-02-18 2001-10-23 Pharmaceutical compositions containing compounds with activity for the enhancement of absorption of active ingredients.

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CH00311/99A CH693625A5 (it) 1999-02-18 1999-02-18 Composizioni farmaceutiche contenenti composti ad attività promotrice di assorbimento di principi attivi.

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AT (1) ATE293995T1 (it)
CA (1) CA2326756C (it)
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DE (1) DE60019693T2 (it)
ES (1) ES2241575T3 (it)
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US7026360B1 (en) 2006-04-11
HK1036931A1 (en) 2002-01-25
PT1073470E (pt) 2005-07-29
KR100689686B1 (ko) 2007-03-09
EP1073470A1 (en) 2001-02-07
ES2241575T3 (es) 2005-11-01
CA2326756A1 (en) 2000-08-24
EP1073470B1 (en) 2005-04-27
WO2000048636A1 (en) 2000-08-24
CN1178699C (zh) 2004-12-08
CN1294519A (zh) 2001-05-09
CA2326756C (en) 2007-05-01
JP2002537417A (ja) 2002-11-05
ATE293995T1 (de) 2005-05-15
DE60019693D1 (de) 2005-06-02
DE60019693T2 (de) 2006-05-04
KR20010042626A (ko) 2001-05-25

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