CH657611A5 - Verfahren zur herstellung von 2,4-diamino-5-benzyl-pyrimidin-derivaten. - Google Patents

Verfahren zur herstellung von 2,4-diamino-5-benzyl-pyrimidin-derivaten. Download PDF

Info

Publication number
CH657611A5
CH657611A5 CH4391/83A CH439183A CH657611A5 CH 657611 A5 CH657611 A5 CH 657611A5 CH 4391/83 A CH4391/83 A CH 4391/83A CH 439183 A CH439183 A CH 439183A CH 657611 A5 CH657611 A5 CH 657611A5
Authority
CH
Switzerland
Prior art keywords
mol
mixture
hours
diamino
reaction mixture
Prior art date
Application number
CH4391/83A
Other languages
German (de)
English (en)
Inventor
Ivan Beck
Janos Egri
Elemer Jakfalvi
Gyoergi Kovanyi
Eva Furdyga
Istvan Simonyi
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of CH657611A5 publication Critical patent/CH657611A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/04—Saturated ethers
    • C07C43/12—Saturated ethers containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oncology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Liquid Crystal Substances (AREA)
CH4391/83A 1982-08-13 1983-08-11 Verfahren zur herstellung von 2,4-diamino-5-benzyl-pyrimidin-derivaten. CH657611A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU822604A HU188588B (en) 1982-08-13 1982-08-13 Process for the production of 2,4-diamino-5-benzyl-pyrimidine-derivatives

Publications (1)

Publication Number Publication Date
CH657611A5 true CH657611A5 (de) 1986-09-15

Family

ID=10960229

Family Applications (1)

Application Number Title Priority Date Filing Date
CH4391/83A CH657611A5 (de) 1982-08-13 1983-08-11 Verfahren zur herstellung von 2,4-diamino-5-benzyl-pyrimidin-derivaten.

Country Status (8)

Country Link
JP (1) JPS5993061A (it)
AT (1) AT387216B (it)
CH (1) CH657611A5 (it)
DE (1) DE3329226A1 (it)
GB (1) GB2125044B (it)
HU (1) HU188588B (it)
IT (1) IT1194372B (it)
SU (1) SU1222194A3 (it)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR94837E (fr) * 1966-02-19 1969-11-28 Wellcome Found Procédé de préparation de dérivés de la pyrimidine.
CH598231A5 (it) * 1973-07-27 1978-04-28 Hoffmann La Roche
JPS6119628B2 (it) * 1973-11-08 1986-05-17 Efu Hofuman Ra Roshu Unto Co Ag
AR207671A1 (es) * 1975-01-03 1976-10-22 Prayon Procedimiento para la obtencion de un pigmento basico de oxido de hierro en forma alfa-fe2o3
DE2559752C3 (de) * 1975-10-17 1978-12-07 Ludwig Heumann & Co Gmbh, 8500 Nuernberg 2,4-Diamino-5-(3-methoxy-4-hydroxy-5-methyl-benzyl)-pyrimidin, Verfahren zu seiner Herstellung und diese Verbindung enthaltendes Arzneimittel
DE2546667C3 (de) * 1975-10-17 1978-10-12 Ludwig Heumann & Co Gmbh, 8500 Nuernberg 2,4-DiamüH»-5-(3-methoxy-4-hydroxy-5-halogenbenzyl)-pyrimidine, und diese Verbindungen enthaltende Arzneimittel
DE2617967C3 (de) * 1976-04-24 1978-11-02 Nordmark-Werke Gmbh, 2000 Hamburg Verfahren zur Herstellung von 2,4-Diamino-5-benzylpyrimidinen
DE2635765C3 (de) * 1976-08-09 1979-02-08 Ludwig Heumann & Co Gmbh, 8500 Nuernberg Verfahren zur Herstellung von 2,4-EMamino-5-(3',4'r5'-trimethoxybenzyl)-pyrimidin
IL57375A0 (en) * 1978-05-24 1979-09-30 Wellcome Found Benzylpyrimidines, their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
IT8322540A0 (it) 1983-08-12
GB8321618D0 (en) 1983-09-14
ATA290583A (de) 1988-05-15
DE3329226A1 (de) 1984-02-23
SU1222194A3 (ru) 1986-03-30
HU188588B (en) 1986-04-28
GB2125044A (en) 1984-02-29
AT387216B (de) 1988-12-27
GB2125044B (en) 1985-09-18
JPS5993061A (ja) 1984-05-29
IT8322540A1 (it) 1985-02-12
IT1194372B (it) 1988-09-22

Similar Documents

Publication Publication Date Title
DE2337813C3 (de) Verfahren zur Herstellung von Monoacetalen aromatischer 1,2-Diketone
CH513157A (de) Verfahren zur Herstellung von Pyrrolinverbindungen
EP0380712B1 (de) Verfahren zur Herstellung von 2,6-Dichlordiphenylaminessigsäurederivaten
EP0165564B1 (de) Verfahren zur Herstellung von 4-Acylamino-2-alkylamino-phenylethern
CH507260A (de) Verfahren zur Herstellung arylsubstituierter Piperazinylcarbonsäureanilide
DE60109829T2 (de) 3-(1-Hydroxy-pentylidene)-5-nitro-3H-benzofuran-2-on, ein Verfahren zu seiner Herstellung und seine Verwendung
EP0184981B1 (de) Neue Pyrrolinone und deren Zwischenprodukte
EP0552758B1 (de) N-5-geschützte 2,5-Diamino-4,6-dichlorpyrimidine und Verfahren zu deren Herstellung
EP0165322A1 (de) Verfahren zur Herstellung basisch substituierter Phenylacetonitrile
CH657611A5 (de) Verfahren zur herstellung von 2,4-diamino-5-benzyl-pyrimidin-derivaten.
DE2725992A1 (de) Benzylcyanoacetale, verfahren zu ihrer herstellung und ihre verwendung
EP0001760B1 (de) Alpha-aminomethylen-beta-formylaminopropionitril, Verfahren zu seiner Herstellung sowie Verwendung zur Herstellung von 2-Methyl-4-amino-5-formylaminomethyl-pyrimidin
EP0345464B1 (de) Verfahren zur Herstellung von substituierten 3-Amino-2(benzoyl)-acrylsäureestern sowie ein Verfahren zur Herstellung von Zwischenprodukten für antibakterielle Wirkstoffe aus diesen Verbindungen
DE4408083C1 (de) Verfahren zur Herstellung von 4-Fluoralkoxyzimtsäurenitrilen
EP0056938B1 (de) Verfahren zur Herstellung von 3,6-disubstituierten 4-Amino-1,2,4-triazin-5-onen
DE19612828C1 (de) Verfahren zur Herstellung von Naphthonitrilderivaten und deren Verwendung zur Herstellung von Faktor-Xa-Inhibitoren
DE2051871A1 (en) Beta-amino-alpha-aryloxymethylacrylonitrile - and 2,4-diamino-5-benzylpyrimidine derivs. useful as antibacterial agents
DE2720771A1 (de) Thiobenzylpyrimidine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE2065698B2 (de) Verfahren zur Herstellung von 2-Isopropyl-6-methyl-4(3H)-pyrimidon
DD202703A5 (de) Verfahren zur herstellung des 2,4-diamino-5-(3',4',5'-trimethoxy-benzyl)-pyrimidin
AT319955B (de) Verfahren zur Herstellung von neuen 2,4-Diamino-5-benzylpyrimidinen
EP0115811A2 (de) 2,4-Dichlor-5-thiazolcarboxaldehyd und ein Verfahren zu seiner Herstellung
DD274620A1 (de) Verfahren zur herstellung von reinem 3-cyan-6-methyl-5-(pyrid-4-yl)-1,2-dihydro-pyrid-2-on
DD159505A3 (de) Verfahren zur herstellung von 5-cyan-2-[4-subst.-phenyl]-pyrimidinen
EP0175264B1 (de) Verfahren zur Herstellung von 2-Amino-3-cyano-5-dialkoxymethyl-pyrazinen und Zwischenprodukte für dieses Verfahren

Legal Events

Date Code Title Description
PL Patent ceased