CH641167A5 - N-Cyano-N'-(2-((4-methyl-5-imidazolyl)-methylthio)ethyl)-N''-alkyny l guanidines - Google Patents

N-Cyano-N'-(2-((4-methyl-5-imidazolyl)-methylthio)ethyl)-N''-alkyny l guanidines Download PDF

Info

Publication number
CH641167A5
CH641167A5 CH609278A CH609278A CH641167A5 CH 641167 A5 CH641167 A5 CH 641167A5 CH 609278 A CH609278 A CH 609278A CH 609278 A CH609278 A CH 609278A CH 641167 A5 CH641167 A5 CH 641167A5
Authority
CH
Switzerland
Prior art keywords
acid
compound
formula
methyl
group
Prior art date
Application number
CH609278A
Other languages
German (de)
English (en)
Inventor
Ronnie Ray Crenshaw
George Michael Luke
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/848,959 external-priority patent/US4112234A/en
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of CH641167A5 publication Critical patent/CH641167A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C07C323/44—X or Y being nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CH609278A 1977-06-03 1978-06-02 N-Cyano-N'-(2-((4-methyl-5-imidazolyl)-methylthio)ethyl)-N''-alkyny l guanidines CH641167A5 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80300977A 1977-06-03 1977-06-03
US82679677A 1977-08-22 1977-08-22
US05/848,959 US4112234A (en) 1977-08-22 1977-11-07 Imidazolylmethylthioethyl alkynyl guanidines

Publications (1)

Publication Number Publication Date
CH641167A5 true CH641167A5 (en) 1984-02-15

Family

ID=27419995

Family Applications (2)

Application Number Title Priority Date Filing Date
CH609278A CH641167A5 (en) 1977-06-03 1978-06-02 N-Cyano-N'-(2-((4-methyl-5-imidazolyl)-methylthio)ethyl)-N''-alkyny l guanidines
CH549283A CH644591A5 (en) 1977-06-03 1983-10-07 N-Cyano-N'-alkynyl-N''-(2-mercaptoethyl)guanidines and S-substituted N-alkynyl-N'-cyanoisothioureas

Family Applications After (1)

Application Number Title Priority Date Filing Date
CH549283A CH644591A5 (en) 1977-06-03 1983-10-07 N-Cyano-N'-alkynyl-N''-(2-mercaptoethyl)guanidines and S-substituted N-alkynyl-N'-cyanoisothioureas

Country Status (26)

Country Link
JP (1) JPS543067A (xx)
AR (2) AR222797A1 (xx)
CA (1) CA1110251A (xx)
CH (2) CH641167A5 (xx)
CY (3) CY1231A (xx)
DD (1) DD140038A5 (xx)
DE (1) DE2824066A1 (xx)
DK (1) DK243178A (xx)
ES (3) ES470474A1 (xx)
FI (1) FI69069C (xx)
FR (2) FR2401143A1 (xx)
GB (3) GB1598628A (xx)
GR (1) GR73860B (xx)
HK (3) HK38084A (xx)
HU (1) HU186766B (xx)
IE (1) IE47543B1 (xx)
IL (1) IL54819A (xx)
KE (1) KE3373A (xx)
LU (1) LU79725A1 (xx)
MY (3) MY8500453A (xx)
NL (1) NL7805935A (xx)
NO (3) NO152214C (xx)
NZ (1) NZ187376A (xx)
SE (3) SE443784B (xx)
SG (1) SG8584G (xx)
YU (4) YU129778A (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS568352A (en) * 1979-07-03 1981-01-28 Shionogi & Co Ltd Aminoalkylvenzene derivative
US4339439A (en) * 1981-01-19 1982-07-13 Bristol-Myers Company Pharmaceutical methods and compositions
JPS57134318A (en) * 1981-02-12 1982-08-19 Nissan Motor Co Ltd Air mixing construction of air conditioner
JPS5848516U (ja) * 1981-09-30 1983-04-01 日産車体株式会社 車両用空気調和装置
JPS6018010U (ja) * 1983-07-18 1985-02-07 日産自動車株式会社 車両用空気調和装置の温度調整機構
JPS60113211U (ja) * 1984-01-06 1985-07-31 松下電器産業株式会社 自動車用空気調和装置
ES2007948A6 (es) * 1988-07-06 1989-07-01 Vinas Lab Procedimiento para la obtencion de derivados propargilguanidicos.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4024271A (en) * 1971-03-09 1977-05-17 Smith Kline & French Laboratories Limited Pharmacologically active guanidine compounds
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
GB1397436A (en) * 1972-09-05 1975-06-11 Smith Kline French Lab Heterocyclic n-cyanoguinidines
GB1531231A (en) * 1974-09-02 1978-11-08 Smith Kline French Lab Process for the production of cyanoguanidine derivatives
GB1531221A (en) * 1974-09-02 1978-11-08 Smith Kline French Lab Process for preparing guanidine derivatives
GB1533380A (en) * 1974-09-02 1978-11-22 Smith Kline French Lab Process for the preparation of heterocyclic substituted thioureas and h-cyanoguanidines

Also Published As

Publication number Publication date
DE2824066A1 (de) 1978-12-14
SE443784B (sv) 1986-03-10
AR222503A1 (es) 1981-05-29
JPS5639313B2 (xx) 1981-09-11
GB1598630A (en) 1981-09-23
SG8584G (en) 1985-02-08
FR2436138B1 (xx) 1982-12-03
FI781737A (fi) 1978-12-04
CY1231A (en) 1984-06-29
CH644591A5 (en) 1984-08-15
HK38084A (en) 1984-05-11
NO833255L (no) 1978-12-05
MY8500452A (en) 1985-12-31
NO791637L (no) 1978-12-05
MY8500451A (en) 1985-12-31
NO151824C (no) 1985-06-12
YU40625B (en) 1986-02-28
HK38184A (en) 1984-05-11
YU41620B (en) 1987-12-31
YU53079A (en) 1983-09-30
HK38284A (en) 1984-05-11
IE47543B1 (en) 1984-04-18
ES470474A1 (es) 1979-09-01
YU129778A (en) 1983-02-28
FR2401143A1 (fr) 1979-03-23
FI69069C (fi) 1985-12-10
FI69069B (fi) 1985-08-30
YU215482A (en) 1983-02-28
CA1110251A (en) 1981-10-06
GB1598629A (en) 1981-09-23
FR2401143B1 (xx) 1981-12-11
CY1230A (en) 1984-06-29
HU186766B (en) 1985-09-30
YU40624B (en) 1986-02-28
ES478202A1 (es) 1979-06-01
IE781112L (en) 1978-12-03
SE8401491L (sv) 1984-03-16
NO151824B (no) 1985-03-04
SE8401492L (sv) 1984-03-16
FR2436138A1 (fr) 1980-04-11
CY1229A (en) 1984-06-29
GR73860B (xx) 1984-05-08
IL54819A (en) 1983-03-31
KE3373A (en) 1984-03-23
SE7806525L (sv) 1978-12-04
NO781928L (no) 1978-12-05
SE8401491D0 (sv) 1984-03-16
DD140038A5 (de) 1980-02-06
AR222797A1 (es) 1981-06-30
GB1598628A (en) 1981-09-23
NZ187376A (en) 1981-05-29
MY8500453A (en) 1985-12-31
NO152214B (no) 1985-05-13
SE8401492D0 (sv) 1984-03-16
JPS543067A (en) 1979-01-11
NO152214C (no) 1985-08-28
NL7805935A (nl) 1978-12-05
DK243178A (da) 1978-12-04
ES478203A1 (es) 1979-06-01
LU79725A1 (fr) 1979-02-02
IL54819A0 (en) 1978-07-31
YU215582A (en) 1983-02-28

Similar Documents

Publication Publication Date Title
CH649527A5 (de) 1,2-diaminocyclobuten-3,4-dione, verfahren zu deren herstellung und pharmazeutische mittel, die diese verbindungen enthalten.
DE2322880C2 (de) 4-(Imidazolin-2-ylamino)-2,1,3-benzothiadiazole und Verfahren zu deren Herstellung
DE2643670C2 (de) 5-Benzyl-4-pyrimidon-Derivate, ihre Salze mit Säuren, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE2847792C2 (xx)
DE2950838A1 (de) Neue thiazolylmethylthioderivate, verfahren zu deren herstellung und arzneimittel
DE2720545C3 (de) Derivate des 2,4-Diamino-6,7-dimethoxychinazolins, ihre Herstellung und pharmazeutische Mittel
DE2938990C2 (xx)
CH641167A5 (en) N-Cyano-N'-(2-((4-methyl-5-imidazolyl)-methylthio)ethyl)-N''-alkyny l guanidines
DE3216843C2 (de) 3-Thiomethyl-pyridin-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
EP0018360B1 (de) N-(5-Methoxybentofuran-2-ylcarbonyl)-N'-benzylpiperazin und Verfahren zu dessen Herstellung
EP0007438B1 (de) Neue substituierte 2-Phenylamino-imidazoline-(2), deren Säureadditionssalze, diese enthaltende Arzneimittel und Verfahren zur Herstellung derselben
DE2427272C3 (de) 1-(2-(β-Naphthyloxy)-äthyl)-3-methyl -pyrazolon-(5), Verfahren sowie Verwendung als Antithrombotikum
DE1934392C3 (de) Neue 2-Pyridylthioamide und Verfahren zu ihrer Herstellung
EP0007024B1 (de) Neue substituierte 2-Phenylamino-1,3-tetrahydropyrimidine-(2), deren Säureadditionssalze, diese enthaltende Arzneimittel und Verfahren zur Herstellung derselben
DE2131625A1 (de) Thioharnstoffderivate,Verfahren zu ihrer Herstellung und Arzneipraeparate
AT390790B (de) Verfahren zur herstellung des neuen 3-amino-4-(2-((2-guanidinothiazol-4-yl)methylth o)-ethylamino)-1,2,5-thiadiazols
DE2410201B2 (de) 6-substituierte 3-carbaethoxyhydrazinopyridazine beziehungsweise ihre salze sowie solche enthaltende arzneimittel und verfahren zur herstellung derselben
DE2628642C2 (de) In 2-Stellung substituierte 1,3-Diaza-fünfringkohlenstoffverbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
DE3107599C2 (de) N-Cyan-N'-methyl-N"-{2-[(5-methylthio-imidazol-4-yl)-methylthio]-äthyl}-guanidin, Verfahren zu seiner Herstellung und diese Verbindung enthaltende Arzneimittel
DE3220185A1 (de) 4-amino-benzylamin-derivate, verfahren zu ihrer herstellung, sowie ihre verwendung als pharmazeutica
CH654575A5 (de) Antiarhythmisch wirksame phenaethylpiperidin-verbindungen.
DD253616A5 (de) Verfahren zur herstellung von neuen pleunromutilinderivaten
DE3012190A1 (de) Pharmazeutisches mittel auf der basis 1,3,5-substituierter biuret-verbindungen
DE2429755A1 (de) Nitroimidazolderivate, ihre salze, verfahren zu ihrer herstellung und arzneimittel
EP0111205B1 (de) Acridanon-Derivate

Legal Events

Date Code Title Description
PL Patent ceased