ES478203A1 - Un procedimiento para la preparacion de derivados de n-ciano-n''-alquinilguanidinas. - Google Patents

Un procedimiento para la preparacion de derivados de n-ciano-n''-alquinilguanidinas.

Info

Publication number
ES478203A1
ES478203A1 ES478203A ES478203A ES478203A1 ES 478203 A1 ES478203 A1 ES 478203A1 ES 478203 A ES478203 A ES 478203A ES 478203 A ES478203 A ES 478203A ES 478203 A1 ES478203 A1 ES 478203A1
Authority
ES
Spain
Prior art keywords
antagonists
chain
guanidine derivatives
histamine
receptors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES478203A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/848,959 external-priority patent/US4112234A/en
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES478203A1 publication Critical patent/ES478203A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C07C323/44—X or Y being nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

-ciano-N''-[2-[(4-metil-5-imidazolil)metiltio]etil]-N''`-alquinilguanidinas que son agentes de bloqueo del recepto H2, que inhiben la secreción de ácidos gástricos y que son útiles en el tratamiento de las úlceras. El objetivo clínico en el tratamiento de las úlceras pépticas es reducir la secreción de ácidos grasos, basándose en el principio de "sin ácido no hay úlcera". La terapia tradicional de las úlceras pépticas implica el control de la dieta y el uso de antiácidos y anticolinérgicos. Existen señales que indican que la histamina puede ser la trayectoria común final para la estimulación de la secreción gástrica. Este efecto de la histamina es mediado por los receptores H2 y no es inhibido por los antihistamínicos clásicos. Que son bloqueadores de los receptores H1. Se conocen ahora varios agentes específicos bloqueadores de los receptores H2 (antagonistas del receptor H2)
ES478203A 1977-06-03 1979-03-01 Un procedimiento para la preparacion de derivados de n-ciano-n''-alquinilguanidinas. Expired ES478203A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80300977A 1977-06-03 1977-06-03
US82679677A 1977-08-22 1977-08-22
US05/848,959 US4112234A (en) 1977-08-22 1977-11-07 Imidazolylmethylthioethyl alkynyl guanidines

Publications (1)

Publication Number Publication Date
ES478203A1 true ES478203A1 (es) 1979-06-01

Family

ID=27419995

Family Applications (3)

Application Number Title Priority Date Filing Date
ES470474A Expired ES470474A1 (es) 1977-06-03 1978-06-02 Un procedimiento para la preparacion de derivados de n-ciano-n -alquinil-guanidinas
ES478203A Expired ES478203A1 (es) 1977-06-03 1979-03-01 Un procedimiento para la preparacion de derivados de n-ciano-n''-alquinilguanidinas.
ES478202A Expired ES478202A1 (es) 1977-06-03 1979-03-01 Un procedimiento para la preparacion de derivados de n-ciano-n''-alquinilguanidinas.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES470474A Expired ES470474A1 (es) 1977-06-03 1978-06-02 Un procedimiento para la preparacion de derivados de n-ciano-n -alquinil-guanidinas

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES478202A Expired ES478202A1 (es) 1977-06-03 1979-03-01 Un procedimiento para la preparacion de derivados de n-ciano-n''-alquinilguanidinas.

Country Status (26)

Country Link
JP (1) JPS543067A (es)
AR (2) AR222797A1 (es)
CA (1) CA1110251A (es)
CH (2) CH641167A5 (es)
CY (3) CY1231A (es)
DD (1) DD140038A5 (es)
DE (1) DE2824066A1 (es)
DK (1) DK243178A (es)
ES (3) ES470474A1 (es)
FI (1) FI69069C (es)
FR (2) FR2401143A1 (es)
GB (3) GB1598629A (es)
GR (1) GR73860B (es)
HK (3) HK38184A (es)
HU (1) HU186766B (es)
IE (1) IE47543B1 (es)
IL (1) IL54819A (es)
KE (1) KE3373A (es)
LU (1) LU79725A1 (es)
MY (3) MY8500451A (es)
NL (1) NL7805935A (es)
NO (3) NO152214C (es)
NZ (1) NZ187376A (es)
SE (3) SE443784B (es)
SG (1) SG8584G (es)
YU (4) YU129778A (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS568352A (en) * 1979-07-03 1981-01-28 Shionogi & Co Ltd Aminoalkylvenzene derivative
US4339439A (en) * 1981-01-19 1982-07-13 Bristol-Myers Company Pharmaceutical methods and compositions
JPS57134318A (en) * 1981-02-12 1982-08-19 Nissan Motor Co Ltd Air mixing construction of air conditioner
JPS5848516U (ja) * 1981-09-30 1983-04-01 日産車体株式会社 車両用空気調和装置
JPS6018010U (ja) * 1983-07-18 1985-02-07 日産自動車株式会社 車両用空気調和装置の温度調整機構
JPS60113211U (ja) * 1984-01-06 1985-07-31 松下電器産業株式会社 自動車用空気調和装置
ES2007948A6 (es) * 1988-07-06 1989-07-01 Vinas Lab Procedimiento para la obtencion de derivados propargilguanidicos.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4024271A (en) * 1971-03-09 1977-05-17 Smith Kline & French Laboratories Limited Pharmacologically active guanidine compounds
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
GB1397436A (en) * 1972-09-05 1975-06-11 Smith Kline French Lab Heterocyclic n-cyanoguinidines
GB1533380A (en) * 1974-09-02 1978-11-22 Smith Kline French Lab Process for the preparation of heterocyclic substituted thioureas and h-cyanoguanidines
GB1531221A (en) * 1974-09-02 1978-11-08 Smith Kline French Lab Process for preparing guanidine derivatives
GB1531231A (en) * 1974-09-02 1978-11-08 Smith Kline French Lab Process for the production of cyanoguanidine derivatives

Also Published As

Publication number Publication date
KE3373A (en) 1984-03-23
HK38284A (en) 1984-05-11
NO151824C (no) 1985-06-12
ES470474A1 (es) 1979-09-01
MY8500451A (en) 1985-12-31
SE8401492L (sv) 1984-03-16
FR2436138A1 (fr) 1980-04-11
NO152214C (no) 1985-08-28
FR2401143B1 (es) 1981-12-11
HU186766B (en) 1985-09-30
JPS5639313B2 (es) 1981-09-11
GB1598630A (en) 1981-09-23
MY8500452A (en) 1985-12-31
CY1229A (en) 1984-06-29
SE8401491L (sv) 1984-03-16
IL54819A0 (en) 1978-07-31
NO781928L (no) 1978-12-05
AR222797A1 (es) 1981-06-30
SG8584G (en) 1985-02-08
FR2401143A1 (fr) 1979-03-23
NO791637L (no) 1978-12-05
LU79725A1 (fr) 1979-02-02
NO833255L (no) 1978-12-05
YU215482A (en) 1983-02-28
NL7805935A (nl) 1978-12-05
CY1230A (en) 1984-06-29
SE7806525L (sv) 1978-12-04
IL54819A (en) 1983-03-31
CA1110251A (en) 1981-10-06
MY8500453A (en) 1985-12-31
IE781112L (en) 1978-12-03
DD140038A5 (de) 1980-02-06
SE443784B (sv) 1986-03-10
YU40625B (en) 1986-02-28
DK243178A (da) 1978-12-04
NZ187376A (en) 1981-05-29
YU40624B (en) 1986-02-28
JPS543067A (en) 1979-01-11
SE8401492D0 (sv) 1984-03-16
CY1231A (en) 1984-06-29
HK38084A (en) 1984-05-11
HK38184A (en) 1984-05-11
GB1598628A (en) 1981-09-23
IE47543B1 (en) 1984-04-18
FI69069B (fi) 1985-08-30
YU41620B (en) 1987-12-31
YU53079A (en) 1983-09-30
FR2436138B1 (es) 1982-12-03
GB1598629A (en) 1981-09-23
FI69069C (fi) 1985-12-10
YU215582A (en) 1983-02-28
FI781737A (fi) 1978-12-04
CH641167A5 (en) 1984-02-15
GR73860B (es) 1984-05-08
ES478202A1 (es) 1979-06-01
YU129778A (en) 1983-02-28
SE8401491D0 (sv) 1984-03-16
DE2824066A1 (de) 1978-12-14
CH644591A5 (en) 1984-08-15
AR222503A1 (es) 1981-05-29
NO152214B (no) 1985-05-13
NO151824B (no) 1985-03-04

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