ES478203A1 - Un procedimiento para la preparacion de derivados de n-ciano-n''-alquinilguanidinas. - Google Patents
Un procedimiento para la preparacion de derivados de n-ciano-n''-alquinilguanidinas.Info
- Publication number
- ES478203A1 ES478203A1 ES478203A ES478203A ES478203A1 ES 478203 A1 ES478203 A1 ES 478203A1 ES 478203 A ES478203 A ES 478203A ES 478203 A ES478203 A ES 478203A ES 478203 A1 ES478203 A1 ES 478203A1
- Authority
- ES
- Spain
- Prior art keywords
- antagonists
- chain
- guanidine derivatives
- histamine
- receptors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/43—Y being a hetero atom
- C07C323/44—X or Y being nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
-ciano-N''-[2-[(4-metil-5-imidazolil)metiltio]etil]-N''`-alquinilguanidinas que son agentes de bloqueo del recepto H2, que inhiben la secreción de ácidos gástricos y que son útiles en el tratamiento de las úlceras. El objetivo clínico en el tratamiento de las úlceras pépticas es reducir la secreción de ácidos grasos, basándose en el principio de "sin ácido no hay úlcera". La terapia tradicional de las úlceras pépticas implica el control de la dieta y el uso de antiácidos y anticolinérgicos. Existen señales que indican que la histamina puede ser la trayectoria común final para la estimulación de la secreción gástrica. Este efecto de la histamina es mediado por los receptores H2 y no es inhibido por los antihistamínicos clásicos. Que son bloqueadores de los receptores H1. Se conocen ahora varios agentes específicos bloqueadores de los receptores H2 (antagonistas del receptor H2)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80300977A | 1977-06-03 | 1977-06-03 | |
| US82679677A | 1977-08-22 | 1977-08-22 | |
| US05/848,959 US4112234A (en) | 1977-08-22 | 1977-11-07 | Imidazolylmethylthioethyl alkynyl guanidines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES478203A1 true ES478203A1 (es) | 1979-06-01 |
Family
ID=27419995
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES470474A Expired ES470474A1 (es) | 1977-06-03 | 1978-06-02 | Un procedimiento para la preparacion de derivados de n-ciano-n -alquinil-guanidinas |
| ES478203A Expired ES478203A1 (es) | 1977-06-03 | 1979-03-01 | Un procedimiento para la preparacion de derivados de n-ciano-n''-alquinilguanidinas. |
| ES478202A Expired ES478202A1 (es) | 1977-06-03 | 1979-03-01 | Un procedimiento para la preparacion de derivados de n-ciano-n''-alquinilguanidinas. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES470474A Expired ES470474A1 (es) | 1977-06-03 | 1978-06-02 | Un procedimiento para la preparacion de derivados de n-ciano-n -alquinil-guanidinas |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES478202A Expired ES478202A1 (es) | 1977-06-03 | 1979-03-01 | Un procedimiento para la preparacion de derivados de n-ciano-n''-alquinilguanidinas. |
Country Status (26)
| Country | Link |
|---|---|
| JP (1) | JPS543067A (es) |
| AR (2) | AR222797A1 (es) |
| CA (1) | CA1110251A (es) |
| CH (2) | CH641167A5 (es) |
| CY (3) | CY1229A (es) |
| DD (1) | DD140038A5 (es) |
| DE (1) | DE2824066A1 (es) |
| DK (1) | DK243178A (es) |
| ES (3) | ES470474A1 (es) |
| FI (1) | FI69069C (es) |
| FR (2) | FR2401143A1 (es) |
| GB (3) | GB1598628A (es) |
| GR (1) | GR73860B (es) |
| HK (3) | HK38284A (es) |
| HU (1) | HU186766B (es) |
| IE (1) | IE47543B1 (es) |
| IL (1) | IL54819A (es) |
| KE (1) | KE3373A (es) |
| LU (1) | LU79725A1 (es) |
| MY (3) | MY8500452A (es) |
| NL (1) | NL7805935A (es) |
| NO (3) | NO152214C (es) |
| NZ (1) | NZ187376A (es) |
| SE (3) | SE443784B (es) |
| SG (1) | SG8584G (es) |
| YU (4) | YU129778A (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS568352A (en) * | 1979-07-03 | 1981-01-28 | Shionogi & Co Ltd | Aminoalkylvenzene derivative |
| US4339439A (en) * | 1981-01-19 | 1982-07-13 | Bristol-Myers Company | Pharmaceutical methods and compositions |
| JPS57134318A (en) * | 1981-02-12 | 1982-08-19 | Nissan Motor Co Ltd | Air mixing construction of air conditioner |
| JPS5848516U (ja) * | 1981-09-30 | 1983-04-01 | 日産車体株式会社 | 車両用空気調和装置 |
| JPS6018010U (ja) * | 1983-07-18 | 1985-02-07 | 日産自動車株式会社 | 車両用空気調和装置の温度調整機構 |
| JPS60113211U (ja) * | 1984-01-06 | 1985-07-31 | 松下電器産業株式会社 | 自動車用空気調和装置 |
| ES2007948A6 (es) * | 1988-07-06 | 1989-07-01 | Vinas Lab | Procedimiento para la obtencion de derivados propargilguanidicos. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4024271A (en) * | 1971-03-09 | 1977-05-17 | Smith Kline & French Laboratories Limited | Pharmacologically active guanidine compounds |
| GB1338169A (en) * | 1971-03-09 | 1973-11-21 | Smith Kline French Lab | Ureas thioureas and guanidines |
| GB1397436A (en) * | 1972-09-05 | 1975-06-11 | Smith Kline French Lab | Heterocyclic n-cyanoguinidines |
| GB1531221A (en) * | 1974-09-02 | 1978-11-08 | Smith Kline French Lab | Process for preparing guanidine derivatives |
| GB1533380A (en) * | 1974-09-02 | 1978-11-22 | Smith Kline French Lab | Process for the preparation of heterocyclic substituted thioureas and h-cyanoguanidines |
| GB1531231A (en) * | 1974-09-02 | 1978-11-08 | Smith Kline French Lab | Process for the production of cyanoguanidine derivatives |
-
1978
- 1978-05-25 NZ NZ187376A patent/NZ187376A/xx unknown
- 1978-05-25 CA CA304,045A patent/CA1110251A/en not_active Expired
- 1978-05-26 CY CY1229A patent/CY1229A/xx unknown
- 1978-05-26 CY CY1231A patent/CY1231A/xx unknown
- 1978-05-26 GB GB23611/78A patent/GB1598628A/en not_active Expired
- 1978-05-26 CY CY1230A patent/CY1230A/xx unknown
- 1978-05-26 GB GB18923/80A patent/GB1598630A/en not_active Expired
- 1978-05-26 GB GB27637/79A patent/GB1598629A/en not_active Expired
- 1978-05-29 GR GR56374A patent/GR73860B/el unknown
- 1978-05-29 LU LU79725A patent/LU79725A1/xx unknown
- 1978-05-31 AR AR272401A patent/AR222797A1/es active
- 1978-05-31 IL IL54819A patent/IL54819A/xx unknown
- 1978-05-31 DK DK243178A patent/DK243178A/da not_active Application Discontinuation
- 1978-05-31 FI FI781737A patent/FI69069C/fi not_active IP Right Cessation
- 1978-05-31 NL NL7805935A patent/NL7805935A/xx not_active Application Discontinuation
- 1978-05-31 YU YU01297/78A patent/YU129778A/xx unknown
- 1978-06-01 DE DE19782824066 patent/DE2824066A1/de not_active Withdrawn
- 1978-06-02 ES ES470474A patent/ES470474A1/es not_active Expired
- 1978-06-02 NO NO781928A patent/NO152214C/no unknown
- 1978-06-02 JP JP6590078A patent/JPS543067A/ja active Granted
- 1978-06-02 FR FR7816601A patent/FR2401143A1/fr active Granted
- 1978-06-02 CH CH609278A patent/CH641167A5/de not_active IP Right Cessation
- 1978-06-02 IE IE1112/78A patent/IE47543B1/en unknown
- 1978-06-02 HU HU811135A patent/HU186766B/hu unknown
- 1978-06-02 SE SE7806525A patent/SE443784B/sv unknown
- 1978-06-05 DD DD78205794A patent/DD140038A5/de unknown
-
1979
- 1979-03-01 ES ES478203A patent/ES478203A1/es not_active Expired
- 1979-03-01 ES ES478202A patent/ES478202A1/es not_active Expired
- 1979-03-05 YU YU530/79A patent/YU41620B/xx unknown
- 1979-05-16 NO NO791637A patent/NO791637L/no unknown
- 1979-10-26 AR AR278645A patent/AR222503A1/es active
- 1979-11-23 FR FR7928943A patent/FR2436138A1/fr active Granted
-
1982
- 1982-09-27 YU YU2155/82A patent/YU40625B/xx unknown
- 1982-09-27 YU YU2154/82A patent/YU40624B/xx unknown
-
1983
- 1983-09-12 NO NO833255A patent/NO151824C/no unknown
- 1983-10-07 CH CH549283A patent/CH644591A5/de not_active IP Right Cessation
-
1984
- 1984-01-30 SG SG85/84A patent/SG8584G/en unknown
- 1984-02-10 KE KE3373A patent/KE3373A/xx unknown
- 1984-03-16 SE SE8401492A patent/SE8401492D0/xx not_active Application Discontinuation
- 1984-03-16 SE SE8401491A patent/SE8401491D0/xx not_active Application Discontinuation
- 1984-05-03 HK HK382/84A patent/HK38284A/xx unknown
- 1984-05-03 HK HK380/84A patent/HK38084A/xx unknown
- 1984-05-03 HK HK381/84A patent/HK38184A/xx unknown
-
1985
- 1985-12-30 MY MY452/85A patent/MY8500452A/xx unknown
- 1985-12-30 MY MY451/85A patent/MY8500451A/xx unknown
- 1985-12-30 MY MY453/85A patent/MY8500453A/xx unknown
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