NZ187376A - N-cyano-n-(2-(4-methyl-5-imidazolyl)methylthio)ethyl)-n-alkynyl guanidines intermediates pharmaceutical compositions - Google Patents

N-cyano-n-(2-(4-methyl-5-imidazolyl)methylthio)ethyl)-n-alkynyl guanidines intermediates pharmaceutical compositions

Info

Publication number
NZ187376A
NZ187376A NZ187376A NZ18737678A NZ187376A NZ 187376 A NZ187376 A NZ 187376A NZ 187376 A NZ187376 A NZ 187376A NZ 18737678 A NZ18737678 A NZ 18737678A NZ 187376 A NZ187376 A NZ 187376A
Authority
NZ
New Zealand
Prior art keywords
guanidines
methylthio
imidazolyl
intermediates
alkynyl
Prior art date
Application number
NZ187376A
Other languages
English (en)
Inventor
R R Crenshaw
G M Luke
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/848,959 external-priority patent/US4112234A/en
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of NZ187376A publication Critical patent/NZ187376A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C07C323/44—X or Y being nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NZ187376A 1977-06-03 1978-05-25 N-cyano-n-(2-(4-methyl-5-imidazolyl)methylthio)ethyl)-n-alkynyl guanidines intermediates pharmaceutical compositions NZ187376A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80300977A 1977-06-03 1977-06-03
US82679677A 1977-08-22 1977-08-22
US05/848,959 US4112234A (en) 1977-08-22 1977-11-07 Imidazolylmethylthioethyl alkynyl guanidines

Publications (1)

Publication Number Publication Date
NZ187376A true NZ187376A (en) 1981-05-29

Family

ID=27419995

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ187376A NZ187376A (en) 1977-06-03 1978-05-25 N-cyano-n-(2-(4-methyl-5-imidazolyl)methylthio)ethyl)-n-alkynyl guanidines intermediates pharmaceutical compositions

Country Status (26)

Country Link
JP (1) JPS543067A (es)
AR (2) AR222797A1 (es)
CA (1) CA1110251A (es)
CH (2) CH641167A5 (es)
CY (3) CY1230A (es)
DD (1) DD140038A5 (es)
DE (1) DE2824066A1 (es)
DK (1) DK243178A (es)
ES (3) ES470474A1 (es)
FI (1) FI69069C (es)
FR (2) FR2401143A1 (es)
GB (3) GB1598629A (es)
GR (1) GR73860B (es)
HK (3) HK38184A (es)
HU (1) HU186766B (es)
IE (1) IE47543B1 (es)
IL (1) IL54819A (es)
KE (1) KE3373A (es)
LU (1) LU79725A1 (es)
MY (3) MY8500453A (es)
NL (1) NL7805935A (es)
NO (3) NO152214C (es)
NZ (1) NZ187376A (es)
SE (3) SE443784B (es)
SG (1) SG8584G (es)
YU (4) YU129778A (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS568352A (en) * 1979-07-03 1981-01-28 Shionogi & Co Ltd Aminoalkylvenzene derivative
US4339439A (en) * 1981-01-19 1982-07-13 Bristol-Myers Company Pharmaceutical methods and compositions
JPS57134318A (en) * 1981-02-12 1982-08-19 Nissan Motor Co Ltd Air mixing construction of air conditioner
JPS5848516U (ja) * 1981-09-30 1983-04-01 日産車体株式会社 車両用空気調和装置
JPS6018010U (ja) * 1983-07-18 1985-02-07 日産自動車株式会社 車両用空気調和装置の温度調整機構
JPS60113211U (ja) * 1984-01-06 1985-07-31 松下電器産業株式会社 自動車用空気調和装置
ES2007948A6 (es) * 1988-07-06 1989-07-01 Vinas Lab Procedimiento para la obtencion de derivados propargilguanidicos.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4024271A (en) * 1971-03-09 1977-05-17 Smith Kline & French Laboratories Limited Pharmacologically active guanidine compounds
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
GB1397436A (en) * 1972-09-05 1975-06-11 Smith Kline French Lab Heterocyclic n-cyanoguinidines
GB1531231A (en) * 1974-09-02 1978-11-08 Smith Kline French Lab Process for the production of cyanoguanidine derivatives
GB1533380A (en) * 1974-09-02 1978-11-22 Smith Kline French Lab Process for the preparation of heterocyclic substituted thioureas and h-cyanoguanidines
GB1531221A (en) * 1974-09-02 1978-11-08 Smith Kline French Lab Process for preparing guanidine derivatives

Also Published As

Publication number Publication date
ES470474A1 (es) 1979-09-01
FR2436138B1 (es) 1982-12-03
DE2824066A1 (de) 1978-12-14
NL7805935A (nl) 1978-12-05
IE781112L (en) 1978-12-03
NO791637L (no) 1978-12-05
DD140038A5 (de) 1980-02-06
CY1230A (en) 1984-06-29
YU41620B (en) 1987-12-31
YU53079A (en) 1983-09-30
DK243178A (da) 1978-12-04
GR73860B (es) 1984-05-08
AR222503A1 (es) 1981-05-29
MY8500453A (en) 1985-12-31
NO151824C (no) 1985-06-12
HK38284A (en) 1984-05-11
ES478202A1 (es) 1979-06-01
CY1229A (en) 1984-06-29
YU215582A (en) 1983-02-28
HK38084A (en) 1984-05-11
NO152214B (no) 1985-05-13
FI69069B (fi) 1985-08-30
NO781928L (no) 1978-12-05
GB1598628A (en) 1981-09-23
JPS5639313B2 (es) 1981-09-11
SE8401492D0 (sv) 1984-03-16
FR2401143A1 (fr) 1979-03-23
IE47543B1 (en) 1984-04-18
HK38184A (en) 1984-05-11
SE7806525L (sv) 1978-12-04
CY1231A (en) 1984-06-29
FR2436138A1 (fr) 1980-04-11
YU40624B (en) 1986-02-28
YU215482A (en) 1983-02-28
CH641167A5 (en) 1984-02-15
FI781737A (fi) 1978-12-04
SG8584G (en) 1985-02-08
SE8401491D0 (sv) 1984-03-16
SE8401491L (sv) 1984-03-16
GB1598630A (en) 1981-09-23
SE8401492L (sv) 1984-03-16
YU40625B (en) 1986-02-28
YU129778A (en) 1983-02-28
JPS543067A (en) 1979-01-11
MY8500452A (en) 1985-12-31
FR2401143B1 (es) 1981-12-11
FI69069C (fi) 1985-12-10
AR222797A1 (es) 1981-06-30
HU186766B (en) 1985-09-30
NO152214C (no) 1985-08-28
ES478203A1 (es) 1979-06-01
CA1110251A (en) 1981-10-06
IL54819A (en) 1983-03-31
KE3373A (en) 1984-03-23
LU79725A1 (fr) 1979-02-02
SE443784B (sv) 1986-03-10
NO151824B (no) 1985-03-04
NO833255L (no) 1978-12-05
CH644591A5 (en) 1984-08-15
MY8500451A (en) 1985-12-31
GB1598629A (en) 1981-09-23
IL54819A0 (en) 1978-07-31

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