CH629253A5 - Process for preparing neothramycin - Google Patents
Process for preparing neothramycin Download PDFInfo
- Publication number
- CH629253A5 CH629253A5 CH1310176A CH1310176A CH629253A5 CH 629253 A5 CH629253 A5 CH 629253A5 CH 1310176 A CH1310176 A CH 1310176A CH 1310176 A CH1310176 A CH 1310176A CH 629253 A5 CH629253 A5 CH 629253A5
- Authority
- CH
- Switzerland
- Prior art keywords
- neothramycin
- strain
- methylneothramycin
- streptomyces
- medium
- Prior art date
Links
- FXMOIYLVKOALHC-UHFFFAOYSA-N 3,9-dihydroxy-2-methoxy-6a,7,8,9-tetrahydropyrrolo[2,1-c][1,4]benzodiazepin-11-one Chemical compound N1=CC2CCC(O)N2C(=O)C2=C1C=C(O)C(OC)=C2 FXMOIYLVKOALHC-UHFFFAOYSA-N 0.000 title claims description 169
- 229930188317 neothramycin Natural products 0.000 title claims description 45
- 238000004519 manufacturing process Methods 0.000 title description 5
- FXMOIYLVKOALHC-MADCSZMMSA-N (6as,9s)-3,9-dihydroxy-2-methoxy-6a,7,8,9-tetrahydropyrrolo[2,1-c][1,4]benzodiazepin-11-one Chemical compound N1=C[C@@H]2CC[C@H](O)N2C(=O)C2=C1C=C(O)C(OC)=C2 FXMOIYLVKOALHC-MADCSZMMSA-N 0.000 claims description 67
- FXMOIYLVKOALHC-JVXZTZIISA-N (6as,9r)-3,9-dihydroxy-2-methoxy-6a,7,8,9-tetrahydropyrrolo[2,1-c][1,4]benzodiazepin-11-one Chemical compound N1=C[C@@H]2CC[C@@H](O)N2C(=O)C2=C1C=C(O)C(OC)=C2 FXMOIYLVKOALHC-JVXZTZIISA-N 0.000 claims description 57
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G11/00—Antibiotics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP50123256A JPS5247992A (en) | 1975-10-15 | 1975-10-15 | Method of manufacturing new antibiotics, neothramycin a and b |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH629253A5 true CH629253A5 (en) | 1982-04-15 |
Family
ID=14856057
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH1310176A CH629253A5 (en) | 1975-10-15 | 1976-10-15 | Process for preparing neothramycin |
Country Status (12)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4464467A (en) * | 1982-07-26 | 1984-08-07 | Bristol-Myers Company | Antitumor antibiotics produced by new streptomyces |
| FR2586683B1 (fr) * | 1985-08-29 | 1988-07-01 | Centre Nat Rech Scient | Nouveaux derives de neothramycine, leur procede de preparation et leur application en tant que medicaments |
-
1975
- 1975-10-15 JP JP50123256A patent/JPS5247992A/ja active Granted
-
1976
- 1976-05-27 CA CA253,467A patent/CA1056748A/en not_active Expired
- 1976-09-24 GB GB39798/76A patent/GB1557271A/en not_active Expired
- 1976-09-27 AU AU18116/76A patent/AU505643B2/en not_active Expired
- 1976-10-08 DE DE2645528A patent/DE2645528C3/de not_active Expired
- 1976-10-11 NL NLAANVRAGE7611211,A patent/NL175198C/xx not_active IP Right Cessation
- 1976-10-12 FR FR7630592A patent/FR2351659A1/fr active Granted
- 1976-10-12 SE SE7611320A patent/SE432443B/xx not_active IP Right Cessation
- 1976-10-14 AT AT764076A patent/AT349630B/de not_active IP Right Cessation
- 1976-10-15 ES ES452443A patent/ES452443A1/es not_active Expired
- 1976-10-15 BE BE171582A patent/BE847372A/xx not_active IP Right Cessation
- 1976-10-15 CH CH1310176A patent/CH629253A5/de not_active IP Right Cessation
-
1978
- 1978-07-20 AT AT527178A patent/AT358172B/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SE7611320L (sv) | 1977-04-16 |
| AU1811676A (en) | 1978-04-06 |
| ES452443A1 (es) | 1977-11-01 |
| FR2351659B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1979-07-06 |
| JPS5247992A (en) | 1977-04-16 |
| CA1056748A (en) | 1979-06-19 |
| NL7611211A (nl) | 1977-04-19 |
| JPS5444759B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1979-12-27 |
| AT358172B (de) | 1980-08-25 |
| DE2645528A1 (de) | 1977-04-21 |
| AT349630B (de) | 1979-04-10 |
| AU505643B2 (en) | 1979-11-29 |
| FR2351659A1 (fr) | 1977-12-16 |
| ATA527178A (de) | 1980-01-15 |
| GB1557271A (en) | 1979-12-05 |
| NL175198C (nl) | 1984-10-01 |
| DE2645528B2 (de) | 1979-06-28 |
| SE432443B (sv) | 1984-04-02 |
| ATA764076A (de) | 1978-09-15 |
| NL175198B (nl) | 1984-05-01 |
| DE2645528C3 (de) | 1980-02-28 |
| BE847372A (fr) | 1977-01-31 |
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| PL | Patent ceased |