GB1557271A - Benzodiazepine derivatives - Google Patents

Benzodiazepine derivatives

Info

Publication number
GB1557271A
GB1557271A GB39798/76A GB3979876A GB1557271A GB 1557271 A GB1557271 A GB 1557271A GB 39798/76 A GB39798/76 A GB 39798/76A GB 3979876 A GB3979876 A GB 3979876A GB 1557271 A GB1557271 A GB 1557271A
Authority
GB
United Kingdom
Prior art keywords
neothramycin
methylneothramycin
fractionated
benzodiazepine derivatives
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB39798/76A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Publication of GB1557271A publication Critical patent/GB1557271A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
    • C07G11/00—Antibiotics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Neothramycin A and neothramycin B are obtained by culturing a neothramycin-producing strain of the genus Streptomyces under aerobic conditions in a medium containing assimilable carbon and sources of nitrogen. The resulting mixture can be fractionated. Treatment of each of the two neothramycins with methanol yields a mixture of methylneothramycin A and methylneothramycin B, which can again be fractionated. All the four compounds are valuable pharmaceuticals for use against leukaemia.
GB39798/76A 1975-10-15 1976-09-24 Benzodiazepine derivatives Expired GB1557271A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP50123256A JPS5247992A (en) 1975-10-15 1975-10-15 Method of manufacturing new antibiotics, neothramycin a and b

Publications (1)

Publication Number Publication Date
GB1557271A true GB1557271A (en) 1979-12-05

Family

ID=14856057

Family Applications (1)

Application Number Title Priority Date Filing Date
GB39798/76A Expired GB1557271A (en) 1975-10-15 1976-09-24 Benzodiazepine derivatives

Country Status (12)

Country Link
JP (1) JPS5247992A (en)
AT (2) AT349630B (en)
AU (1) AU505643B2 (en)
BE (1) BE847372A (en)
CA (1) CA1056748A (en)
CH (1) CH629253A5 (en)
DE (1) DE2645528C3 (en)
ES (1) ES452443A1 (en)
FR (1) FR2351659A1 (en)
GB (1) GB1557271A (en)
NL (1) NL175198C (en)
SE (1) SE432443B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4464467A (en) * 1982-07-26 1984-08-07 Bristol-Myers Company Antitumor antibiotics produced by new streptomyces
FR2586683B1 (en) * 1985-08-29 1988-07-01 Centre Nat Rech Scient NOVEL NEOTHRAMYCIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS

Also Published As

Publication number Publication date
AT358172B (en) 1980-08-25
NL175198C (en) 1984-10-01
DE2645528C3 (en) 1980-02-28
BE847372A (en) 1977-01-31
FR2351659A1 (en) 1977-12-16
DE2645528B2 (en) 1979-06-28
AU505643B2 (en) 1979-11-29
SE7611320L (en) 1977-04-16
SE432443B (en) 1984-04-02
CH629253A5 (en) 1982-04-15
FR2351659B1 (en) 1979-07-06
ATA527178A (en) 1980-01-15
JPS5444759B2 (en) 1979-12-27
DE2645528A1 (en) 1977-04-21
CA1056748A (en) 1979-06-19
JPS5247992A (en) 1977-04-16
AU1811676A (en) 1978-04-06
NL7611211A (en) 1977-04-19
ES452443A1 (en) 1977-11-01
AT349630B (en) 1979-04-10
ATA764076A (en) 1978-09-15
NL175198B (en) 1984-05-01

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19930924