SE7611320L - TWO NEW ANTIBIOTICS WHICH ONE AND ONE SHOW A HIGH INHIBITING EFFECT ON THE GROWTH OF LEUKEMICELLS - Google Patents

TWO NEW ANTIBIOTICS WHICH ONE AND ONE SHOW A HIGH INHIBITING EFFECT ON THE GROWTH OF LEUKEMICELLS

Info

Publication number
SE7611320L
SE7611320L SE7611320A SE7611320A SE7611320L SE 7611320 L SE7611320 L SE 7611320L SE 7611320 A SE7611320 A SE 7611320A SE 7611320 A SE7611320 A SE 7611320A SE 7611320 L SE7611320 L SE 7611320L
Authority
SE
Sweden
Prior art keywords
leukemicells
growth
show
inhibiting effect
neothramycin
Prior art date
Application number
SE7611320A
Other languages
Swedish (sv)
Other versions
SE432443B (en
Inventor
H Umezawa
T Takeuchi
M Hamada
S Kondo
M Ishizuka
H Naganawa
Original Assignee
Microbial Chem Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chem Res Found filed Critical Microbial Chem Res Found
Publication of SE7611320L publication Critical patent/SE7611320L/en
Publication of SE432443B publication Critical patent/SE432443B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
    • C07G11/00—Antibiotics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Neothramycin A and neothramycin B are obtained by culturing a neothramycin-producing strain of the genus Streptomyces under aerobic conditions in a medium containing assimilable carbon and sources of nitrogen. The resulting mixture can be fractionated. Treatment of each of the two neothramycins with methanol yields a mixture of methylneothramycin A and methylneothramycin B, which can again be fractionated. All the four compounds are valuable pharmaceuticals for use against leukaemia.
SE7611320A 1975-10-15 1976-10-12 PROCEDURE FOR THE PREPARATION OF NEW ANTIBIOTICS NAMED NEOTRAMYCIN A AND B BY CULTIVATION OF A STREPTOMYCES STAND IDENTIFIED AS ATCC 31123 SE432443B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP50123256A JPS5247992A (en) 1975-10-15 1975-10-15 Method of manufacturing new antibiotics, neothramycin a and b

Publications (2)

Publication Number Publication Date
SE7611320L true SE7611320L (en) 1977-04-16
SE432443B SE432443B (en) 1984-04-02

Family

ID=14856057

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7611320A SE432443B (en) 1975-10-15 1976-10-12 PROCEDURE FOR THE PREPARATION OF NEW ANTIBIOTICS NAMED NEOTRAMYCIN A AND B BY CULTIVATION OF A STREPTOMYCES STAND IDENTIFIED AS ATCC 31123

Country Status (12)

Country Link
JP (1) JPS5247992A (en)
AT (2) AT349630B (en)
AU (1) AU505643B2 (en)
BE (1) BE847372A (en)
CA (1) CA1056748A (en)
CH (1) CH629253A5 (en)
DE (1) DE2645528C3 (en)
ES (1) ES452443A1 (en)
FR (1) FR2351659A1 (en)
GB (1) GB1557271A (en)
NL (1) NL175198C (en)
SE (1) SE432443B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4464467A (en) * 1982-07-26 1984-08-07 Bristol-Myers Company Antitumor antibiotics produced by new streptomyces
FR2586683B1 (en) * 1985-08-29 1988-07-01 Centre Nat Rech Scient NOVEL NEOTHRAMYCIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS

Also Published As

Publication number Publication date
SE432443B (en) 1984-04-02
FR2351659A1 (en) 1977-12-16
DE2645528C3 (en) 1980-02-28
DE2645528A1 (en) 1977-04-21
DE2645528B2 (en) 1979-06-28
NL175198C (en) 1984-10-01
NL175198B (en) 1984-05-01
AT358172B (en) 1980-08-25
CA1056748A (en) 1979-06-19
ES452443A1 (en) 1977-11-01
AU505643B2 (en) 1979-11-29
FR2351659B1 (en) 1979-07-06
NL7611211A (en) 1977-04-19
JPS5444759B2 (en) 1979-12-27
GB1557271A (en) 1979-12-05
JPS5247992A (en) 1977-04-16
ATA764076A (en) 1978-09-15
ATA527178A (en) 1980-01-15
AT349630B (en) 1979-04-10
AU1811676A (en) 1978-04-06
BE847372A (en) 1977-01-31
CH629253A5 (en) 1982-04-15

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