BE797862A - Pepsinostreptin and pepsinostreptin-p and their methyl - esters - protease inhibitors used to treat ulcers, hyperpepsia, hyper - Google Patents

Pepsinostreptin and pepsinostreptin-p and their methyl - esters - protease inhibitors used to treat ulcers, hyperpepsia, hyper

Info

Publication number
BE797862A
BE797862A BE129716A BE129716A BE797862A BE 797862 A BE797862 A BE 797862A BE 129716 A BE129716 A BE 129716A BE 129716 A BE129716 A BE 129716A BE 797862 A BE797862 A BE 797862A
Authority
BE
Belgium
Prior art keywords
pepsinostreptin
methyl
hyperpepsia
hyper
esters
Prior art date
Application number
BE129716A
Other languages
French (fr)
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of BE797862A publication Critical patent/BE797862A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8142—Aspartate protease (E.C. 3.4.23) inhibitors, e.g. HIV protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • AIDS & HIV (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Novel title cpds of formula (where R1 = ethyl or isopropyl and R2 = H or methyl) are prepd. by aerobic cultivation of Streptomyces e.g. strains ramulosus, citricolor and catenulae.
BE129716A 1972-07-07 1973-04-06 Pepsinostreptin and pepsinostreptin-p and their methyl - esters - protease inhibitors used to treat ulcers, hyperpepsia, hyper BE797862A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6841572A JPS557236B2 (en) 1972-07-07 1972-07-07

Publications (1)

Publication Number Publication Date
BE797862A true BE797862A (en) 1973-07-31

Family

ID=13373007

Family Applications (1)

Application Number Title Priority Date Filing Date
BE129716A BE797862A (en) 1972-07-07 1973-04-06 Pepsinostreptin and pepsinostreptin-p and their methyl - esters - protease inhibitors used to treat ulcers, hyperpepsia, hyper

Country Status (2)

Country Link
JP (1) JPS557236B2 (en)
BE (1) BE797862A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5013586A (en) * 1973-06-11 1975-02-13
JPS5625315B2 (en) * 1973-11-15 1981-06-11

Also Published As

Publication number Publication date
JPS4926485A (en) 1974-03-08
JPS557236B2 (en) 1980-02-23

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: TAKEDA CHEMICAL INDUSTRIES LTD

Effective date: 19890430