CH620912A5 - - Google Patents

Download PDF

Info

Publication number
CH620912A5
CH620912A5 CH520277A CH520277A CH620912A5 CH 620912 A5 CH620912 A5 CH 620912A5 CH 520277 A CH520277 A CH 520277A CH 520277 A CH520277 A CH 520277A CH 620912 A5 CH620912 A5 CH 620912A5
Authority
CH
Switzerland
Prior art keywords
mice
acetic acid
dose
products
animals
Prior art date
Application number
CH520277A
Other languages
English (en)
French (fr)
Inventor
Henri Demarne
Andre Hallot
Original Assignee
Clin Midy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clin Midy filed Critical Clin Midy
Publication of CH620912A5 publication Critical patent/CH620912A5/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CH520277A 1976-05-05 1977-04-27 CH620912A5 (xx)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB18492/76A GB1538164A (en) 1976-05-05 1976-05-05 Benzodiazepine derivatives

Publications (1)

Publication Number Publication Date
CH620912A5 true CH620912A5 (xx) 1980-12-31

Family

ID=10113358

Family Applications (2)

Application Number Title Priority Date Filing Date
CH520277A CH620912A5 (xx) 1976-05-05 1977-04-27
CH520377A CH620686A5 (xx) 1976-05-05 1977-04-27

Family Applications After (1)

Application Number Title Priority Date Filing Date
CH520377A CH620686A5 (xx) 1976-05-05 1977-04-27

Country Status (31)

Country Link
US (2) US4235897A (xx)
JP (3) JPS52156883A (xx)
AR (1) AR219924A1 (xx)
AT (1) AT356655B (xx)
AU (1) AU509147B2 (xx)
BE (1) BE854249A (xx)
CA (1) CA1083146A (xx)
CH (2) CH620912A5 (xx)
CS (3) CS207398B2 (xx)
DD (1) DD129446A5 (xx)
DE (2) DE2719608A1 (xx)
DK (2) DK195077A (xx)
EG (1) EG12724A (xx)
ES (1) ES458481A1 (xx)
FI (1) FI771413A (xx)
FR (2) FR2350345A1 (xx)
GB (1) GB1538164A (xx)
GR (1) GR63203B (xx)
HU (1) HU177573B (xx)
IE (1) IE44830B1 (xx)
IL (2) IL51998A (xx)
MX (1) MX4720E (xx)
NL (2) NL7704911A (xx)
NO (2) NO771560L (xx)
NZ (1) NZ184012A (xx)
PH (1) PH12641A (xx)
PT (1) PT66500B (xx)
SE (2) SE431543B (xx)
SU (1) SU888820A3 (xx)
YU (1) YU41818B (xx)
ZA (1) ZA772628B (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2900017A1 (de) * 1978-01-10 1979-07-12 Clin Midy 3-alkoxycarbonyl-benzodiazepin- derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
FR2460938A1 (fr) * 1979-07-12 1981-01-30 Cm Ind Procede d'obtention de benzodiazepines-1,4
DE3021107A1 (de) * 1980-06-04 1981-12-17 Hoechst Ag, 6000 Frankfurt Carbamoyloxyamino-1,4-benzodiazepine, verfahren zu irer herstellung und diese enthaltende arzneimittel
JPS6038380A (ja) * 1983-08-11 1985-02-27 Shionogi & Co Ltd １−ピペリジニル−１，４−ベンゾジアゼピン類の改良合成法
JPH04200396A (ja) * 1990-11-30 1992-07-21 Sanwa Kagaku Kenkyusho Co Ltd 過酸化水素の酵素学的高感度測定法及びそのための試薬
AU678503B2 (en) * 1993-09-24 1997-05-29 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds and their use as squalene synthetase inhibitors
KR100668045B1 (ko) * 2005-08-17 2007-01-16 한국과학기술연구원 ω-[2-(폴리알킬렌옥시)에틸티오]알킬알콕시실레인유도체와 이의 제조방법

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US28315A (en) * 1860-05-15 Improvement in method of decomposing fats into fatty acids and glycerine
US3136815A (en) * 1959-12-10 1964-06-09 Hoffmann La Roche Amino substituted benzophenone oximes and derivatives thereof
US3236838A (en) * 1964-06-09 1966-02-22 Hoffmann La Roche Certain 1-substituted-benzodiazepin-2-one compounds
FR1497456A (fr) * 1964-06-15 1967-10-13 Clin Byla Ets Ortho-amino aryl cétimines, composés hétérocycliques qui s'y rattachent et prépaation de ces divers corps
USRE28315E (en) 1964-06-15 1975-01-21 Cooc.hi
US3812103A (en) * 1967-04-11 1974-05-21 Hoffmann La Roche 2,3-dihydro-1,4-benzodiazepines
CH498846A (de) * 1967-08-09 1970-11-15 Hoffmann La Roche Verfahren zur Herstellung von Benzodiazepin-Derivaten
CH500997A (de) * 1967-08-09 1970-12-31 Hoffmann La Roche Verfahren zur Herstellung von Benzodiazepin-Derivaten
US3657223A (en) * 1969-01-17 1972-04-18 Hoffmann La Roche Process for the preparation of benzodiazepin-2-one derivatives
DE2008612A1 (de) * 1969-03-13 1970-10-01 F. Hoffmann-La Roche & Co Ag, Basel (Schweiz) Benzodiazepin-Derivate
US3718646A (en) * 1970-10-05 1973-02-27 Upjohn Co N-lower alkenyl-2,3-dihydro-2-oxo-5-phenyl-1h-1,4-benzodiazepine-1-carboxamides
IT1044223B (it) * 1972-08-09 1980-03-20 Zambeletti Spa L I propargil 1 4 benzodiazepine

Also Published As

Publication number Publication date
PT66500A (fr) 1977-06-01
SE7705183L (sv) 1977-11-06
SE431543B (sv) 1984-02-13
NO149208C (no) 1984-03-07
JPS6137249B2 (xx) 1986-08-22
YU113977A (en) 1982-08-31
AU2481377A (en) 1978-11-09
NL7704912A (nl) 1977-11-08
FR2350345A1 (fr) 1977-12-02
FR2350346A1 (fr) 1977-12-02
DE2719607A1 (de) 1977-11-17
CS207399B2 (en) 1981-07-31
ES458481A1 (es) 1978-04-01
IL51998A0 (en) 1977-07-31
NO771560L (no) 1977-11-08
CH620686A5 (xx) 1980-12-15
SU888820A3 (ru) 1981-12-07
JPS52156883A (en) 1977-12-27
NZ184012A (en) 1981-11-19
CS207398B2 (en) 1981-07-31
DK195177A (da) 1977-11-06
DE2719608A1 (de) 1977-11-24
PT66500B (fr) 1978-10-13
SE7705182L (sv) 1977-11-06
HU177573B (en) 1981-11-28
AU509147B2 (en) 1980-04-24
NL7704911A (nl) 1977-11-08
SE432099B (sv) 1984-03-19
FR2350345B1 (xx) 1980-07-18
AR219924A1 (es) 1980-09-30
ZA772628B (en) 1978-03-29
FI771413A (xx) 1977-11-06
MX4720E (es) 1982-08-13
GB1538164A (en) 1979-01-10
PH12641A (en) 1979-07-11
CS207400B2 (en) 1981-07-31
JPS52156882A (en) 1977-12-27
YU41818B (en) 1988-02-29
NO813180L (no) 1977-11-08
DD129446A5 (de) 1978-01-18
ATA320177A (de) 1979-10-15
AT356655B (de) 1980-05-12
IL58648A0 (en) 1980-02-29
EG12724A (en) 1979-12-31
CA1083146A (en) 1980-08-05
IL51998A (en) 1981-05-20
DE2719607C2 (xx) 1987-07-16
GR63203B (en) 1979-10-08
IE44830L (en) 1977-11-05
US4235897A (en) 1980-11-25
US4587245A (en) 1986-05-06
BE854249A (fr) 1977-11-04
NO149208B (no) 1983-11-28
JPS5781472A (en) 1982-05-21
FR2350346B1 (xx) 1980-11-21
IE44830B1 (en) 1982-04-07
JPS5711317B2 (xx) 1982-03-03
DK195077A (da) 1977-11-06

Similar Documents

Publication Publication Date Title
EP0059391B1 (de) Imidazodiazepine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
EP0340064B1 (fr) Benzodiazépines, leur procédé et intermédiaires de préparation et leurs applications en thérapeutique
EP0497659A1 (fr) Dérivés d'aryl (ou hétéroaryl)-piperaz inyl-alkyl-azoles, leur préparation et leur application en tant que médicaments
FR2612187A1 (fr) Derives du thiazole actifs sur le systeme cholinergique, leur procede de preparation et compositions pharmaceutiques en contenant
EP0094271A2 (fr) Nouveaux dérivés d'arène et d'hétéroarènecarboxamides, leur procédé de préparation et médicaments les contenant
FR2515179A1 (fr) Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique
EP0343050B1 (fr) Dérivés de phényl-6 pipérazinyl-alkyl-3 1H,3H-pyrimidinedione-2,4, leur préparation et leur application en thérapeutique
FR2511366A1 (fr) Nouveaux derives de la pyridazine, leur procede de preparation et les medicaments, actifs sur le systeme nerveux central, qui en contiennent
CH620912A5 (xx)
EP0248735A1 (fr) Nouvelles 2-thiazolyl imidazo /1,2-a/ pyrimidines et leurs sels, leur procédé de préparation, leur application à titre de médicaments et les compositions les renformant
EP0346207B1 (fr) Dérivés d'amino-4 carboxy-3 naphtyridines, leur préparation et compositions pharmaceutiques qui les contiennent
EP0239436B1 (fr) Nouveau dérivé tricyclique dénommé acide (chloro-3 méthyl-6 dioxo-5,5 dihydro-6, 11 dibenzo (c,f) thiazépine (1,2) yl-11 amino) -5 pentanoique, son procédé de préparation et les compositions pharmaceutiques qui le contiennent
CH661046A5 (fr) Derives de benzodioxinopyrrole et procedes de preparation.
DK174686B1 (da) Antikonvulsive aminosyreforbindelsesholdige midler, anvendelse af disse forbindelser til fremstilling af antikonvulsive lægemidler samt forbindelserne selv
EP0443918A1 (fr) Nouveaux dérivés de la 20,21-dinoréburnaménine, leur procédé de préparation et les nouveaux intermédiaires ainsi obtenus, leur application comme médicaments et les compositions les renfermant
CH634311A5 (fr) Derives du benzo(d)thiazole, leur procede de preparation et leurs applications en therapeutique.
CH637644A5 (en) 3-(Alkoxycarbonyl)benzodiazepine derivatives, process for their preparation and their application in therapeutics
EP0499527B1 (fr) Composés dérivés des beta-carbolines ligands du récepteur des benzodiazépines ayant un effet agoniste inverse et antagoniste vis-à-vis des benzodiazépines et médicaments les contenant
WO1989004830A1 (fr) Nouveaux derives substitues de 20,21-dinoreburnamenine, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions pharmaceutiques les renfermant
EP0446133B1 (fr) Nouveaux dérivés de la 4H-pyrrolo[1,2-a]thieno[3,2-f][1,4]-diazépine leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
FR2609715A1 (fr) Nouveaux diazepinoindoles, leur preparation et leur utilisation comme medicaments
EP0446140A1 (fr) Nouvelles pyrrolo[1,2-a]thiéno[3,2-f]diazépines[1,4], leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
EP0072029A2 (de) Triazolobenzazepine, Verfahren und Zwischenprodukte zu deren Herstellung und diese enthaltende Arzneimittel
BE1009516A3 (fr) Derives de 1-[2-(vinyl-substitues)]-5h-2,3-benzodiazepine.
EP1224182A1 (fr) 1-(butyrolactone)-isoquinolines n-substituees pour le traitement des troubles nerveux

Legal Events

Date Code Title Description
PUE Assignment

Owner name: SANOFI S.A.

PL Patent ceased