CH457434A - Verfahren zur Herstellung des t-Butylesters von 3-indol-niederaliphatischen Säuren - Google Patents

Verfahren zur Herstellung des t-Butylesters von 3-indol-niederaliphatischen Säuren

Info

Publication number
CH457434A
CH457434A CH235868A CH235868A CH457434A CH 457434 A CH457434 A CH 457434A CH 235868 A CH235868 A CH 235868A CH 235868 A CH235868 A CH 235868A CH 457434 A CH457434 A CH 457434A
Authority
CH
Switzerland
Prior art keywords
indole
preparation
butyl ester
lower aliphatic
aliphatic acids
Prior art date
Application number
CH235868A
Other languages
German (de)
English (en)
Inventor
Gal George
Sletzinger Meyer
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of CH457434A publication Critical patent/CH457434A/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/281-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32Oxygen atoms
    • C07D209/36Oxygen atoms in position 3, e.g. adrenochrome

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CH235868A 1963-02-01 1964-01-31 Verfahren zur Herstellung des t-Butylesters von 3-indol-niederaliphatischen Säuren CH457434A (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25564263A 1963-02-01 1963-02-01

Publications (1)

Publication Number Publication Date
CH457434A true CH457434A (de) 1968-06-15

Family

ID=22969254

Family Applications (16)

Application Number Title Priority Date Filing Date
CH236068A CH457435A (de) 1963-02-01 1964-01-31 Verfahren zur Herstellung von Estern von 3-indol-aliphatischen Säuren
CH236268A CH557815A (de) 1963-02-01 1964-01-31 Verfahren zur herstellung von 3-indol-aliphatischen saeuren.
CH1674768A CH466290A (de) 1963-02-01 1964-01-31 Verfahren zur Herstellung von 1-Acyl-indolyl-aliphatischen Säuren
CH444166A CH466285A (de) 1963-02-01 1964-01-31 Verfahren zur Herstellung von 1-Acyl-3-indolyl-essigsäure oder deren Ester
CH236168A CH464202A (de) 1963-02-01 1964-01-31 Verfahren zur Herstellung von 3-Indol-niederaliphatischen Säuren
CH490268A CH466286A (de) 1963-02-01 1964-01-31 Verfahren zur Herstellung von 1-Acyl-3-Indolyl-aliphatischen Säuren
CH1674468A CH466288A (de) 1963-02-01 1964-01-31 Verfahren zur Herstellung von 3-Indolyl-niederaliphatischen Säuren
CH236368A CH457436A (de) 1963-02-01 1964-01-31 Verfahren zur Herstellung von Estern von 3-Indolyl-niederaliphatischen Säuren
CH236568A CH464203A (de) 1963-02-01 1964-01-31 Verfahren zur Herstellung von 1-Acyl-3-indolyl-aliphatischen Säuren oder deren t-Butyl-Estern
CH235868A CH457434A (de) 1963-02-01 1964-01-31 Verfahren zur Herstellung des t-Butylesters von 3-indol-niederaliphatischen Säuren
CH490368A CH466287A (de) 1963-02-01 1964-01-31 Verfahren zur Herstellung von 3-Indolyl-niederaliphatischen Säuren
CH1674568A CH466289A (de) 1963-02-01 1964-01-31 Verfahren zur Herstellung von 1-Alcyl-3-Indolyl-aliphatischen Säuren
CH419468A CH466284A (de) 1963-02-01 1964-01-31 Verfahren zur Herstellung von 3-Indolyl-niederaliphatischen Säuren
CH236668A CH457437A (de) 1963-02-01 1964-01-31 Verfahren zur Herstellung von 3-Indolyl-niederaliphatischen Säuren
CH236468A CH466283A (de) 1963-02-01 1964-01-31 Verfahren zur Herstellung von 3-Indolyl-aliphatischen Säuren
CH115364A CH489495A (de) 1963-02-01 1967-02-23 Verfahren zur Herstellung von 3-Indolyl-niederaliphatischen Säuren

Family Applications Before (9)

Application Number Title Priority Date Filing Date
CH236068A CH457435A (de) 1963-02-01 1964-01-31 Verfahren zur Herstellung von Estern von 3-indol-aliphatischen Säuren
CH236268A CH557815A (de) 1963-02-01 1964-01-31 Verfahren zur herstellung von 3-indol-aliphatischen saeuren.
CH1674768A CH466290A (de) 1963-02-01 1964-01-31 Verfahren zur Herstellung von 1-Acyl-indolyl-aliphatischen Säuren
CH444166A CH466285A (de) 1963-02-01 1964-01-31 Verfahren zur Herstellung von 1-Acyl-3-indolyl-essigsäure oder deren Ester
CH236168A CH464202A (de) 1963-02-01 1964-01-31 Verfahren zur Herstellung von 3-Indol-niederaliphatischen Säuren
CH490268A CH466286A (de) 1963-02-01 1964-01-31 Verfahren zur Herstellung von 1-Acyl-3-Indolyl-aliphatischen Säuren
CH1674468A CH466288A (de) 1963-02-01 1964-01-31 Verfahren zur Herstellung von 3-Indolyl-niederaliphatischen Säuren
CH236368A CH457436A (de) 1963-02-01 1964-01-31 Verfahren zur Herstellung von Estern von 3-Indolyl-niederaliphatischen Säuren
CH236568A CH464203A (de) 1963-02-01 1964-01-31 Verfahren zur Herstellung von 1-Acyl-3-indolyl-aliphatischen Säuren oder deren t-Butyl-Estern

Family Applications After (6)

Application Number Title Priority Date Filing Date
CH490368A CH466287A (de) 1963-02-01 1964-01-31 Verfahren zur Herstellung von 3-Indolyl-niederaliphatischen Säuren
CH1674568A CH466289A (de) 1963-02-01 1964-01-31 Verfahren zur Herstellung von 1-Alcyl-3-Indolyl-aliphatischen Säuren
CH419468A CH466284A (de) 1963-02-01 1964-01-31 Verfahren zur Herstellung von 3-Indolyl-niederaliphatischen Säuren
CH236668A CH457437A (de) 1963-02-01 1964-01-31 Verfahren zur Herstellung von 3-Indolyl-niederaliphatischen Säuren
CH236468A CH466283A (de) 1963-02-01 1964-01-31 Verfahren zur Herstellung von 3-Indolyl-aliphatischen Säuren
CH115364A CH489495A (de) 1963-02-01 1967-02-23 Verfahren zur Herstellung von 3-Indolyl-niederaliphatischen Säuren

Country Status (11)

Country Link
AT (1) AT277992B (xx)
BE (1) BE643268A (xx)
BR (1) BR6456479D0 (xx)
CH (16) CH457435A (xx)
DE (16) DE1695492A1 (xx)
DK (11) DK109334C (xx)
FI (9) FI46955C (xx)
FR (1) FR1559559A (xx)
GB (13) GB1050738A (xx)
NL (1) NL6400813A (xx)
SE (12) SE302463B (xx)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU163233B (xx) * 1970-07-31 1973-07-28
DE58902127D1 (de) * 1988-06-21 1992-10-01 Rauter Vita Zahnfabrik Dispergierte keramikmasse.
GB9518994D0 (en) * 1995-09-16 1995-11-15 Agrevo Uk Ltd Fungicides

Also Published As

Publication number Publication date
DK113501B (da) 1969-03-31
FI47099C (fi) 1973-09-10
DE1695487A1 (de) 1970-10-01
FI47101B (xx) 1973-05-31
CH466283A (de) 1968-12-15
FI47097B (xx) 1973-05-31
DK109514C (da) 1968-05-06
FI47101C (fi) 1973-09-10
DE1770134A1 (de) 1971-09-30
CH466288A (de) 1968-12-15
SE317975B (xx) 1969-12-01
FI47100C (fi) 1973-09-10
GB1050733A (xx)
DE1770116A1 (de) 1971-10-14
GB1050735A (xx)
GB1050728A (xx)
FI46955B (xx) 1973-05-02
SE302463B (xx) 1968-07-22
SE320666B (xx) 1970-02-16
GB1050740A (xx)
SE304995B (xx) 1968-10-14
DE1470059B1 (de) 1970-01-29
DK109334C (da) 1968-04-16
FI47096B (xx) 1973-05-31
FR1559559A (xx) 1969-03-14
SE302131B (xx) 1968-07-08
FI47098C (fi) 1973-09-10
CH457436A (de) 1968-06-15
CH457437A (de) 1968-06-15
DK112447B (da) 1968-12-16
DE1695488A1 (de) 1970-09-17
CH557815A (de) 1975-01-15
BR6456479D0 (pt) 1973-09-20
NL6400813A (xx) 1964-08-03
SE320069B (xx) 1970-02-02
DE1770802A1 (de) 1972-02-17
DK112239B (da) 1968-11-25
SE307948B (xx) 1969-01-27
SE320367B (xx) 1970-02-09
CH466286A (de) 1968-12-15
CH457435A (de) 1968-06-15
SE302133B (sv) 1968-07-08
FI47099B (xx) 1973-05-31
FI47100B (xx) 1973-05-31
AT277992B (de) 1970-01-12
DK112446B (da) 1968-12-16
DK112238B (da) 1968-11-25
GB1050739A (xx)
GB1050729A (xx)
GB1050731A (xx)
FI47096C (fi) 1973-09-10
CH464202A (de) 1968-10-31
CH466289A (de) 1968-12-15
CH466284A (de) 1968-12-15
DK111751B (da) 1968-10-07
DE1695490A1 (de) 1971-04-15
FI47185C (fi) 1973-10-10
DE1695493A1 (de) 1971-04-01
DK109562C (da) 1968-05-13
CH466287A (de) 1968-12-15
DK112314B (da) 1968-12-02
DE1695491A1 (de) 1971-04-15
SE307133B (xx) 1968-12-23
DE1793561A1 (de) 1972-01-20
DE1695492A1 (de) 1971-04-01
FI47097C (fi) 1973-09-10
DE1695484A1 (de) 1971-04-15
GB1050737A (xx)
GB1050734A (xx)
GB1050736A (xx)
CH464203A (de) 1968-10-31
GB1050730A (xx)
CH466285A (de) 1968-12-15
DK112313B (da) 1968-12-02
CH466290A (de) 1968-12-15
FI47185B (xx) 1973-07-02
DE1695489A1 (de) 1970-08-13
CH489495A (de) 1970-04-30
BE643268A (xx) 1964-07-31
GB1050738A (xx)
DE1695485A1 (de) 1971-04-15
SE302130B (sv) 1968-07-08
FI46955C (fi) 1973-08-10
DE1695486A1 (de) 1971-04-15
DE1770132A1 (de) 1971-09-30
FI47098B (xx) 1973-05-31
GB1050732A (xx)
SE302132B (sv) 1968-07-08

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