CH478796A - Verfahren zur Herstellung von 1-acylierten 3-Indol-aliphatischen Säuren - Google Patents

Verfahren zur Herstellung von 1-acylierten 3-Indol-aliphatischen Säuren

Info

Publication number
CH478796A
CH478796A CH236768A CH236768A CH478796A CH 478796 A CH478796 A CH 478796A CH 236768 A CH236768 A CH 236768A CH 236768 A CH236768 A CH 236768A CH 478796 A CH478796 A CH 478796A
Authority
CH
Switzerland
Prior art keywords
acylated
indole
preparation
aliphatic acids
aliphatic
Prior art date
Application number
CH236768A
Other languages
English (en)
Inventor
Gal George
Sletzinger Meyer
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Priority claimed from CH115364A external-priority patent/CH489495A/de
Publication of CH478796A publication Critical patent/CH478796A/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/281-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32Oxygen atoms
    • C07D209/36Oxygen atoms in position 3, e.g. adrenochrome

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
CH236768A 1963-02-01 1964-01-31 Verfahren zur Herstellung von 1-acylierten 3-Indol-aliphatischen Säuren CH478796A (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25564263A 1963-02-01 1963-02-01
CH115364A CH489495A (de) 1963-02-01 1967-02-23 Verfahren zur Herstellung von 3-Indolyl-niederaliphatischen Säuren

Publications (1)

Publication Number Publication Date
CH478796A true CH478796A (de) 1969-09-30

Family

ID=25686821

Family Applications (3)

Application Number Title Priority Date Filing Date
CH1674668A CH474510A (de) 1963-02-01 1964-01-31 Verfahren zur Herstellung von 1-Acyl-3-indolyl-aliphatischen Säuren
CH235968A CH478795A (de) 1963-02-01 1964-01-31 Verfahren zur Herstellung von a-(3-Indolyl)-niederaliphatischen Säuren oder Estern
CH236768A CH478796A (de) 1963-02-01 1964-01-31 Verfahren zur Herstellung von 1-acylierten 3-Indol-aliphatischen Säuren

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CH1674668A CH474510A (de) 1963-02-01 1964-01-31 Verfahren zur Herstellung von 1-Acyl-3-indolyl-aliphatischen Säuren
CH235968A CH478795A (de) 1963-02-01 1964-01-31 Verfahren zur Herstellung von a-(3-Indolyl)-niederaliphatischen Säuren oder Estern

Country Status (1)

Country Link
CH (3) CH474510A (de)

Also Published As

Publication number Publication date
CH478795A (de) 1969-09-30
CH474510A (de) 1969-06-30

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Legal Events

Date Code Title Description
PL Patent ceased