CA3174215A1 - Coronavirus vaccine - Google Patents
Coronavirus vaccine Download PDFInfo
- Publication number
- CA3174215A1 CA3174215A1 CA3174215A CA3174215A CA3174215A1 CA 3174215 A1 CA3174215 A1 CA 3174215A1 CA 3174215 A CA3174215 A CA 3174215A CA 3174215 A CA3174215 A CA 3174215A CA 3174215 A1 CA3174215 A1 CA 3174215A1
- Authority
- CA
- Canada
- Prior art keywords
- sars
- cov
- seq
- protein
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
- A61K48/0033—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being non-polymeric
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/335—Modified T or U
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/18011—Comoviridae
- C12N2770/18022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/18011—Comoviridae
- C12N2770/18034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/18011—Comoviridae
- C12N2770/18071—Demonstrated in vivo effect
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nanotechnology (AREA)
- Mycology (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Optics & Photonics (AREA)
- Dispersion Chemistry (AREA)
- Pulmonology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medical Informatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
Applications Claiming Priority (47)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EPPCT/EP2020/061239 | 2020-04-22 | ||
| EP2020061239 | 2020-04-22 | ||
| EP2020066968 | 2020-06-18 | ||
| EPPCT/EP2020/066968 | 2020-06-18 | ||
| EPPCT/EP2020/068174 | 2020-06-26 | ||
| EP2020068174 | 2020-06-26 | ||
| EPPCT/EP2020/069805 | 2020-07-13 | ||
| EP2020069805 | 2020-07-13 | ||
| EP2020071733 | 2020-07-31 | ||
| EPPCT/EP2020/071733 | 2020-07-31 | ||
| EP2020071839 | 2020-08-03 | ||
| EPPCT/EP2020/071839 | 2020-08-03 | ||
| EP2020073668 | 2020-08-24 | ||
| EPPCT/EP2020/073668 | 2020-08-24 | ||
| EP2020081544 | 2020-11-09 | ||
| EPPCT/EP2020/081544 | 2020-11-09 | ||
| EP2020081981 | 2020-11-12 | ||
| EPPCT/EP2020/081981 | 2020-11-12 | ||
| EP2020082601 | 2020-11-18 | ||
| EPPCT/EP2020/082601 | 2020-11-18 | ||
| EPPCT/EP2020/082989 | 2020-11-20 | ||
| EP2020082989 | 2020-11-20 | ||
| EPPCT/EP2020/083435 | 2020-11-25 | ||
| EP2020083435 | 2020-11-25 | ||
| EPPCT/EP2020/084342 | 2020-12-02 | ||
| EP2020084342 | 2020-12-02 | ||
| EP2020085145 | 2020-12-08 | ||
| EPPCT/EP2020/085145 | 2020-12-08 | ||
| EPPCT/EP2020/085653 | 2020-12-10 | ||
| EP2020085653 | 2020-12-10 | ||
| EP2020087844 | 2020-12-23 | ||
| EPPCT/EP2020/087844 | 2020-12-23 | ||
| EP2021050027 | 2021-01-04 | ||
| EPPCT/EP2021/050027 | 2021-01-04 | ||
| EPPCT/EP2021/050875 | 2021-01-15 | ||
| EP2021050874 | 2021-01-15 | ||
| EP2021050875 | 2021-01-15 | ||
| EPPCT/EP2021/050874 | 2021-01-15 | ||
| EPPCT/EP2021/051772 | 2021-01-26 | ||
| EP2021051772 | 2021-01-26 | ||
| EP2021052572 | 2021-02-03 | ||
| EPPCT/EP2021/052572 | 2021-02-03 | ||
| EP2021052716 | 2021-02-04 | ||
| EPPCT/EP2021/052716 | 2021-02-04 | ||
| EPPCT/EP2021/054622 | 2021-02-24 | ||
| EP2021054622 | 2021-02-24 | ||
| PCT/EP2021/059947 WO2021213924A1 (en) | 2020-04-22 | 2021-04-16 | Coronavirus vaccine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3174215A1 true CA3174215A1 (en) | 2021-10-28 |
Family
ID=75438688
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3174215A Pending CA3174215A1 (en) | 2020-04-22 | 2021-04-16 | Coronavirus vaccine |
| CA3173922A Pending CA3173922A1 (en) | 2020-04-22 | 2021-04-22 | Rna constructs and uses thereof |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3173922A Pending CA3173922A1 (en) | 2020-04-22 | 2021-04-22 | Rna constructs and uses thereof |
Country Status (14)
| Country | Link |
|---|---|
| US (8) | US11547673B1 (enExample) |
| EP (6) | EP3901260A1 (enExample) |
| JP (5) | JP7514206B2 (enExample) |
| KR (2) | KR102813425B1 (enExample) |
| CN (7) | CN118490818A (enExample) |
| AU (3) | AU2021261471B2 (enExample) |
| BR (1) | BR112022019781A2 (enExample) |
| CA (2) | CA3174215A1 (enExample) |
| GB (3) | GB2594365B (enExample) |
| IL (5) | IL297419B2 (enExample) |
| MX (4) | MX2022013254A (enExample) |
| TW (2) | TWI860474B (enExample) |
| WO (2) | WO2021213924A1 (enExample) |
| ZA (2) | ZA202210526B (enExample) |
Families Citing this family (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005046490A1 (de) | 2005-09-28 | 2007-03-29 | Johannes-Gutenberg-Universität Mainz | Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen |
| WO2016005004A1 (en) | 2014-07-11 | 2016-01-14 | Biontech Rna Pharmaceuticals Gmbh | Stabilization of poly(a) sequence encoding dna sequences |
| DK4276189T3 (da) | 2015-09-21 | 2026-05-26 | Trilink Biotechnologies Llc | Initierende oligonukleotidprimere med kappe til syntesering af 5'-ende RNA'er med kappe |
| US20180128545A1 (en) | 2016-11-08 | 2018-05-10 | Berry Metal Company | Modular furnace cooling wall |
| DK3864163T3 (da) | 2018-10-09 | 2024-05-06 | Univ British Columbia | Sammensætninger og systemer omfattende transfektionskompetente vesikler fri for organiske opløsningsmidler og rengøringsmidler og fremgangsmåder forbundet dermed |
| CA3131096A1 (en) | 2019-04-05 | 2020-10-08 | Chi-Huey Wong | Sialidase-resistant saccharide and method of making and using the same |
| US12194089B2 (en) | 2020-02-04 | 2025-01-14 | CureVac SE | Coronavirus vaccine |
| CN113527510A (zh) * | 2020-04-22 | 2021-10-22 | 上海交通大学 | 融合蛋白分子及其制备方法和用途 |
| CN118490818A (zh) | 2020-04-22 | 2024-08-16 | 生物技术欧洲股份公司 | 冠状病毒疫苗 |
| WO2025056938A1 (en) | 2023-09-11 | 2025-03-20 | BioNTech SE | Rna compositions for delivery of incretin agents |
| CN112029781B (zh) * | 2020-08-14 | 2023-01-03 | 中山大学 | 一种新型冠状病毒SARS-CoV-2的安全型复制子系统及其应用 |
| GB202017649D0 (en) * | 2020-11-09 | 2020-12-23 | Autolus Ltd | Polypeptide |
| JP7895943B2 (ja) * | 2020-11-12 | 2026-07-28 | ティースキャン セラピューティクス インコーポレイテッド | Sars-cov-2免疫優性ペプチドの構築物及びその使用 |
| CN117098541A (zh) | 2020-11-25 | 2023-11-21 | 阿卡格拉医药公司 | 用于递送核酸的脂质纳米粒及相关使用方法 |
| MX2023007574A (es) | 2020-12-22 | 2023-09-29 | CureVac SE | "vacuna de arn contra variantes de sars-cov-2. |
| EP4274592A4 (en) * | 2021-01-11 | 2025-03-19 | The Trustees of The University of Pennsylvania | COMPOSITIONS FOR THE TREATMENT OF FRIEDREICH'S ATAXIA |
| CA3170747A1 (en) * | 2021-01-27 | 2022-08-04 | Moritz THRAN | Method of reducing the immunostimulatory properties of in vitro transcribed rna |
| EP4319803B1 (en) | 2021-04-08 | 2025-11-26 | Vaxthera SAS | Coronavirus vaccine comprising a mosaic protein |
| WO2022235847A1 (en) | 2021-05-04 | 2022-11-10 | BioNTech SE | Technologies for early detection of variants of interest |
| AU2021470029A1 (en) * | 2021-10-21 | 2024-05-02 | BioNTech SE | Coronavirus vaccine |
| US12186387B2 (en) | 2021-11-29 | 2025-01-07 | BioNTech SE | Coronavirus vaccine |
| CN116200403A (zh) * | 2021-11-30 | 2023-06-02 | 石药集团巨石生物制药有限公司 | 预防突变株的新型冠状病毒mRNA疫苗 |
| WO2023110422A1 (en) | 2021-12-16 | 2023-06-22 | Stefan Grabuschnig | Vaccine preparation |
| KR20230095025A (ko) * | 2021-12-20 | 2023-06-28 | 아이진 주식회사 | 변이 SARS-CoV-2 백신 조성물 및 이의 용도 |
| CN114031675B (zh) * | 2022-01-10 | 2022-06-07 | 广州市锐博生物科技有限公司 | 基于SARS-CoV-2的S蛋白的疫苗和组合物 |
| TW202334412A (zh) * | 2022-01-11 | 2023-09-01 | 北京大學 | 針對 sars-cov-2 變體的環狀 rna 疫苗及其使用方法 |
| JP2025507234A (ja) * | 2022-02-07 | 2025-03-18 | セキラス・インコーポレイテッド | 自己複製rna及びその使用配列表 本出願は、電子形態の配列表とともに出願される。配列表の全内容は、参照によって本明細書に組み込まれる。 |
| TW202345863A (zh) * | 2022-02-09 | 2023-12-01 | 美商現代公司 | 黏膜投與方法及調配物 |
| EP4476546A1 (en) * | 2022-02-11 | 2024-12-18 | Attana AB | Analytical method |
| CN116768987A (zh) * | 2022-03-09 | 2023-09-19 | 中生复诺健生物科技(上海)有限公司 | 编码新型冠状病毒S蛋白的mRNA疫苗 |
| US20250127882A1 (en) * | 2022-03-11 | 2025-04-24 | Chiou-Hwa YUH | Nucleic acid-lipid nanoparticle and method using the same |
| CA3253732A1 (en) * | 2022-03-22 | 2023-09-28 | Osivax | mRNA VACCINE COMPOSITIONS AND THEIR USE |
| WO2023202711A1 (zh) * | 2022-04-22 | 2023-10-26 | 仁景(苏州)生物科技有限公司 | 一种基于新型冠状病毒的mRNA疫苗 |
| US20250288659A1 (en) | 2022-04-27 | 2025-09-18 | Shanghai Regenelead Therapies Co., Ltd. | Nucleic acid construct and use thereof |
| EP4522754A1 (en) * | 2022-05-12 | 2025-03-19 | Sunvax MRNA Therapeutics Inc. | Synthetic self-amplifying mrna molecules with secretion antigen and immunomodulator |
| CN114989308B (zh) * | 2022-05-12 | 2023-04-04 | 中国科学院微生物研究所 | 新冠病毒嵌合核酸疫苗及其用途 |
| AU2023268051A1 (en) | 2022-05-13 | 2025-01-02 | BioNTech SE | Rna compositions targeting hiv |
| WO2023220842A1 (en) * | 2022-05-19 | 2023-11-23 | Shenzhen Genius Biotech Service Co.,Ltd. | A fusion protein as a subunit vaccine immunogen against sars-cov-2 and the preparation thereof |
| WO2023228116A1 (en) * | 2022-05-24 | 2023-11-30 | Access To Advanced Health Institute | Intranasal administration of thermostable rna vaccines |
| WO2023230587A2 (en) | 2022-05-25 | 2023-11-30 | Akagera Medicines, Inc. | Lipid nanoparticles for delivery of nucleic acids and methods of use thereof |
| US11654121B1 (en) | 2022-06-22 | 2023-05-23 | Flagship Pioneering Innovations Vi, Llc | Combination therapies for the treatment of viral infections |
| US20250375464A1 (en) * | 2022-06-22 | 2025-12-11 | Flagship Pioneering Innovations V, Inc. | Formulations for modulating myc expression |
| WO2023250111A1 (en) | 2022-06-22 | 2023-12-28 | Flagship Pioneering Innovations Vi, Llc | Combination therapies for the treatment of viral infections |
| CN114934056B (zh) * | 2022-06-24 | 2023-10-20 | 仁景(苏州)生物科技有限公司 | 一种基于新型冠状病毒奥密克戎突变株的mRNA疫苗 |
| US11878055B1 (en) | 2022-06-26 | 2024-01-23 | BioNTech SE | Coronavirus vaccine |
| KR102918706B1 (ko) * | 2022-07-14 | 2026-01-29 | 엠큐렉스 주식회사 | mRNA 백신 및 치료제의 제조를 위한 변형된 RNA |
| WO2024014770A1 (ko) * | 2022-07-14 | 2024-01-18 | 엠큐렉스 주식회사 | mRNA 백신 및 치료제의 제조를 위한 변형된 RNA |
| CN117414418A (zh) * | 2022-07-19 | 2024-01-19 | 深圳深信生物科技有限公司 | 一种新型冠状病毒变异株的mRNA疫苗及其应用 |
| AU2023310896A1 (en) * | 2022-07-19 | 2025-01-30 | Shenzhen Shenxin Biotechnology Co., Ltd. | Mrna for sars-cov-2 s protein and use thereof |
| WO2024026287A2 (en) * | 2022-07-25 | 2024-02-01 | University Of Utah Research Foundation | Synthesis of substoichiometric chemically modified mrnas by in vitro transcription |
| CN115716866A (zh) * | 2022-09-30 | 2023-02-28 | 珠海丽凡达生物技术有限公司 | 新型冠状病毒疫苗及其制备方法和应用 |
| WO2024057237A1 (en) | 2022-09-16 | 2024-03-21 | Pfizer Inc. | Lipid nanoparticles |
| IL319652A (en) | 2022-10-04 | 2025-05-01 | BioNTech SE | RNA structures and their uses |
| CN120129702A (zh) | 2022-10-06 | 2025-06-10 | 生物技术公司 | 靶向密蛋白-18.2的rna组合物 |
| EP4604995A1 (en) | 2022-10-17 | 2025-08-27 | BioNTech SE | Combination vaccines against coronavirus infection, influenza infection, and/or rsv infection |
| CN115869332A (zh) * | 2022-10-27 | 2023-03-31 | 北京新合睿恩生物医疗科技有限公司 | 递送至体内后在肝脏少表达的mRNA药物及其制备方法 |
| WO2024089638A1 (en) | 2022-10-28 | 2024-05-02 | Glaxosmithkline Biologicals Sa | Nucleic acid based vaccine |
| CN118045169A (zh) * | 2022-11-10 | 2024-05-17 | 中国科学院化学研究所 | 脂质-带电分子偶联物、可吸入式脂质纳米颗粒及其制备方法和应用 |
| JP2025537033A (ja) | 2022-11-24 | 2025-11-12 | スージョウ・アボジェン・バイオサイエンシズ・カンパニー・リミテッド | タンパク質発現量を増加させるutr分子 |
| US20260209719A1 (en) * | 2022-12-16 | 2026-07-23 | Shenzhen Shenxin Biotechnology Co., Ltd. | Utr for improving translation efficiency and/or stability of rna molecule and use thereof |
| CN121127490A (zh) | 2022-12-28 | 2025-12-12 | 生物技术欧洲股份公司 | 靶向hiv的rna组合物 |
| WO2024151687A1 (en) | 2023-01-09 | 2024-07-18 | Flagship Pioneering Innovations V, Inc. | Genetic switches and their use in treating cancer |
| WO2024153324A1 (en) | 2023-01-18 | 2024-07-25 | BioNTech SE | Rna formulations for pharmaceutical use |
| JP2026510608A (ja) | 2023-02-14 | 2026-04-08 | ラーディオファックス ゲーエムベーハー | 薬物及び処置の方法 |
| CN116410992A (zh) * | 2023-03-10 | 2023-07-11 | 北京新合睿恩生物医疗科技有限公司 | 预防和/或治疗新型冠状病毒的mRNA、疫苗及其制备方法和应用 |
| CN115998714B (zh) * | 2023-03-20 | 2023-06-30 | 威瑞生物科技(昆明)有限责任公司 | 一种脂质纳米颗粒、递送系统及递送系统的制备方法 |
| WO2024197098A2 (en) * | 2023-03-20 | 2024-09-26 | Cartesian Therapeutics, Inc. | Local conditioning of lymph nodes with diffusion-limited particles for in vivo car therapy |
| CA3268566A1 (en) | 2023-04-08 | 2024-10-17 | Rock Biomedical Inc. | METHODS AND COMPOSITIONS FOR TARGETED DISTRIBUTION BY POLYMERSOMES |
| NZ825394A (en) | 2023-04-08 | 2026-03-27 | Rock Biomedical Inc | Methods and compositions for dendritic cell targeting nano-delivery |
| WO2024216212A1 (en) * | 2023-04-14 | 2024-10-17 | BioNTech SE | Rna for preventing or treating tuberculosis |
| CN121605193A (zh) * | 2023-04-28 | 2026-03-03 | 先为(海南)生物科技有限公司 | 工程化的mRNA及其用途 |
| CN121175414A (zh) | 2023-05-17 | 2025-12-19 | 磐石医药生技股份有限公司 | Mgat1缺乏细胞及其用途 |
| WO2024245344A1 (zh) * | 2023-05-30 | 2024-12-05 | 石药集团巨石生物制药有限公司 | 预防新型冠状病毒奥密克戎突变株的mRNA疫苗 |
| TW202515531A (zh) | 2023-07-07 | 2025-04-16 | 美商輝瑞股份有限公司 | 兩親性tlr7/8佐劑及其用途 |
| EP4746924A1 (en) * | 2023-07-17 | 2026-05-27 | Eleven Therapeutics Ltd | Non-natural building blocks for enhanced translation and stability of mrna |
| CN121866336A (zh) | 2023-08-03 | 2026-04-14 | 百欧恩泰欧洲股份公司 | 靶向hiv的rna组合物 |
| EP4754130A2 (en) | 2023-08-03 | 2026-06-10 | BioNTech SE | Rna compositions targeting hiv |
| CN117224662B (zh) * | 2023-08-24 | 2025-05-16 | 北京悦康科创医药科技股份有限公司 | 测定多价新冠mRNA疫苗各组分含量的方法 |
| EP4774281A2 (en) * | 2023-09-06 | 2026-07-15 | TriLink BioTechnologies, LLC | Cap analogs and methods of use thereof |
| CN121844046A (zh) | 2023-09-11 | 2026-04-10 | C·米库尔卡 | 用于递送肠促胰岛素剂的rna组合物 |
| KR20260062985A (ko) * | 2023-10-13 | 2026-05-07 | 스마트셀라 솔루션즈 아베 | 중간엽 줄기세포를 이용한 비변형 mRNA 작제물의 전달을 위한 방법 및 조성물 |
| WO2025179238A2 (en) | 2024-02-23 | 2025-08-28 | BioNTech SE | Coronavirus vaccine |
| WO2025201315A1 (zh) * | 2024-03-25 | 2025-10-02 | 南京金斯瑞生物科技有限公司 | 利用自复制rna制备与多次跨膜蛋白特异结合的抗体的方法 |
| CN118389495B (zh) * | 2024-06-24 | 2024-10-01 | 北京悦康科创医药科技股份有限公司 | 一种核糖修饰的加帽类似物及其应用 |
| EP4650358A3 (en) | 2024-04-26 | 2026-01-14 | Beijing Youcare Kechuang Pharmaceutical Technology Co., Ltd. | Ribose-modified cap analog and use thereof |
| WO2026061971A1 (en) | 2024-09-17 | 2026-03-26 | Lonza Ltd | Nucleic acid untranslated regions |
| WO2026088119A1 (en) | 2024-10-24 | 2026-04-30 | Pfizer Inc. | Lipidated tlr7/8 modulators as adjuvants and uses thereof |
| WO2026088120A1 (en) | 2024-10-24 | 2026-04-30 | Pfizer Inc. | Lipidated tlr7/8 modulators as adjuvants and uses thereof |
| KR102832944B1 (ko) | 2024-12-27 | 2025-07-15 | 대한민국 | 제2형 중증급성호흡기증후군 코로나바이러스 변이들의 공통 서열을 포함하는 코로나바이러스감염증-19 범용 백신 조성물 |
Family Cites Families (367)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4898278A (en) | 1986-12-05 | 1990-02-06 | Nalge Company | Storage container |
| JPH10113117A (ja) | 1996-10-11 | 1998-05-06 | Tomoji Tanaka | 保冷箱 |
| CA2289702C (en) | 1997-05-14 | 2008-02-19 | Inex Pharmaceuticals Corp. | High efficiency encapsulation of charged therapeutic agents in lipid vesicles |
| EP1021549A2 (en) | 1997-09-19 | 2000-07-26 | Sequitur, Inc. | SENSE mRNA THERAPY |
| EP1163251A1 (en) | 1999-03-24 | 2001-12-19 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | N-acylphosphoramidites and their use in oligonucleotide synthesis |
| US6381981B1 (en) | 2001-05-02 | 2002-05-07 | Advanced Tissue Sciences, Inc. | Container for shipping and storing frozen products |
| ATE291925T1 (de) | 2001-06-05 | 2005-04-15 | Curevac Gmbh | Stabilisierte mrna mit erhöhtem g/c-gehalt und optimierter codon usage für die gentherapie |
| US20030082357A1 (en) | 2001-09-05 | 2003-05-01 | Cem Gokay | Multi-layer core for vacuum insulation panel and insulated container including vacuum insulation panel |
| US7074596B2 (en) | 2002-03-25 | 2006-07-11 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Synthesis and use of anti-reverse mRNA cap analogues |
| WO2004002415A2 (en) | 2002-06-27 | 2004-01-08 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for modulating a cytotoxic t lymphocyte immune response |
| EP1519714B1 (en) | 2002-06-28 | 2010-10-20 | Protiva Biotherapeutics Inc. | Method and apparatus for producing liposomes |
| DE10229872A1 (de) | 2002-07-03 | 2004-01-29 | Curevac Gmbh | Immunstimulation durch chemisch modifizierte RNA |
| US8575110B2 (en) * | 2003-02-17 | 2013-11-05 | Alpha-O Peptides G | Peptidic nanoparticles as drug delivery and antigen display systems |
| CA2523875A1 (en) | 2003-04-28 | 2004-11-11 | Public Health Agency Of Canada | Sars virus nucleotide and amino acid sequences and uses thereof |
| US20050002953A1 (en) | 2003-05-06 | 2005-01-06 | Jens Herold | SARS-coronavirus virus-like particles and methods of use |
| AU2003304189B2 (en) | 2003-06-10 | 2008-01-24 | Nokia Technologies Oy | Method and apparatus for switching mobile station between autonomous and scheduled transmissions |
| EP1649053A4 (en) | 2003-06-18 | 2006-10-18 | Chinese Nat Human Genome Ct Sh | CHARACTERIZATION OF THE EARLY LEVELS OF THE VIRUS OF HEAVY ACUTE RESPIRATORY SYNDROME (SARS) AND USES THEREOF |
| WO2005012337A2 (en) | 2003-07-15 | 2005-02-10 | Crucell Holland B.V. | Antigenic peptides of sars coronavirus and uses thereof |
| AU2004260884B2 (en) | 2003-07-22 | 2009-11-19 | Crucell Holland B.V. | Binding molecules against SARS-coronavirus and uses thereof |
| CN1977045A (zh) | 2003-08-04 | 2007-06-06 | 马萨诸塞大学 | Sars核酸,蛋白质,疫苗以及它们的用途 |
| WO2005027963A2 (en) | 2003-09-15 | 2005-03-31 | The United States Of America As Represented By Thesecretary Of Health And Human Services, Nih | METHODS AND COMPOSITIONS FOR THE GENERATION OF A PROTECTIVE IMMUNE RESPONSE AGAINTS SARS-CoV |
| US7129042B2 (en) | 2003-11-03 | 2006-10-31 | Diagnostic Hybrids, Inc. | Compositions and methods for detecting severe acute respiratory syndrome coronavirus |
| EP2361974A1 (fr) | 2003-12-02 | 2011-08-31 | Institut Pasteur | Utilisation des proteines et des peptides codés par le genome d'une nouvelle souche de coronavirus associé au SRAS |
| US20050178142A1 (en) | 2004-02-17 | 2005-08-18 | Perry Ralph J. | 96 hour duration insulated cryo-pack for maintaining -40 degree fahrenheit |
| CA2568838A1 (en) | 2004-06-04 | 2005-12-15 | Institut Pasteur | Nucleic acids, polypeptides, methods of expression, and immunogenic compositions associated with sars corona virus spike protein |
| US7870748B2 (en) | 2005-02-25 | 2011-01-18 | Byrne Kathleen H | Method for controlled rate freezing and long term cryogenic storage |
| EP1882392A4 (en) | 2005-05-10 | 2009-07-01 | Monsanto Technology Llc | GENES AND THEIR USES FOR PLANT IMPROVEMENTS |
| WO2006138380A2 (en) | 2005-06-15 | 2006-12-28 | Massachusetts Institute Of Technology | Amine-containing lipids and uses thereof |
| PL2578685T3 (pl) | 2005-08-23 | 2020-01-31 | The Trustees Of The University Of Pennsylvania | Rna zawierający zmodyfikowane nukleozydy i sposoby jego zastosowania |
| DE102005046490A1 (de) | 2005-09-28 | 2007-03-29 | Johannes-Gutenberg-Universität Mainz | Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen |
| EP2049665A2 (en) | 2006-07-28 | 2009-04-22 | Applera Corporation | Dinucleotide mrna cap analogs |
| US8865398B2 (en) | 2006-09-01 | 2014-10-21 | Abbott Laboratories | Combination hepatitis C virus antigen and antibody detection method |
| DE102006051516A1 (de) | 2006-10-31 | 2008-05-08 | Curevac Gmbh | (Basen-)modifizierte RNA zur Expressionssteigerung eines Proteins |
| US8153773B2 (en) | 2007-06-19 | 2012-04-10 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Synthesis and use of anti-reverse phosphorothioate analogs of the messenger RNA cap |
| WO2009030254A1 (en) | 2007-09-04 | 2009-03-12 | Curevac Gmbh | Complexes of rna and cationic peptides for transfection and for immunostimulation |
| EP2279254B1 (en) | 2008-04-15 | 2017-07-05 | Protiva Biotherapeutics Inc. | Novel lipid formulations for nucleic acid delivery |
| PL215513B1 (pl) | 2008-06-06 | 2013-12-31 | Univ Warszawski | Nowe boranofosforanowe analogi dinukleotydów, ich zastosowanie, czasteczka RNA, sposób otrzymywania RNA oraz sposób otrzymywania peptydów lub bialka |
| AU2015210364B2 (en) | 2008-10-09 | 2017-03-09 | Arbutus Biopharma Corporation | Improved amino lipids and methods for the delivery of nucleic acids |
| GB0818663D0 (en) * | 2008-10-10 | 2008-11-19 | Ark Therapeutics Ltd | Gene regulation and its use in therapy |
| ES2987238T3 (es) | 2008-12-09 | 2024-11-14 | Novavax Inc | Proteínas F del RSV modificadas y métodos de su uso |
| EP2391343B1 (en) | 2009-01-29 | 2017-03-01 | Arbutus Biopharma Corporation | Improved lipid formulation for the delivery of nucleic acids |
| EP2451475A2 (en) | 2009-07-06 | 2012-05-16 | Novartis AG | Self replicating rna molecules and uses thereof |
| EP2281579A1 (en) | 2009-08-05 | 2011-02-09 | BioNTech AG | Vaccine composition comprising 5'-Cap modified RNA |
| SI2506857T1 (en) | 2009-12-01 | 2018-08-31 | Translate Bio, Inc. | Delivery of mRNA for the enrichment of proteins and enzymes in human genetic diseases |
| US10487332B2 (en) | 2010-07-06 | 2019-11-26 | Glaxosmithkline Biologicals Sa | Immunisation of large mammals with low doses of RNA |
| CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| AU2015210336B2 (en) | 2010-08-17 | 2017-05-25 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA) |
| RS63890B1 (sr) * | 2010-08-31 | 2023-02-28 | Glaxosmithkline Biologicals Sa | Mali lipozomi za isporuku rnk koja kodira imunogen |
| EP2857499A1 (en) | 2010-10-01 | 2015-04-08 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| WO2012116715A1 (en) | 2011-03-02 | 2012-09-07 | Curevac Gmbh | Vaccination in newborns and infants |
| WO2012116714A1 (en) | 2011-03-02 | 2012-09-07 | Curevac Gmbh | Vaccination in elderly patients |
| CA2831613A1 (en) | 2011-03-31 | 2012-10-04 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| CN103687957A (zh) | 2011-05-17 | 2014-03-26 | 现代治疗公司 | 工程化核酸及其用于非人类脊椎动物的方法 |
| KR20220025112A (ko) | 2011-06-08 | 2022-03-03 | 샤이어 휴먼 지네틱 테라피즈 인크. | Mrna 전달을 위한 지질 나노입자 조성물 및 방법 |
| EP3384938A1 (en) | 2011-09-12 | 2018-10-10 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| PT3682905T (pt) | 2011-10-03 | 2022-04-07 | Modernatx Inc | Nucleósidos, nucleótidos e ácidos nucleicos modificados e respetivas utilizações |
| US20140308304A1 (en) | 2011-12-07 | 2014-10-16 | Alnylam Pharmaceuticals, Inc. | Lipids for the delivery of active agents |
| WO2013130161A1 (en) | 2011-12-14 | 2013-09-06 | modeRNA Therapeutics | Methods of responding to a biothreat |
| ES2923757T3 (es) | 2011-12-16 | 2022-09-30 | Modernatx Inc | Composiciones de ARNm modificado |
| AU2012358384A1 (en) | 2011-12-21 | 2014-07-31 | Moderna Therapeutics, Inc. | Methods of increasing the viability or longevity of an organ or organ explant |
| WO2013120499A1 (en) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly (a) sequence or a polyadenylation signal for increasing the expression of an encoded pathogenic antigen |
| WO2013151664A1 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins |
| WO2013143555A1 (en) | 2012-03-26 | 2013-10-03 | Biontech Ag | Rna formulation for immunotherapy |
| DK3260541T3 (da) | 2012-03-27 | 2019-08-12 | Curevac Ag | Kunstige nukleinsyremolekyler til forbedret protein- eller preptidekspression |
| RU2658490C2 (ru) | 2012-03-27 | 2018-06-21 | Кьюрвак Аг | Искусственные молекулы нуклеиновых кислот для улучшенной экспрессии белков или пептидов |
| US10501513B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides for the production of oncology-related proteins and peptides |
| US10501512B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides |
| US20150050354A1 (en) * | 2012-04-02 | 2015-02-19 | Moderna Therapeutics, Inc. | Modified polynucleotides for the treatment of otic diseases and conditions |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9512456B2 (en) | 2012-08-14 | 2016-12-06 | Modernatx, Inc. | Enzymes and polymerases for the synthesis of RNA |
| WO2014093924A1 (en) | 2012-12-13 | 2014-06-19 | Moderna Therapeutics, Inc. | Modified nucleic acid molecules and uses thereof |
| PT2922554T (pt) | 2012-11-26 | 2022-06-28 | Modernatx Inc | Arn modificado nas porções terminais |
| AU2013355258A1 (en) | 2012-12-07 | 2015-06-11 | Alnylam Pharmaceuticals, Inc. | Improved nucleic acid lipid particle formulations |
| WO2014093574A1 (en) | 2012-12-13 | 2014-06-19 | Moderna Therapeutics, Inc. | Modified polynucleotides for altering cell phenotype |
| SG11201506052PA (en) | 2013-02-22 | 2015-09-29 | Curevac Gmbh | Combination of vaccination and inhibition of the pd-1 pathway |
| EP3578200A1 (en) | 2013-02-22 | 2019-12-11 | CureVac AG | Combination of vaccination and inhibition of the pd-1 pathway |
| WO2014164253A1 (en) | 2013-03-09 | 2014-10-09 | Moderna Therapeutics, Inc. | Heterologous untranslated regions for mrna |
| US20160024181A1 (en) | 2013-03-13 | 2016-01-28 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
| EA201591283A1 (ru) | 2013-03-14 | 2016-02-29 | Шир Хьюман Дженетик Терапис, Инк. | Количественная оценка эффективности кэп матричной рнк |
| US10258698B2 (en) | 2013-03-14 | 2019-04-16 | Modernatx, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| EA201591229A1 (ru) | 2013-03-14 | 2016-01-29 | Шир Хьюман Дженетик Терапис, Инк. | Способы очистки матричной рнк |
| WO2014144767A1 (en) | 2013-03-15 | 2014-09-18 | Moderna Therapeutics, Inc. | Ion exchange purification of mrna |
| WO2014144711A1 (en) | 2013-03-15 | 2014-09-18 | Moderna Therapeutics, Inc. | Analysis of mrna heterogeneity and stability |
| US10077439B2 (en) | 2013-03-15 | 2018-09-18 | Modernatx, Inc. | Removal of DNA fragments in mRNA production process |
| US20160032273A1 (en) | 2013-03-15 | 2016-02-04 | Moderna Therapeutics, Inc. | Characterization of mrna molecules |
| EP4279610A3 (en) | 2013-03-15 | 2024-01-03 | ModernaTX, Inc. | Ribonucleic acid purification |
| CN105143456A (zh) | 2013-03-15 | 2015-12-09 | 不列颠哥伦比亚大学 | 用于转染的脂质纳米粒子和相关方法 |
| EP2971033B8 (en) | 2013-03-15 | 2019-07-10 | ModernaTX, Inc. | Manufacturing methods for production of rna transcripts |
| TW201534578A (zh) | 2013-07-08 | 2015-09-16 | Daiichi Sankyo Co Ltd | 新穎脂質 |
| EP3450561A1 (en) | 2013-08-21 | 2019-03-06 | CureVac AG | Method for increasing expression of rna-encoded proteins |
| SG10201801428RA (en) | 2013-08-21 | 2018-03-28 | Curevac Ag | Method for increasing expression of rna-encoded proteins |
| EP3052511A4 (en) | 2013-10-02 | 2017-05-31 | Moderna Therapeutics, Inc. | Polynucleotide molecules and uses thereof |
| US20160243221A1 (en) | 2013-10-18 | 2016-08-25 | Moderna Therapeutics, Inc. | Compositions and methods for tolerizing cellular systems |
| EP3542802A1 (en) | 2013-11-01 | 2019-09-25 | CureVac AG | Modified rna with decreased immunostimulatory properties |
| WO2015062738A1 (en) | 2013-11-01 | 2015-05-07 | Curevac Gmbh | Modified rna with decreased immunostimulatory properties |
| WO2015080973A1 (en) * | 2013-11-26 | 2015-06-04 | Baylor College Of Medicine | A novel sars immunogenic composition |
| EP3090060B2 (en) | 2013-12-30 | 2025-05-21 | CureVac Manufacturing GmbH | Methods for rna analysis |
| SG11201604198YA (en) | 2013-12-30 | 2016-07-28 | Curevac Ag | Methods for rna analysis |
| WO2015130584A2 (en) | 2014-02-25 | 2015-09-03 | Merck Sharp & Dohme Corp. | Lipid nanoparticle vaccine adjuvants and antigen delivery systems |
| HRP20220070T1 (hr) | 2014-04-23 | 2022-04-01 | Modernatx, Inc. | Cjepiva nukleinske kiseline |
| EP4729528A3 (en) | 2014-04-25 | 2026-06-24 | Translate Bio, Inc. | Methods for purification of messenger rna |
| US10286086B2 (en) | 2014-06-19 | 2019-05-14 | Modernatx, Inc. | Alternative nucleic acid molecules and uses thereof |
| CA2953341C (en) | 2014-06-25 | 2023-01-24 | Acuitas Therapeutics Inc. | Lipids and lipid nanoparticle formulations for delivery of nucleic acids |
| WO2016005004A1 (en) | 2014-07-11 | 2016-01-14 | Biontech Rna Pharmaceuticals Gmbh | Stabilization of poly(a) sequence encoding dna sequences |
| CN106794141B (zh) | 2014-07-16 | 2021-05-28 | 诺华股份有限公司 | 将核酸包封在脂质纳米粒主体中的方法 |
| WO2016011226A1 (en) | 2014-07-16 | 2016-01-21 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
| US20170202979A1 (en) | 2014-07-17 | 2017-07-20 | Modernatx, Inc. | Terminal modifications of polynucleotides |
| WO2016045732A1 (en) | 2014-09-25 | 2016-03-31 | Biontech Rna Pharmaceuticals Gmbh | Stable formulations of lipids and liposomes |
| EP4324473A3 (en) | 2014-11-10 | 2024-05-29 | ModernaTX, Inc. | Multiparametric nucleic acid optimization |
| EP4023755B1 (en) | 2014-12-12 | 2023-04-26 | CureVac SE | Artificial nucleic acid molecules for improved protein expression |
| WO2016118724A1 (en) | 2015-01-21 | 2016-07-28 | Moderna Therapeutics, Inc. | Lipid nanoparticle compositions |
| WO2016164762A1 (en) | 2015-04-08 | 2016-10-13 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor egf-a and intracellular domain mutants and methods of using the same |
| US10780054B2 (en) | 2015-04-17 | 2020-09-22 | Curevac Real Estate Gmbh | Lyophilization of RNA |
| WO2016176330A1 (en) | 2015-04-27 | 2016-11-03 | The Trustees Of The University Of Pennsylvania | Nucleoside-modified rna for inducing an adaptive immune response |
| WO2016180430A1 (en) | 2015-05-08 | 2016-11-17 | Curevac Ag | Method for producing rna |
| CN107530448A (zh) | 2015-05-20 | 2018-01-02 | 库瑞瓦格股份公司 | 包含长链rna的干粉组合物 |
| WO2016184575A1 (en) | 2015-05-20 | 2016-11-24 | Curevac Ag | Dry powder composition comprising long-chain rna |
| DK3303583T3 (da) | 2015-05-29 | 2020-07-13 | Curevac Real Estate Gmbh | Fremgangsmåde til fremstilling og oprensning af rna, omfattende mindst et trin til tangential-flow-filtrering |
| WO2016201377A1 (en) | 2015-06-10 | 2016-12-15 | Moderna Therapeutics, Inc. | Targeted adaptive vaccines |
| MA42502A (fr) | 2015-07-21 | 2018-05-30 | Modernatx Inc | Vaccins contre une maladie infectieuse |
| WO2017015457A1 (en) | 2015-07-21 | 2017-01-26 | Modernatx, Inc. | Ebola vaccine |
| US20190008887A1 (en) | 2015-07-30 | 2019-01-10 | ModernaTX Inc. | Multimeric mrna |
| EP3328394A4 (en) | 2015-07-30 | 2019-03-13 | ModernaTX, Inc. | CONCATEMEE peptide epitope RNAs |
| WO2017025447A1 (en) | 2015-08-10 | 2017-02-16 | Curevac Ag | Method of increasing the replication of a circular dna molecule |
| WO2017031232A1 (en) | 2015-08-17 | 2017-02-23 | Modernatx, Inc. | Methods for preparing particles and related compositions |
| US20180237849A1 (en) | 2015-08-17 | 2018-08-23 | Modernatx, Inc. | Rna mapping/fingerprinting |
| EP3341026B1 (en) | 2015-08-28 | 2022-01-05 | BioNTech SE | Method for reducing immunogenicity of rna |
| HRP20220156T1 (hr) | 2015-09-17 | 2022-04-15 | Modernatx, Inc. | Spojevi i pripravci za unutarstaničnu isporuku terapeutskih sredstava |
| EP4101930A1 (en) | 2015-09-17 | 2022-12-14 | ModernaTX, Inc. | Polynucleotides containing a stabilizing tail region |
| WO2017049286A1 (en) | 2015-09-17 | 2017-03-23 | Moderna Therapeutics, Inc. | Polynucleotides containing a morpholino linker |
| DK4276189T3 (da) | 2015-09-21 | 2026-05-26 | Trilink Biotechnologies Llc | Initierende oligonukleotidprimere med kappe til syntesering af 5'-ende RNA'er med kappe |
| EP3359670B2 (en) | 2015-10-05 | 2024-02-14 | ModernaTX, Inc. | Methods for therapeutic administration of messenger ribonucleic acid drugs |
| WO2017059902A1 (en) | 2015-10-07 | 2017-04-13 | Biontech Rna Pharmaceuticals Gmbh | 3' utr sequences for stabilization of rna |
| US11866754B2 (en) | 2015-10-16 | 2024-01-09 | Modernatx, Inc. | Trinucleotide mRNA cap analogs |
| JP2018530587A (ja) | 2015-10-16 | 2018-10-18 | モデルナティエックス インコーポレイテッドModernaTX,Inc. | mRNAキャップ類似体およびmRNAキャッピングの方法 |
| WO2017066789A1 (en) | 2015-10-16 | 2017-04-20 | Modernatx, Inc. | Mrna cap analogs with modified sugar |
| DK3362461T3 (da) | 2015-10-16 | 2022-05-09 | Modernatx Inc | Mrna-cap-analoger med modificeret phosphatbinding |
| DE20164728T1 (de) | 2015-10-22 | 2021-09-30 | Modernatx, Inc. | Impfstoffe gegen atemwegsvirus |
| MA46023A (fr) | 2015-10-22 | 2019-07-03 | Modernatx Inc | Vaccin contre le virus de la grippe à large spectre |
| PE20181531A1 (es) | 2015-10-22 | 2018-09-26 | Modernatx Inc | Vacuna del virus herpes simple |
| SG11201803360UA (en) | 2015-10-22 | 2018-05-30 | Modernatx Inc | Nucleic acid vaccines for varicella zoster virus (vzv) |
| EP3364949A4 (en) | 2015-10-22 | 2019-07-31 | ModernaTX, Inc. | CANCER VACCINES |
| EP3364981A4 (en) | 2015-10-22 | 2019-08-07 | ModernaTX, Inc. | VACCINE AGAINST THE HUMAN CYTOMEGALOVIRUS |
| MA45209A (fr) | 2015-10-22 | 2019-04-17 | Modernatx Inc | Vaccins contre les maladies sexuellement transmissibles |
| US20180271970A1 (en) | 2015-10-22 | 2018-09-27 | Modernatx, Inc. | Respiratory syncytial virus vaccine |
| WO2017070624A1 (en) | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Tropical disease vaccines |
| WO2018081480A1 (en) | 2016-10-26 | 2018-05-03 | Acuitas Therapeutics, Inc. | Lipid nanoparticle formulations |
| CN108368028B (zh) | 2015-10-28 | 2021-09-03 | 爱康泰生治疗公司 | 用于递送核酸的新型脂质和脂质纳米颗粒制剂 |
| WO2017100551A1 (en) | 2015-12-09 | 2017-06-15 | Alexion Pharmaceuticals, Inc. | HETEROLOGOUS UTR SEQUENCES FOR ENHANCED mRNA EXPRESSION |
| DK3386484T3 (da) | 2015-12-10 | 2022-07-04 | Modernatx Inc | Sammensætninger og fremgangsmåder til afgivelse af terapeutiske midler |
| WO2017106799A1 (en) | 2015-12-17 | 2017-06-22 | Modernatx, Inc. | POLYNUCLEOTIDES ENCODING METHYLMALONYL-CoA MUTASE |
| RS63051B1 (sr) | 2015-12-22 | 2022-04-29 | Modernatx Inc | Jedinjenja i kompozicije za intracelularnu isporuku agenasa |
| US10465190B1 (en) | 2015-12-23 | 2019-11-05 | Modernatx, Inc. | In vitro transcription methods and constructs |
| GB2546257A (en) | 2016-01-08 | 2017-07-19 | The Wool Packaging Company Ltd | Temperature controlled packaging and transportation method |
| EP3405579A1 (en) | 2016-01-22 | 2018-11-28 | Modernatx, Inc. | Messenger ribonucleic acids for the production of intracellular binding polypeptides and methods of use thereof |
| WO2017162266A1 (en) * | 2016-03-21 | 2017-09-28 | Biontech Rna Pharmaceuticals Gmbh | Rna replicon for versatile and efficient gene expression |
| EP3442590A2 (en) | 2016-04-13 | 2019-02-20 | Modernatx, Inc. | Lipid compositions and their uses for intratumoral polynucleotide delivery |
| WO2017191274A2 (en) | 2016-05-04 | 2017-11-09 | Curevac Ag | Rna encoding a therapeutic protein |
| AU2017268396B2 (en) | 2016-05-18 | 2023-05-18 | Modernatx, Inc. | Polynucleotides encoding citrin for the treatment of citrullinemia type 2 |
| US12128113B2 (en) | 2016-05-18 | 2024-10-29 | Modernatx, Inc. | Polynucleotides encoding JAGGED1 for the treatment of Alagille syndrome |
| JP2019519601A (ja) | 2016-05-18 | 2019-07-11 | モダーナティエックス・インコーポレイテッドModernaTX, Inc. | 急性間欠性ポルフィリン症の治療のためのポルホビリノゲン脱アミノ酵素をコードするポリヌクレオチド |
| JP7114485B2 (ja) | 2016-05-18 | 2022-08-08 | モデルナティエックス インコーポレイテッド | ファブリー病の治療のためのα-ガラクトシダーゼAをコードするポリヌクレオチド |
| WO2017201332A1 (en) | 2016-05-18 | 2017-11-23 | Modernatx, Inc. | Polynucleotides encoding acyl-coa dehydrogenase, very long-chain for the treatment of very long-chain acyl-coa dehydrogenase deficiency |
| US11801227B2 (en) | 2016-05-18 | 2023-10-31 | Modernatx, Inc. | Polynucleotides encoding cystic fibrosis transmembrane conductance regulator for the treatment of cystic fibrosis |
| CN115837014A (zh) | 2016-05-18 | 2023-03-24 | 摩登纳特斯有限公司 | 编码松弛素的多核苷酸 |
| CA3024509A1 (en) | 2016-05-18 | 2017-11-23 | Modernatx, Inc. | Mrna combination therapy for the treatment of cancer |
| US11001861B2 (en) | 2016-05-18 | 2021-05-11 | Modernatx, Inc. | Polynucleotides encoding galactose-1-phosphate uridylyltransferase for the treatment of galactosemia type 1 |
| US20190382774A1 (en) | 2016-05-18 | 2019-12-19 | Modernatx, Inc. | Polyribonucleotides containing reduced uracil content and uses thereof |
| EP3458106A4 (en) | 2016-05-18 | 2020-03-18 | Modernatx, Inc. | POLYNUCLEOTIDS FOR CODING LIPOPROTEIN LIPASE FOR TREATING HYPERLIPIDEMIA |
| EP3468537A1 (en) | 2016-06-14 | 2019-04-17 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
| GB201611050D0 (en) | 2016-06-24 | 2016-08-10 | Softbox Systems Ltd | A passive temperature control system for transport and storage containers |
| SG11201901941YA (en) | 2016-09-14 | 2019-04-29 | Modernatx Inc | High purity rna compositions and methods for preparation thereof |
| US10487105B2 (en) * | 2016-10-19 | 2019-11-26 | Arcturus Therapeutics, Inc. | Trinucleotide MRNA cap analogs |
| EP3528821A4 (en) | 2016-10-21 | 2020-07-01 | ModernaTX, Inc. | HUMAN CYTOMEGALOVIRUS VACCINE |
| WO2018081318A1 (en) * | 2016-10-25 | 2018-05-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Prefusion coronavirus spike proteins and their use |
| CA3042015A1 (en) | 2016-10-26 | 2018-05-03 | Modernatx, Inc. | Messenger ribonucleic acids for enhancing immune responses and methods of use thereof |
| KR20190093816A (ko) | 2016-10-26 | 2019-08-26 | 큐어백 아게 | 지질 나노입자 mRNA 백신 |
| MA46643A (fr) | 2016-10-26 | 2019-09-04 | Modernatx Inc | Méthodes et compositions pour le mappage d'arn |
| EP3538067A1 (en) | 2016-11-08 | 2019-09-18 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
| MA46766A (fr) | 2016-11-11 | 2019-09-18 | Modernatx Inc | Vaccin antigrippal |
| EP3551193A4 (en) | 2016-12-08 | 2020-08-19 | Modernatx, Inc. | NUCLEIC ACID VACCINES AGAINST RESPIRATORY VIRUSES |
| EP3555289A1 (en) | 2016-12-13 | 2019-10-23 | ModernaTX, Inc. | Rna affinity purification |
| WO2018115527A2 (en) * | 2016-12-23 | 2018-06-28 | Curevac Ag | Mers coronavirus vaccine |
| US20180243225A1 (en) | 2017-01-25 | 2018-08-30 | Modernatx, Inc. | Ebola/marburg vaccines |
| CA3052255A1 (en) | 2017-02-01 | 2018-08-09 | Modernatx, Inc. | Rna cancer vaccines |
| WO2018144778A1 (en) | 2017-02-01 | 2018-08-09 | Modernatx, Inc. | Polynucleotide secondary structure |
| MX2019009070A (es) | 2017-02-01 | 2019-10-30 | Modernatx Inc | Composiciones de arnm terapeuticas inmunomoduladoras que codifican peptidos de mutacion de oncogenes de activacion. |
| MA47515A (fr) | 2017-02-16 | 2019-12-25 | Modernatx Inc | Compositions immunogènes très puissantes |
| US20200368162A1 (en) | 2017-02-24 | 2020-11-26 | Modernatx, Inc. | Nucleic Acid-Based Therapy of Muscular Dystrophies |
| KR20240144261A (ko) * | 2017-02-28 | 2024-10-02 | 사노피 | 치료적 rna |
| WO2018170256A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Herpes simplex virus vaccine |
| JP7332478B2 (ja) | 2017-03-15 | 2023-08-23 | モデルナティエックス インコーポレイテッド | 脂質ナノ粒子製剤 |
| US11576961B2 (en) | 2017-03-15 | 2023-02-14 | Modernatx, Inc. | Broad spectrum influenza virus vaccine |
| WO2018170270A1 (en) * | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Varicella zoster virus (vzv) vaccine |
| WO2018170260A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Respiratory syncytial virus vaccine |
| WO2018170322A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Crystal forms of amino lipids |
| KR20240005989A (ko) | 2017-03-15 | 2024-01-12 | 큐 바이오파마, 인크. | 면역 반응을 조절하는 방법 |
| RS63953B1 (sr) | 2017-03-15 | 2023-02-28 | Modernatx Inc | Jedinjenje i kompozicije za intracelularnu isporuku terapeutskih sredstava |
| WO2018170347A1 (en) * | 2017-03-17 | 2018-09-20 | Modernatx, Inc. | Zoonotic disease rna vaccines |
| US20200038499A1 (en) | 2017-03-22 | 2020-02-06 | Modernatx, Inc. | Rna bacterial vaccines |
| MA48047A (fr) | 2017-04-05 | 2020-02-12 | Modernatx Inc | Réduction ou élimination de réponses immunitaires à des protéines thérapeutiques administrées par voie non intraveineuse, par exemple par voie sous-cutanée |
| WO2018188730A1 (en) * | 2017-04-11 | 2018-10-18 | Biontech Rna Pharmaceuticals Gmbh | Rna for treatment of autoimmune diseases |
| MA49463A (fr) | 2017-04-26 | 2021-05-05 | Modernatx Inc | Vaccin contre le virus de l'herpès simplex |
| EP4253544A3 (en) | 2017-05-18 | 2023-12-20 | ModernaTX, Inc. | Modified messenger rna comprising functional rna elements |
| CN107033250B (zh) | 2017-05-23 | 2020-01-21 | 山东省农业科学院奶牛研究中心 | 牛冠状病毒重组多表位抗原及其应用 |
| MA49421A (fr) | 2017-06-15 | 2020-04-22 | Modernatx Inc | Formulations d'arn |
| WO2018232355A1 (en) | 2017-06-15 | 2018-12-20 | Modernatx, Inc. | Rna antibodies |
| WO2019035998A1 (en) | 2017-08-17 | 2019-02-21 | Modernatx, Inc. | SYSTEMS WITH CONTROL AND REGULATION OF FLUID PATH |
| EP3668977A4 (en) | 2017-08-18 | 2021-04-21 | Modernatx, Inc. | HPLC ANALYTICAL PROCESSES |
| WO2019036682A1 (en) | 2017-08-18 | 2019-02-21 | Modernatx, Inc. | RNA VARIANTS POLYMERASE |
| WO2019036670A2 (en) | 2017-08-18 | 2019-02-21 | Modernatx, Inc. | EFFECTIVE MRNA VACCINES |
| WO2019036685A1 (en) | 2017-08-18 | 2019-02-21 | Modernatx, Inc. | METHODS FOR HPLC ANALYSIS |
| EP3681514A4 (en) | 2017-09-14 | 2021-07-14 | ModernaTX, Inc. | RNA VACZINE AGAINST ZIKA VIRUS |
| US20190192646A1 (en) | 2017-11-03 | 2019-06-27 | Modernatx, Inc. | Salmonella vaccines |
| WO2019092002A1 (en) | 2017-11-07 | 2019-05-16 | Valneva Se | Pharmaceutical compositions for treatment or prevention of viral infections |
| GB201718660D0 (en) | 2017-11-10 | 2017-12-27 | Ucl Business Plc | Improved liposome for mRNA delivery to cells |
| MA50813A (fr) | 2017-11-21 | 2020-09-30 | Modernatx Inc | Vaccins contre le virus d'epstein-barr |
| US11911453B2 (en) | 2018-01-29 | 2024-02-27 | Modernatx, Inc. | RSV RNA vaccines |
| US20190314291A1 (en) | 2018-01-30 | 2019-10-17 | Modernatx, Inc. | Compositions and methods for delivery of agents to immune cells |
| CA3106812A1 (en) | 2018-04-27 | 2019-10-31 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Homology-directed repair template design and delivery to edit hemoglobin-related mutations |
| AU2019277355A1 (en) | 2018-05-30 | 2020-12-17 | Translate Bio, Inc. | Phosphoester cationic lipids |
| US20210268086A1 (en) | 2018-06-27 | 2021-09-02 | Modernatx, Inc. | Personalized cancer vaccine epitope selection |
| TW202019955A (zh) | 2018-07-31 | 2020-06-01 | 德商英麥提克生物技術股份有限公司 | B*07 限制肽和肽組合的抗癌免疫治療和相關方法 |
| US20220054653A1 (en) | 2018-09-13 | 2022-02-24 | Modernatx, Inc. | Modified mrna for the treatment of progressive familial intrahepatic cholestasis disorders |
| CN112996854B (zh) | 2018-09-19 | 2024-08-30 | 摩登纳特斯有限公司 | 高纯度peg脂质和其用途 |
| US12151029B2 (en) | 2018-09-19 | 2024-11-26 | Modernatx, Inc. | PEG lipids and uses thereof |
| EP3853202A1 (en) | 2018-09-19 | 2021-07-28 | ModernaTX, Inc. | Compounds and compositions for intracellular delivery of therapeutic agents |
| US12090235B2 (en) | 2018-09-20 | 2024-09-17 | Modernatx, Inc. | Preparation of lipid nanoparticles and methods of administration thereof |
| MX2021003455A (es) | 2018-10-02 | 2021-09-21 | Intellia Therapeutics Inc | Lípidos con amina ionizables. |
| KR102076917B1 (ko) * | 2018-10-25 | 2020-02-13 | 연세대학교 산학협력단 | 자가조립 나노 입자를 제조하기 위한 유전자 재조합 발현 벡터 시스템 및 이를 이용하는 방법 |
| MA54192A (fr) | 2018-11-07 | 2021-09-15 | Modernatx Inc | Vaccins à arn contre le cancer |
| CN111200358B (zh) | 2018-11-19 | 2021-09-03 | 广东美的白色家电技术创新中心有限公司 | 抑制冷媒散热器的电磁干扰的系统及家用电器 |
| CN115120716A (zh) | 2019-01-14 | 2022-09-30 | 健泰科生物技术公司 | 用pd-1轴结合拮抗剂和rna疫苗治疗癌症的方法 |
| CN113939282A (zh) | 2019-01-31 | 2022-01-14 | 摩登纳特斯有限公司 | 制备脂质纳米颗粒的方法 |
| MX2021010075A (es) | 2019-02-20 | 2021-12-10 | Modernatx Inc | Variantes de arn polimerasa para la formacion de casquetes cotranscripcionales. |
| MX2021011031A (es) | 2019-03-11 | 2021-12-10 | Modernatx Inc | Proceso de transcripción in vitro en lotes alimentados. |
| MA55321A (fr) | 2019-03-15 | 2022-01-19 | Modernatx Inc | Vaccins à base d'arn contre le vih |
| CN114207134B (zh) * | 2019-03-25 | 2024-11-15 | 俄亥俄州国家创新基金会 | 工程化的mRNA序列及其用途 |
| JP2022535006A (ja) | 2019-05-31 | 2022-08-04 | モデルナティエックス インコーポレイテッド | 増殖t細胞アッセイ |
| MA56517A (fr) | 2019-06-24 | 2022-04-27 | Modernatx Inc | Arn messager comprenant des éléments d'arn fonctionnels et leurs utilisations |
| TWI817018B (zh) * | 2019-06-28 | 2023-10-01 | 美商艾瑞生藥股份有限公司 | 用於治療braf相關的疾病和失調症之化合物 |
| CN110378000B (zh) | 2019-07-11 | 2020-11-24 | 上海理工大学 | 基于强度场的结构静强度设计方法 |
| US20220348900A1 (en) | 2019-08-14 | 2022-11-03 | Modernatx, Inc. | Processes for purifying downstream products of in vitro transcription |
| GB2600859B (en) | 2019-08-14 | 2024-04-03 | Acuitas Therapeutics Inc | Improved lipid nanoparticles for delivery of nucleic acids |
| EP4028030A4 (en) | 2019-09-11 | 2023-09-27 | ModernaTX, Inc. | VACCINE AGAINST HUMAN CYTOMEGALOVIRUS |
| CN114729159A (zh) | 2019-09-16 | 2022-07-08 | 阿尔托大学基金会 | 基于生物油和/或水的均质纤维产品及其生产方法 |
| JP2022548957A (ja) | 2019-09-19 | 2022-11-22 | モデルナティエックス インコーポレイテッド | キャップガイド及びrnaマッピングのためのその使用方法 |
| GB201915905D0 (en) | 2019-11-01 | 2019-12-18 | Spybiotech Ltd | Viruses with modified capsid proteins |
| KR102764120B1 (ko) | 2019-12-31 | 2025-02-06 | 엘릭서젠 쎄라퓨틱스, 인크. | 핵산 및 단백질의 세포 및 조직으로의 온도-기반 일시적 전달 |
| EP4088281A4 (en) | 2020-01-10 | 2024-02-21 | ModernaTX, Inc. | VARIOUS AUTOCECODER FOR GENERATING BIOLOGICAL SEQUENCE |
| WO2021147025A1 (en) | 2020-01-22 | 2021-07-29 | The University Of Hong Kong-Shenzhen Hospital | Anti 2019-ncov vaccine |
| US10953089B1 (en) | 2020-01-27 | 2021-03-23 | Novavax, Inc. | Coronavirus vaccine formulations |
| AU2021214064A1 (en) | 2020-01-27 | 2022-08-18 | Novavax, Inc. | Coronavirus vaccine formulations |
| WO2021154763A1 (en) * | 2020-01-28 | 2021-08-05 | Modernatx, Inc. | Coronavirus rna vaccines |
| US20210228707A1 (en) | 2020-01-28 | 2021-07-29 | Modernatx, Inc. | Coronavirus rna vaccines |
| KR20220133911A (ko) | 2020-01-30 | 2022-10-05 | 모더나티엑스, 인크. | 호흡기 바이러스 면역화 조성물 |
| TW202204380A (zh) | 2020-01-31 | 2022-02-01 | 美商詹森藥物公司 | 用於預防及治療冠狀病毒感染之組合物及方法-sars-cov-2疫苗 |
| WO2021155760A1 (zh) | 2020-02-03 | 2021-08-12 | 康希诺生物股份公司 | 用于2019-nCoV型冠状病毒mRNA疫苗、制备方法及其应用 |
| US12194089B2 (en) | 2020-02-04 | 2025-01-14 | CureVac SE | Coronavirus vaccine |
| DE202021004130U1 (de) * | 2020-02-04 | 2022-10-26 | Curevac Ag | Coronavirus-Vakzine |
| US11241493B2 (en) | 2020-02-04 | 2022-02-08 | Curevac Ag | Coronavirus vaccine |
| KR102848852B1 (ko) | 2020-02-05 | 2025-08-20 | 샨시 진보 바이오-파르마시우티컬 씨오., 엘티디. | 폴리펩티드, 이의 제조방법 및 용도 |
| MX2022009688A (es) | 2020-02-07 | 2022-12-15 | Rnaimmune Inc | Composición y métodos de vacunas de arnm contra la nueva infección por coronavirus. |
| BR112022015565A2 (pt) | 2020-02-07 | 2022-09-27 | Modernatx Inc | Vacinas de domínio de mrna para sars-cov-2 |
| CN113416259B (zh) | 2020-02-10 | 2023-04-18 | 中国科学院微生物研究所 | 一种β冠状病毒抗原、其制备方法和应用 |
| CN115515627A (zh) * | 2020-02-11 | 2022-12-23 | 美国政府(由卫生和人类服务部的部长所代表) | SARS-CoV-2疫苗 |
| WO2021163371A1 (en) | 2020-02-12 | 2021-08-19 | La Jolla Institute For Immunology | Coronavirus t cell epitopes and uses thereof |
| CN113186203B (zh) | 2020-02-13 | 2022-12-30 | 斯微(上海)生物科技股份有限公司 | 治疗或者预防冠状病毒病的疫苗试剂 |
| AU2021218985A1 (en) | 2020-02-13 | 2022-08-25 | Institut Pasteur | Measles-vectored COVID-19 immunogenic compositions and vaccines |
| EP4103228A1 (en) | 2020-02-13 | 2022-12-21 | Institut Pasteur | Nucleic acid vaccine against the sars-cov-2 coronavirus |
| WO2021163456A1 (en) | 2020-02-14 | 2021-08-19 | Epivax, Inc. | T cell epitopes and related compositions useful in the prevention, diagnosis, and treatment of covid-19 |
| GB2594683A (en) | 2020-02-17 | 2021-11-10 | Vaxbio Ltd | Vaccine |
| CN111303254A (zh) | 2020-02-20 | 2020-06-19 | 北京新创生物工程有限公司 | 新型冠状病毒(SARS-CoV-2)抗原检测试剂盒 |
| WO2021000968A2 (zh) | 2020-02-23 | 2021-01-07 | 广州恩宝生物医药科技有限公司 | 一种用于预防SARS-CoV-2感染的腺病毒载体疫苗 |
| CN110951756B (zh) | 2020-02-23 | 2020-08-04 | 广州恩宝生物医药科技有限公司 | 表达SARS-CoV-2病毒抗原肽的核酸序列及其应用 |
| CN110974950B (zh) | 2020-03-05 | 2020-08-07 | 广州恩宝生物医药科技有限公司 | 一种用于预防SARS-CoV-2感染的腺病毒载体疫苗 |
| CN112300251B (zh) | 2020-02-24 | 2022-04-05 | 成都威斯克生物医药有限公司 | 抗SARS-CoV-2感染的蛋白及疫苗 |
| CN111218458B (zh) | 2020-02-27 | 2020-11-20 | 珠海丽凡达生物技术有限公司 | 编码SARS-CoV-2病毒抗原的mRNA和疫苗及疫苗的制备方法 |
| WO2021178306A1 (en) | 2020-03-01 | 2021-09-10 | Dynavax Technologies Corporation | Coronavirus vaccines comprising a tlr9 agonist |
| US12269846B2 (en) | 2020-03-05 | 2025-04-08 | Swey-Shen Chen | CoV-2 (CoV-n) antibody neutralizing and CTL vaccines using protein scaffolds and molecular evolution |
| US11213482B1 (en) | 2020-03-05 | 2022-01-04 | University of Pittsburgh—Of the Commonwealth System of Higher Educat | SARS-CoV-2 subunit vaccine and microneedle array delivery system |
| AU2021230334A1 (en) | 2020-03-05 | 2022-09-29 | New York Blood Center, Inc. | Immunogenic compositions against severe acute respiratory syndrome coronavirus 2 |
| JP2023517644A (ja) | 2020-03-09 | 2023-04-26 | アークトゥラス・セラピューティクス・インコーポレイテッド | コロナウイルスワクチン組成物及び方法 |
| US12285480B2 (en) | 2020-03-11 | 2025-04-29 | Nantcell, Inc. | Method of inducing immunity against SARS-CoV-2 using spike and nucleocapsid-ETSD immunogens delivered by RNA and replication-defective adenoviruses |
| KR20220152248A (ko) | 2020-03-13 | 2022-11-15 | 옥스포드 유니버시티 이노베이션 리미티드 | 면역 반응을 유도하기 위한 조성물 및 방법 |
| CN111218459B (zh) | 2020-03-18 | 2020-09-11 | 中国人民解放军军事科学院军事医学研究院 | 一种以人复制缺陷腺病毒为载体的重组新型冠状病毒疫苗 |
| US20230136960A1 (en) | 2020-03-19 | 2023-05-04 | Nature's Toolbox, Inc. | Novel MRNA-Based COVID-19 Multi-Valent Vaccine and Methods of Scaled Production of the Same |
| CN111560074B (zh) | 2020-03-20 | 2021-07-09 | 中山大学 | 一种基于幽门螺旋杆菌铁蛋白的新型冠状病毒s蛋白单区域亚单位纳米疫苗 |
| CN111088283B (zh) | 2020-03-20 | 2020-06-23 | 苏州奥特铭医药科技有限公司 | mVSV病毒载体及其病毒载体疫苗、一种基于mVSV介导的新冠肺炎疫苗 |
| TW202200199A (zh) | 2020-03-20 | 2022-01-01 | 美商百歐恩泰美國公司 | 冠狀病毒疫苗及使用方法 |
| WO2021189056A2 (en) | 2020-03-20 | 2021-09-23 | Kansas State University Research Foundation | Sars-coronavirus 2 (sars-cov-2) subunit vaccine candidates |
| US20240210415A1 (en) | 2020-03-24 | 2024-06-27 | Icahn School Of Medicine At Mount Sinai | Recombinant sars-cov-2 spike protein and uses thereof |
| GB202004493D0 (en) | 2020-03-27 | 2020-05-13 | Imp College Innovations Ltd | Coronavirus vaccine |
| WO2021200800A1 (ja) | 2020-03-30 | 2021-10-07 | 国立大学法人大阪大学 | コロナウイルス感染またはコロナウイルス感染に伴う症状の予防または治療ワクチン |
| US11278617B2 (en) | 2020-03-31 | 2022-03-22 | Engimata, Inc | Immunogenic composition forming a SARS-CoV-2 vaccine, and a method for its manufacture |
| WO2021201612A1 (ko) | 2020-03-31 | 2021-10-07 | 주식회사 에스엘백시젠 | 신규 코로나바이러스 예방 및 치료용 백신 조성물 |
| US11559577B2 (en) | 2020-03-31 | 2023-01-24 | Engimata, Inc. | Immunogenic composition forming a vaccine, and a method for its manufacture |
| WO2021202599A2 (en) | 2020-04-01 | 2021-10-07 | Valiant Biosciences, Llc | Adeno-associated virus based compositions and related methods for inducing humoral immunity |
| AU2021247163A1 (en) | 2020-04-01 | 2022-10-20 | University Of Florida Research Foundation, Incorporated | Multilamellar RNA nanoparticle vaccine against SARS-CoV-2 |
| WO2021198706A2 (en) | 2020-04-01 | 2021-10-07 | Diosynvax Ltd | Coronavirus vaccines |
| TW202202169A (zh) | 2020-04-02 | 2022-01-16 | 中央研究院 | 預防嚴重急性呼吸症候群冠狀病毒第二型(sars-cov-2)感染的生物可降解奈米複合物疫苗及方法 |
| JP2023520562A (ja) | 2020-04-03 | 2023-05-17 | ペップティーシー ヴァクシーンズ リミテッド | コロナウイルスワクチン |
| GB202004974D0 (en) | 2020-04-03 | 2020-05-20 | Treos Bio Ltd | Coronavirus vaccine |
| WO2021203044A2 (en) | 2020-04-03 | 2021-10-07 | Icahn School Of Medicine At Mount Sinai | High-throughput assay for circulating antibodies against severe acute respiratory syndrome coronavirus 2 |
| CN111139241B (zh) | 2020-04-03 | 2020-09-01 | 苏州吉玛基因股份有限公司 | 抑制新型冠状病毒的小干扰核酸及组合物和应用 |
| RU2747762C1 (ru) | 2020-04-05 | 2021-05-13 | Илья Владимирович Духовлинов | Вакцина для профилактики или лечения коронавирусной инфекции на основе генетической конструкции |
| WO2021205455A1 (en) | 2020-04-07 | 2021-10-14 | Ramot At Tel-Aviv University Ltd. | Sars-cov2 coronavirus reconstituted rbm and uses thereof |
| CN112023035A (zh) | 2020-04-07 | 2020-12-04 | 中国医学科学院医学生物学研究所 | 一种以SARS-CoV-2病毒S蛋白RBD区为抗原的纳米疫苗及其制备 |
| WO2021204179A1 (en) | 2020-04-09 | 2021-10-14 | Suzhou Abogen Biosciences Co., Ltd. | Nucleic acid vaccines for coronavirus |
| EP4135762A4 (en) | 2020-04-14 | 2024-05-15 | The Regents of the University of California | Large sequence pan-coronavirus vaccine compositions |
| EP4135677A4 (en) | 2020-04-14 | 2024-08-21 | Duke University | SARS-2 SPIKE PROTEIN DESIGNS, COMPOSITIONS AND METHODS FOR THEIR USE |
| WO2021209824A1 (en) | 2020-04-17 | 2021-10-21 | Institut Pasteur | Methods and products for serological analysis of sars-cov-2 infection |
| WO2021211279A1 (en) | 2020-04-17 | 2021-10-21 | Regents Of The University Of Minnesota | SARS-CoV-2 SPIKE RECEPTOR BINDING DOMAIN AND COMPOSITIONS AND METHODS THEREOF |
| TWI891771B (zh) | 2020-04-17 | 2025-08-01 | 美商Vlp醫療股份有限公司 | 冠狀病毒疫苗 |
| WO2021214081A2 (en) | 2020-04-20 | 2021-10-28 | Nec Oncoimmunity As | Sars-cov-2 vaccines |
| WO2021212568A1 (zh) | 2020-04-21 | 2021-10-28 | 苏州方科生物科技有限公司 | 新型冠状病毒特异性抗原肽及其用途 |
| WO2021216743A2 (en) | 2020-04-21 | 2021-10-28 | Emory University | Coronavirus vaccines, compositions, and methods related thereto |
| EP4138893A4 (en) | 2020-04-21 | 2024-06-12 | Intima Bioscience, Inc. | Cellular vaccine platform and methods of use |
| WO2021216738A2 (en) | 2020-04-21 | 2021-10-28 | Intima Bioscience, Inc. | Compositions and methods of generating an immune response |
| CN118490818A (zh) | 2020-04-22 | 2024-08-16 | 生物技术欧洲股份公司 | 冠状病毒疫苗 |
| EP4139616A1 (en) | 2020-04-22 | 2023-03-01 | Pfizer Inc. | Coronavirus vaccine |
| WO2021222304A1 (en) | 2020-04-27 | 2021-11-04 | Modernatx, Inc. | Sars-cov-2 rna vaccines |
| KR102482994B1 (ko) | 2020-04-29 | 2022-12-29 | 에스케이바이오사이언스(주) | 사스-코로나바이러스-2 감염증 예방 또는 치료용 백신 조성물 |
| IT202000009625A1 (it) | 2020-04-30 | 2021-10-30 | Takis S R L | Polinucleotidi codificanti antigeni di sars-cov-2 e relativo uso in campo medico come vaccini. |
| WO2021223647A1 (en) | 2020-05-06 | 2021-11-11 | The University Of Hong Kong | Compositions and methods for making and using vaccines against covid-19 |
| AU2021269042A1 (en) | 2020-05-07 | 2023-02-02 | Translate Bio, Inc. | Optimized nucleotide sequences encoding SARS-CoV-2 antigens |
| US20240123053A1 (en) | 2020-05-07 | 2024-04-18 | Bharat Biotech International Limited | Coronavirus vaccine through nasal immunization |
| CN111518175B (zh) | 2020-05-11 | 2021-02-26 | 广东珩达生物医药科技有限公司 | Sars-cov-2抗原多肽及其重组腺相关病毒和在制备疫苗中的应用 |
| US20230226170A1 (en) | 2020-05-12 | 2023-07-20 | Greffex, Inc. | Engineering coronavirus spike proteins as vaccine antigens, their design and uses |
| WO2021159130A2 (en) | 2020-05-15 | 2021-08-12 | Modernatx, Inc. | Coronavirus rna vaccines and methods of use |
| WO2021231929A1 (en) | 2020-05-15 | 2021-11-18 | Modernatx, Inc. | Rna formulations for high volume distribution |
| US12331078B2 (en) | 2020-05-18 | 2025-06-17 | The Regents Of The University Of Colorado, A Body Corporate | Stabilizing mutants of prefusion SARS-CoV-2 (COVID-19) spike protein and improved yeast surface display engineering platform for the same |
| CN111363858B (zh) | 2020-05-26 | 2020-09-29 | 南京黎明生物制品有限公司 | 2019-nCoV S基因检测核酸组合物及试剂盒与生产方法 |
| WO2021239880A1 (en) | 2020-05-29 | 2021-12-02 | Curevac Ag | Nucleic acid based combination vaccines |
| WO2021253172A1 (zh) | 2020-06-15 | 2021-12-23 | 上海市公共卫生临床中心 | 利用受体识别域诱导抗新冠病毒中和抗体的方法 |
| US10906944B2 (en) | 2020-06-29 | 2021-02-02 | The Scripps Research Institute | Stabilized coronavirus spike (S) protein immunogens and related vaccines |
| WO2022003119A1 (en) | 2020-07-01 | 2022-01-06 | CEBINA GmbH | Cross-reactive coronavirus vaccine |
| WO2022000845A1 (zh) | 2020-07-01 | 2022-01-06 | 江苏省疾病预防控制中心(江苏省公共卫生研究院) | 一种预防SARS-CoV-2的重组蛋白疫苗及其制备方法 |
| WO2022006565A1 (en) | 2020-07-03 | 2022-01-06 | Kang Zhang | Polypeptides, vaccine compositions, and use thereof for inducing immune response to sars-cov-2 in primates |
| GB2596820A (en) | 2020-07-07 | 2022-01-12 | Spicona Inc | Combination vaccine |
| EP4178544A4 (en) | 2020-07-08 | 2024-09-25 | The Trustees of the University of Pennsylvania | NUCLEOSIDE-MODIFIED RNA TO INDUCE AN IMMUNE RESPONSE AGAINST SARS-COV-2 VIRUS |
| CN111978377B (zh) | 2020-07-09 | 2022-05-31 | 苏州和锐生物科技有限公司 | Covid-19抗原、制备方法和应用 |
| WO2022011332A2 (en) | 2020-07-10 | 2022-01-13 | Engimata, Inc | Immunogenic composition forming a vaccine, and a method for its manufacture |
| CN112043825B (zh) | 2020-07-13 | 2023-12-05 | 中国医学科学院医学生物学研究所 | 一种基于新型冠状病毒突刺蛋白s1区域预防新型冠状病毒感染的亚单位疫苗 |
| CN111848753B (zh) | 2020-07-20 | 2022-03-15 | 中国科学院过程工程研究所 | 新型冠状病毒抗原表位及其应用 |
| RU2733834C1 (ru) | 2020-07-28 | 2020-10-07 | Федеральное бюджетное учреждение науки Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) | Искусственный ген EctoS_SC2, кодирующий эктодомен гликопротеина S коронавируса SARS-CoV-2 с C-концевым тримеризующим доменом, рекомбинантная плазмида pStem-rVSV-EctoS_SC2, обеспечивающая экспрессию искусственного гена, и рекомбинантный штамм вируса везикулярного стоматита rVSV-EctoS_SC2, используемый для создания вакцины против коронавируса SARS-CoV-2 |
| CN112028976A (zh) | 2020-08-05 | 2020-12-04 | 上海裕隆生物科技有限公司 | 2019新型冠状病毒刺突蛋白受体结合结构域蛋白及应用 |
| CN111939250B (zh) | 2020-08-17 | 2022-07-29 | 郑州大学 | 一种预防covid-19的疫苗及其制备方法 |
| RU2731356C9 (ru) | 2020-08-22 | 2021-10-05 | федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации | Экспрессионный вектор для создания иммунобиологического средства для индукции специфического иммунитета против вируса тяжелого острого респираторного синдрома SARS-CoV-2 (варианты) |
| RU2731342C9 (ru) | 2020-08-22 | 2021-10-05 | федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации | Фармацевтическое средство и способ его использования для индукции специфического иммунитета против вируса тяжелого острого респираторного синдрома SARS-CoV-2 (варианты) |
| CN112048005B (zh) | 2020-09-04 | 2022-09-09 | 江苏省中国科学院植物研究所 | 新型冠状病毒s蛋白片段多倍体及其制备方法、检测试剂盒、疫苗及药物 |
| CN112266411B (zh) | 2020-09-25 | 2022-06-24 | 北京诺思兰德生物技术股份有限公司 | 一种新型冠状病毒疫苗及其应用 |
| CN112094327A (zh) | 2020-09-25 | 2020-12-18 | 军事科学院军事医学研究院军事兽医研究所 | 基于新型冠状病毒rbd-sd1蛋白的截短体及其应用 |
| CN112226445B (zh) | 2020-10-20 | 2021-05-11 | 成都欧林生物科技股份有限公司 | 编码SARS-CoV-2病毒刺突蛋白的核酸及其的应用 |
| US20230416309A1 (en) | 2020-10-23 | 2023-12-28 | Jiangsu Provincial Center For Disease Control And Prevention (Public Health Research Institute Of Ji | Fusion protein and application thereof |
| CN112220920B (zh) | 2020-10-30 | 2023-06-13 | 上海泽润生物科技有限公司 | 一种重组新型冠状病毒疫苗组合物 |
| CN112358533B (zh) | 2020-10-30 | 2023-07-14 | 上海泽润生物科技有限公司 | 重组刺突蛋白及其制备方法和用途 |
| US20240041785A1 (en) | 2020-11-16 | 2024-02-08 | BioNTech SE | Compositions and methods for stabilization of lipid nanoparticle mrna vaccines |
| CN114517205A (zh) | 2020-11-20 | 2022-05-20 | 北京震旦鼎泰生物科技有限公司 | 融合基因及一种重组新型冠状病毒高效免疫鼎分子dna疫苗及其构建方法和应用 |
| CN112480217B (zh) | 2020-11-30 | 2022-04-08 | 广州阿格纳生物医药制造有限公司 | 基于SARS-CoV-2的S抗原蛋白的疫苗和组合物 |
| CN112626089B (zh) | 2020-12-08 | 2022-03-11 | 杭州百凌生物科技有限公司 | 一种SARS-CoV-2病毒S蛋白受体结合区域编码基因、抗体及应用 |
| MX2023007574A (es) | 2020-12-22 | 2023-09-29 | CureVac SE | "vacuna de arn contra variantes de sars-cov-2. |
| CN112794884B (zh) | 2020-12-28 | 2022-02-18 | 中国科学院微生物研究所 | 新型冠状病毒蛋白、制备方法及中和抗体检测试剂盒 |
| CN112321688B (zh) | 2021-01-06 | 2021-03-26 | 广东华南疫苗股份有限公司 | 稳定的冠状病毒重组蛋白二聚体及其表达载体 |
| JP2024511346A (ja) | 2021-03-15 | 2024-03-13 | モデルナティエックス インコーポレイテッド | Sars-cov-2 mrnaドメインワクチンの治療的使用 |
| CN116003496A (zh) * | 2021-11-24 | 2023-04-25 | 南京吉迈生物技术有限公司 | 经修饰的mRNA5`-帽类似物 |
-
2021
- 2021-04-16 CN CN202410650527.2A patent/CN118490818A/zh active Pending
- 2021-04-16 GB GB2105481.2A patent/GB2594365B/en active Active
- 2021-04-16 JP JP2021069705A patent/JP7514206B2/ja active Active
- 2021-04-16 KR KR1020227040676A patent/KR102813425B1/ko active Active
- 2021-04-16 EP EP21168938.5A patent/EP3901260A1/en not_active Withdrawn
- 2021-04-16 TW TW110113684A patent/TWI860474B/zh active
- 2021-04-16 EP EP21168950.0A patent/EP3901261A1/en not_active Withdrawn
- 2021-04-16 CN CN202110413326.7A patent/CN113521268A/zh active Pending
- 2021-04-16 WO PCT/EP2021/059947 patent/WO2021213924A1/en not_active Ceased
- 2021-04-16 TW TW113143512A patent/TW202508622A/zh unknown
- 2021-04-16 JP JP2021069840A patent/JP2021185136A/ja active Pending
- 2021-04-16 GB GBGB2307565.8A patent/GB202307565D0/en not_active Ceased
- 2021-04-16 CN CN202110414349.XA patent/CN113521269A/zh active Pending
- 2021-04-16 IL IL297419A patent/IL297419B2/en unknown
- 2021-04-16 EP EP21720413.0A patent/EP4138897A1/en not_active Withdrawn
- 2021-04-16 US US17/233,396 patent/US11547673B1/en active Active
- 2021-04-16 JP JP2022564006A patent/JP2023522249A/ja active Pending
- 2021-04-16 BR BR112022019781A patent/BR112022019781A2/pt unknown
- 2021-04-16 CA CA3174215A patent/CA3174215A1/en active Pending
- 2021-04-16 MX MX2022013254A patent/MX2022013254A/es unknown
- 2021-04-16 CN CN202180029692.0A patent/CN115811986A/zh active Pending
- 2021-04-16 GB GB2105465.5A patent/GB2594364A/en not_active Withdrawn
- 2021-04-16 IL IL315743A patent/IL315743A/en unknown
- 2021-04-16 AU AU2021261471A patent/AU2021261471B2/en active Active
- 2021-04-22 CN CN202310385622.XA patent/CN116585464A/zh active Pending
- 2021-04-22 EP EP21720748.9A patent/EP4139452A1/en active Pending
- 2021-04-22 IL IL297417A patent/IL297417B2/en unknown
- 2021-04-22 JP JP2022563994A patent/JP7604519B2/ja active Active
- 2021-04-22 KR KR1020227040675A patent/KR102796212B1/ko active Active
- 2021-04-22 EP EP25151261.2A patent/EP4549449A3/en active Pending
- 2021-04-22 CN CN202410244486.7A patent/CN118121722A/zh active Pending
- 2021-04-22 EP EP25176988.1A patent/EP4592306A3/en active Pending
- 2021-04-22 CA CA3173922A patent/CA3173922A1/en active Pending
- 2021-04-22 IL IL315928A patent/IL315928A/en unknown
- 2021-04-22 AU AU2021260099A patent/AU2021260099B2/en active Active
- 2021-04-22 CN CN202180041726.8A patent/CN115867654A/zh active Pending
- 2021-04-22 WO PCT/EP2021/060508 patent/WO2021214204A1/en not_active Ceased
- 2021-04-22 MX MX2022013255A patent/MX2022013255A/es unknown
- 2021-04-22 IL IL317516A patent/IL317516A/en unknown
- 2021-12-30 US US17/565,921 patent/US11951185B2/en active Active
- 2021-12-30 US US17/565,842 patent/US11779659B2/en active Active
-
2022
- 2022-03-18 US US17/699,035 patent/US20230073461A1/en not_active Abandoned
- 2022-03-18 US US17/698,829 patent/US11925694B2/en active Active
- 2022-09-22 ZA ZA2022/10526A patent/ZA202210526B/en unknown
- 2022-09-22 ZA ZA2022/10524A patent/ZA202210524B/en unknown
- 2022-10-20 MX MX2024009072A patent/MX2024009072A/es unknown
- 2022-10-20 MX MX2024011779A patent/MX2024011779A/es unknown
- 2022-11-16 US US17/988,742 patent/US12133899B2/en active Active
-
2024
- 2024-04-05 US US18/628,304 patent/US20240390524A1/en active Pending
- 2024-09-10 US US18/830,483 patent/US20250242059A1/en active Pending
- 2024-12-11 JP JP2024216309A patent/JP7888699B2/ja active Active
-
2025
- 2025-01-24 AU AU2025200483A patent/AU2025200483A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA3176481A1 (en) | Coronavirus vaccine | |
| US12133899B2 (en) | Coronavirus vaccine | |
| US11718647B2 (en) | Virus-like particles and methods of use | |
| CA3238757A1 (en) | Coronavirus vaccine | |
| US20230234992A1 (en) | Modified betacoronavirus spike proteins | |
| US20250000968A1 (en) | Sars-cov-2 spike fused to a hepatitis b surface antigen | |
| WO2014128568A2 (en) | Compositions and methods for treatment of hepatitis c | |
| KR20250071877A (ko) | Sars-cov-2 면역원성 조성물 | |
| Kim et al. | Construction of a novel tetravalent dengue vaccine with a Salmonella Typhimurium bacterial ghost and evaluation of its immunogenicity and protective efficacy using a murine model | |
| WO2025106754A1 (en) | Coronavirus vaccine | |
| AU2021470029A1 (en) | Coronavirus vaccine | |
| RU2849033C1 (ru) | Вакцина против коронавируса | |
| HK40063947A (en) | Coronavirus vaccine | |
| HK40063946A (en) | Coronavirus vaccine | |
| WO2024238911A1 (en) | Recombinant murine pneumonia virus expressing severe acute respiratory syndrome coronavirus 2 (sars-cov-2) spike protein | |
| HK40061540A (en) | Coronavirus vaccine | |
| HK40061535A (en) | Coronavirus vaccine | |
| HK40061489A (zh) | 冠状病毒疫苗 | |
| HK40061483A (en) | Coronavirus vaccine | |
| WO2015128731A2 (en) | Compositions and methods for treatment of hepatitis c |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20220929 |
|
| D16 | Fast track examination requested |
Free format text: ST27 STATUS EVENT CODE: N-6-6-D10-D16-D106 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: ADVANCED EXAMINATION REQUESTED - PARAGRAPH 84(1)(A) OF THE PATENT RULES Effective date: 20240705 |
|
| P11 | Amendment of application requested |
Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-P100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT RECEIVED - RESPONSE TO EXAMINER'S REQUISITION Effective date: 20240705 |
|
| B12 | Application deemed to be withdrawn, abandoned or lapsed |
Free format text: ST27 STATUS EVENT CODE: N-2-6-B10-B12-B303 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: DEEMED ABANDONED - FAILURE TO RESPOND TO AN EXAMINER'S REQUISITION Effective date: 20240903 |
|
| D16 | Fast track examination requested |
Free format text: ST27 STATUS EVENT CODE: N-6-6-D10-D16-D114 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: ADVANCED EXAMINATION REFUSED - PARAGRAPH 84(1)(A) OF THE PATENT RULES Effective date: 20241112 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: N-6-6-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT Effective date: 20241112 |
|
| P11 | Amendment of application requested |
Free format text: ST27 STATUS EVENT CODE: N-6-6-P10-P11-P102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT DETERMINED COMPLIANT Effective date: 20250210 |
|
| P13 | Application amended |
Free format text: ST27 STATUS EVENT CODE: N-6-6-P10-P13-X000 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: APPLICATION AMENDED Effective date: 20250210 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: N-6-6-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT Effective date: 20250210 |
|
| MFA | Maintenance fee for application paid |
Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 4TH ANNIV.) - STANDARD Year of fee payment: 4 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: N-6-6-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20250404 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: N-6-6-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20250404 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: N-6-6-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT Effective date: 20250516 |
|
| D17 | Fast track examination accepted |
Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D17-D110 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: ADVANCED EXAMINATION DETERMINED COMPLIANT - PARAGRAPH 84(1)(A) OF THE PATENT RULES Effective date: 20250530 |
|
| D15 | Examination report completed |
Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D15-D126 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: EXAMINER'S REPORT Effective date: 20250806 |
|
| B12 | Application deemed to be withdrawn, abandoned or lapsed |
Free format text: ST27 STATUS EVENT CODE: N-2-6-B10-B12-B303 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: DEEMED ABANDONED - FAILURE TO RESPOND TO AN EXAMINER'S REQUISITION Effective date: 20251208 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: N-6-6-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT Effective date: 20260528 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: N-6-6-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT Effective date: 20260708 |