CA3117687C - Polytherapy comprising a KRASG12C inhibitor and one or more additional pharmaceutically active agents for the treatment of cancer - Google Patents

Polytherapy comprising a KRASG12C inhibitor and one or more additional pharmaceutically active agents for the treatment of cancer

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Publication number
CA3117687C
CA3117687C CA3117687A CA3117687A CA3117687C CA 3117687 C CA3117687 C CA 3117687C CA 3117687 A CA3117687 A CA 3117687A CA 3117687 A CA3117687 A CA 3117687A CA 3117687 C CA3117687 C CA 3117687C
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CA
Canada
Prior art keywords
cancer
inhibitor
present
amg
compound
Prior art date
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Application number
CA3117687A
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English (en)
French (fr)
Other versions
CA3117687A1 (en
Inventor
James Russell LIPFORD
Jude Robert CANON
Anne Y. SAIKI
Karen Louise REX
Original Assignee
Amgen Inc
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Priority to CA3252495A priority Critical patent/CA3252495A1/en
Publication of CA3117687A1 publication Critical patent/CA3117687A1/en
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Publication of CA3117687C publication Critical patent/CA3117687C/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39566—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against immunoglobulins, e.g. anti-idiotypic antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
CA3117687A 2018-11-19 2019-11-18 Polytherapy comprising a KRASG12C inhibitor and one or more additional pharmaceutically active agents for the treatment of cancer Active CA3117687C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3252495A CA3252495A1 (en) 2018-11-19 2019-11-18 Combination therapy including a krasg12c inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862769355P 2018-11-19 2018-11-19
US62/769,355 2018-11-19
US201962821376P 2019-03-20 2019-03-20
US62/821,376 2019-03-20
US201962865819P 2019-06-24 2019-06-24
US62/865,819 2019-06-24
PCT/US2019/062064 WO2020106647A2 (en) 2018-11-19 2019-11-18 Combination therapy including a krasg12c inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3252495A Division CA3252495A1 (en) 2018-11-19 2019-11-18 Combination therapy including a krasg12c inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers

Publications (2)

Publication Number Publication Date
CA3117687A1 CA3117687A1 (en) 2020-05-28
CA3117687C true CA3117687C (en) 2025-05-06

Family

ID=70774750

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3117687A Active CA3117687C (en) 2018-11-19 2019-11-18 Polytherapy comprising a KRASG12C inhibitor and one or more additional pharmaceutically active agents for the treatment of cancer
CA3252495A Pending CA3252495A1 (en) 2018-11-19 2019-11-18 Combination therapy including a krasg12c inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3252495A Pending CA3252495A1 (en) 2018-11-19 2019-11-18 Combination therapy including a krasg12c inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers

Country Status (28)

Country Link
US (5) US11439645B2 (enExample)
EP (2) EP4685160A3 (enExample)
JP (3) JP7377679B2 (enExample)
KR (2) KR20250102109A (enExample)
CN (1) CN113038953B (enExample)
AU (2) AU2019384119B8 (enExample)
BR (1) BR112021009595A2 (enExample)
CA (2) CA3117687C (enExample)
CL (4) CL2021001292A1 (enExample)
DK (1) DK3883579T3 (enExample)
ES (1) ES3063562T3 (enExample)
FI (1) FI3883579T3 (enExample)
HR (1) HRP20260108T1 (enExample)
IL (1) IL282727B2 (enExample)
LT (1) LT3883579T (enExample)
MA (1) MA55145B1 (enExample)
MX (1) MX2021005898A (enExample)
NZ (1) NZ775660A (enExample)
PL (1) PL3883579T3 (enExample)
PT (1) PT3883579T (enExample)
RS (1) RS67775B1 (enExample)
SG (1) SG11202105158VA (enExample)
SI (1) SI3883579T1 (enExample)
SM (1) SMT202600101T1 (enExample)
TW (3) TWI851405B (enExample)
UA (1) UA128921C2 (enExample)
UY (1) UY38481A (enExample)
WO (1) WO2020106647A2 (enExample)

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