CA3021068A1 - Combinations and methods comprising a capsid assembly inhibitor - Google Patents
Combinations and methods comprising a capsid assembly inhibitor Download PDFInfo
- Publication number
- CA3021068A1 CA3021068A1 CA3021068A CA3021068A CA3021068A1 CA 3021068 A1 CA3021068 A1 CA 3021068A1 CA 3021068 A CA3021068 A CA 3021068A CA 3021068 A CA3021068 A CA 3021068A CA 3021068 A1 CA3021068 A1 CA 3021068A1
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- Prior art keywords
- compound
- formula
- pharmaceutically acceptable
- reverse transcriptase
- transcriptase inhibitor
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Classifications
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
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Landscapes
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
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| US201662421035P | 2016-11-11 | 2016-11-11 | |
| US62/421,035 | 2016-11-11 | ||
| PCT/US2017/027802 WO2017181141A2 (en) | 2016-04-15 | 2017-04-14 | Combinations and methods comprising a capsid assembly inhibitor |
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| CA3021068A1 true CA3021068A1 (en) | 2017-10-19 |
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| EP3102225B1 (en) | 2014-02-05 | 2020-03-25 | Novira Therapeutics Inc. | Combination therapy for treatment of hbv infections |
| TW201718496A (zh) * | 2015-09-29 | 2017-06-01 | 諾維拉治療公司 | B型肝炎抗病毒劑之晶型 |
| CN109640980A (zh) | 2016-04-15 | 2019-04-16 | 诺维拉治疗公司 | 包含壳体装配抑制剂的组合和方法 |
| WO2018116894A1 (ja) | 2016-12-19 | 2018-06-28 | パイオニア株式会社 | 発光装置及び発光システム |
| TW201945003A (zh) | 2018-03-01 | 2019-12-01 | 愛爾蘭商健生科學愛爾蘭無限公司 | ２，４－二胺基喹唑啉衍生物及其醫學用途 |
| JP2021515769A (ja) * | 2018-03-14 | 2021-06-24 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | カプシド集合調節剤の投薬レジメン |
| MA55720A (fr) * | 2019-04-18 | 2022-02-23 | Janssen Pharmaceuticals Inc | Polythérapie pour le traitement d'une infection par le virus de l'hépatite b |
| AR119732A1 (es) | 2019-05-06 | 2022-01-05 | Janssen Sciences Ireland Unlimited Co | Derivados de amida útiles en el tratamiento de la infección por vhb o de enfermedades inducidas por vhb |
| US20220241402A1 (en) | 2019-06-18 | 2022-08-04 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and quinazoline derivatives |
| US20220305116A1 (en) * | 2019-06-18 | 2022-09-29 | Janssen Sciences lreland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and capsid assembly modulators being sulfonamide derivatives |
| TW202146008A (zh) * | 2020-02-27 | 2021-12-16 | 愛爾蘭商健生科學愛爾蘭無限公司 | Ｈｂｖ的治療 |
| WO2021178612A1 (en) * | 2020-03-05 | 2021-09-10 | Janssen Pharmaceuticals, Inc. | Combination therapy for treating hepatitis b virus infection |
| JP7706475B2 (ja) * | 2020-05-15 | 2025-07-11 | 福建▲広▼生中霖生物科技有限公司 | 三環式化合物を含む組み合わせ及びｈｂｖ治療薬物の製造におけるその使用 |
| JP2023547150A (ja) * | 2020-11-05 | 2023-11-09 | チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド | カプシドタンパク質阻害剤及びヌクレオシド類似体を含む医薬組合せ |
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-
2017
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- 2017-04-14 EP EP17737399.0A patent/EP3442524A2/en not_active Withdrawn
- 2017-04-14 AU AU2017248828A patent/AU2017248828A1/en not_active Withdrawn
- 2017-04-14 SG SG10202011827YA patent/SG10202011827YA/en unknown
- 2017-04-14 WO PCT/US2017/027802 patent/WO2017181141A2/en not_active Ceased
- 2017-04-14 MX MX2018012557A patent/MX2018012557A/es unknown
- 2017-04-14 MA MA044671A patent/MA44671A/fr unknown
- 2017-04-14 EP EP20211452.6A patent/EP3848026A1/en not_active Withdrawn
- 2017-04-14 KR KR1020187032801A patent/KR20180129943A/ko not_active Withdrawn
- 2017-04-14 CA CA3021068A patent/CA3021068A1/en not_active Withdrawn
- 2017-04-14 JP JP2018553947A patent/JP2019511542A/ja not_active Withdrawn
- 2017-04-14 SG SG11201808949SA patent/SG11201808949SA/en unknown
- 2017-04-14 BR BR112018071048-2A patent/BR112018071048A2/pt not_active Application Discontinuation
- 2017-04-14 US US15/488,368 patent/US10441589B2/en not_active Expired - Fee Related
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2018
- 2018-10-12 MX MX2020011808A patent/MX2020011808A/es unknown
- 2018-10-15 IL IL262378A patent/IL262378A/en unknown
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2019
- 2019-08-15 US US16/541,490 patent/US11129834B2/en not_active Expired - Fee Related
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| MX2020011808A (es) | 2020-12-07 |
| BR112018071048A2 (pt) | 2019-05-07 |
| EP3442524A2 (en) | 2019-02-20 |
| SG11201808949SA (en) | 2018-11-29 |
| JP2019511542A (ja) | 2019-04-25 |
| US11129834B2 (en) | 2021-09-28 |
| SG10202011827YA (en) | 2021-01-28 |
| IL262378A (en) | 2018-11-29 |
| US10441589B2 (en) | 2019-10-15 |
| EP3848026A1 (en) | 2021-07-14 |
| KR20180129943A (ko) | 2018-12-05 |
| MA44671A (fr) | 2019-02-20 |
| AU2017248828A1 (en) | 2018-11-01 |
| MX2018012557A (es) | 2019-07-04 |
| CN109640980A (zh) | 2019-04-16 |
| US20170340642A1 (en) | 2017-11-30 |
| WO2017181141A2 (en) | 2017-10-19 |
| US20190365767A1 (en) | 2019-12-05 |
| WO2017181141A3 (en) | 2018-01-11 |
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