CA3018991A1 - Compounds that induce degradation of anti-apoptotic bcl-2 family proteins and the uses thereof - Google Patents
Compounds that induce degradation of anti-apoptotic bcl-2 family proteins and the uses thereof Download PDFInfo
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- CA3018991A1 CA3018991A1 CA3018991A CA3018991A CA3018991A1 CA 3018991 A1 CA3018991 A1 CA 3018991A1 CA 3018991 A CA3018991 A CA 3018991A CA 3018991 A CA3018991 A CA 3018991A CA 3018991 A1 CA3018991 A1 CA 3018991A1
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
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- Health & Medical Sciences (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| WO2016014625A1 (en) | 2014-07-22 | 2016-01-28 | Board Of Trustees Of The University Of Arkansas | Compositions and methods for selectively depleting senescent cells |
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| IL290809B2 (en) | 2016-11-01 | 2024-01-01 | Arvinas Operations Inc | Tau-protein targeting protacs and associated methods of use |
| KR102656934B1 (ko) | 2017-07-10 | 2024-04-16 | 셀진 코포레이션 | 항증식성 화합물 및 이의 사용 방법 |
| KR20200108298A (ko) | 2018-01-10 | 2020-09-17 | 리커리엄 아이피 홀딩스, 엘엘씨 | 벤즈아미드 화합물 |
| CA3088253A1 (en) * | 2018-01-22 | 2019-07-25 | Bioventures, Llc | Bcl-2 proteins degraders for cancer treatment |
| US12084423B2 (en) | 2018-05-18 | 2024-09-10 | Bioventures, Llc | Piperlongumine analogues and uses thereof |
| WO2019218904A1 (zh) * | 2018-05-18 | 2019-11-21 | 四川科伦博泰生物医药股份有限公司 | 非天然氨基酸类衍生物、其制备方法及用途 |
| EP3790861A4 (en) * | 2018-07-11 | 2022-03-30 | Rubedo Life Sciences, Inc. | SENOLYTIC COMPOSITIONS AND THEIR USES |
| US20220169628A1 (en) * | 2019-02-08 | 2022-06-02 | University Of Florida Research Foundation, Incorporated | Therapeutic agents and methods of treatment |
| CN114144411A (zh) * | 2019-07-10 | 2022-03-04 | 里科瑞尔姆Ip控股有限责任公司 | Bcl-2蛋白抑制剂 |
| JP7548992B2 (ja) * | 2019-07-17 | 2024-09-10 | アルビナス・オペレーションズ・インコーポレイテッド | タウタンパク質標的化化合物および関連する使用方法 |
| EP4038066A1 (en) * | 2019-10-01 | 2022-08-10 | Arvinas Operations, Inc. | Brm targeting compounds and associated methods of use |
| CN112707900B (zh) * | 2019-10-24 | 2022-06-10 | 上海科技大学 | 蛋白降解剂及其在疾病治疗中的应用 |
| WO2021126973A1 (en) * | 2019-12-17 | 2021-06-24 | Orionis Biosciences, Inc. | Compounds modulating protein recruitment and/or degradation |
| WO2021146536A1 (en) * | 2020-01-15 | 2021-07-22 | University Of Florida Research Foundation, Incorporated | Therapeutic agents and methods of treatment |
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| KR20230002483A (ko) * | 2020-04-28 | 2023-01-05 | 리커리엄 아이피 홀딩스, 엘엘씨 | Bcl-2 단백질 억제제 |
| JP2023524599A (ja) | 2020-05-09 | 2023-06-12 | アルビナス・オペレーションズ・インコーポレイテッド | 二官能性化合物を製造する方法、二官能性化合物の超高純度形態、及びそれらを含む剤形 |
| JP2024504932A (ja) | 2021-01-13 | 2024-02-02 | モンテ ローザ セラピューティクス， インコーポレイテッド | イソインドリノン化合物 |
| IL304891A (en) | 2021-02-02 | 2023-10-01 | Servier Lab | Selective Protech BCL-XL compounds and methods of use |
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| WO2022255888A1 (en) * | 2021-06-01 | 2022-12-08 | Captor Therapeutics S.A. | Targeted protein degradation using bifunctional compounds that bind ubiquitin ligase and target mcl-1 protein |
| CN117897385A (zh) * | 2021-09-01 | 2024-04-16 | 西藏海思科制药有限公司 | 一种降解Bcl-2家族蛋白的化合物及其在医药上的应用 |
| US20250197387A1 (en) * | 2021-09-17 | 2025-06-19 | Kymera Therapeutics, Inc. | Bcl-xl degraders and uses thereof |
| TW202320769A (zh) * | 2021-11-17 | 2023-06-01 | 大陸商成都先導藥物開發股份有限公司 | 一種降解劑及其用途 |
| US20250154146A1 (en) * | 2022-01-04 | 2025-05-15 | Shanghaitech University | Protein degraders developed on basis of bcl-2 family protein ligand compounds and use thereof |
| WO2023205802A2 (en) * | 2022-04-22 | 2023-10-26 | Sens Research Foundation | Senolytic targets of senescent cells |
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| CN119768402A (zh) * | 2022-07-12 | 2025-04-04 | 正大天晴药业集团股份有限公司 | 含有三氟甲基基团的化合物 |
| WO2024027706A1 (en) * | 2022-08-02 | 2024-02-08 | Beijing Neox Biotech Limited | Bcl-xl degrading compounds |
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| CN119923390A (zh) * | 2022-09-06 | 2025-05-02 | 西藏海思科制药有限公司 | 一种抑制Bcl-2或Bcl-xL的化合物及其在医药上的应用 |
| CN115286689B (zh) * | 2022-09-29 | 2023-01-06 | 上海睿跃生物科技有限公司 | 靶向降解Bcl-2蛋白的化合物及其应用和药物 |
| CN115260191B (zh) * | 2022-09-29 | 2022-12-27 | 上海睿跃生物科技有限公司 | 哌啶类化合物及其制备方法和应用 |
| WO2024067818A1 (zh) * | 2022-09-30 | 2024-04-04 | 江苏恒瑞医药股份有限公司 | 一种用于bcl-2蛋白靶向降解的嵌合体化合物、其制备方法及其在医药上的应用 |
| CN115286630B (zh) * | 2022-10-09 | 2022-12-27 | 上海睿跃生物科技有限公司 | 哌嗪类化合物及其制备方法和应用 |
| WO2024078581A1 (en) * | 2022-10-12 | 2024-04-18 | Appicine Therapeutics (Hk) Limited | Selective bcl-xl protac compounds and uses thereof |
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| AU2023389065A1 (en) * | 2022-12-06 | 2025-06-19 | Captor Therapeutics S.A. | Targeted protein degradation using bifunctional compounds that bind ubiquitin ligase and target mcl-1 protein |
| KR20250142929A (ko) * | 2023-02-17 | 2025-09-30 | 치아타이 티안큉 파마수티컬 그룹 주식회사 | 트리플루오로메틸설포닐을 포함하는 화합물 |
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| JP6936498B2 (ja) | 2021-09-15 |
| US20200331905A1 (en) | 2020-10-22 |
| CN109152933A (zh) | 2019-01-04 |
| KR20180134908A (ko) | 2018-12-19 |
| JP2019514877A (ja) | 2019-06-06 |
| CN109152933B (zh) | 2022-12-02 |
| WO2017184995A1 (en) | 2017-10-26 |
| AU2017254687B2 (en) | 2021-09-30 |
| AU2017254687A1 (en) | 2018-10-18 |
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