KR102447884B1 - 항-세포자멸적 bcl-2 계열 단백질의 열화를 유도하는 화합물 및 이의 용도 - Google Patents

항-세포자멸적 bcl-2 계열 단백질의 열화를 유도하는 화합물 및 이의 용도 Download PDF

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KR102447884B1
KR102447884B1 KR1020187029999A KR20187029999A KR102447884B1 KR 102447884 B1 KR102447884 B1 KR 102447884B1 KR 1020187029999 A KR1020187029999 A KR 1020187029999A KR 20187029999 A KR20187029999 A KR 20187029999A KR 102447884 B1 KR102447884 B1 KR 102447884B1
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구안그롱 정
다오홍 조우
수안 장
잉잉 왕
지안후이 창
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바이오벤처스, 엘엘씨
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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KR1020187029999A 2016-04-21 2017-04-21 항-세포자멸적 bcl-2 계열 단백질의 열화를 유도하는 화합물 및 이의 용도 Active KR102447884B1 (ko)

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US201662325856P 2016-04-21 2016-04-21
US62/325,856 2016-04-21
PCT/US2017/028875 WO2017184995A1 (en) 2016-04-21 2017-04-21 Compounds that induce degradation of anti-apoptotic bcl-2 family proteins and the uses thereof

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KR20180134908A KR20180134908A (ko) 2018-12-19
KR102447884B1 true KR102447884B1 (ko) 2022-09-27

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US (2) US10807977B2 (cg-RX-API-DMAC7.html)
EP (1) EP3445452A4 (cg-RX-API-DMAC7.html)
JP (1) JP6936498B2 (cg-RX-API-DMAC7.html)
KR (1) KR102447884B1 (cg-RX-API-DMAC7.html)
CN (1) CN109152933B (cg-RX-API-DMAC7.html)
AU (1) AU2017254687B2 (cg-RX-API-DMAC7.html)
CA (1) CA3018991A1 (cg-RX-API-DMAC7.html)
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