CA3013639A1 - Exogenous gene expression in therapeutic adenovirus for minimal impact on viral kinetics - Google Patents

Exogenous gene expression in therapeutic adenovirus for minimal impact on viral kinetics Download PDF

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Publication number
CA3013639A1
CA3013639A1 CA3013639A CA3013639A CA3013639A1 CA 3013639 A1 CA3013639 A1 CA 3013639A1 CA 3013639 A CA3013639 A CA 3013639A CA 3013639 A CA3013639 A CA 3013639A CA 3013639 A1 CA3013639 A1 CA 3013639A1
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Prior art keywords
recombinant adenovirus
orf
adenovirus
subject
protein
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CA3013639A
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English (en)
French (fr)
Inventor
Clodagh O'shea
William Partlo
Colin Powers
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Salk Institute for Biological Studies
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Salk Institute for Biological Studies
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
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    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10351—Methods of production or purification of viral material
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CA3013639A 2016-02-23 2017-02-23 Exogenous gene expression in therapeutic adenovirus for minimal impact on viral kinetics Pending CA3013639A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662298653P 2016-02-23 2016-02-23
US62/298,653 2016-02-23
PCT/US2017/019086 WO2017147269A1 (en) 2016-02-23 2017-02-23 Exogenous gene expression in therapeutic adenovirus for minimal impact on viral kinetics

Publications (1)

Publication Number Publication Date
CA3013639A1 true CA3013639A1 (en) 2017-08-31

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CA3013639A Pending CA3013639A1 (en) 2016-02-23 2017-02-23 Exogenous gene expression in therapeutic adenovirus for minimal impact on viral kinetics

Country Status (9)

Country Link
US (4) US10738325B2 (https=)
EP (2) EP4155411A1 (https=)
JP (3) JP7015551B2 (https=)
KR (3) KR102471633B1 (https=)
CN (2) CN108699566B (https=)
AU (2) AU2017223589B2 (https=)
CA (1) CA3013639A1 (https=)
ES (1) ES2933174T3 (https=)
WO (1) WO2017147269A1 (https=)

Families Citing this family (16)

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SG11201507393TA (en) 2013-03-14 2015-10-29 Salk Inst For Biological Studi Oncolytic adenovirus compositions
KR102608590B1 (ko) 2014-09-24 2023-12-01 솔크 인스티튜트 포 바이올로지칼 스터디즈 종양 살상 바이러스 및 이의 사용방법
EP3359175B1 (en) 2015-10-05 2020-09-16 Salk Institute for Biological Studies Synthetic adenoviruses with tropism to damaged tissue for use in promoting wound repair and tissue regeneration
WO2017147269A1 (en) * 2016-02-23 2017-08-31 Salk Institute For Biological Studies Exogenous gene expression in therapeutic adenovirus for minimal impact on viral kinetics
WO2017147265A1 (en) 2016-02-23 2017-08-31 Salk Institute For Biological Studies High throughput assay for measuring adenovirus replication kinetics
EP3532082A4 (en) 2016-12-12 2020-08-26 Salk Institute for Biological Studies SYNTHETIC ADENOVIRUS TUMOR TARGETING AND THEIR USES
CN112292449A (zh) * 2018-04-09 2021-01-29 萨克生物研究学院 具有增强的复制特性的溶瘤腺病毒组合物
CN109758467B (zh) * 2019-03-08 2020-12-25 中国农业科学院兰州兽医研究所 一种吉西他滨在制备预防口蹄疫病毒感染的药物中的应用
CN119410708A (zh) * 2019-06-10 2025-02-11 高级健康研究所 星状病毒复制子的方法和组合物
EP4133091A4 (en) * 2020-04-10 2024-07-03 Washington State University UNIVERSAL GENE EXPRESSION SYSTEM FOR THE EXPRESSION OF GENES IN OILY YEASTS
CA3188762A1 (en) * 2020-07-06 2022-01-13 Salk Institute For Biological Studies Recombinant adenovirus genome having a synthetic transcriptional unit and two step transcriptional regulation and amplification
CN112592388A (zh) * 2020-12-14 2021-04-02 河南普诺易生物制品研究院有限公司 一种2a肽、双顺反子表达载体、重组蛋白表达系统及应用
KR20230153529A (ko) * 2021-02-19 2023-11-06 프리트 엠. 쇼드하리 다양한 면역세포를 위한 단일사슬 및 다중사슬 합성 항원 수용체
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