CA2935651A1 - Broad spectrum beta-lactamase inhibitors - Google Patents

Broad spectrum beta-lactamase inhibitors Download PDF

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Publication number
CA2935651A1
CA2935651A1 CA2935651A CA2935651A CA2935651A1 CA 2935651 A1 CA2935651 A1 CA 2935651A1 CA 2935651 A CA2935651 A CA 2935651A CA 2935651 A CA2935651 A CA 2935651A CA 2935651 A1 CA2935651 A1 CA 2935651A1
Authority
CA
Canada
Prior art keywords
group
hydrogen
compound
alkyl
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2935651A
Other languages
English (en)
French (fr)
Inventor
Larry Sutton
Sophia Yu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GLADIUS PHARMACEUTICALS Corp
Original Assignee
GLADIUS PHARMACEUTICALS Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GLADIUS PHARMACEUTICALS Corp filed Critical GLADIUS PHARMACEUTICALS Corp
Publication of CA2935651A1 publication Critical patent/CA2935651A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/60—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 3 and 4

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Agronomy & Crop Science (AREA)
  • Plant Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Pest Control & Pesticides (AREA)
  • Dentistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
CA2935651A 2007-10-09 2008-10-09 Broad spectrum beta-lactamase inhibitors Abandoned CA2935651A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US99794107P 2007-10-09 2007-10-09
US99789807P 2007-10-09 2007-10-09
US60/997,941 2007-10-09
US60/997,898 2007-10-09
CA2702257A CA2702257C (en) 2007-10-09 2008-10-09 Broad spectrum beta-lactamase inhibitors

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2702257A Division CA2702257C (en) 2007-10-09 2008-10-09 Broad spectrum beta-lactamase inhibitors

Publications (1)

Publication Number Publication Date
CA2935651A1 true CA2935651A1 (en) 2009-04-16

Family

ID=40549565

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2935651A Abandoned CA2935651A1 (en) 2007-10-09 2008-10-09 Broad spectrum beta-lactamase inhibitors
CA2702257A Expired - Fee Related CA2702257C (en) 2007-10-09 2008-10-09 Broad spectrum beta-lactamase inhibitors

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2702257A Expired - Fee Related CA2702257C (en) 2007-10-09 2008-10-09 Broad spectrum beta-lactamase inhibitors

Country Status (5)

Country Link
US (6) US8883772B2 (https=)
EP (1) EP2209474A4 (https=)
JP (4) JP5733856B2 (https=)
CA (2) CA2935651A1 (https=)
WO (1) WO2009049086A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050227309A1 (en) 2004-01-21 2005-10-13 Corry Schuyler B Optically-detectable enzyme substrates and their method of use
EP2209474A4 (en) 2007-10-09 2013-07-24 Sopharmia Inc BROAD SPECTRUM BETA-LACTAMASE INHIBITORS
WO2013036783A2 (en) 2011-09-09 2013-03-14 Cubist Pharmaceuticals, Inc. Methods for treating intrapulmonary infections
JP6403289B2 (ja) * 2013-03-12 2018-10-10 グラディウス ファーマシューティカルズ コーポレーションＧｌａｄｉｕｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｃｏｒｐｏｒａｔｉｏｎ 誘導体化３−スチリル−セファロスポリン
CN104805066B (zh) * 2015-05-18 2018-04-24 武汉菲吉乐科生物科技有限公司 一种葡萄球菌裂解酶及其应用
US20190100534A1 (en) * 2017-10-04 2019-04-04 Gladius Pharmaceuticals, Inc. Cephem Compounds with Latent Reactive Groups
EP3795149A4 (en) 2018-05-14 2022-01-05 National University Corporation Tokai National Higher Education and Research System BETA-LACTAMASE INHIBITOR
WO2020018462A1 (en) 2018-07-16 2020-01-23 Brown University A chromogenic beta-lactamase substrate
US12195755B2 (en) 2019-05-20 2025-01-14 Brown University Placental lipid bilayer for cell-free molecular interaction studies
US12509559B2 (en) 2019-10-28 2025-12-30 Brown University Bacterial beta-lactamase responsive hydrogels
WO2024160247A1 (zh) * 2023-02-02 2024-08-08 苏州信诺维医药科技股份有限公司 含β-内酰胺酶抑制剂的药物组合物及其应用

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TWI547496B (zh) 2011-10-04 2016-09-01 葛蘭素集團公司 抗菌化合物
JP6403289B2 (ja) 2013-03-12 2018-10-10 グラディウス ファーマシューティカルズ コーポレーションＧｌａｄｉｕｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｃｏｒｐｏｒａｔｉｏｎ 誘導体化３−スチリル−セファロスポリン

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US8883772B2 (en) 2014-11-11
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