CA2919948C - Novel quinazolinones as bromodomain inhibitors - Google Patents

Novel quinazolinones as bromodomain inhibitors Download PDF

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Publication number
CA2919948C
CA2919948C CA2919948A CA2919948A CA2919948C CA 2919948 C CA2919948 C CA 2919948C CA 2919948 A CA2919948 A CA 2919948A CA 2919948 A CA2919948 A CA 2919948A CA 2919948 C CA2919948 C CA 2919948C
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Canada
Prior art keywords
amino
dimethoxy
cancer
dimethoxyquinazolin
pyridin
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Expired - Fee Related
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CA2919948A
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English (en)
French (fr)
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CA2919948A1 (en
Inventor
John Frederick Quinn
Vladimir Khlebnikov
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Zenith Epigenetics Ltd
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Zenith Epigenetics Ltd
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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CA2919948A 2013-07-31 2014-07-30 Novel quinazolinones as bromodomain inhibitors Expired - Fee Related CA2919948C (en)

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Application Number Priority Date Filing Date Title
US201361860403P 2013-07-31 2013-07-31
US61/860,403 2013-07-31
PCT/IB2014/002510 WO2015015318A2 (en) 2013-07-31 2014-07-30 Novel quinazolinones as bromodomain inhibitors

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CA2919948A1 CA2919948A1 (en) 2015-02-05
CA2919948C true CA2919948C (en) 2020-07-21

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CA2919948A Expired - Fee Related CA2919948C (en) 2013-07-31 2014-07-30 Novel quinazolinones as bromodomain inhibitors

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US (2) US9855271B2 (https=)
EP (1) EP3027604B1 (https=)
JP (1) JP6542212B2 (https=)
KR (1) KR20160038008A (https=)
CN (1) CN105593224B (https=)
AU (1) AU2014298051B2 (https=)
CA (1) CA2919948C (https=)
EA (1) EA201690087A1 (https=)
IL (1) IL243479B (https=)
WO (1) WO2015015318A2 (https=)

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