CA2911990C - A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors - Google Patents

A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors Download PDF

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Publication number
CA2911990C
CA2911990C CA2911990A CA2911990A CA2911990C CA 2911990 C CA2911990 C CA 2911990C CA 2911990 A CA2911990 A CA 2911990A CA 2911990 A CA2911990 A CA 2911990A CA 2911990 C CA2911990 C CA 2911990C
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Prior art keywords
cancer
compound
cells
stat3
cell
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Expired - Fee Related
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CA2911990A
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English (en)
French (fr)
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CA2911990A1 (en
Inventor
Chiang Jia Li
Zhiwei Jiang
Harry Rogoff
Youzhi Li
Jifeng Liu
Wei Li
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Sumitomo Pharma Oncology Inc
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Boston Biomedical Inc
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/74—Naphthothiophenes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
CA2911990A 2007-09-10 2008-09-10 A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors Expired - Fee Related CA2911990C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US97114407P 2007-09-10 2007-09-10
US60/971,144 2007-09-10
US1337207P 2007-12-13 2007-12-13
US61/013,372 2007-12-13
CA2736563A CA2736563C (en) 2007-09-10 2008-09-10 A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2736563A Division CA2736563C (en) 2007-09-10 2008-09-10 A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors

Publications (2)

Publication Number Publication Date
CA2911990A1 CA2911990A1 (en) 2009-03-19
CA2911990C true CA2911990C (en) 2018-03-20

Family

ID=40452461

Family Applications (4)

Application Number Title Priority Date Filing Date
CA2911990A Expired - Fee Related CA2911990C (en) 2007-09-10 2008-09-10 A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors
CA2736532A Expired - Fee Related CA2736532C (en) 2007-09-10 2008-09-10 Stat3 pathway inhibitors and cancer stem cell inhibitors
CA2736564A Abandoned CA2736564A1 (en) 2007-09-10 2008-09-10 Novel compositions and methods for cancer treatment
CA2736563A Expired - Fee Related CA2736563C (en) 2007-09-10 2008-09-10 A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors

Family Applications After (3)

Application Number Title Priority Date Filing Date
CA2736532A Expired - Fee Related CA2736532C (en) 2007-09-10 2008-09-10 Stat3 pathway inhibitors and cancer stem cell inhibitors
CA2736564A Abandoned CA2736564A1 (en) 2007-09-10 2008-09-10 Novel compositions and methods for cancer treatment
CA2736563A Expired - Fee Related CA2736563C (en) 2007-09-10 2008-09-10 A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors

Country Status (14)

Country Link
US (12) US9745278B2 (enExample)
EP (6) EP2194987B1 (enExample)
JP (16) JP5701603B2 (enExample)
CN (6) CN101854802B (enExample)
CA (4) CA2911990C (enExample)
CY (3) CY1117604T1 (enExample)
DK (4) DK3050566T3 (enExample)
ES (3) ES2569215T3 (enExample)
HR (3) HRP20160949T1 (enExample)
HU (3) HUE027657T2 (enExample)
PL (4) PL2200431T3 (enExample)
PT (2) PT2200431T (enExample)
SI (3) SI2194987T1 (enExample)
WO (3) WO2009036101A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10851075B2 (en) 2007-09-10 2020-12-01 Sumitomo Dainippon Pharma Oncology, Inc. Stat3 pathway inhibitors and cancer stem cell inhibitors

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