CA2910417C - Delivery of immunosuppressants having a specified pharmacodynamic effective-life and antigen for the induction of immune tolerance - Google Patents
Delivery of immunosuppressants having a specified pharmacodynamic effective-life and antigen for the induction of immune tolerance Download PDFInfo
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- CA2910417C CA2910417C CA2910417A CA2910417A CA2910417C CA 2910417 C CA2910417 C CA 2910417C CA 2910417 A CA2910417 A CA 2910417A CA 2910417 A CA2910417 A CA 2910417A CA 2910417 C CA2910417 C CA 2910417C
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- immunosuppressant
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- synthetic nanocarriers
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- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
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| PCT/US2014/036697 WO2014179770A1 (en) | 2013-05-03 | 2014-05-02 | Delivery of immunosuppressants having a specified pharmacodynamic effective-life and antigen for the inducation of immune tolerance |
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| CA2798739A1 (en) | 2010-05-26 | 2011-12-01 | Selecta Biosciences, Inc. | Nanocarrier compositions with uncoupled adjuvant |
| EA201390660A1 (ru) | 2010-11-05 | 2013-11-29 | Селекта Байосайенсиз, Инк. | Модифицированные никотиновые соединения и связанные способы |
| MX374963B (es) | 2011-04-29 | 2025-03-06 | Selecta Biosciences Inc | Nanoportadores sintéticos tolerogénicos para reducir las respuestas de anticuerpos. |
| KR20140050698A (ko) | 2011-07-29 | 2014-04-29 | 셀렉타 바이오사이언시즈, 인크. | 체액성 및 세포독성 t 림프구(ctl) 면역 반응을 발생시키는 합성 나노운반체 |
| BR122020023215B1 (pt) | 2013-05-03 | 2022-11-22 | Selecta Biosciences, Inc | Composição e kit de nanocarreadores sintéticos tolerogênicos para reduzir ou prevenir anafilaxia em resposta a um antígeno não alergênico |
| JP7242180B2 (ja) | 2014-09-07 | 2023-03-20 | セレクタ バイオサイエンシーズ インコーポレーテッド | 抗ウイルス導入ベクター免疫応答を減弱化するための方法および組成物 |
| WO2017025889A1 (en) * | 2015-08-13 | 2017-02-16 | Pfizer Inc. | Polymeric nanoparticles with dec-205 ligand and co-encapsulating an antigen subject to an autoimmune response and a glucocorticoid receptor agonist |
| US10744209B2 (en) | 2015-11-12 | 2020-08-18 | New York University | Biodegradable polymeric nanoparticle conjugates and use thereof |
| KR20180120753A (ko) * | 2016-03-11 | 2018-11-06 | 셀렉타 바이오사이언시즈, 인크. | Peg화 우리카제의 제제 및 용량 |
| US11458106B2 (en) | 2016-05-09 | 2022-10-04 | Astrazeneca Ab | Lipid nanoparticles comprising lipophilic anti-inflammatory agents and methods of use thereof |
| US11365392B2 (en) * | 2016-08-05 | 2022-06-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Ex vivo generation of MHCII restricted CD4+ FOXP3+ regulatory T cells and therapeutic uses thereof |
| JP2019530470A (ja) * | 2016-08-05 | 2019-10-24 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | γδFoxp3+調節性T細胞のエクスビボ生成及びその治療的使用 |
| MX2019008143A (es) * | 2017-01-07 | 2020-01-13 | Selecta Biosciences Inc | Dosificación sistemática de inmunosupresores acoplados a nanoportadores sintéticos. |
| ES3036482T3 (en) * | 2017-03-11 | 2025-09-19 | Cartesian Therapeutics Inc | Methods and compositions related to combined treatment with anti-inflammatories and synthetic nanocarriers comprising an immunosuppressant |
| BR112020007157A2 (pt) * | 2017-10-13 | 2020-09-24 | Selecta Biosciences, Inc. | métodos e composições para a atenuação de respostas de igm antivetor de transferência viral |
| WO2019129824A1 (en) * | 2017-12-27 | 2019-07-04 | Vito Nv | Biomarkers for typing allograft recipients |
| CN108295303A (zh) * | 2018-02-08 | 2018-07-20 | 中山大学附属第三医院(中山大学肝脏病医院) | 一种钛金属植入物及其制备方法和用途 |
| CN110314236A (zh) * | 2018-03-29 | 2019-10-11 | 天津键凯科技有限公司 | 聚乙二醇与雷帕霉素的结合物及其用途 |
| CN109045304B (zh) * | 2018-04-13 | 2022-04-05 | 中山大学 | 一种携带Polymerase I抑制剂的核仁靶向纳米载体及其制备方法和应用 |
| AU2020287627A1 (en) | 2019-06-04 | 2021-11-18 | Selecta Biosciences, Inc. | Formulations and doses of PEGylated uricase |
| WO2021016293A1 (en) * | 2019-07-22 | 2021-01-28 | University Of Louisville Research Foundation, Inc. | Immunomodulatory compositions and methods of using |
| EP4058006A4 (en) * | 2019-11-11 | 2023-06-28 | The Regents Of The University Of California | Polymeric nanoparticles that target liver sinusoidal endothelial cells to induce antigen-specific immune tolerance |
| CN110747276B (zh) * | 2019-11-22 | 2020-06-30 | 山东大学齐鲁医院 | Bace2作为胶质瘤预后/诊断/治疗标志物的应用 |
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| KR20230167405A (ko) | 2021-04-09 | 2023-12-08 | 셀렉타 바이오사이언시즈, 인크. | 면역 관용을 증진시키기 위해 고친화도 il-2 수용체 효능제와 조합된 면역억제제를 포함하는 합성 나노담체 |
| EP4079848A1 (en) | 2021-04-22 | 2022-10-26 | Genovis Ab | Immunoglobulin cleaving enzyme |
| US20230141563A1 (en) | 2021-10-12 | 2023-05-11 | Selecta Biosciences, Inc. | Methods and compositions for attenuating anti-viral transfer vector igm responses |
| WO2023064350A1 (en) | 2021-10-12 | 2023-04-20 | Selecta Biosciences, Inc. | Viral vector dosing protocols |
| WO2023172624A1 (en) | 2022-03-09 | 2023-09-14 | Selecta Biosciences, Inc. | Immunosuppressants in combination with anti-igm agents and related dosing |
| CN120813689A (zh) | 2022-08-11 | 2025-10-17 | 笛卡尔疗法股份有限公司 | 与免疫球蛋白蛋白酶及其融合体相关的组合物和方法 |
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