BR112015027288A8 - uso de uma dose de imunossupressor, composição de nanocarreadores sintéticos tolerogênicos e kit - Google Patents

uso de uma dose de imunossupressor, composição de nanocarreadores sintéticos tolerogênicos e kit Download PDF

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Publication number
BR112015027288A8
BR112015027288A8 BR112015027288A BR112015027288A BR112015027288A8 BR 112015027288 A8 BR112015027288 A8 BR 112015027288A8 BR 112015027288 A BR112015027288 A BR 112015027288A BR 112015027288 A BR112015027288 A BR 112015027288A BR 112015027288 A8 BR112015027288 A8 BR 112015027288A8
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effects
compositions
kit
composition
therapeutic macromolecules
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BR112015027288A
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BR112015027288A2 (pt
BR112015027288B1 (pt
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A Maldonado Roberto
Kei Kishimoto Takashi
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Selecta Biosciences Inc
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Publication of BR112015027288B1 publication Critical patent/BR112015027288B1/pt

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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Abstract

abstract disclosed are compositions and methods that provide pharmacodynamic effects specific to therapeutic macromolecules. the effects may result from reduced doses of therapeutic macromolecules in combination with immunosuppressant doses. the effects may also be enhanced with such compositions. tradução do resumo resumo patente de invenção: "nanocarreadores sintéticos tolerogênicos e macromoléculas terapêuticas para efeitos farmacodinâmicos acentuados ou reduzidos" a presente invenção refere-se a composições e métodos que fornecem efeitos farmacodinâmicos específicos para macromoléculas terapêuticas. os efeitos podem resultar de doses reduzidas de macromoléculas terapêuticas em combinação com doses de imunossupressor. os efeitos também podem ser acentuados com tais composições. 1/1
BR112015027288-6A 2013-05-03 2014-05-02 Composição que compreende um inibidor de mtor ligado a nanocarreadores sintéticos poliméricos BR112015027288B1 (pt)

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US201361819517P 2013-05-03 2013-05-03
US61/819,517 2013-05-03
US201361881913P 2013-09-24 2013-09-24
US201361881851P 2013-09-24 2013-09-24
US201361881921P 2013-09-24 2013-09-24
US61/881,851 2013-09-24
US201361907177P 2013-11-21 2013-11-21
US61/907,177 2013-11-21
US201461948313P 2014-03-05 2014-03-05
US201461948384P 2014-03-05 2014-03-05
US61/948,313 2014-03-05
US61/948,384 2014-03-05
PCT/US2014/036687 WO2014179762A1 (en) 2013-05-03 2014-05-02 Tolerogenic synthetic nanocarriers and therapeutic macromolecules for reduced or enhanced pharmacodynamic effects

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BR112015027281-9A BR112015027281B1 (pt) 2013-05-03 2014-05-02 Composições compreendendo macromoléculas terapêuticas e uma população de nanocarreadores sintéticos que são fixados a imunossupressores
BR122020023215-3A BR122020023215B1 (pt) 2013-05-03 2014-05-02 Composição e kit de nanocarreadores sintéticos tolerogênicos para reduzir ou prevenir anafilaxia em resposta a um antígeno não alergênico
BR112015027288-6A BR112015027288B1 (pt) 2013-05-03 2014-05-02 Composição que compreende um inibidor de mtor ligado a nanocarreadores sintéticos poliméricos
BR112015027279A BR112015027279A8 (pt) 2013-05-03 2014-05-02 métodos e composições para acentuar células t reguladoras cd4+
BR112015027291A BR112015027291A8 (pt) 2013-05-03 2014-05-02 uso de um imunossupressor que têm uma vida eficaz farmacodinâmica especificada e composição compreendendo o referido imunossupressor
BR112015027297-5A BR112015027297B1 (pt) 2013-05-03 2014-05-02 Uso de nanocarreadores sintéticos que são fixados a imunossupressores e de uma composição compreendendo os referidos nanocarreadores

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BR112015027281-9A BR112015027281B1 (pt) 2013-05-03 2014-05-02 Composições compreendendo macromoléculas terapêuticas e uma população de nanocarreadores sintéticos que são fixados a imunossupressores
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BR112015027297-5A BR112015027297B1 (pt) 2013-05-03 2014-05-02 Uso de nanocarreadores sintéticos que são fixados a imunossupressores e de uma composição compreendendo os referidos nanocarreadores

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