US20140335186A1 - Methods and compositions for enhancing cd4+ regulatory t cells - Google Patents

Methods and compositions for enhancing cd4+ regulatory t cells Download PDF

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US20140335186A1
US20140335186A1 US14/269,042 US201414269042A US2014335186A1 US 20140335186 A1 US20140335186 A1 US 20140335186A1 US 201414269042 A US201414269042 A US 201414269042A US 2014335186 A1 US2014335186 A1 US 2014335186A1
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synthetic nanocarriers
therapeutic
factor
cells
protein
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Takashi Kei Kishimoto
Roberto A. Maldonado
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Cartesian Therapeutics Inc
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Selecta Biosciences Inc
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Assigned to SELECTA BIOSCIENCES, INC. reassignment SELECTA BIOSCIENCES, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: KISHIMOTO, TAKASHI KEI, MALDONADO, Roberto A.
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US201361907177P 2013-11-21 2013-11-21
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US14/269,054 Active 2035-02-04 US10357482B2 (en) 2013-05-03 2014-05-02 Methods providing a therapeutic macromolecule and synthetic nanocarriers comprising immunosuppressant locally and concomitantly to reduce both type I and type IV hypersensitivity
US14/269,047 Active 2035-03-28 US10434088B2 (en) 2013-05-03 2014-05-02 Methods related to administering immunosuppressants and therapeutic macromolecules at a reduced pharmacodynamically effective dose
US14/269,056 Active 2035-04-20 US10357483B2 (en) 2013-05-03 2014-05-02 Methods comprising dosing combinations for reducing undesired humoral immune responses
US14/269,042 Pending US20140335186A1 (en) 2013-05-03 2014-05-02 Methods and compositions for enhancing cd4+ regulatory t cells
US16/410,876 Abandoned US20200069659A1 (en) 2013-05-03 2019-05-13 Methods of administering immunosuppressants having a specified pharmacodynamic effective life and therapeutic macromolecules for the induction of immune tolerance
US16/433,622 Pending US20200069660A1 (en) 2013-05-03 2019-06-06 Methods comprising dosing combinations for reducing undesired humoral immune responses
US16/438,147 Active US11298342B2 (en) 2013-05-03 2019-06-11 Methods providing a therapeutic macromolecule and synthetic nanocarriers comprising immunosuppressant locally and concomitantly to reduce both type I and type IV hypersensitivity
US16/550,725 Pending US20200113874A1 (en) 2013-05-03 2019-08-26 Methods related to administering immunosuppressants and therapeutic macromolecules at a reduced pharmacodynamically effective dose
US16/858,349 Pending US20200360350A1 (en) 2013-05-03 2020-04-24 Tolerogenic synthetic nanocarriers to reduce or prevent anaphylaxis in response to a non-allergenic antigen
US17/211,459 Abandoned US20220071968A1 (en) 2013-05-03 2021-03-24 Methods of administering immunosuppressants having a specified pharmacodynamic effective life and therapeutic macromolecules for the induction of immune tolerance
US17/690,437 Pending US20230032226A1 (en) 2013-05-03 2022-03-09 Methods providing a therapeutic macromolecule and synthetic nanocarriers comprising immunosuppressant locally and concomitantly to reduce both type 1 and type iv hypersensitivity

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US14/269,054 Active 2035-02-04 US10357482B2 (en) 2013-05-03 2014-05-02 Methods providing a therapeutic macromolecule and synthetic nanocarriers comprising immunosuppressant locally and concomitantly to reduce both type I and type IV hypersensitivity
US14/269,047 Active 2035-03-28 US10434088B2 (en) 2013-05-03 2014-05-02 Methods related to administering immunosuppressants and therapeutic macromolecules at a reduced pharmacodynamically effective dose
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US16/433,622 Pending US20200069660A1 (en) 2013-05-03 2019-06-06 Methods comprising dosing combinations for reducing undesired humoral immune responses
US16/438,147 Active US11298342B2 (en) 2013-05-03 2019-06-11 Methods providing a therapeutic macromolecule and synthetic nanocarriers comprising immunosuppressant locally and concomitantly to reduce both type I and type IV hypersensitivity
US16/550,725 Pending US20200113874A1 (en) 2013-05-03 2019-08-26 Methods related to administering immunosuppressants and therapeutic macromolecules at a reduced pharmacodynamically effective dose
US16/858,349 Pending US20200360350A1 (en) 2013-05-03 2020-04-24 Tolerogenic synthetic nanocarriers to reduce or prevent anaphylaxis in response to a non-allergenic antigen
US17/211,459 Abandoned US20220071968A1 (en) 2013-05-03 2021-03-24 Methods of administering immunosuppressants having a specified pharmacodynamic effective life and therapeutic macromolecules for the induction of immune tolerance
US17/690,437 Pending US20230032226A1 (en) 2013-05-03 2022-03-09 Methods providing a therapeutic macromolecule and synthetic nanocarriers comprising immunosuppressant locally and concomitantly to reduce both type 1 and type iv hypersensitivity

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US9987354B2 (en) 2011-04-29 2018-06-05 Selecta Biosciences, Inc. Tolerogenic synthetic nanocarriers for antigen-specific deletion of T effector cells
US10046064B2 (en) 2014-09-07 2018-08-14 Selecta Biosciences, Inc. Methods and compositions for attenuating exon skipping anti-viral transfer vector immune responses
US10335395B2 (en) 2013-05-03 2019-07-02 Selecta Biosciences, Inc. Methods of administering immunosuppressants having a specified pharmacodynamic effective life and therapeutic macromolecules for the induction of immune tolerance
US10933129B2 (en) 2011-07-29 2021-03-02 Selecta Biosciences, Inc. Methods for administering synthetic nanocarriers that generate humoral and cytotoxic T lymphocyte responses
US11426451B2 (en) 2017-03-11 2022-08-30 Selecta Biosciences, Inc. Methods and compositions related to combined treatment with antiinflammatories and synthetic nanocarriers comprising an immunosuppressant

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