CA2909226A1 - Purification of beta-hydroxy-beta-methyl butyrate via recrystallization and organic extraction - Google Patents

Purification of beta-hydroxy-beta-methyl butyrate via recrystallization and organic extraction

Info

Publication number
CA2909226A1
CA2909226A1 CA2909226A CA2909226A CA2909226A1 CA 2909226 A1 CA2909226 A1 CA 2909226A1 CA 2909226 A CA2909226 A CA 2909226A CA 2909226 A CA2909226 A CA 2909226A CA 2909226 A1 CA2909226 A1 CA 2909226A1
Authority
CA
Canada
Prior art keywords
beta
hydroxyl
methyl butyrate
methyl
crude
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2909226A
Other languages
English (en)
French (fr)
Inventor
Ling LONG
Yongchun Tang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TSI (CHINA) Co Ltd
Tsi Pharmaceutical (jiangyin) Co Ltd
Original Assignee
TSI (CHINA) Co Ltd
Tsi Pharmaceutical (jiangyin) Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TSI (CHINA) Co Ltd, Tsi Pharmaceutical (jiangyin) Co Ltd filed Critical TSI (CHINA) Co Ltd
Publication of CA2909226A1 publication Critical patent/CA2909226A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C07C51/29—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with halogen-containing compounds which may be formed in situ

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA2909226A 2013-04-12 2013-12-06 Purification of beta-hydroxy-beta-methyl butyrate via recrystallization and organic extraction Abandoned CA2909226A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201310127262.XA CN104098461B (zh) 2013-04-12 2013-04-12 一种β‑羟基‑β‑甲基丁酸的纯化方法
CN201310127262.X 2013-04-12
PCT/CN2013/088762 WO2014166273A1 (zh) 2013-04-12 2013-12-06 一种β−羟基−β−甲基丁酸的纯化方法

Publications (1)

Publication Number Publication Date
CA2909226A1 true CA2909226A1 (en) 2014-10-16

Family

ID=51667047

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2909226A Abandoned CA2909226A1 (en) 2013-04-12 2013-12-06 Purification of beta-hydroxy-beta-methyl butyrate via recrystallization and organic extraction

Country Status (12)

Country Link
US (1) US9598344B2 (zh)
EP (1) EP2985275B1 (zh)
JP (2) JP2016514733A (zh)
CN (1) CN104098461B (zh)
AU (2) AU2013386219B2 (zh)
CA (1) CA2909226A1 (zh)
DK (1) DK2985275T3 (zh)
ES (1) ES2763547T3 (zh)
HU (1) HUE048326T2 (zh)
PL (1) PL2985275T3 (zh)
PT (1) PT2985275T (zh)
WO (1) WO2014166273A1 (zh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10647653B2 (en) 2015-11-19 2020-05-12 Kyowa Hakko Bio Co., Ltd. Crystal of monovalent cation salt of 3-hydroxyisovaleric acid and process for producing the crystal
EP3476825A4 (en) 2016-06-24 2020-02-26 Kyowa Hakko Bio Co., Ltd. BETA-HYDROXY BETA-METHYLBUTYRIC ACID AMINO ACID SALT CRYSTAL AND METHOD FOR PRODUCING THE SAME
CN106699802B (zh) * 2016-12-21 2019-01-25 北京嘉林药业股份有限公司 一种阿托伐他汀钙中间体的纯化方法
WO2019016883A1 (ja) 2017-07-19 2019-01-24 小林香料株式会社 ３－ヒドロキシ－３－メチルブタン酸又はその塩の製造方法
CN108129294A (zh) * 2018-01-24 2018-06-08 穆云 一种HMB-Ca生产工艺方法
CN108484359A (zh) * 2018-03-20 2018-09-04 江阴技源药业有限公司 基于HMB-Ca乙醇残液回收乙醇及有效成分的方法
CN108558641A (zh) * 2018-05-15 2018-09-21 江苏玺鑫维生素有限公司 一种β-羟基-β-甲基丁酸钙的制备及纯化方法
CN110092714A (zh) * 2019-04-26 2019-08-06 江西科技师范大学 一种2,2-二羟甲基丁酸的制备方法
CN111410605A (zh) * 2020-04-07 2020-07-14 苏州永健生物医药有限公司 一种β-羟基-β-甲基丁酸钙的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3228963A (en) * 1961-12-22 1966-01-11 Union Oil Co Process for purification of complex acids
US4992470A (en) 1990-02-08 1991-02-12 Iowa State University Research Foundation, Inc. Method of enhancing immune response of mammals
US6090978A (en) * 1996-07-19 2000-07-18 Met-Rx Usa, Inc. Process for manufacturing 3-hydroxy-3-methylbutanoic acid
CN1417190A (zh) * 2002-12-05 2003-05-14 迈特（上海）生物科技有限公司 β－羟基－β－甲基丁酸钙（HMB－Ca）的制备方法
JP2014525410A (ja) * 2011-08-15 2014-09-29 アボット・ラボラトリーズ Ｈｍｂ及びその塩を製造する方法
CN102911085A (zh) * 2012-10-24 2013-02-06 甘肃省化工研究院 化合物d-2-氨氧基-3-甲基丁酸的合成工艺

Also Published As

Publication number Publication date
DK2985275T3 (da) 2020-01-20
US9598344B2 (en) 2017-03-21
CN104098461B (zh) 2017-06-16
PT2985275T (pt) 2020-01-07
AU2018260972A1 (en) 2018-11-29
WO2014166273A1 (zh) 2014-10-16
US20160052856A1 (en) 2016-02-25
HUE048326T2 (hu) 2020-07-28
EP2985275A1 (en) 2016-02-17
PL2985275T3 (pl) 2020-04-30
CN104098461A (zh) 2014-10-15
EP2985275B1 (en) 2019-10-30
EP2985275A4 (en) 2016-11-23
JP2016514733A (ja) 2016-05-23
AU2013386219A1 (en) 2015-12-03
JP2018158936A (ja) 2018-10-11
AU2013386219B2 (en) 2018-08-09
AU2018260972B2 (en) 2020-09-03
ES2763547T3 (es) 2020-05-29

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20180928

FZDE Discontinued

Effective date: 20220505

FZDE Discontinued

Effective date: 20220505