CN108530516A - 高手性纯度匹多莫德的合成提纯工艺 - Google Patents
高手性纯度匹多莫德的合成提纯工艺 Download PDFInfo
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- CN108530516A CN108530516A CN201810331512.4A CN201810331512A CN108530516A CN 108530516 A CN108530516 A CN 108530516A CN 201810331512 A CN201810331512 A CN 201810331512A CN 108530516 A CN108530516 A CN 108530516A
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- pidotimod
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- chiral purity
- monocrystalline
- high chiral
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
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CN201810331512.4A CN108530516B (zh) | 2018-04-13 | 2018-04-13 | 高手性纯度匹多莫德的合成提纯工艺 |
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CN201810331512.4A CN108530516B (zh) | 2018-04-13 | 2018-04-13 | 高手性纯度匹多莫德的合成提纯工艺 |
Publications (2)
Publication Number | Publication Date |
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CN108530516A true CN108530516A (zh) | 2018-09-14 |
CN108530516B CN108530516B (zh) | 2022-02-15 |
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CN201810331512.4A Active CN108530516B (zh) | 2018-04-13 | 2018-04-13 | 高手性纯度匹多莫德的合成提纯工艺 |
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CN (1) | CN108530516B (zh) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102167727A (zh) * | 2011-01-29 | 2011-08-31 | 浙江金立源药业有限公司 | 一种匹多莫德的合成方法 |
CN102492020A (zh) * | 2011-11-28 | 2012-06-13 | 海南灵康制药有限公司 | 一种匹多莫德化合物及其新制法 |
CN102952172A (zh) * | 2011-08-18 | 2013-03-06 | 北京澳林森科技有限公司 | 匹多莫德的制备方法 |
CN105037175A (zh) * | 2014-07-18 | 2015-11-11 | 大丰海天医药科技有限公司 | 一种用于提高依非韦伦中间体光学纯度的方法 |
-
2018
- 2018-04-13 CN CN201810331512.4A patent/CN108530516B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102167727A (zh) * | 2011-01-29 | 2011-08-31 | 浙江金立源药业有限公司 | 一种匹多莫德的合成方法 |
CN102952172A (zh) * | 2011-08-18 | 2013-03-06 | 北京澳林森科技有限公司 | 匹多莫德的制备方法 |
CN102492020A (zh) * | 2011-11-28 | 2012-06-13 | 海南灵康制药有限公司 | 一种匹多莫德化合物及其新制法 |
CN105037175A (zh) * | 2014-07-18 | 2015-11-11 | 大丰海天医药科技有限公司 | 一种用于提高依非韦伦中间体光学纯度的方法 |
Non-Patent Citations (4)
Title |
---|
R.J. DAVEY等: "The chiral purity of a triazolylketone crystallised from racemic solu", 《JOURNAL OF CRYSTAL GROWTH》 * |
周晓云: "《酶学原理与酶工程》", 31 August 2005 * |
张开诚主编: "《普通高等教育"十三五"规划教材 化学实验教程》", 31 March 2018 * |
章璐幸: "手性固定相HPLC法分离测定匹多莫德对映异构体", 《中国药科大学学报》 * |
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Publication number | Publication date |
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CN108530516B (zh) | 2022-02-15 |
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Address after: 061199 West District, east of Jingwu Road, Cangzhou Lingang Economic and Technological Development Zone, Cangzhou City, Hebei Province Applicant after: CANGZHOU BRANCH OF BEIJING JINCHENG TAIER PHARM Co.,Ltd. Applicant after: Beijing Jincheng Taier Pharmaceutical Co.,Ltd. Applicant after: SHANDONG JINCHENG PHARMACEUTICAL GROUP CO.,LTD. Address before: 061199 West District, east of Jingwu Road, Cangzhou Lingang Economic and Technological Development Zone, Cangzhou City, Hebei Province Applicant before: CANGZHOU BRANCH COMPANY OF BEIJING LANEVA PHARMACEUTICAL CO.,LTD. Applicant before: BEIJING LANEVA PHARMACEUTICAL CO.,LTD. Applicant before: SHANDONG JINCHENG PHARMACEUTICAL GROUP CO.,LTD. |
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TA01 | Transfer of patent application right | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20220124 Address after: 061199 West District, east of Jingwu Road, Cangzhou Lingang Economic and Technological Development Zone, Cangzhou City, Hebei Province Applicant after: CANGZHOU BRANCH OF BEIJING JINCHENG TAIER PHARM Co.,Ltd. Applicant after: Beijing Jincheng Taier Pharmaceutical Co.,Ltd. Address before: 061199 West District, east of Jingwu Road, Cangzhou Lingang Economic and Technological Development Zone, Cangzhou City, Hebei Province Applicant before: CANGZHOU BRANCH OF BEIJING JINCHENG TAIER PHARM Co.,Ltd. Applicant before: Beijing Jincheng Taier Pharmaceutical Co.,Ltd. Applicant before: SHANDONG JINCHENG PHARMACEUTICAL GROUP CO.,LTD. |
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