CN104098461A - 一种β-羟基-β-甲基丁酸的纯化方法 - Google Patents
一种β-羟基-β-甲基丁酸的纯化方法 Download PDFInfo
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- CN104098461A CN104098461A CN201310127262.XA CN201310127262A CN104098461A CN 104098461 A CN104098461 A CN 104098461A CN 201310127262 A CN201310127262 A CN 201310127262A CN 104098461 A CN104098461 A CN 104098461A
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- beta
- hydroxy
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- methyl
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
- C07C51/29—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with halogen-containing compounds which may be formed in situ
Abstract
Description
原辅料名称 | 质量 | 投料量(每批) |
HMB酸粗品 | 自产 | 40kg |
乙醇 | 食品级 | 200kg |
氢氧化钙 | 食品级 | 根据pH |
硅藻土 | 食品级 | 2kg |
盐酸 | 食品级 | 根据pH |
乙酸乙酯 | 食品级 | 600kg |
Claims (10)
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310127262.XA CN104098461B (zh) | 2013-04-12 | 2013-04-12 | 一种β‑羟基‑β‑甲基丁酸的纯化方法 |
EP13881969.3A EP2985275B1 (en) | 2013-04-12 | 2013-12-06 | Beta-hydroxy-beta-methylbutyric acid purification method |
CA2909226A CA2909226A1 (en) | 2013-04-12 | 2013-12-06 | Purification of beta-hydroxy-beta-methyl butyrate via recrystallization and organic extraction |
HUE13881969A HUE048326T2 (hu) | 2013-04-12 | 2013-12-06 | Béta-hidroxi-béta-metil-vajsav tisztítási módszer |
DK13881969.3T DK2985275T3 (da) | 2013-04-12 | 2013-12-06 | Fremgangsmåde til oprensning af beta-hydroxy-beta-methylsmørsyre |
PCT/CN2013/088762 WO2014166273A1 (zh) | 2013-04-12 | 2013-12-06 | 一种β−羟基−β−甲基丁酸的纯化方法 |
PL13881969T PL2985275T3 (pl) | 2013-04-12 | 2013-12-06 | Sposób oczyszczania kwasu beta-hydroksy-beta-metylomasłowego |
US14/783,949 US9598344B2 (en) | 2013-04-12 | 2013-12-06 | β-Hydroxy-β-methylbutyric (HMB) acid purification method |
ES13881969T ES2763547T3 (es) | 2013-04-12 | 2013-12-06 | Método de purificación del ácido beta-hidroxi-beta-metilbutírico |
PT138819693T PT2985275T (pt) | 2013-04-12 | 2013-12-06 | Método de purificação do ácido beta-hidroxi-beta-metilbutírico |
AU2013386219A AU2013386219B2 (en) | 2013-04-12 | 2013-12-06 | Beta-hydroxy-beta-methylbutyric acid purification method |
JP2016506755A JP2016514733A (ja) | 2013-04-12 | 2013-12-06 | β‐ヒドロキシ‐β‐メチル酪酸の精製方法 |
JP2018113345A JP2018158936A (ja) | 2013-04-12 | 2018-06-14 | β‐ヒドロキシ‐β‐メチル酪酸の精製方法 |
AU2018260972A AU2018260972B2 (en) | 2013-04-12 | 2018-11-09 | ß-hydroxy-ß-methylbutyric acid purification method |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310127262.XA CN104098461B (zh) | 2013-04-12 | 2013-04-12 | 一种β‑羟基‑β‑甲基丁酸的纯化方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104098461A true CN104098461A (zh) | 2014-10-15 |
CN104098461B CN104098461B (zh) | 2017-06-16 |
Family
ID=51667047
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310127262.XA Active CN104098461B (zh) | 2013-04-12 | 2013-04-12 | 一种β‑羟基‑β‑甲基丁酸的纯化方法 |
Country Status (12)
Country | Link |
---|---|
US (1) | US9598344B2 (zh) |
EP (1) | EP2985275B1 (zh) |
JP (2) | JP2016514733A (zh) |
CN (1) | CN104098461B (zh) |
AU (2) | AU2013386219B2 (zh) |
CA (1) | CA2909226A1 (zh) |
DK (1) | DK2985275T3 (zh) |
ES (1) | ES2763547T3 (zh) |
HU (1) | HUE048326T2 (zh) |
PL (1) | PL2985275T3 (zh) |
PT (1) | PT2985275T (zh) |
WO (1) | WO2014166273A1 (zh) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106699802A (zh) * | 2016-12-21 | 2017-05-24 | 北京嘉林药业股份有限公司 | 一种阿托伐他汀钙中间体的纯化方法 |
CN108129294A (zh) * | 2018-01-24 | 2018-06-08 | 穆云 | 一种HMB-Ca生产工艺方法 |
CN108484359A (zh) * | 2018-03-20 | 2018-09-04 | 江阴技源药业有限公司 | 基于HMB-Ca乙醇残液回收乙醇及有效成分的方法 |
CN108558641A (zh) * | 2018-05-15 | 2018-09-21 | 江苏玺鑫维生素有限公司 | 一种β-羟基-β-甲基丁酸钙的制备及纯化方法 |
CN110092714A (zh) * | 2019-04-26 | 2019-08-06 | 江西科技师范大学 | 一种2,2-二羟甲基丁酸的制备方法 |
CN110785396A (zh) * | 2017-07-19 | 2020-02-11 | 小林香料株式会社 | 3-羟基-3-甲基丁酸或其盐的制备方法 |
CN111410605A (zh) * | 2020-04-07 | 2020-07-14 | 苏州永健生物医药有限公司 | 一种β-羟基-β-甲基丁酸钙的制备方法 |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6875288B2 (ja) * | 2015-11-19 | 2021-05-19 | 協和発酵バイオ株式会社 | 3−ヒドロキシイソ吉草酸の一価カチオン塩の結晶および該結晶の製造方法 |
SG11201811493UA (en) | 2016-06-24 | 2019-01-30 | Otsuka Pharma Factory Inc | Crystal of amino acid salt of 3-hydroxyisovaleric acid and production method thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6090978A (en) * | 1996-07-19 | 2000-07-18 | Met-Rx Usa, Inc. | Process for manufacturing 3-hydroxy-3-methylbutanoic acid |
CN1417190A (zh) * | 2002-12-05 | 2003-05-14 | 迈特(上海)生物科技有限公司 | β-羟基-β-甲基丁酸钙(HMB-Ca)的制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3228963A (en) * | 1961-12-22 | 1966-01-11 | Union Oil Co | Process for purification of complex acids |
US4992470A (en) | 1990-02-08 | 1991-02-12 | Iowa State University Research Foundation, Inc. | Method of enhancing immune response of mammals |
BR112014003434A2 (pt) * | 2011-08-15 | 2017-03-01 | Abbott Lab | processo para produção de hmb e seus sais |
CN102911085A (zh) * | 2012-10-24 | 2013-02-06 | 甘肃省化工研究院 | 化合物d-2-氨氧基-3-甲基丁酸的合成工艺 |
-
2013
- 2013-04-12 CN CN201310127262.XA patent/CN104098461B/zh active Active
- 2013-12-06 AU AU2013386219A patent/AU2013386219B2/en not_active Ceased
- 2013-12-06 PT PT138819693T patent/PT2985275T/pt unknown
- 2013-12-06 WO PCT/CN2013/088762 patent/WO2014166273A1/zh active Application Filing
- 2013-12-06 US US14/783,949 patent/US9598344B2/en active Active
- 2013-12-06 PL PL13881969T patent/PL2985275T3/pl unknown
- 2013-12-06 CA CA2909226A patent/CA2909226A1/en not_active Abandoned
- 2013-12-06 JP JP2016506755A patent/JP2016514733A/ja active Pending
- 2013-12-06 ES ES13881969T patent/ES2763547T3/es active Active
- 2013-12-06 EP EP13881969.3A patent/EP2985275B1/en active Active
- 2013-12-06 HU HUE13881969A patent/HUE048326T2/hu unknown
- 2013-12-06 DK DK13881969.3T patent/DK2985275T3/da active
-
2018
- 2018-06-14 JP JP2018113345A patent/JP2018158936A/ja active Pending
- 2018-11-09 AU AU2018260972A patent/AU2018260972B2/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6090978A (en) * | 1996-07-19 | 2000-07-18 | Met-Rx Usa, Inc. | Process for manufacturing 3-hydroxy-3-methylbutanoic acid |
CN1417190A (zh) * | 2002-12-05 | 2003-05-14 | 迈特(上海)生物科技有限公司 | β-羟基-β-甲基丁酸钙(HMB-Ca)的制备方法 |
Non-Patent Citations (2)
Title |
---|
吉卯祉等: "《有机化学》", 31 December 2002, 科学出版社 * |
孟津等: "β-羟基-β-甲基丁酸钙生产工艺的优化控制", 《河南化工》 * |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106699802A (zh) * | 2016-12-21 | 2017-05-24 | 北京嘉林药业股份有限公司 | 一种阿托伐他汀钙中间体的纯化方法 |
CN106699802B (zh) * | 2016-12-21 | 2019-01-25 | 北京嘉林药业股份有限公司 | 一种阿托伐他汀钙中间体的纯化方法 |
CN110785396A (zh) * | 2017-07-19 | 2020-02-11 | 小林香料株式会社 | 3-羟基-3-甲基丁酸或其盐的制备方法 |
CN112142590A (zh) * | 2017-07-19 | 2020-12-29 | 小林香料株式会社 | 3-羟基-3-甲基丁酸或其盐的制备方法 |
CN112159319A (zh) * | 2017-07-19 | 2021-01-01 | 小林香料株式会社 | 3-羟基-3-甲基丁酸或其盐的制备方法 |
CN110785396B (zh) * | 2017-07-19 | 2021-01-29 | 小林香料株式会社 | 3-羟基-3-甲基丁酸或其盐的制备方法 |
CN108129294A (zh) * | 2018-01-24 | 2018-06-08 | 穆云 | 一种HMB-Ca生产工艺方法 |
CN108484359A (zh) * | 2018-03-20 | 2018-09-04 | 江阴技源药业有限公司 | 基于HMB-Ca乙醇残液回收乙醇及有效成分的方法 |
CN108558641A (zh) * | 2018-05-15 | 2018-09-21 | 江苏玺鑫维生素有限公司 | 一种β-羟基-β-甲基丁酸钙的制备及纯化方法 |
CN110092714A (zh) * | 2019-04-26 | 2019-08-06 | 江西科技师范大学 | 一种2,2-二羟甲基丁酸的制备方法 |
CN111410605A (zh) * | 2020-04-07 | 2020-07-14 | 苏州永健生物医药有限公司 | 一种β-羟基-β-甲基丁酸钙的制备方法 |
Also Published As
Publication number | Publication date |
---|---|
AU2018260972A1 (en) | 2018-11-29 |
US20160052856A1 (en) | 2016-02-25 |
WO2014166273A1 (zh) | 2014-10-16 |
PL2985275T3 (pl) | 2020-04-30 |
ES2763547T3 (es) | 2020-05-29 |
EP2985275A4 (en) | 2016-11-23 |
AU2013386219A1 (en) | 2015-12-03 |
JP2016514733A (ja) | 2016-05-23 |
CA2909226A1 (en) | 2014-10-16 |
AU2018260972B2 (en) | 2020-09-03 |
CN104098461B (zh) | 2017-06-16 |
PT2985275T (pt) | 2020-01-07 |
JP2018158936A (ja) | 2018-10-11 |
AU2013386219B2 (en) | 2018-08-09 |
HUE048326T2 (hu) | 2020-07-28 |
DK2985275T3 (da) | 2020-01-20 |
EP2985275A1 (en) | 2016-02-17 |
US9598344B2 (en) | 2017-03-21 |
EP2985275B1 (en) | 2019-10-30 |
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GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20210623 Address after: 2 Jinxiu Road, Shizhuang Industrial Park, Huangtu Town, Jiangyin City, Wuxi City, Jiangsu Province Patentee after: JIANGYIN JIYUAN PHARMACEUTICAL Co.,Ltd. Address before: 214446 No.2 Jinxiu Road, Shizhuang Park, Jiangyin Economic Development Zone, Jiangsu Province Patentee before: JIANGYIN JIYUAN PHARMACEUTICAL Co.,Ltd. Patentee before: TSI (CHINA) Co.,Ltd. |
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TR01 | Transfer of patent right | ||
CP01 | Change in the name or title of a patent holder |
Address after: 2 Jinxiu Road, Shizhuang Industrial Park, Huangtu Town, Jiangyin City, Wuxi City, Jiangsu Province Patentee after: Jiyuan Group Co.,Ltd. Address before: 2 Jinxiu Road, Shizhuang Industrial Park, Huangtu Town, Jiangyin City, Wuxi City, Jiangsu Province Patentee before: JIANGYIN JIYUAN PHARMACEUTICAL Co.,Ltd. |
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CP01 | Change in the name or title of a patent holder |