CA2873404C - Membrane encapsulated nanoparticles and method of use - Google Patents

Membrane encapsulated nanoparticles and method of use Download PDF

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Publication number
CA2873404C
CA2873404C CA2873404A CA2873404A CA2873404C CA 2873404 C CA2873404 C CA 2873404C CA 2873404 A CA2873404 A CA 2873404A CA 2873404 A CA2873404 A CA 2873404A CA 2873404 C CA2873404 C CA 2873404C
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nanoparticle
cell
membrane
derived
plasma membrane
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French (fr)
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CA2873404A1 (en
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Liangfang Zhang
Ronnie Hongbo Fang
Che-ming HU (jack)
Jonathan COPP
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University of California San Diego UCSD
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University of California San Diego UCSD
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/148—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/085—Staphylococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
    • A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5176—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/80—Vaccine for a specifically defined cancer

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Physics & Mathematics (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
CA2873404A 2011-06-02 2012-05-24 Membrane encapsulated nanoparticles and method of use Active CA2873404C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161492626P 2011-06-02 2011-06-02
US61/492,626 2011-06-02
PCT/US2012/039411 WO2013052167A2 (en) 2011-06-02 2012-05-24 Membrane encapsulated nanoparticles and method of use

Publications (2)

Publication Number Publication Date
CA2873404A1 CA2873404A1 (en) 2013-04-11
CA2873404C true CA2873404C (en) 2022-08-30

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Country Status (9)

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US (5) US12097290B2 (https=)
EP (2) EP2714017B1 (https=)
JP (1) JP6100762B2 (https=)
CN (2) CN107115314B (https=)
CA (1) CA2873404C (https=)
DK (1) DK2714017T3 (https=)
ES (1) ES2685333T3 (https=)
TW (2) TWI638667B (https=)
WO (1) WO2013052167A2 (https=)

Families Citing this family (179)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012019168A2 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP2625189B1 (en) 2010-10-01 2018-06-27 ModernaTX, Inc. Engineered nucleic acids and methods of use thereof
AU2012236099A1 (en) 2011-03-31 2013-10-03 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
EP2714017B1 (en) 2011-06-02 2018-08-01 The Regents of The University of California Membrane encapsulated nanoparticles and method of use
US9541512B2 (en) * 2011-06-13 2017-01-10 President And Fellows Of Harvard College Multi-color nanoscale imaging based on nanoparticle cathodoluminescence
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
DE19216461T1 (de) 2011-10-03 2021-10-07 Modernatx, Inc. Modifizierte nukleoside, nukleotide und nukleinsäuren und verwendungen davon
CA3018046A1 (en) 2011-12-16 2013-06-20 Moderna Therapeutics, Inc. Modified nucleoside, nucleotide, and nucleic acid compositions
EP2805143A4 (en) * 2012-01-17 2015-08-12 Scripps Research Inst DEVICE AND METHOD FOR PRODUCING SAMPLES FOR ELECTRONIC MICROSCOPY
WO2013109405A1 (en) * 2012-01-17 2013-07-25 The Scripps Research Institute Preparation of specimen arrays on an em grid
US9254311B2 (en) 2012-04-02 2016-02-09 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
WO2013151665A2 (en) 2012-04-02 2013-10-10 modeRNA Therapeutics Modified polynucleotides for the production of proteins associated with human disease
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
EP2833893B1 (en) * 2012-04-03 2018-08-29 Reneuron Limited Stem cell microparticles
PL2922554T3 (pl) 2012-11-26 2022-06-20 Modernatx, Inc. Na zmodyfikowany na końcach
WO2014152211A1 (en) 2013-03-14 2014-09-25 Moderna Therapeutics, Inc. Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
WO2014197622A2 (en) * 2013-06-04 2014-12-11 The Regents Of The University Of California Liver-mimetic device and method for simulation of hepatic function using such device
WO2015021390A2 (en) 2013-08-08 2015-02-12 The Regents Of The University Of California Nanoparticles leverage biological membranes to target pathogens for disease treatment and diagnosis
GB201317887D0 (en) 2013-10-09 2013-11-20 Reneuron Ltd Product
EP3041934A1 (en) 2013-09-03 2016-07-13 Moderna Therapeutics, Inc. Chimeric polynucleotides
WO2015034925A1 (en) 2013-09-03 2015-03-12 Moderna Therapeutics, Inc. Circular polynucleotides
WO2015048744A2 (en) 2013-09-30 2015-04-02 Moderna Therapeutics, Inc. Polynucleotides encoding immune modulating polypeptides
EP3052521A1 (en) 2013-10-03 2016-08-10 Moderna Therapeutics, Inc. Polynucleotides encoding low density lipoprotein receptor
US20170000875A1 (en) 2013-12-02 2017-01-05 Arytha Biosciences, Llc Toxoid preparation and uses thereof
CN106163504B (zh) * 2014-03-20 2021-02-09 加利福尼亚大学董事会 水凝胶毒素-吸收或结合纳米颗粒
PL4023249T3 (pl) 2014-04-23 2025-03-10 Modernatx, Inc. Szczepionki z kwasem nukleinowym
US10117886B2 (en) 2014-05-30 2018-11-06 Hao Cheng Hyaluronidase and a low density second PEG layer on the surface of therapeutic-encapsulated nanoparticles to enhance nanoparticle diffusion and circulation
WO2015187502A1 (en) * 2014-06-02 2015-12-10 Cellics Therapeutics, Inc. Use of nanoparticles coated with red blood cell membranes to treat hemolytic diseases and disorders
US20170204152A1 (en) 2014-07-16 2017-07-20 Moderna Therapeutics, Inc. Chimeric polynucleotides
EP3171895A1 (en) 2014-07-23 2017-05-31 Modernatx, Inc. Modified polynucleotides for the production of intrabodies
WO2016028965A1 (en) * 2014-08-20 2016-02-25 The Regents Of The University Of California Self-antigen displaying nanoparticles targeting auto-reactive immune factors and uses thereof
WO2016044483A1 (en) 2014-09-16 2016-03-24 The Regents Of The University Of California Method for fabrication of microwells for controlled formation of 3-dimensional multicellular-shapes
EA035898B1 (ru) 2014-10-03 2020-08-28 НАНОТИКС, ЭлЭлСи Композиции и способы для ингибирования биологической активности растворимых биомолекул
US10434070B2 (en) 2015-01-02 2019-10-08 Cellics Therapeutics, Inc. Use of nanoparticles coated with red blood cell membranes to enable blood transfusion
KR101720851B1 (ko) * 2015-01-29 2017-03-28 포항공과대학교 산학협력단 세포의 지질막에서 유래된 나노소포체 및 이의 용도
EP3265063A4 (en) 2015-03-03 2018-11-07 Cureport, Inc. Dual loaded liposomal pharmaceutical formulations
US9895313B2 (en) 2015-03-03 2018-02-20 Cureport, Inc. Combination liposomal pharmaceutical formulations
WO2016153979A1 (en) * 2015-03-20 2016-09-29 The Regents Of The University Of California Modulating antibacterial immunity via bacterial membrane-coated nanoparticles
EP3285742A4 (en) * 2015-04-20 2018-11-21 Academia Sinica Platelet-like proteo-microparticles and method of using such in drug delivery
WO2016176041A1 (en) * 2015-04-29 2016-11-03 The Regents Of The University Of California Detoxification using nanoparticles
CN104922671B (zh) * 2015-06-09 2017-12-08 深圳先进技术研究院 一种吲哚菁绿复合纳米颗粒及其制备方法和应用
EP3307890A1 (en) * 2015-06-10 2018-04-18 Board of Regents, The University of Texas System Use of exosomes for the treatment of disease
WO2016205009A1 (en) * 2015-06-19 2016-12-22 The Regents Of The University Of California Treating infection by a platelet-targeting microbe using nanoparticles
WO2016205010A1 (en) * 2015-06-19 2016-12-22 The Regents Of The University Of California Treating vasculature related diseases or disorders using nanoparticles
CN114129737A (zh) * 2015-06-30 2022-03-04 纳米提克斯有限责任公司 与清除颗粒相关的组合物和方法
US11491115B2 (en) * 2015-07-09 2022-11-08 The Board Of Regents Of The University Of Texas System Nanoparticles containing extracellular matrix for drug delivery
US11364292B2 (en) 2015-07-21 2022-06-21 Modernatx, Inc. CHIKV RNA vaccines
MA42502A (fr) 2015-07-21 2018-05-30 Modernatx Inc Vaccins contre une maladie infectieuse
CN108136023B (zh) * 2015-08-12 2021-07-27 北卡罗莱纳州立大学 血小板膜包覆的药物递送系统
WO2017030929A1 (en) * 2015-08-14 2017-02-23 The Johns Hopkins University Decoy nanoparticles to disrupt cancer cell-stormal cell networks
JP6948313B6 (ja) 2015-09-17 2022-01-14 モデルナティエックス インコーポレイテッド 治療剤の細胞内送達のための化合物および組成物
AU2016342376A1 (en) 2015-10-22 2018-06-07 Modernatx, Inc. Sexually transmitted disease vaccines
WO2017070601A1 (en) 2015-10-22 2017-04-27 Modernatx, Inc. Nucleic acid vaccines for varicella zoster virus (vzv)
WO2017070624A1 (en) 2015-10-22 2017-04-27 Modernatx, Inc. Tropical disease vaccines
EP4011451A1 (en) 2015-10-22 2022-06-15 ModernaTX, Inc. Metapneumovirus mrna vaccines
WO2017087897A1 (en) 2015-11-18 2017-05-26 Arytha Biosciences, Llc Processes and systems for preparing cellular or viral membranes and nanoparticles
PL3386484T3 (pl) 2015-12-10 2022-07-25 Modernatx, Inc. Kompozycje i sposoby dostarczania środków terapeutycznych
LT3394030T (lt) 2015-12-22 2022-04-11 Modernatx, Inc. Junginiai ir kompozicijos terapinei medžiagai teikti intraceliuliniu būdu
PL3394093T3 (pl) 2015-12-23 2022-05-16 Modernatx, Inc. Metody stosowania polinukleotydów kodujących ligand ox40
WO2017117275A1 (en) * 2015-12-31 2017-07-06 City Of Hope Silica nanoparticle with platinum anti-cancer agent
US11000593B2 (en) 2016-01-08 2021-05-11 The Regents Of The University Of California Cellular or viral membrane coated nanostructures and uses thereof
MA43587A (fr) 2016-01-10 2018-11-14 Modernatx Inc Arnm thérapeutiques codant pour des anticorps anti-ctla-4
CN105497912A (zh) * 2016-01-21 2016-04-20 华东师范大学 红细胞膜包裹的酸敏感高分子前药纳米递药系统的制备方法及用途
CN105769818B (zh) * 2016-03-16 2019-03-01 华东师范大学 用于抗体药物递送的红细胞膜包裹的抗体纳米粒子及制备方法
US20200289666A1 (en) * 2016-03-28 2020-09-17 The Johns Hopkins University Biomimetic anisotropic polymeric particles with naturally derived cell membranes for enhanced drug delivery
CN106362148B (zh) * 2016-09-12 2019-08-27 中南大学 一种普鲁士蓝纳米介晶细胞膜包覆修饰方法
US11564889B2 (en) 2016-09-29 2023-01-31 North Carolina State University Stem cell biomimetic microparticles
CN110114072A (zh) * 2016-11-02 2019-08-09 纳米珀特伊根公司 聚合物纳米颗粒
US11583504B2 (en) 2016-11-08 2023-02-21 Modernatx, Inc. Stabilized formulations of lipid nanoparticles
MA46766A (fr) 2016-11-11 2019-09-18 Modernatx Inc Vaccin antigrippal
CN106620684A (zh) * 2016-11-18 2017-05-10 上海交通大学医学院附属新华医院 一种泛耐药菌的纳米疫苗及其制备方法
WO2018107088A2 (en) 2016-12-08 2018-06-14 Modernatx, Inc. Respiratory virus nucleic acid vaccines
US11065345B2 (en) 2017-01-04 2021-07-20 Nanotics, Llc Methods for assembling scavenging particles
CA3055653A1 (en) 2017-03-15 2018-09-20 Modernatx, Inc. Lipid nanoparticle formulation
WO2018170322A1 (en) 2017-03-15 2018-09-20 Modernatx, Inc. Crystal forms of amino lipids
EP4186888B1 (en) 2017-03-15 2025-11-26 ModernaTX, Inc. Compound and compositions for intracellular delivery of therapeutic agents
EP3595713A4 (en) 2017-03-15 2021-01-13 ModernaTX, Inc. RESPIRATORY SYNCYTIAL VIRUS Vaccine
WO2018170245A1 (en) 2017-03-15 2018-09-20 Modernatx, Inc. Broad spectrum influenza virus vaccine
WO2018170256A1 (en) 2017-03-15 2018-09-20 Modernatx, Inc. Herpes simplex virus vaccine
WO2018170270A1 (en) 2017-03-15 2018-09-20 Modernatx, Inc. Varicella zoster virus (vzv) vaccine
CN108653236B (zh) 2017-03-31 2025-03-25 上海惠永药物研究有限公司 一种生物膜包载药物纳米晶体的制备方法及其用途
JP7329839B2 (ja) * 2017-04-21 2023-08-21 コアスター セラピューティクス インク． 膜脂質被覆されたナノ粒子および使用方法
WO2018232120A1 (en) 2017-06-14 2018-12-20 Modernatx, Inc. Compounds and compositions for intracellular delivery of agents
MA49421A (fr) 2017-06-15 2020-04-22 Modernatx Inc Formulations d'arn
WO2019022671A1 (en) * 2017-07-28 2019-01-31 National University Of Singapore BIOMOLECULAR COMPOSITES COMPRISING MODIFIED CELLULAR PHANTOMS
EP3675817A1 (en) 2017-08-31 2020-07-08 Modernatx, Inc. Methods of making lipid nanoparticles
WO2019055807A1 (en) 2017-09-14 2019-03-21 Modernatx, Inc. RNA VACCINES AGAINST ZIKA VIRUS
US20210187018A1 (en) * 2017-12-07 2021-06-24 Flagship Pioneering Innovations V, Inc. Cytobiologics and therapeutic uses thereof
CN108066317B (zh) * 2017-12-19 2020-04-03 中南大学湘雅三医院 纳米药物控释体系的制备方法及其产品与应用
WO2019143637A1 (en) 2018-01-18 2019-07-25 Cellics Therapeutics, Inc. Methods and compositions for quantifying hemoglobin
EP3746090A4 (en) 2018-01-29 2021-11-17 ModernaTX, Inc. RSV RNA Vaccines
CN108042510A (zh) * 2018-02-11 2018-05-18 复旦大学附属中山医院 一种靶向动脉粥样硬化斑块的血小板膜包被的雷帕霉素仿生纳米颗粒及其用途
US10842755B2 (en) 2018-03-23 2020-11-24 University Of South Carolina Nanoparticles for brain targeted drug delivery
EP3773520A4 (en) 2018-04-09 2021-12-22 Orgenesis Inc. BIOXOMES AND REDOXOMES PARTICLES, PROCESS AND COMPOSITION
CN108498805B (zh) * 2018-04-20 2021-04-09 中国科学院化学研究所 一种利用生物细胞膜提高阳离子共轭聚合物生物相容性的方法
US12478588B2 (en) 2018-05-25 2025-11-25 The Penn State Research Foundation Nanoparticle for protein delivery
US20230142496A1 (en) * 2018-06-18 2023-05-11 North Carolina State University Stem cell biomimetic nanoparticle therapeutic agents and uses thereof
CN112955174A (zh) 2018-07-09 2021-06-11 旗舰先锋创新V股份有限公司 融合剂脂质体组合物和其用途
WO2020023436A1 (en) * 2018-07-23 2020-01-30 Campbell Robert B Cell membrane lipid-extracted nanoparticles (clens) for selective targeting, image analysis and cancer therapy
US11096899B2 (en) * 2018-09-07 2021-08-24 Wisconsin Alumni Research Foundation Bacterial membrane nanoparticles as an immunotherapy system for cancer treatment
WO2020061367A1 (en) 2018-09-19 2020-03-26 Modernatx, Inc. Compounds and compositions for intracellular delivery of therapeutic agents
CA3113025A1 (en) 2018-09-19 2020-03-26 Modernatx, Inc. Peg lipids and uses thereof
WO2020061295A1 (en) 2018-09-19 2020-03-26 Modernatx, Inc. High-purity peg lipids and uses thereof
WO2020061457A1 (en) 2018-09-20 2020-03-26 Modernatx, Inc. Preparation of lipid nanoparticles and methods of administration thereof
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
WO2020080876A1 (ko) * 2018-10-18 2020-04-23 고려대학교 세종산학협력단 생체 물질 검출 센서 및 그 제조방법
CN113631718A (zh) 2018-11-14 2021-11-09 旗舰先锋创新V股份有限公司 用于特定隔室货物递送的组合物和方法
EP3883601A4 (en) * 2018-11-22 2022-07-20 Ramot at Tel-Aviv University Ltd. IMMUNOGENIC COMPOSITIONS WITH N-GLYCOLYLNEURAMINIC ACID CONTAINING NANOPARTICLES
CN111214439B (zh) * 2018-11-23 2023-02-10 复旦大学 一种具有细菌成孔毒素吸附性能的纳米药物系统及其用途
WO2020112694A1 (en) * 2018-11-26 2020-06-04 Arytha Biosciences Llc Nanoparticles containing cellular membrane and uses thereof
AU2019387353A1 (en) * 2018-11-28 2021-07-15 University Of Delaware Biomembrane-covered nanoparticles (BioNPs) for delivering active agents to stem cells
US10265017B1 (en) * 2018-12-12 2019-04-23 Lucas J. Myslinski Device, method and system for implementing a physical area network for cancer immunotherapy
US11351242B1 (en) 2019-02-12 2022-06-07 Modernatx, Inc. HMPV/hPIV3 mRNA vaccine composition
US12024709B2 (en) 2019-02-27 2024-07-02 Actym Therapeutics, Inc. Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment
JP2022524951A (ja) 2019-02-27 2022-05-11 アクティム・セラピューティクス・インコーポレイテッド 腫瘍、腫瘍常在免疫細胞および腫瘍微小環境にコロニー形成するよう操作した免疫刺激性細菌
US12070495B2 (en) 2019-03-15 2024-08-27 Modernatx, Inc. HIV RNA vaccines
US12522874B2 (en) 2019-04-30 2026-01-13 The Regents Of The University Of California Broad-spectrum nanoparticle enabled genomic detection
CN111956947A (zh) * 2019-05-20 2020-11-20 安行生物技术有限公司 向细胞内递送纳米颗粒的方法和装置
WO2020247576A1 (en) * 2019-06-07 2020-12-10 President And Fellows Of Harvard College Compositions and methods relating to erythrocytes with adhered particles
CN110179769A (zh) * 2019-06-11 2019-08-30 北京大学深圳医院 一种可以诱导病灶部位局部免疫应答的微纳米粒子药物载体
CN110269847A (zh) * 2019-06-21 2019-09-24 温州医科大学 一种用于中和细菌毒素的仿生纳米材料及其制备方法与应用
CN110302369B (zh) * 2019-06-28 2022-04-29 中国人民解放军陆军军医大学 以壳聚糖修饰PLGA的大肠杆菌Vo外膜蛋白纳米粒疫苗及其制备方法和应用
CN114144198A (zh) * 2019-07-16 2022-03-04 科斯塔治疗公司 膜脂包覆的纳米颗粒的制备方法
US20220331365A1 (en) * 2019-09-03 2022-10-20 The Regents Of The University Of California Biomimetic nanoemulsions for oxygen delivery
EP4031582A4 (en) * 2019-09-18 2023-10-04 The Regents of the University of California IMMUNOACTIVE MICROPARTICLES AND ASSOCIATED USES
AU2020350759A1 (en) 2019-09-19 2022-03-31 Modernatx, Inc. Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents
CA3155015A1 (en) 2019-09-19 2021-03-25 Modernatx, Inc. Carbonate containing lipid compounds and compositions for intracellular delivery of therapeutic agents
WO2021091582A1 (en) * 2019-11-08 2021-05-14 The Methodist Hospital Neurosome/astrosome compositions and methods of use
CA3107857A1 (en) * 2019-12-20 2021-06-20 Mcmaster University Hybrid biological membranes, methods of making and uses thereof
CN113041345B (zh) * 2019-12-26 2023-09-01 复旦大学 一种纳米类毒素疫苗及其用途
CN111111480B (zh) * 2020-01-09 2021-09-14 南京工业大学 一种唑来磷酸改性纳滤膜及其制备方法
CN115768499A (zh) * 2020-01-20 2023-03-07 阿瑞萨生物科技有限责任公司 含有细胞膜的装置及其用途
WO2021158939A1 (en) * 2020-02-07 2021-08-12 The Johns Hopkins University Compositions of alum nanoparticles for immunomodulation and methods for producing the same
WO2021163455A1 (en) * 2020-02-14 2021-08-19 The Trustees Of Columbia University In The City Of New York Scalable and facile cell-membrane-coating technology for both positively and negatively charged particles
CN111265549B (zh) * 2020-03-02 2022-03-01 苏州大学 表面pd-l1分子过表达的间充质干细胞膜包被的仿生纳米颗粒及其制备和应用
WO2021194938A1 (en) * 2020-03-24 2021-09-30 The Regents Of The University Of California Universal nanosponge for treating respiratory viral infection
CN113679829B (zh) * 2020-05-18 2024-01-02 北京繁易纳维科技有限公司 一种预防癌症术后复发的肿瘤疫苗及其制备方法和应用
CN111603454A (zh) * 2020-06-08 2020-09-01 上海交通大学医学院附属第九人民医院 一种多重靶向的融合细胞膜修饰的仿生纳米递送系统及其制备方法与应用
WO2022020985A1 (zh) * 2020-07-27 2022-02-03 上海市公共卫生临床中心 利用呼吸道上皮细胞膜防治呼吸道传染病的方法及应用
CN113041356B (zh) * 2020-10-28 2022-07-22 湖南中医药大学 血筒素靶向载药体系、制备方法及其应用
US20250009678A1 (en) * 2020-12-07 2025-01-09 Fortuga Bio Dendritic cell-mimicked nanostructure for application to cancer immunotherapy, and fabrication method therefor
US12041939B2 (en) 2020-12-08 2024-07-23 Cornell University Enzyme-loaded pollen-mimicking microparticles for organophosphate detoxification of insect pollinators
CN112730324B (zh) * 2020-12-17 2022-11-08 中山大学 基于量子点掺杂的pla纳米线共振散射折射率传感器
CN114762726A (zh) * 2021-01-15 2022-07-19 上海交通大学医学院附属仁济医院 抗原递呈细胞膜包裹的纳米颗粒及制备方法与应用
CN113209044A (zh) * 2021-01-29 2021-08-06 广州医科大学 靶向递送HDACIs的仿生纳米颗粒及其制备方法和应用
US11524023B2 (en) 2021-02-19 2022-12-13 Modernatx, Inc. Lipid nanoparticle compositions and methods of formulating the same
CN113244189A (zh) * 2021-02-22 2021-08-13 温州医科大学附属第二医院（温州医科大学附属育英儿童医院） 一种基于红细胞膜的超小仿生纳米颗粒制备方法
EP4323411A4 (en) * 2021-04-13 2025-04-02 McMaster University Functionalized biological membranes with modifying protein molecules, and methods of making and uses thereof
CN113181354B (zh) * 2021-04-25 2023-05-26 中国农业科学院兰州兽医研究所 基于树突状细胞的口蹄疫仿生纳米疫苗及其制备方法和应用
CN113133988B (zh) * 2021-04-26 2023-04-07 西南医科大学附属医院 一种红细胞膜仿生修饰的肾靶向纳米载药系统、制备方法及应用
CN113197880B (zh) * 2021-05-07 2021-11-12 皖南医学院第一附属医院（皖南医学院弋矶山医院） 一种巨噬细胞外泌体膜包被仿生纳米颗粒及其制备方法和应用
CN113633625B (zh) * 2021-05-19 2022-12-09 河南大学 一种杂膜负载氧化磷酸化抑制剂的纳米药物及其制备方法
CN113398900B (zh) * 2021-07-14 2023-03-31 广州汇标检测技术中心 一种针对黄曲霉毒素的分子印迹材料及其制备方法和应用
US20230032473A1 (en) * 2021-07-23 2023-02-02 Wisconsin Alumni Research Foundation Nad(h) nanoparticles and methods of use
CN113893229B (zh) * 2021-08-06 2023-09-05 四川省医学科学院·四川省人民医院 一种红细胞膜包裹藤黄酸的仿生纳米颗粒、制备方法及其应用
CN113925836A (zh) * 2021-09-29 2022-01-14 苏州大学 清除rankl的细胞膜包被纳米诱饵、其制备及应用
CN114129536A (zh) * 2021-12-03 2022-03-04 深圳市融创金石科技有限公司 仿生普鲁士蓝复合材料及其制备方法和应用
CN114470223B (zh) * 2022-01-13 2023-09-29 苏州大学 清除促炎因子和抑制t细胞活化的细胞膜包被纳米诱饵及其制备方法与应用
WO2023153832A1 (ko) * 2022-02-14 2023-08-17 가천대학교 산학협력단 병소에 대한 표적능이 강화된 엑토좀-생분해성 고분자 나노입자 복합체 및 그의 제조방법
US20250327041A1 (en) 2022-02-24 2025-10-23 Io Biotech Aps Nucleotide delivery of cancer therapy
CN114668772B (zh) * 2022-03-15 2024-12-10 温州医科大学附属第二医院（温州医科大学附属育英儿童医院） 负载两性霉素b仿生纳米系统的组合物、制备方法及应用
WO2023220067A1 (en) * 2022-05-09 2023-11-16 Yale University Immunotherapy of skin cancer using mpla-loaded hpg nanoparticles
CN115068606B (zh) * 2022-05-23 2023-05-16 山东大学 一种肿瘤靶向纳米制剂、制备方法及在抗肿瘤药物制备中的应用
CN115227671B (zh) * 2022-07-13 2024-01-19 中山大学附属第一医院 一种药物递送系统及其制备方法和应用
CN115590836B (zh) * 2022-09-27 2024-06-21 浙江大学 一种提高mRNA疫苗诱导免疫应答能力的脂质纳米颗粒及其应用
CN115708864A (zh) * 2022-11-24 2023-02-24 东南大学 血小板硼替佐米的药物组合物、方法及应用
CN116139104A (zh) * 2022-11-29 2023-05-23 深圳先进技术研究院 一种靶向性仿生聚多肽纳米递送载体、纳米核酸递送系统及其制备方法和应用
CN115804762B (zh) * 2022-12-20 2024-05-31 浙江大学 一种巨噬细胞膜包覆的异位子宫内膜靶向纳米粒、制备方法及应用
CN116270525B (zh) * 2023-02-22 2024-12-13 南京华盖制药有限公司 一种用于治疗肺部细菌感染性肺炎的可吸入仿生纳米材料及其制备方法和应用
CN118717701A (zh) * 2023-03-29 2024-10-01 国家纳米科学中心 细菌矿化金属纳米颗粒用于治疗肿瘤
WO2024249782A2 (en) * 2023-06-02 2024-12-05 The Methodist Hospital Biomimetic proteolipid nanovesicles for delivery of nucleic acids
CN116531344A (zh) * 2023-06-07 2023-08-04 重庆医科大学附属儿童医院 一种巨噬细胞膜修饰的纳米颗粒及其制备方法和应用
KR20250000043A (ko) * 2023-06-23 2025-01-02 한양대학교 산학협력단 나노입자, 이의 제조 방법 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물
CN116652180B (zh) * 2023-07-31 2023-09-26 环保桥(湖南)生态环境工程股份有限公司 一种基于零价铁粉的复合颗粒及其制备方法与应用
EP4520345A1 (en) 2023-09-06 2025-03-12 Myneo Nv Product
EP4556028A1 (en) 2023-11-14 2025-05-21 Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie - Hans-Knöll-Institut - Functionalized nanoparticles for viral clearance
CN120053376A (zh) * 2025-01-24 2025-05-30 深圳市龙岗中心医院 用于肿瘤光动力治疗的仿生纳米脂质体及其制备方法、在制备治疗肿瘤的药物中的应用

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59157033A (ja) * 1983-02-28 1984-09-06 Hidetoshi Tsuchida 赤血球ゴ−スト膜フラグメントからなる小胞体の製造方法および小胞体
US4891208A (en) 1985-04-10 1990-01-02 The Liposome Company, Inc. Steroidal liposomes
DK0487615T3 (da) * 1989-08-18 1994-03-14 Monsanto Co Ferritin-analoger
US5643577A (en) * 1990-04-24 1997-07-01 The University Of Newcastle Research Associates Limited Oral vaccine comprising antigen surface-associated with red blood cells
US5612034A (en) * 1990-10-03 1997-03-18 Redcell, Inc. Super-globuling for in vivo extended lifetimes
US5491219A (en) * 1993-06-11 1996-02-13 Protein Magnetics Ferritin with ferrimagnetically ordered ferrite core and method technical field
CA2150617C (en) * 1995-02-07 2001-10-30 Universite Laval Nanoerythrosome as bioactive agent carrier
CA2213906A1 (en) * 1996-09-23 1998-03-23 Dusica Maysinger Pharmaceutical composition and method for neuron rescue in ischemic stroke
US6395029B1 (en) * 1999-01-19 2002-05-28 The Children's Hospital Of Philadelphia Sustained delivery of polyionic bioactive agents
GB0007150D0 (en) * 2000-03-24 2000-05-17 Lamellar Therapeutics Limited Immunotherapeutic methods and compositions
AUPR011700A0 (en) 2000-09-14 2000-10-05 Austin Research Institute, The Composition comprising immunogenic virus sized particles (VSP)
FR2839260B1 (fr) * 2002-05-03 2005-02-25 Inst Nat Sante Rech Med Microparticules a base d'un materiau bicompatible et biodegradable, supportant des cellules et des substances biologiquement actives
US20040180094A1 (en) * 2003-03-11 2004-09-16 Hemolytics, Inc. Activation agents on the surface of encapsulation vesicles
JP5557415B2 (ja) 2003-06-02 2014-07-23 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド 吸着させたトキソイドおよび多糖類含有抗原を含む微粒子に基づく免疫原性組成物
EP1773303A2 (en) * 2004-05-25 2007-04-18 Chimeracore, Inc. Self-assembling nanoparticle drug delivery system
US20070258889A1 (en) * 2005-11-09 2007-11-08 Montana State University Novel nanoparticles and use thereof
EP2476433A1 (en) 2006-03-30 2012-07-18 GlaxoSmithKline Biologicals S.A. Immunogenic composition
US20070243137A1 (en) * 2006-04-18 2007-10-18 Nanoprobes, Inc. Cell and sub-cell methods for imaging and therapy
GB2439747A (en) 2006-07-03 2008-01-09 Uni Degli Studi Di Urbino Carl Delivery of contrasting agents for magnetic resonance imaging
WO2008013952A2 (en) * 2006-07-27 2008-01-31 The University Of North Carolina At Chapel Hill Nanoparticle fabrication methods, systems, and materials for fabricating artificial red blood cells
WO2008150276A2 (en) * 2006-09-26 2008-12-11 The Board Of Regents Of The University Of Texas System Virus coated nanoparticles and uses thereof
RU2345805C1 (ru) 2007-07-04 2009-02-10 Государственное образовательное учреждение высшего профессионального образования "Саратовский государственный университет им. Н.Г. Чернышевского" Способ лазерного фототермолиза серповидно-клеточных эритроцитов
US8329161B2 (en) * 2008-05-01 2012-12-11 National Health Research Institutes Red blood cell-derived vesicles as a nanoparticle drug delivery system
EP2711021B1 (en) 2008-05-02 2016-03-09 BliNK Therapeutics Limited Products and methods for stimulating an immune response
CN101306196B (zh) 2008-07-03 2011-05-11 中国科学院长春应用化学研究所 一种生物降解的键合了血红蛋白分子的纳米粒子及制法
US20110262415A1 (en) * 2008-12-21 2011-10-27 Cnr - Consiglio Nazionale Delle Ricerche Erythrocyte-based delivery system, method of preparation and uses thereof
CN102596177B (zh) * 2009-07-01 2014-05-28 阿昂梅迪克斯公司 来源于有核哺乳动物细胞的微囊泡及其应用
CN101735613B (zh) 2009-12-08 2012-09-05 四川大学 一种聚合物多孔纳米微球及其制备方法
EP2547370A4 (en) * 2010-03-17 2014-06-25 Univ Texas UNIVERSAL CELL-ORIENTED THEROSTICISM
CA2798739A1 (en) * 2010-05-26 2011-12-01 Selecta Biosciences, Inc. Nanocarrier compositions with uncoupled adjuvant
GB201011968D0 (en) 2010-07-16 2010-09-01 Secr Defence Toxoiding method
CN101926984B (zh) * 2010-08-05 2012-09-05 中国人民解放军第四军医大学 一种人工纳米红细胞的制备方法
CN101934080B (zh) * 2010-09-08 2012-05-23 西北大学 一种利用静电自组装涂层改善材料血液相容性的方法
AU2012249474A1 (en) * 2011-04-28 2013-11-07 Stc.Unm Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery and methods of using same
EP2714017B1 (en) 2011-06-02 2018-08-01 The Regents of The University of California Membrane encapsulated nanoparticles and method of use
WO2015021390A2 (en) * 2013-08-08 2015-02-12 The Regents Of The University Of California Nanoparticles leverage biological membranes to target pathogens for disease treatment and diagnosis
US20170000875A1 (en) 2013-12-02 2017-01-05 Arytha Biosciences, Llc Toxoid preparation and uses thereof
CN106163504B (zh) * 2014-03-20 2021-02-09 加利福尼亚大学董事会 水凝胶毒素-吸收或结合纳米颗粒
WO2015187502A1 (en) 2014-06-02 2015-12-10 Cellics Therapeutics, Inc. Use of nanoparticles coated with red blood cell membranes to treat hemolytic diseases and disorders
WO2016028965A1 (en) * 2014-08-20 2016-02-25 The Regents Of The University Of California Self-antigen displaying nanoparticles targeting auto-reactive immune factors and uses thereof
US10434070B2 (en) 2015-01-02 2019-10-08 Cellics Therapeutics, Inc. Use of nanoparticles coated with red blood cell membranes to enable blood transfusion
WO2016153979A1 (en) * 2015-03-20 2016-09-29 The Regents Of The University Of California Modulating antibacterial immunity via bacterial membrane-coated nanoparticles
WO2016176041A1 (en) * 2015-04-29 2016-11-03 The Regents Of The University Of California Detoxification using nanoparticles
WO2016205009A1 (en) * 2015-06-19 2016-12-22 The Regents Of The University Of California Treating infection by a platelet-targeting microbe using nanoparticles
WO2016205010A1 (en) 2015-06-19 2016-12-22 The Regents Of The University Of California Treating vasculature related diseases or disorders using nanoparticles
WO2017087897A1 (en) * 2015-11-18 2017-05-26 Arytha Biosciences, Llc Processes and systems for preparing cellular or viral membranes and nanoparticles
US11000593B2 (en) * 2016-01-08 2021-05-11 The Regents Of The University Of California Cellular or viral membrane coated nanostructures and uses thereof

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