CA2850264C - Pyrrolobenzodiazepines - Google Patents
Pyrrolobenzodiazepines Download PDFInfo
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- CA2850264C CA2850264C CA2850264A CA2850264A CA2850264C CA 2850264 C CA2850264 C CA 2850264C CA 2850264 A CA2850264 A CA 2850264A CA 2850264 A CA2850264 A CA 2850264A CA 2850264 C CA2850264 C CA 2850264C
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- YUOCYTRGANSSRY-UHFFFAOYSA-N pyrrolo[2,3-i][1,2]benzodiazepine Chemical class C1=CN=NC2=C3C=CN=C3C=CC2=C1 YUOCYTRGANSSRY-UHFFFAOYSA-N 0.000 title description 4
- 150000001875 compounds Chemical class 0.000 claims abstract description 87
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 76
- 125000003118 aryl group Chemical group 0.000 claims abstract description 76
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- 125000001424 substituent group Chemical group 0.000 claims abstract description 54
- 125000002947 alkylene group Chemical group 0.000 claims abstract description 25
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 18
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract description 17
- 150000001768 cations Chemical class 0.000 claims abstract description 16
- 125000005843 halogen group Chemical group 0.000 claims abstract description 16
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 14
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 13
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- 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 claims abstract description 8
- IBAHLNWTOIHLKE-UHFFFAOYSA-N cyano cyanate Chemical compound N#COC#N IBAHLNWTOIHLKE-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 5
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract description 4
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- OMRPLUKQNWNZAV-CONSDPRKSA-N (6as)-3-[3-[[(6as)-2-methoxy-8-(4-methoxyphenyl)-11-oxo-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-3-yl]oxy]propoxy]-8-(4-aminophenyl)-2-methoxy-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-11-one Chemical compound C1=CC(OC)=CC=C1C1=CN2C(=O)C3=CC(OC)=C(OCCCOC=4C(=CC=5C(=O)N6C=C(C[C@H]6C=NC=5C=4)C=4C=CC(N)=CC=4)OC)C=C3N=C[C@@H]2C1 OMRPLUKQNWNZAV-CONSDPRKSA-N 0.000 claims description 14
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- QWHNJUXXYKPLQM-UHFFFAOYSA-N dimethyl cyclopentane Natural products CC1(C)CCCC1 QWHNJUXXYKPLQM-UHFFFAOYSA-N 0.000 description 7
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161547204P | 2011-10-14 | 2011-10-14 | |
| US61/547,204 | 2011-10-14 | ||
| PCT/EP2012/070231 WO2013053871A1 (en) | 2011-10-14 | 2012-10-12 | Pyrrolobenzodiazepines |
Publications (2)
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| CA2850264A1 CA2850264A1 (en) | 2013-04-18 |
| CA2850264C true CA2850264C (en) | 2019-11-05 |
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| Application Number | Title | Priority Date | Filing Date |
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| CA2850264A Expired - Fee Related CA2850264C (en) | 2011-10-14 | 2012-10-12 | Pyrrolobenzodiazepines |
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| US (1) | US9388187B2 (OSRAM) |
| EP (1) | EP2751110B1 (OSRAM) |
| JP (1) | JP6117801B2 (OSRAM) |
| CN (2) | CN110183470A (OSRAM) |
| AU (1) | AU2012322932B2 (OSRAM) |
| BR (1) | BR112014008981A2 (OSRAM) |
| CA (1) | CA2850264C (OSRAM) |
| EA (1) | EA027386B1 (OSRAM) |
| WO (1) | WO2013053871A1 (OSRAM) |
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| GB0819095D0 (en) | 2008-10-17 | 2008-11-26 | Spirogen Ltd | Pyrrolobenzodiazepines |
| MX2012011900A (es) | 2010-04-15 | 2013-03-21 | Seattle Genetics Inc | Conjugados de pirrolobenzodiazepina diana. |
| US8697688B2 (en) | 2010-04-15 | 2014-04-15 | Seattle Genetics Inc. | Pyrrolobenzodiazepines used to treat proliferative diseases |
| EP2751120B1 (en) | 2011-09-20 | 2018-08-22 | MedImmune Limited | Pyrrolobenzodiazepines as unsymmetrical dimeric pbd compounds for inclusion in targeted conjugates |
| US9387259B2 (en) | 2011-10-14 | 2016-07-12 | Seattle Genetics, Inc. | Pyrrolobenzodiazepines and targeted conjugates |
| CA2850373C (en) | 2011-10-14 | 2019-07-16 | Seattle Genetics, Inc. | Pyrrolobenzodiazepines and targeted conjugates |
| CN103998450B (zh) | 2011-10-14 | 2017-03-08 | 麦迪穆有限责任公司 | 吡咯并苯并二氮杂卓 |
| CN110183470A (zh) | 2011-10-14 | 2019-08-30 | 麦迪穆有限责任公司 | 吡咯并苯并二氮杂卓 |
| ES2680153T3 (es) | 2012-10-12 | 2018-09-04 | Adc Therapeutics Sa | Conjugados de anticuerpos anti-PSMA-pirrolobenzodiazepinas |
| WO2014057120A1 (en) | 2012-10-12 | 2014-04-17 | Adc Therapeutics Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
| PL2906251T3 (pl) | 2012-10-12 | 2018-02-28 | Adc Therapeutics Sa | Koniugaty pirolobenzodiazepina-przeciwciało anty-CD22 |
| DK2839860T3 (da) | 2012-10-12 | 2019-06-17 | Medimmune Ltd | Pyrrolobenzodiazepiner og konjugater deraf |
| MX364329B (es) | 2012-10-12 | 2019-04-23 | Medimmune Ltd | Conjugados del anticuerpo pirrolobenzodiazepina. |
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| CN105848685B (zh) | 2013-12-16 | 2020-09-22 | 健泰科生物技术公司 | 拟肽化合物及其抗体药物偶联物 |
| GB201406767D0 (en) | 2014-04-15 | 2014-05-28 | Cancer Rec Tech Ltd | Humanized anti-Tn-MUC1 antibodies anf their conjugates |
-
2012
- 2012-10-12 CN CN201910395572.7A patent/CN110183470A/zh active Pending
- 2012-10-12 AU AU2012322932A patent/AU2012322932B2/en not_active Ceased
- 2012-10-12 EP EP12772780.8A patent/EP2751110B1/en not_active Not-in-force
- 2012-10-12 CA CA2850264A patent/CA2850264C/en not_active Expired - Fee Related
- 2012-10-12 JP JP2014535095A patent/JP6117801B2/ja active Active
- 2012-10-12 EA EA201490554A patent/EA027386B1/ru not_active IP Right Cessation
- 2012-10-12 US US14/351,175 patent/US9388187B2/en not_active Expired - Fee Related
- 2012-10-12 BR BR112014008981A patent/BR112014008981A2/pt not_active Application Discontinuation
- 2012-10-12 CN CN201280061972.0A patent/CN103998449A/zh active Pending
- 2012-10-12 WO PCT/EP2012/070231 patent/WO2013053871A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP2751110B1 (en) | 2017-04-19 |
| JP2014528466A (ja) | 2014-10-27 |
| AU2012322932B2 (en) | 2016-11-10 |
| JP6117801B2 (ja) | 2017-04-19 |
| WO2013053871A1 (en) | 2013-04-18 |
| EA027386B1 (ru) | 2017-07-31 |
| BR112014008981A2 (pt) | 2017-05-02 |
| CN103998449A (zh) | 2014-08-20 |
| AU2012322932A1 (en) | 2014-05-29 |
| CN110183470A (zh) | 2019-08-30 |
| CA2850264A1 (en) | 2013-04-18 |
| US9388187B2 (en) | 2016-07-12 |
| EP2751110A1 (en) | 2014-07-09 |
| EA201490554A1 (ru) | 2015-06-30 |
| US20140234346A1 (en) | 2014-08-21 |
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