CA2803802A1 - Pyrrolo- pyrazine derivatives useful as inhibitors of atr kinase - Google Patents
Pyrrolo- pyrazine derivatives useful as inhibitors of atr kinase Download PDFInfo
- Publication number
- CA2803802A1 CA2803802A1 CA2803802A CA2803802A CA2803802A1 CA 2803802 A1 CA2803802 A1 CA 2803802A1 CA 2803802 A CA2803802 A CA 2803802A CA 2803802 A CA2803802 A CA 2803802A CA 2803802 A1 CA2803802 A1 CA 2803802A1
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- Prior art keywords
- compound
- nitrogen
- group
- carcinoma
- sulfur
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Classifications
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61N5/00—Radiation therapy
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- A61P35/00—Antineoplastic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
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- A61N2005/1092—Details
- A61N2005/1098—Enhancing the effect of the particle by an injected agent or implanted device
Landscapes
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- Radiology & Medical Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US35774510P | 2010-06-23 | 2010-06-23 | |
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| PCT/US2011/041705 WO2011163527A1 (en) | 2010-06-23 | 2011-06-23 | Pyrrolo- pyrazine derivatives useful as inhibitors of atr kinase |
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| CA2803802A1 true CA2803802A1 (en) | 2011-12-29 |
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| JP (2) | JP2013529643A (enExample) |
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| MX (1) | MX2013000103A (enExample) |
| NZ (1) | NZ605627A (enExample) |
| WO (1) | WO2011163527A1 (enExample) |
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| CA2798760A1 (en) | 2010-05-12 | 2011-11-17 | Vertex Pharmaceuticals Incorporated | 2-aminopyridine derivatives useful as inhibitors of atr kinase |
| US9630956B2 (en) | 2010-05-12 | 2017-04-25 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| EP2569287B1 (en) | 2010-05-12 | 2014-07-09 | Vertex Pharmaceuticals Inc. | Compounds useful as inhibitors of atr kinase |
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-
2011
- 2011-06-23 CA CA2803802A patent/CA2803802A1/en not_active Abandoned
- 2011-06-23 EP EP11729535.2A patent/EP2585468A1/en not_active Withdrawn
- 2011-06-23 NZ NZ605627A patent/NZ605627A/en not_active IP Right Cessation
- 2011-06-23 AU AU2011270807A patent/AU2011270807A1/en not_active Abandoned
- 2011-06-23 MX MX2013000103A patent/MX2013000103A/es not_active Application Discontinuation
- 2011-06-23 JP JP2013516779A patent/JP2013529643A/ja active Pending
- 2011-06-23 US US13/167,654 patent/US8623869B2/en not_active Expired - Fee Related
- 2011-06-23 WO PCT/US2011/041705 patent/WO2011163527A1/en not_active Ceased
-
2013
- 2013-12-13 US US14/105,778 patent/US20140288347A1/en not_active Abandoned
-
2015
- 2015-05-01 JP JP2015093810A patent/JP2015134834A/ja active Pending
- 2015-07-15 US US14/800,029 patent/US20160009723A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2011163527A1 (en) | 2011-12-29 |
| US20140288347A1 (en) | 2014-09-25 |
| US20160009723A1 (en) | 2016-01-14 |
| JP2013529643A (ja) | 2013-07-22 |
| EP2585468A1 (en) | 2013-05-01 |
| US8623869B2 (en) | 2014-01-07 |
| NZ605627A (en) | 2015-06-26 |
| MX2013000103A (es) | 2013-06-13 |
| AU2011270807A1 (en) | 2013-01-31 |
| US20120046295A1 (en) | 2012-02-23 |
| JP2015134834A (ja) | 2015-07-27 |
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